The unexpected link between osteoclasts and the immune system

Advances in Experimental Medicine and Biology

Volumn 658, Issue , 2010, Pages 61-68

  Takayanagi, Hiroshi ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Cathepsin K; NFATc1; Osteoclast; RANKL; T cells

Indexed keywords

BETA3 INTEGRIN; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CATHEPSIN K; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 4; KILLER CELL ACTIVATING RECEPTOR ASSOCIATED PROTEIN; MEMBRANE PROTEIN; NUCLEAR FACTOR OF ACTIVATED T CELL CYTOPLASMIC 1; OSTEOCLAST ASSOCIATED RECEPTOR; OSTEOCLAST DIFFERENTIATION FACTOR; PAIRED IMMUNOGLOBULIN LIKE RECEPTOR A; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SIGNAL REGULATORY PROTEIN BETA 1; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR NFAT; TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2; UNCLASSIFIED DRUG;

B LYMPHOCYTE; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL FUNCTION; CELL INTERACTION; CONFERENCE PAPER; DENDRITIC CELL; GENE EXPRESSION REGULATION; HUMAN; IMMUNE SYSTEM; IMMUNOMODULATION; IMMUNOREGULATION; MACROPHAGE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TH17 CELL; UPREGULATION;

ANIMALS; B-LYMPHOCYTES; CATHEPSIN K; DENDRITIC CELLS; HUMANS; IMMUNE SYSTEM; MICE; MODELS, BIOLOGICAL; OSTEOCLASTS; PROTEIN-TYROSINE KINASES; RANK LIGAND; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC;

EID: 79957931329     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-1050-9_7     Document Type: Conference Paper

References (18)

1. Asagiri M. Hirai T. Kunigami T. et al. 2008 Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science 319 624-627 (Pubitemid 351197065)
2. Asagiri M. Sato K. Usami T. et al. 2005 Autoamplification of NFATc1 expression determines its essential role in bone homeostasis. J Exp Med 202 1261-1269 (Pubitemid 41586956)
3. Dewhirst F.E. Stashenko P.P. Mole J.E. et al. 1985 Purification and partial sequence of human osteoclast-activating factor: identity with interleukin 1β. J Immunol 135 2562-2568 (Pubitemid 16215850)
4. Horton J.E. Raisz L.G. Simmons H.A. et al. 1972 Bone resorbing activity in supernatant fluid from cultured human peripheral blood leukocytes. Science 177 793-795
5. Kaifu T. Nakahara J. InuiM. et al. 2003 Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J Clin Invest 111 323-332 (Pubitemid 36182208)
6. Kim N. Takami M. Rho J. et al. 2002 A novel member of the leukocyte receptor complex regulates osteoclast differentiation. J Exp Med 195 201-209 (Pubitemid 34461264)
7. Koga T. Inui M. Inoue K. et al.(2004) Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 428 758-763 (Pubitemid 38508286)
8. Kong Y.Y. Feige U. Sarosi I. et al. 1999 Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Nature 402 304-309
9. Mocsai A. Humphrey M.B. Van Ziffle J.A. et al. 2004 The immunomodulatory adapter proteins DAP12 and Fc receptor-chain (FcR) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad Sci U S A 101 6158-6163 (Pubitemid 38520544)
10. Mundy G.R. Raisz L.G. Cooper R.A. et al. 1974 Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Engl J Med 291 1041-1046
11. Sato K. Suematsu A. Nakashima T. et al. 2006a Regulation of osteoclast differentiation and function by the CaMK-CREB pathway. Nat Med 12 1410-1416 (Pubitemid 44924500)
12. Sato K. Suematsu A. Okamoto K. et al. 2006b Th17 functions as an osteoclastogenic helper T cell subset that links T cell activation and bone destruction. J Exp Med 203 2673-2682 (Pubitemid 44833343)
13. Shinohara M. Koga T. Okamoto K. et al. 2008 Tyrosine kinases Btk and Tec regulate osteoclast differentiation by linking RANK and ITAM signals. Cell 132 794-806 (Pubitemid 351312796)
14. Takayanagi H. 2007 Osteoimmunology: shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol 7 292-304 (Pubitemid 46480961)
15. Takayanagi H. Kim S. Koga T. et al. 2002 Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling for terminal differentiation of osteoclasts. Dev Cell 3 889-901 (Pubitemid 35460788)
16. Takayanagi H. Ogasawara K. Hida S. et al. 2000 T cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-. Nature 408 600-605
17. Wagner E.F. & Eferl R. 2005 Fos/AP-1 proteins in bone and the immune system. Immunol Rev 208 126-140 (Pubitemid 41746389)
18. Yamashita T. Yao Z. Li F. et al. 2007 NF-κB p50 and p52 regulate receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1. J Biol Chem 282 18245-18253 (Pubitemid 47100255)