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Volumn 70, Issue 2, 2015, Pages 470-478

In vitro interactions between farnesol and fluconazole, amphotericin b or micafungin against candida albicans biofilms

Author keywords

Antifungals; C. albicans; Combinations

Indexed keywords

AMPHOTERICIN B; FARNESOL; FLUCONAZOLE; MICAFUNGIN; ANTIFUNGAL AGENT;

EID: 84922453920     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dku374     Document Type: Article
Times cited : (100)

References (51)
  • 1
    • 0035887796 scopus 로고    scopus 로고
    • Biofilm formation: a clinically relevant microbiological process
    • Donlan RM. Biofilm formation: a clinically relevant microbiological process. Clin Infect Dis 2001; 33: 1387-92.
    • (2001) Clin Infect Dis , vol.33 , pp. 1387-1392
    • Donlan, R.M.1
  • 2
    • 84859742950 scopus 로고    scopus 로고
    • Quorum sensing in fungi-a review
    • Albuquerque P, Casadevall A. Quorum sensing in fungi-a review. Med Mycol 2012; 50: 337-45.
    • (2012) Med Mycol , vol.50 , pp. 337-345
    • Albuquerque, P.1    Casadevall, A.2
  • 3
    • 74549181298 scopus 로고    scopus 로고
    • The isoprenoid pathway and transcriptional response to its inhibitors in the yeast Saccharomyces cerevisiae
    • Kuranda K, Francois J, Palamarczyk G. The isoprenoid pathway and transcriptional response to its inhibitors in the yeast Saccharomyces cerevisiae. FEMS Yeast Res 2010; 10: 14-27.
    • (2010) FEMS Yeast Res , vol.10 , pp. 14-27
    • Kuranda, K.1    Francois, J.2    Palamarczyk, G.3
  • 4
    • 0032851111 scopus 로고    scopus 로고
    • Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway
    • Edwards PA, Ericsson J. Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annu Rev Biochem 1999; 68: 157-85.
    • (1999) Annu Rev Biochem , vol.68 , pp. 157-185
    • Edwards, P.A.1    Ericsson, J.2
  • 5
    • 0036840116 scopus 로고    scopus 로고
    • Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule
    • Ramage G, Saville SP, Wickes BL et al. Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. Appl Environ Microbiol 2002; 68: 5459-63.
    • (2002) Appl Environ Microbiol , vol.68 , pp. 5459-5463
    • Ramage, G.1    Saville, S.P.2    Wickes, B.L.3
  • 6
    • 33750026798 scopus 로고    scopus 로고
    • Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance
    • Jabra-Rizk MA, Shirtliff M, James C et al. Effect of farnesol on Candida dubliniensis biofilm formation and fluconazole resistance. FEMS Yeast Res 2006; 6: 1063-73.
    • (2006) FEMS Yeast Res , vol.6 , pp. 1063-1073
    • Jabra-Rizk, M.A.1    Shirtliff, M.2    James, C.3
  • 7
    • 23744445246 scopus 로고    scopus 로고
    • Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum
    • Mosel DD, Dumitru R, Hornby JM et al. Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum. Appl Environ Microbiol 2005; 71: 4938-40.
    • (2005) Appl Environ Microbiol , vol.71 , pp. 4938-4940
    • Mosel, D.D.1    Dumitru, R.2    Hornby, J.M.3
  • 8
    • 0034863427 scopus 로고    scopus 로고
    • Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms
    • Ramage G, Vande Walle K, Wickes BL et al. Standardized method for in vitro antifungal susceptibility testing of Candida albicans biofilms. Antimicrob Agents Chemother 2001; 45: 2475-9.
    • (2001) Antimicrob Agents Chemother , vol.45 , pp. 2475-2479
    • Ramage, G.1    Vande Walle, K.2    Wickes, B.L.3
  • 9
    • 15844363195 scopus 로고    scopus 로고
    • Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts-Second Edition: Approved Standard M27-A2
    • NCCLS, Wayne, PA, USA
    • National Committee for Clinical Laboratory Standards. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts-Second Edition: Approved Standard M27-A2. NCCLS, Wayne, PA, USA, 2002.
