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Volumn 26, Issue 3, 2011, Pages 404-411

Pregabalin as a neuroprotector after spinal cord injury in rats: Biochemical analysis and effect on glial cells

Author keywords

Apoptosis; Astrocytes; Microglia; Pregabalin; Spinal cord injuries

Indexed keywords

4 AMINOBUTYRIC ACID; CASPASE 3; DRUG DERIVATIVE; METHYLPREDNISOLONE; MITOGEN ACTIVATED PROTEIN KINASE P38; NEUROPROTECTIVE AGENT; PREGABALIN; PROTEIN BCL 2;

EID: 79953764725     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2011.26.3.404     Document Type: Article
Times cited : (55)

References (30)
  • 1
    • 3342967871 scopus 로고    scopus 로고
    • Pathophysiology and pharmacologic treatment of acute spinal cord injury
    • Kwon BK, Tetzlaff W, Grauer JN, Beiner J, Vaccaro AR. Pathophysiology and pharmacologic treatment of acute spinal cord injury. Spine J 2004; 4: 451-64.
    • (2004) Spine J , vol.4 , pp. 451-464
    • Kwon, B.K.1    Tetzlaff, W.2    Grauer, J.N.3    Beiner, J.4    Vaccaro, A.R.5
  • 3
    • 21344461953 scopus 로고    scopus 로고
    • Current status of clinical trials for acute spinal cord injury
    • Fehlings MG, Baptiste DC. Current status of clinical trials for acute spinal cord injury. Injury 2005; 36 Suppl 2: B113-22.
    • (2005) Injury , vol.36 , Issue.SUPPL. 2
    • Fehlings, M.G.1    Baptiste, D.C.2
  • 4
    • 63849340879 scopus 로고    scopus 로고
    • Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon
    • Rowland JW, Hawryluk GW, Kwon B, Fehlings MG. Current status of acute spinal cord injury pathophysiology and emerging therapies: promise on the horizon. Neurosurg Focus 2008; 25: E2.
    • (2008) Neurosurg Focus , vol.25
    • Rowland, J.W.1    Hawryluk, G.W.2    Kwon, B.3    Fehlings, M.G.4
  • 5
    • 26444580828 scopus 로고    scopus 로고
    • Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release
    • Zhang Y, Bhavnani BR. Glutamate-induced apoptosis in primary cortical neurons is inhibited by equine estrogens via down-regulation of caspase-3 and prevention of mitochondrial cytochrome c release. BMC Neurosci 2005; 6: 13.
    • (2005) BMC Neurosci , vol.6 , pp. 13
    • Zhang, Y.1    Bhavnani, B.R.2
  • 6
    • 43949100274 scopus 로고    scopus 로고
    • Glutamate-induced losses of oligodendrocytes and neurons and activation of caspase-3 in the rat spinal cord
    • Xu GY, Liu S, Hughes MG, McAdoo DJ. Glutamate-induced losses of oligodendrocytes and neurons and activation of caspase-3 in the rat spinal cord. Neuroscience 2008; 153: 1034-47.
    • (2008) Neuroscience , vol.153 , pp. 1034-1047
    • Xu, G.Y.1    Liu, S.2    Hughes, M.G.3    McAdoo, D.J.4
  • 7
    • 0029130550 scopus 로고
    • Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia
    • Globus MY, Alonso O, Dietrich WD, Busto R, Ginsberg MD. Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia. J Neurochem 1995; 65: 1704-11.
    • (1995) J Neurochem , vol.65 , pp. 1704-1711
    • Globus, M.Y.1    Alonso, O.2    Dietrich, W.D.3    Busto, R.4    Ginsberg, M.D.5
  • 8
    • 3042816808 scopus 로고    scopus 로고
    • The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration
    • Park E, Velumian AA, Fehlings MG. The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration. J Neurotrauma 2004; 21: 754-74.
    • (2004) J Neurotrauma , vol.21 , pp. 754-774
    • Park, E.1    Velumian, A.A.2    Fehlings, M.G.3
  • 9
    • 29244440745 scopus 로고    scopus 로고
