Farnesol decreases biofilms of staphylococcus epidermidis and exhibits synergy with nafcillin and vancomycin

Pediatric Research

Volumn 70, Issue 6, 2011, Pages 578-583

  Pammi, Mohan ^a   Liang, Rong ^a   Hicks, John M ^a   Barrish, Jim ^a   Versalovic, James ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FARNESOL; NAFCILLIN; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; BACTERIUM COLONY; BIOFILM; BIOLUMINESCENCE; BLOOD CULTURE; CATHETER INFECTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; STAPHYLOCOCCUS EPIDERMIDIS; STAPHYLOCOCCUS INFECTION;

ANIMALS; BIOFILMS; CATHETER-RELATED INFECTIONS; COLONY COUNT, MICROBIAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; FARNESOL; INHIBITORY CONCENTRATION 50; MICE; MICROSCOPY, CONFOCAL; NAFCILLIN; STAPHYLOCOCCUS EPIDERMIDIS; VANCOMYCIN;

EID: 80855130787     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e318232a984     Document Type: Article

References (25)

1. Fey PD 2010 Modality of bacterial growth presents unique targets: how do we treat biofilm-mediated infections? Curr Opin Microbiol 13:610-615
2. Potera C 1999 Forging a link between biofilms and disease. Science 283:1837-1839 (Pubitemid 29144179)
3. Raad I, Hanna H, Maki D 2007 Intravascular catheter-related infections: advances in diagnosis, prevention, and management. Lancet Infect Dis 7:645-657 (Pubitemid 47444563)
4. Fey PD, Olson ME 2010 Current concepts in biofilm formation of Staphylococcus epidermidis. Future Microbiol 5:917-933
5. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, Lemons JA, Donovan EF, Stark AR, Tyson JE, Oh W, Bauer CR, Korones SB, Shankaran S, Laptook AR, Stevenson DK, Papile LA, Poole WK 2002 Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 110:285-291 (Pubitemid 34833012)
6. Adams-Chapman I, Stoll BJ 2006 Neonatal infection and long-term neurodevelopmental outcome in the preterm infant. Curr Opin Infect Dis 19:290-297 (Pubitemid 43740369)
7. Hornby JM, Jensen EC, Lisec AD, Tasto JJ, Jahnke B, Shoemaker R, Dussault P, Nickerson KW 2001 Quorum sensing in the dimorphic fungus Candida albicans is mediated by farnesol. Appl Environ Microbiol 67:2982-2992 (Pubitemid 33644762)
8. Weber K, Sohr R, Schulz B, Fleischhacker M, Ruhnke M 2008 Secretion of E,E-farnesol and biofilm formation in eight different Candida species. Antimicrob Agents Chemother 52:1859-1861 (Pubitemid 351614688)
9. Ramage G, Saville SP, Wickes BL, Lopez-Ribot JL 2002 Inhibition of Candida albicans biofilm formation by farnesol, a quorum-sensing molecule. Appl Environ Microbiol 68:5459-5463 (Pubitemid 35265681)
10. Jabra-Rizk MA, Meiller TF, James CE, Shirtliff ME 2006 Effect of farnesol on Staphylococcus aureus biofilm formation and antimicrobial susceptibility. Antimicrob Agents Chemother 50:1463-1469
11. Vuong C, Kocianova S, Yao Y, Carmody AB, Otto M 2004 Increased colonization of indwelling medical devices by quorum-sensing mutants of Staphylococcus epidermidis in vivo. J Infect Dis 190:1498-1505 (Pubitemid 39332191)
12. Vuong C, Kocianova S, Yu J, Kadurugamuwa JL, Otto M 2008 Development of real-time in vivo imaging of device-related Staphylococcus epidermidis infection in mice and influence of animal immune status on susceptibility to infection. J Infect Dis 198:258-261 (Pubitemid 352019291)