    • (2002)
  • 10
    • 0031980747 scopus 로고    scopus 로고
    • Comparison of a 2,3-bis(2-methoxy- 4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTT) colorimetric method with the standardized National Committee for Clinical Laboratory Standards method of testing clinical yeast isolates for susceptibility to antifungal agents
    • Hawser SP, Norris H, Jessup CJ et al. Comparison of a 2,3-bis(2-methoxy- 4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-tetrazolium hydroxide (XTT) colorimetric method with the standardized National Committee for Clinical Laboratory Standards method of testing clinical yeast isolates for susceptibility to antifungal agents. J Clin Microbiol 1998; 36: 1450-2.
    • (1998) J Clin Microbiol , vol.36 , pp. 1450-1452
    • Hawser, S.P.1    Norris, H.2    Jessup, C.J.3
  • 11
    • 37849031478 scopus 로고    scopus 로고
    • Differential activities of newer antifungal agents against Candida albicans and Candida parapsilosis biofilms
    • Katragkou A, Chatzimoschou A, Simitsopoulou M et al. Differential activities of newer antifungal agents against Candida albicans and Candida parapsilosis biofilms. Antimicrob Agents Chemother 2008; 52: 357-60.
    • (2008) Antimicrob Agents Chemother , vol.52 , pp. 357-360
    • Katragkou, A.1    Chatzimoschou, A.2    Simitsopoulou, M.3
  • 12
    • 0036096359 scopus 로고    scopus 로고
    • Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins
    • Kuhn DM, George T, Chandra J et al. Antifungal susceptibility of Candida biofilms: unique efficacy of amphotericin B lipid formulations and echinocandins. Antimicrob Agents Chemother 2002; 46: 1773-80.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 1773-1780
    • Kuhn, D.M.1    George, T.2    Chandra, J.3
  • 13
    • 12244250808 scopus 로고    scopus 로고
    • In vitro drug interactionmodeling of combinations of azoles with terbinafine against clinical Scedosporium prolificans isolates
    • Meletiadis J, Mouton JW, Meis JF et al. In vitro drug interactionmodeling of combinations of azoles with terbinafine against clinical Scedosporium prolificans isolates. Antimicrob Agents Chemother 2003; 47: 106-17.
    • (2003) Antimicrob Agents Chemother , vol.47 , pp. 106-117
    • Meletiadis, J.1    Mouton, J.W.2    Meis, J.F.3
  • 14
    • 0001663843 scopus 로고
    • The problem of synergism and antagonism of combined drugs
    • Loewe S. The problem of synergism and antagonism of combined drugs. Arzneimittelforschung 1953; 3: 285-90.
    • (1953) Arzneimittelforschung , vol.3 , pp. 285-290
    • Loewe, S.1
  • 15
    • 84872636175 scopus 로고
    • 2 X 2 Factorial experiments in incomplete groups for use in biological assays
    • Bliss CI. 2 X 2 Factorial experiments in incomplete groups for use in biological assays. Biometrics 1947; 3: 69-88.
    • (1947) Biometrics , vol.3 , pp. 69-88
    • Bliss, C.I.1
  • 16
    • 75749101383 scopus 로고    scopus 로고
    • Defining fractional inhibitory concentration index cutoffs for additive interactions based on self-drug additive combinations, Monte Carlo simulation analysis, and in vitro-in vivo correlation data for antifungal drug combinations against Aspergillus fumigatus
    • Meletiadis J, Pournaras S, Roilides E et al. Defining fractional inhibitory concentration index cutoffs for additive interactions based on self-drug additive combinations, Monte Carlo simulation analysis, and in vitro-in vivo correlation data for antifungal drug combinations against Aspergillus fumigatus. Antimicrob Agents Chemother 2010; 54: 602-9.