    • NMDA receptors are expressed in oligodendrocytes and activated in ischaemia
    • Káradóttir R, Cavelier P, Bergersen LH, Attwell D. NMDA receptors are expressed in oligodendrocytes and activated in ischaemia. Nature 2005; 438: 1162-6.
    • (2005) Nature , vol.438 , pp. 1162-1166
    • Káradóttir, R.1    Cavelier, P.2    Bergersen, L.H.3    Attwell, D.4
  • 10
    • 33751163714 scopus 로고    scopus 로고
    • Pregabalin action at a model synapse: binding to presynaptic calcium channel alpha2-delta subunit reduces neurotransmission in mice
    • Joshi I, Taylor CP. Pregabalin action at a model synapse: binding to presynaptic calcium channel alpha2-delta subunit reduces neurotransmission in mice. Eur J Pharmacol 2006; 553: 82-8.
    • (2006) Eur J Pharmacol , vol.553 , pp. 82-88
    • Joshi, I.1    Taylor, C.P.2
  • 11
    • 33947254401 scopus 로고    scopus 로고
    • Pregabalin: a novel gammaaminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders
    • Tassone DM, Boyce E, Guyer J, Nuzum D. Pregabalin: a novel gammaaminobutyric acid analogue in the treatment of neuropathic pain, partial-onset seizures, and anxiety disorders. Clin Ther 2007; 29: 26-48.
    • (2007) Clin Ther , vol.29 , pp. 26-48
    • Tassone, D.M.1    Boyce, E.2    Guyer, J.3    Nuzum, D.4
  • 12
    • 0141738762 scopus 로고    scopus 로고
    • Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C
    • Fehrenbacher JC, Taylor CP, Vasko MR. Pregabalin and gabapentin reduce release of substance P and CGRP from rat spinal tissues only after inflammation or activation of protein kinase C. Pain 2003; 105: 133-41.
    • (2003) Pain , vol.105 , pp. 133-141
    • Fehrenbacher, J.C.1    Taylor, C.P.2    Vasko, M.R.3
  • 13
    • 34948851724 scopus 로고    scopus 로고
    • Pregabalin decreases visceral pain and prevents spinal neuronal activation in rats
    • Million M, Wang L, Adelson DW, Roman F, Diop L, Taché Y. Pregabalin decreases visceral pain and prevents spinal neuronal activation in rats. Gut 2007; 56: 1482-4.
    • (2007) Gut , vol.56 , pp. 1482-1484
    • Million, M.1    Wang, L.2    Adelson, D.W.3    Roman, F.4    Diop, L.5    Taché, Y.6
  • 14
    • 45449084807 scopus 로고    scopus 로고
    • Pregabalin as a neuroprotector after spinal cord injury in rats
    • Ha KY, Kim YH, Rhyu KW, Kwon SE. Pregabalin as a neuroprotector after spinal cord injury in rats. Eur Spine J 2008; 17: 864-72.
    • (2008) Eur Spine J , vol.17 , pp. 864-872
    • Ha, K.Y.1    Kim, Y.H.2    Rhyu, K.W.3    Kwon, S.E.4
  • 17
    • 0141851235 scopus 로고    scopus 로고
    • Continuous intrathecal infusion of SB203580, a selective inhibitor of p38 mitogen-activated protein kinase, reduces the damage of hind-limb function after thoracic spinal cord injury in rat
    • Horiuchi H, Ogata T, Morino T, Chuai M, Yamamoto H. Continuous intrathecal infusion of SB203580, a selective inhibitor of p38 mitogen-activated protein kinase, reduces the damage of hind-limb function after thoracic spinal cord injury in rat. Neurosci Res 2003; 47: 209-17.
    • (2003) Neurosci Res , vol.47 , pp. 209-217
    • Horiuchi, H.1    Ogata, T.2    Morino, T.3    Chuai, M.4    Yamamoto, H.5
  • 18
    • 35848946825 scopus 로고    scopus 로고
    • p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action
    • Guo G, Bhat NR. p38alpha MAP kinase mediates hypoxia-induced motor neuron cell death: a potential target of minocycline's neuroprotective action. Neurochem Res 2007; 32: 2160-6.