13. Wikler MA, Clinical and Laboratory Standards Institute 2009 Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard, eighth edition. CLSI document M07-A8. Clinical and Laboratory Standards Institute, Wayne. Available at: http://www.clsi.org/source/orders/ free/m07-a8.pdf (Accessed, June 10, 2011)
14. Hawser SP, Norris H, Jessup CJ, Ghannoum MA 1998 Comparison of a 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-[(phenylamino)carbonyl]-2H-t etrazolium hydroxide (XTT) colorimetric method with the standardized National Committee for Clinical Laboratory Standards method of testing clinical yeast isolates for susceptibility to antifungal agents. J Clin Microbiol 36:1450-1452 (Pubitemid 28208050)
15. Cerca N, Martins S, Cerca F, Jefferson KK, Pier GB, Oliveira R, Azeredo J 2005 Comparative assessment of antibiotic susceptibility of coagulase-negative staphylococci in biofilm versus planktonic culture as assessed by bacterial enumeration or rapid XTT colorimetry. J Antimicrob Chemother 56:331-336 (Pubitemid 41158521)
16. Mueller LN, de Brouwer JFC, Almeida JS, Stal LJ, Xavier JB 2006 Analysis of a marine phototrophic biofilm by confocal laser scanning microscopy using the new image quantification software PHLIP. BMC Ecol 6:1
17. Chou TC 2006 Theoretical basis, experimental design, and computerized simulation of synergism and antagonism in drug combination studies. Pharmacol Rev 58:621-681
18. Chaudhary SC, Alam MS, Siddiqui MS, Athar M 2009 Chemopreventive effect of farnesol on DMBA/TPA-induced skin tumorigenesis: involvement of inflammation, Ras-ERK pathway and apoptosis. Life Sci 85:196-205
19. Bjarnsholt T, Jensen PO, Burmolle M, Hentzer M, Haagensen JA, Hougen HP, Calum H, Madsen KG, Moser C, Molin S, Hoiby N, Givskov M 2005 Pseudomonas aeruginosa tolerance to tobramycin, hydrogen peroxide and polymorphonuclear leukocytes is quorum-sensing dependent. Microbiology 151:373-383 (Pubitemid 40277742)
20. Gomes FI, Teixeira P, Azeredo J, Oliveira R 2009 Effect of farnesol on planktonic and biofilm cells of Staphylococcus epidermidis. Curr Microbiol 59:118-122
21. Akiyama H, Oono T, Huh WK, Yamasaki O, Ogawa S, Katsuyama M, Ichikawa H, Iwatsuki K 2002 Actions of farnesol and xylitol against Staphylococcus aureus. Chemotherapy 48:122-128
22. Inoue Y, Shiraishi A, Hada T, Hirose K, Hamashima H, Shimada J 2004 The antibacterial effects of terpene alcohols on Staphylococcus aureus and their mode of action. FEMS Microbiol Lett 237:325-331 (Pubitemid 39091968)
23. Navarathna DH, Nickerson KW, Duhamel GE, Jerrels TR, Petro TM 2007 Exogenous farnesol interferes with the normal progression of cytokine expression during candidiasis in a mouse model. Infect Immun 75:4006-4011 (Pubitemid 47206299)
24. Navarathna DH, Hornby JM, Krishnan N, Parkhurst A, Duhamel GE, Nickerson KW 2007 Effect of farnesol on a mouse model of systemic candidiasis, determined by use of a DPP3 knockout mutant of Candida albicans. Infect Immun 75:1609-1618 (Pubitemid 46559424)
25. Francis KP, Yu J, Bellinger-Kawahara C, Joh D, Hawkinson MJ, Xiao G, Purchio TF, Caparon MG, Lipsitch M, Contag PR 2001 Visualizing pneumococcal infections in the lungs of live mice using bioluminescent Streptococcus pneumoniae transformed with a novel gram-positive lux transposon. Infect Immun 69:3350-3358 (Pubitemid 32332234)