    • (2010) Antimicrob Agents Chemother , vol.54 , pp. 602-609
    • Meletiadis, J.1    Pournaras, S.2    Roilides, E.3
  • 17
    • 0038601510 scopus 로고    scopus 로고
    • Synergy, antagonism, and what the chequerboard puts between them
    • Odds FC. Synergy, antagonism, and what the chequerboard puts between them. J Antimicrob Chemother 2003; 52: 1.
    • (2003) J Antimicrob Chemother , vol.52 , pp. 1
    • Odds, F.C.1
  • 18
    • 79955545195 scopus 로고    scopus 로고
    • Activities of triazole-echinocandin combinations against Candida species in biofilms and as planktonic cells
    • Chatzimoschou A, Katragkou A, Simitsopoulou M et al. Activities of triazole-echinocandin combinations against Candida species in biofilms and as planktonic cells. Antimicrob Agents Chemother 2011; 55: 1968-74.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 1968-1974
    • Chatzimoschou, A.1    Katragkou, A.2    Simitsopoulou, M.3
  • 19
    • 0031596029 scopus 로고    scopus 로고
    • Nucleoside analog 1592U89 and human immunodeficiency virus protease inhibitor 141W94 are synergistic in vitro
    • Drusano GL, D'Argenio DZ, Symonds W et al. Nucleoside analog 1592U89 and human immunodeficiency virus protease inhibitor 141W94 are synergistic in vitro. Antimicrob Agents Chemother 1998; 42: 2153-9.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2153-2159
    • Drusano, G.L.1    D'Argenio, D.Z.2    Symonds, W.3
  • 20
    • 15944377364 scopus 로고    scopus 로고
    • Assessing in vitro combinations of antifungal drugs against yeasts and filamentous fungi: comparison of different drug interaction models
    • Meletiadis J, Verweij PE, TeDorsthorst DT et al. Assessing in vitro combinations of antifungal drugs against yeasts and filamentous fungi: comparison of different drug interaction models. Med Mycol 2005; 43: 133-52.
    • (2005) Med Mycol , vol.43 , pp. 133-152
    • Meletiadis, J.1    Verweij, P.E.2    TeDorsthorst, D.T.3
  • 21
    • 0030788865 scopus 로고    scopus 로고
    • Development of the FUN-1 family of fluorescent probes for vacuole labeling and viability testing of yeasts
    • Millard PJ, Roth BL, Thi HP et al. Development of the FUN-1 family of fluorescent probes for vacuole labeling and viability testing of yeasts. Appl Environ Microbiol 1997; 63: 2897-905.
    • (1997) Appl Environ Microbiol , vol.63 , pp. 2897-2905
    • Millard, P.J.1    Roth, B.L.2    Thi, H.P.3
  • 22
    • 74949107171 scopus 로고    scopus 로고
    • Epidemiology of invasive mycoses in North America
    • Pfaller MA, Diekema DJ. Epidemiology of invasive mycoses in North America. Crit Rev Microbiol 2010; 36: 1-53.
    • (2010) Crit Rev Microbiol , vol.36 , pp. 1-53
    • Pfaller, M.A.1    Diekema, D.J.2
  • 23
    • 0036228505 scopus 로고    scopus 로고
    • Biofilms: survival mechanisms of clinically relevant microorganisms
    • Donlan RM, Costerton JW. Biofilms: survival mechanisms of clinically relevant microorganisms. Clin Microbiol Rev 2002; 15: 167-93.
    • (2002) Clin Microbiol Rev , vol.15 , pp. 167-193
    • Donlan, R.M.1    Costerton, J.W.2
  • 24
    • 73249114946 scopus 로고    scopus 로고
    • Molecular mechanisms involved in farnesol-induced apoptosis
    • Joo JH, Jetten AM. Molecular mechanisms involved in farnesol-induced apoptosis. Cancer Lett 2010; 287: 123-35.
