Adding pregabalin to a multimodal analgesic regimen does not reduce pain scores following cosmetic surgery: A randomized trial

Journal of Anesthesia

Volumn 26, Issue 6, 2012, Pages 829-835

  Chaparro, Luis Enrique ^a   Clarke, Hance ^b,c   Valdes, Paola A ^d   Mira, Mauricio ^d   Duque, Lorena ^d   Mitsakakis, Nicholas ^c  

^a QUEEN S UNIVERSITY   (Canada)

^b TORONTO GENERAL HOSPITAL   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSIDAD DE ANTIOQUIA   (Colombia)

Author keywords

Double blind method; Female; Gamma aminobutyric acid therapeutic use; Lipectomy methods; Pain, postoperative drug therapy

Indexed keywords

ANTIEMETIC AGENT; NONSTEROID ANTIINFLAMMATORY AGENT; OPIATE; PLACEBO; PREGABALIN; 4 AMINOBUTYRIC ACID; ANALGESIC AGENT; DRUG DERIVATIVE; NARCOTIC ANALGESIC AGENT;

ADULT; ANALGESIA; ARTICLE; BREAST AUGMENTATION; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ESTHETIC SURGERY; FEMALE; HUMAN; LIPOSUCTION; MAJOR CLINICAL STUDY; NAUSEA; OPERATION DURATION; PAIN ASSESSMENT; PARALLEL DESIGN; POSTOPERATIVE NAUSEA; POSTOPERATIVE PAIN; POSTOPERATIVE VOMITING; RANDOMIZED CONTROLLED TRIAL; REST; SOMNOLENCE; SURGICAL PATIENT; VOMITING; ADOLESCENT; CONTROLLED CLINICAL TRIAL; DRUG COMBINATION; DRUG EFFECT; LIPECTOMY; MIDDLE AGED; PLASTIC SURGERY; POSTOPERATIVE NAUSEA AND VOMITING; SAMPLE SIZE; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANALGESICS; ANALGESICS, OPIOID; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; GAMMA-AMINOBUTYRIC ACID; HUMANS; LIPECTOMY; MIDDLE AGED; PAIN MEASUREMENT; PAIN, POSTOPERATIVE; POSTOPERATIVE NAUSEA AND VOMITING; SAMPLE SIZE; SURGERY, PLASTIC; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84878359872     PISSN: 09138668     EISSN: 14388359     Source Type: Journal    
DOI: 10.1007/s00540-012-1447-x     Document Type: Article

References (33)