    • (2007) Neurochem Res , vol.32 , pp. 2160-2166
    • Guo, G.1    Bhat, N.R.2
  • 20
    • 0021956433 scopus 로고
    • Spinal cord contusion in the rat; behavioral analysis of functional neurologic impairment
    • Gale K, Kerasidis H, Wrathall JR. Spinal cord contusion in the rat; behavioral analysis of functional neurologic impairment. Exp Neurol 1985; 88: 123-34.
    • (1985) Exp Neurol , vol.88 , pp. 123-134
    • Gale, K.1    Kerasidis, H.2    Wrathall, J.R.3
  • 21
    • 43649105315 scopus 로고    scopus 로고
    • Molecular mechanisms of Fas-mediated cell death in oligodendrocytes
    • Austin JW, Fehlings MG. Molecular mechanisms of Fas-mediated cell death in oligodendrocytes. J Neurotrauma 2008; 25: 411-26.
    • (2008) J Neurotrauma , vol.25 , pp. 411-426
    • Austin, J.W.1    Fehlings, M.G.2
  • 22
    • 8544239374 scopus 로고    scopus 로고
    • Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation
    • Obata K, Yamanaka H, Kobayashi K, Dai Y, Mizushima T, Katsura H, Fukuoka T, Tokunaga A, Noguchi K. Role of mitogen-activated protein kinase activation in injured and intact primary afferent neurons for mechanical and heat hypersensitivity after spinal nerve ligation. J Neurosci 2004; 24: 10211-22.
    • (2004) J Neurosci , vol.24 , pp. 10211-10222
    • Obata, K.1    Yamanaka, H.2    Kobayashi, K.3    Dai, Y.4    Mizushima, T.5    Katsura, H.6    Fukuoka, T.7    Tokunaga, A.8    Noguchi, K.9
  • 23
    • 0032895885 scopus 로고    scopus 로고
    • Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis
    • Nakahara S, Yone K, Sakou T, Wada S, Nagamine T, Niiyama T, Ichijo H. Induction of apoptosis signal regulating kinase 1 (ASK1) after spinal cord injury in rats: possible involvement of ASK1-JNK and -p38 pathways in neuronal apoptosis. J Neuropathol Exp Neurol 1999; 58: 442-50.
    • (1999) J Neuropathol Exp Neurol , vol.58 , pp. 442-450
    • Nakahara, S.1    Yone, K.2    Sakou, T.3    Wada, S.4    Nagamine, T.5    Niiyama, T.6    Ichijo, H.7
  • 25
    • 0033779559 scopus 로고    scopus 로고
    • Astrocyte glutamate transport: review of properties, regulation, and physiological functions
    • Anderson CM, Swanson RA. Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 2000; 32: 1-14.
    • (2000) Glia , vol.32 , pp. 1-14
    • Anderson, C.M.1    Swanson, R.A.2
  • 26
    • 34548206670 scopus 로고    scopus 로고
    • Astrocytes-friends or foes in multiple sclerosis?
    • Williams A, Piaton G, Lubetzki C. Astrocytes-friends or foes in multiple sclerosis? Glia 2007; 55: 1300-12.
    • (2007) Glia , vol.55 , pp. 1300-1312
    • Williams, A.1    Piaton, G.2    Lubetzki, C.3
  • 29
    • 71749103005 scopus 로고    scopus 로고
    • Astrocytes in the damaged brain: molecular and cellular insights into their reactive response and healing potential
    • Buffo A, Rolando C, Ceruti S. Astrocytes in the damaged brain: molecular and cellular insights into their reactive response and healing potential. Biochem Pharmacol 2010; 79: 77-89.
    • (2010) Biochem Pharmacol , vol.79 , pp. 77-89
    • Buffo, A.1    Rolando, C.2    Ceruti, S.3
  • 30
    • 2342667384 scopus 로고    scopus 로고
    • New roles for VEGF in nervous tissue-beyond blood vessels
    • Rosenstein JM, Krum JM. New roles for VEGF in nervous tissue-beyond blood vessels. Exp Neurol 2004; 187: 246-53.
    • (2004) Exp Neurol , vol.187 , pp. 246-253
    • Rosenstein, J.M.1    Krum, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.