    • (2010) Cancer Lett , vol.287 , pp. 123-135
    • Joo, J.H.1    Jetten, A.M.2
  • 25
    • 34447249251 scopus 로고    scopus 로고
    • Transcriptional response of Candida parapsilosis following exposure to farnesol
    • Rossignol T, Logue ME, Reynolds K et al. Transcriptional response of Candida parapsilosis following exposure to farnesol. Antimicrob Agents Chemother 2007; 51: 2304-12.
    • (2007) Antimicrob Agents Chemother , vol.51 , pp. 2304-2312
    • Rossignol, T.1    Logue, M.E.2    Reynolds, K.3
  • 26
    • 57649178179 scopus 로고    scopus 로고
    • Quorum sensing and Candida albicans
    • Kruppa M. Quorum sensing and Candida albicans. Mycoses 2009; 52: 1-10.
    • (2009) Mycoses , vol.52 , pp. 1-10
    • Kruppa, M.1
  • 27
    • 79959572449 scopus 로고    scopus 로고
    • The metabolic basis of Candida albicans morphogenesis and quorum sensing
    • Han TL, Cannon RD, Villas-Boas SG. The metabolic basis of Candida albicans morphogenesis and quorum sensing. Fungal Genet Biol 2011; 48: 747-63.
    • (2011) Fungal Genet Biol , vol.48 , pp. 747-763
    • Han, T.L.1    Cannon, R.D.2    Villas-Boas, S.G.3
  • 28
    • 36849075751 scopus 로고    scopus 로고
    • Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis
    • Davis-Hanna A, Piispanen AE, Stateva LI et al. Farnesol and dodecanol effects on the Candida albicans Ras1-cAMP signalling pathway and the regulation of morphogenesis. Mol Microbiol 2008; 67: 47-62.
    • (2008) Mol Microbiol , vol.67 , pp. 47-62
    • Davis-Hanna, A.1    Piispanen, A.E.2    Stateva, L.I.3
  • 29
    • 68849099102 scopus 로고    scopus 로고
    • The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogen Candida albicans
    • Roman E, Alonso-Monge R, Gong Q et al. The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogen Candida albicans. FEMS Yeast Res 2009; 9: 942-55.
    • (2009) FEMS Yeast Res , vol.9 , pp. 942-955
    • Roman, E.1    Alonso-Monge, R.2    Gong, Q.3
  • 30
    • 31444450560 scopus 로고    scopus 로고
    • Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans
    • Phillips AJ, Crowe JD, Ramsdale M. Ras pathway signaling accelerates programmed cell death in the pathogenic fungus Candida albicans. Proc Natl Acad Sci USA 2006; 103: 726-31.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 726-731
    • Phillips, A.J.1    Crowe, J.D.2    Ramsdale, M.3
  • 32
    • 83655181842 scopus 로고    scopus 로고
    • Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione
    • Zhu J, Krom BP, Sanglard D et al. Farnesol-induced apoptosis in Candida albicans is mediated by Cdr1-p extrusion and depletion of intracellular glutathione. PLoS One 2011; 6: e28830.
    • (2011) PLoS One , vol.6
    • Zhu, J.1    Krom, B.P.2    Sanglard, D.3
  • 33
    • 34147176061 scopus 로고    scopus 로고
    • Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans
    • Navarathna DH, Hornby JM, Krishnan N et al. Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. Infect Immun 2007; 75: 1609-18.
    • (2007) Infect Immun , vol.75 , pp. 1609-1618
    • Navarathna, D.H.1    Hornby, J.M.2    Krishnan, N.3
  • 34
    • 34547646534 scopus 로고    scopus 로고
    • Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model
    • Navarathna DH, Nickerson KW, Duhamel GE et al. Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model. Infect Immun 2007; 75: 4006-11.