1. Horowitz MD, Rosensweig JA, Jones CA. Medical tourism: globalization of the healthcare marketplace. MedGenMed. 2007;9:33.
2. Kalkman CJ, Visser K, Moen J, Bonsel GJ, Grobbee DE, Moons KG. Preoperative prediction of severe postoperative pain. Pain. 2003;105:415-23.
3. Taenzer P, Melzack R, Jeans ME. Influence of psychological factors on postoperative pain, mood and analgesic requirements. Pain. 1986;24:331-42.
4. Rankin M, Borah GL. Anxiety disorders in plastic surgery. Plast Reconstr Surg. 1997;100:535-42.
5. Kehlet H, Dahl JB. The value of "multimodal" or "balanced analgesia" in postoperative pain treatment. Anesth Analg. 1993;77:1048-56.
6. Kehlet H, Wilmore DW. Evidence-based surgical care and the evolution of fast-track surgery. Ann Surg. 2008;248:189-98.
7. White PF. The changing role of non-opioid analgesic techniques in the management of postoperative pain. Anesth Analg. 2005;101:S5-22.
8. Peng PW, Wijeysundera DN, Li CC. Use of gabapentin for perioperative pain control - a meta-analysis. Pain Res Manag. 2007;12:85-92.
9. Clarke H, Pereira S, Kennedy D, Andrion J, Mitsakakis N, Gollish J, Katz J, Kay J. Adding gabapentin to a multimodal regimen does not reduce acute pain, opioid consumption or chronic pain after total hip arthroplasty. Acta Anaesthesiol Scand. 2009;53:1073-83.
10. Rasmussen ML, Mathiesen O, Dierking G, Christensen BV, Hilsted KL, Larsen TK, Dahl JB. Multimodal analgesia with gabapentin, ketamine and dexamethasone in combination with paracetamol and ketorolac after hip arthroplasty: a preliminary study. Eur J Anaesthesiol. 2010;27:324-30.
11. Engelman E, Cateloy F. Efficacy and safety of perioperative pregabalin for post-operative pain: a meta-analysis of randomized-controlled trials. Acta Anaesthesiol Scand. 2011;55:927-43.
12. Chaparro LE, Lezcano W, Alvarez HD, Joaqui W. Analgesic effectiveness of dipyrone (metamizol) for postoperative pain after herniorrhaphy: a randomized, double-blind, dose-response study. Pain Pract. 2012;12:142-7.
13. Foley KM. The treatment of cancer pain. N Engl J Med. 1985;313:84-95.
14. Schug SA, Gandham N. Opioids: clinical use. In: McMahon SB, Koltzenburg M, editors. Wall and Melzack's Textbook of Pain. London: Elsevier; 2006. pp. 443-57.
15. Edwards JE, McQuay HJ, Moore RA. Combination analgesic efficacy: individual patient data meta-analysis of single-dose oral tramadol plus acetaminophen in acute postoperative pain. J Pain Symptom Manag. 2002;23:121-30.
16. Fricke JR Jr, Karim R, Jordan D, Rosenthal N. A double-blind, single-dose comparison of the analgesic efficacy of tramadol/acetaminophen combination tablets, hydrocodone/acetaminophen combination tablets, and placebo after oral surgery. Clin Ther. 2002;24:953-68.
17. Toms L, Derry S, Moore RA, McQuay HJ. Single dose oral paracetamol (acetaminophen) with codeine for postoperative pain in adults. Cochrane Database Syst Rev 2009;CD001547.
18. Derry C, Derry S, Moore RA, McQuay HJ. Single dose oral ibuprofen for acute postoperative pain in adults. Cochrane Database Syst Rev 2009;CD001548.
19. Derry P, Derry S, Moore RA, McQuay HJ. Single dose oral diclofenac for acute postoperative pain in adults. Cochrane Database Syst Rev 2009;CD004768.
20. De Oliveira GS Jr, Almeida MD, Benzon HT, McCarthy RJ. Perioperative single dose systemic dexamethasone for postoperative pain: a meta-analysis of randomized controlled trials. Anesthesiology. 2011;115:575-88.
21. Marret E, Kurdi O, Zufferey P, Bonnet F. Effects of nonsteroidal antiinflammatory drugs on patient-controlled analgesia morphine side effects: meta-analysis of randomized controlled trials. Anesthesiology. 2005;102:1249-60.
22. Mahabir RC, Peterson BD, Williamson JS, Valnicek SM, Williamson DG, East WE. Locally administered ketorolac and bupivacaine for control of postoperative pain in breast augmentation patients. Plast Reconstr Surg. 2004;114:1910-6.
23. Elia N, Lysakowski C, Tramer MR. Does multimodal analgesia with acetaminophen, nonsteroidal antiinflammatory drugs, or selective cyclooxygenase-2 inhibitors and patient-controlled analgesia morphine offer advantages over morphine alone? Meta-analyses of randomized trials. Anesthesiology. 2005;103:1296-304.
24. Ong CK, Seymour RA, Lirk P, Merry AF. Combining paracetamol (acetaminophen) with nonsteroidal antiinflammatory drugs: a qualitative systematic review of analgesic efficacy for acute postoperative pain. Anesth Analg. 2010;110:1170-9.
25. Chaparro LE, Muñoz Y, Gallo CA, Alvarez HA, Restrepo SM, Perez N, Restrepo L. Pain and sensory symptoms following augmentation mammaplasty: a long-term follow up study with intraoperative ketamine use. Revista Colombiana de Anestesiologia 2010;38:204-12.
26. Klein JA, Kassarjdian N. Lidocaine toxicity with tumescent liposuction. A case report of probable drug interactions. Dermatol Surg. 1997;23:1169-74.
27. Freynhagen R, Strojek K, Griesing T, Whalen E, Balkenohl M. Efficacy of pregabalin in neuropathic pain evaluated in a 12-week, randomised, double-blind, multicentre, placebo-controlled trial of flexible- and fixed-dose regimens. Pain. 2005;115:254-63.
28. Kim JC, Choi YS, Kim KN, Shim JK, Lee JY, Kwak YL. Effective dose of peri-operative oral pregabalin as an adjunct to multimodal analgesic regimen in lumbar spinal fusion surgery. Spine (Phila Pa 1976) 2011;36: 428-33.
29. Kim SY, Song JW, Park B, Park S, An YJ, Shim YH. Pregabalin reduces post-operative pain after mastectomy: a double-blind, randomized, placebo-controlled study. Acta Anaesthesiol Scand. 2011;55:290-6.
30. Pesonen A, Suojaranta-Ylinen R, Hammaren E, Kontinen VK, Raivio P, Tarkkila P, Rosenberg PH. Pregabalin has an opioid-sparing effect in elderly patients after cardiac surgery: a randomized placebo-controlled trial. Br J Anaesth. 2011;106:873-81.
31. Hopewell S, Loudon K, Clarke MJ, Oxman AD, Dickersin K. Publication bias in clinical trials due to statistical significance or direction of trial results. Cochrane Database Syst Rev 2009;MR000006.
32. Elia E, Tramer MR. Is opioid sparing clinically relevant? In McQuay HJ, Kalso E, Moore RA, editors. Systematic reviews in pain research: methodology refined. Seattle: IASP Press; 2008. pp. 119-31.
33. Ho KY, Gan TJ, Habib AS. Gabapentin and postoperative pain-a systematic review of randomized controlled trials. Pain. 2006;126:91-101.