    • (2007) Infect Immun , vol.75 , pp. 4006-4011
    • Navarathna, D.H.1    Nickerson, K.W.2    Duhamel, G.E.3
  • 35
    • 84864793854 scopus 로고    scopus 로고
    • Effect of exogenous administration of Candida albicans autoregulatory alcohols in a murine model of hematogenously disseminated candidiasis
    • Martins M, Lazzell AL, Lopez-Ribot JL et al. Effect of exogenous administration of Candida albicans autoregulatory alcohols in a murine model of hematogenously disseminated candidiasis. J Basic Microbiol 2012; 52: 487-91.
    • (2012) J Basic Microbiol , vol.52 , pp. 487-491
    • Martins, M.1    Lazzell, A.L.2    Lopez-Ribot, J.L.3
  • 36
    • 52049086895 scopus 로고    scopus 로고
    • Protective effects of farnesol against oral candidiasis in mice
    • Hisajima T, Maruyama N, Tanabe Y et al. Protective effects of farnesol against oral candidiasis in mice. Microbiol Immunol 2008; 52: 327-33.
    • (2008) Microbiol Immunol , vol.52 , pp. 327-333
    • Hisajima, T.1    Maruyama, N.2    Tanabe, Y.3
  • 37
    • 84870936277 scopus 로고    scopus 로고
    • Minimum inhibitory concentrations of amphotericin B, azoles and caspofungin against Candida species are reduced by farnesol
    • Cordeiro RA, Teixeira CE, Brilhante RS et al. Minimum inhibitory concentrations of amphotericin B, azoles and caspofungin against Candida species are reduced by farnesol. Med Mycol 2013; 51: 53-9.
    • (2013) Med Mycol , vol.51 , pp. 53-59
    • Cordeiro, R.A.1    Teixeira, C.E.2    Brilhante, R.S.3
  • 38
    • 0242606151 scopus 로고    scopus 로고
    • Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol
    • Koo H, Hayacibara MF, Schobel BD et al. Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. J Antimicrob Chemother 2003; 52: 782-9.
    • (2003) J Antimicrob Chemother , vol.52 , pp. 782-789
    • Koo, H.1    Hayacibara, M.F.2    Schobel, B.D.3
  • 39
    • 33645786322 scopus 로고    scopus 로고
    • Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility
    • Jabra-Rizk MA, Meiller TF, James CE et al. Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility. Antimicrob Agents Chemother 2006; 50: 1463-9.
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 1463-1469
    • Jabra-Rizk, M.A.1    Meiller, T.F.2    James, C.E.3
  • 40
    • 79952069898 scopus 로고    scopus 로고
    • Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro
    • Gomes F, Leite B, Teixeira P et al. Farnesol as antibiotics adjuvant in Staphylococcus epidermidis control in vitro. Am J Med Sci 2011; 341: 191-5.
    • (2011) Am J Med Sci , vol.341 , pp. 191-195
    • Gomes, F.1    Leite, B.2    Teixeira, P.3
  • 41
    • 80855130787 scopus 로고    scopus 로고
    • Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin
    • Pammi M, Liang R, Hicks JM et al. Farnesol decreases biofilms of Staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin. Pediatr Res 2011; 70: 578-83.
    • (2011) Pediatr Res , vol.70 , pp. 578-583
    • Pammi, M.1    Liang, R.2    Hicks, J.M.3
  • 42
    • 80052777068 scopus 로고    scopus 로고
    • Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix
    • Gomes F, Teixeira P, Cerca N et al. Effect of farnesol on structure and composition of Staphylococcus epidermidis biofilm matrix. Curr Microbiol 2011; 63: 354-9.
    • (2011) Curr Microbiol , vol.63 , pp. 354-359
    • Gomes, F.1    Teixeira, P.2    Cerca, N.3
  • 43
    • 84862910708 scopus 로고    scopus 로고
    • Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm
    • Yu LH, Wei X, Ma M et al. Possible inhibitory molecular mechanism of farnesol on the development of fluconazole resistance in Candida albicans biofilm. Antimicrob Agents Chemother 2012; 56: 770-5.
    • (2012) Antimicrob Agents Chemother , vol.56 , pp. 770-775
    • Yu, L.H.1    Wei, X.2    Ma, M.3
  • 44
    • 80052862301 scopus 로고    scopus 로고
    • The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicans
    • Sharma M, Prasad R. The quorum-sensing molecule farnesol is a modulator of drug efflux mediated by ABC multidrug transporters and synergizes with drugs in Candida albicans. Antimicrob Agents Chemother 2011; 55: 4834-43.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4834-4843
    • Sharma, M.1    Prasad, R.2
  • 45
    • 0034777854 scopus 로고    scopus 로고
    • Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases
    • Costa V, Moradas-Ferreira P. Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases. Mol Aspects Med 2001; 22: 217-46.
    • (2001) Mol Aspects Med , vol.22 , pp. 217-246
    • Costa, V.1    Moradas-Ferreira, P.2
  • 46
    • 0033134233 scopus 로고    scopus 로고
    • Mitochondrial superoxide decreases yeast survival in stationary phase
    • Longo VD, Liou LL, Valentine JS et al. Mitochondrial superoxide decreases yeast survival in stationary phase. Arch Biochem Biophys 1999; 365: 131-42.
    • (1999) Arch Biochem Biophys , vol.365 , pp. 131-142
    • Longo, V.D.1    Liou, L.L.2    Valentine, J.S.3
  • 47
    • 50949114194 scopus 로고    scopus 로고
    • Farnesol, a fungal quorumsensing molecule triggers apoptosis in human oral squamous carcinoma cells
    • Scheper MA, Shirtliff ME, Meiller TF et al. Farnesol, a fungal quorumsensing molecule triggers apoptosis in human oral squamous carcinoma cells. Neoplasia 2008; 10: 954-63.
    • (2008) Neoplasia , vol.10 , pp. 954-963
    • Scheper, M.A.1    Shirtliff, M.E.2    Meiller, T.F.3
  • 48
    • 84884553759 scopus 로고    scopus 로고
    • Ras signaling gets fine-tuned: regulation of multiple pathogenic traits of Candida albicans
    • Inglis DO, Sherlock G. Ras signaling gets fine-tuned: regulation of multiple pathogenic traits of Candida albicans. Eukaryot Cell 2013; 12: 1316-25.
    • (2013) Eukaryot Cell , vol.12 , pp. 1316-1325
    • Inglis, D.O.1    Sherlock, G.2
  • 49
    • 27744474113 scopus 로고    scopus 로고
    • Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts
    • Svegliati S, Cancello R, Sambo P et al. Platelet-derived growth factor and reactive oxygen species (ROS) regulate Ras protein levels in primary human fibroblasts via ERK1/2. Amplification of ROS and Ras in systemic sclerosis fibroblasts. J Biol Chem 2005; 280: 36474-82.
    • (2005) J Biol Chem , vol.280 , pp. 36474-36482
    • Svegliati, S.1    Cancello, R.2    Sambo, P.3
  • 50
    • 0038263852 scopus 로고    scopus 로고
    • The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS
    • Hlavata L, Aguilaniu H, Pichova A et al. The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS. EMBO J 2003; 22: 3337-45.
    • (2003) EMBO J , vol.22 , pp. 3337-3345
    • Hlavata, L.1    Aguilaniu, H.2    Pichova, A.3
  • 51
    • 84891305354 scopus 로고    scopus 로고
    • Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms
    • Delattin N, Cammue BP, Thevissen K. Reactive oxygen species-inducing antifungal agents and their activity against fungal biofilms. Future Med Chem 2014; 6: 77-90.
    • (2014) Future Med Chem , vol.6 , pp. 77-90
    • Delattin, N.1    Cammue, B.P.2    Thevissen, K.3


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