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Volumn 106, Issue 12, 2014, Pages

MAX-ing out MYC: A novel small molecule inhibitor against MYC-dependent tumors

Author keywords

[No Author keywords available]

Indexed keywords

ONCOPROTEIN; SMALL MOLECULE TRANSPORT AGENT; 5-(4-ETHYLBENZYLIDENE)-2-THIOXOTHIAZOLIDIN-4-ONE; ANTINEOPLASTIC AGENT; KRAS2 PROTEIN, MOUSE; MYC PROTEIN; MYC PROTEIN, MOUSE; PROTEIN P21; THIAZOLE DERIVATIVE;

EID: 84922391687     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/dju365     Document Type: Editorial
Times cited : (7)

References (22)
  • 1
    • 84887147170 scopus 로고    scopus 로고
    • MYC activation is a hallmark of cancer initiation and maintenance
    • Gabay M, Li Y, Felsher DW. MYC Activation Is a Hallmark of Cancer Initiation and Maintenance. Cold Spring Harb Perspect Med. 2014;4(6):a014241-a014241.
    • (2014) Cold Spring Harb Perspect Med. , vol.4 , Issue.6 , pp. a014241-a014241
    • Gabay, M.1    Li, Y.2    Felsher, D.W.3
  • 2
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang CV. MYC on the Path to Cancer. Cell. 2012;149(1):22-35.
    • (2012) Cell , vol.149 , Issue.1 , pp. 22-35
    • Dang, C.V.1
  • 4
    • 84874835799 scopus 로고    scopus 로고
    • Inhibition of myc family proteins eradicates KRas-driven lung cancer in mice
    • Soucek L, Whitfield JR, Sodir NM, et al. Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice. Genes Dev. 2013;27(5):504-513.
    • (2013) Genes Dev. , vol.27 , Issue.5 , pp. 504-513
    • Soucek, L.1    Whitfield, J.R.2    Sodir, N.M.3
  • 5
    • 80052955256 scopus 로고    scopus 로고
    • BET bromodomain inhibition as a therapeutic strategy to target c-myc
    • Delmore JE, Issa GC, Lemieux ME, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011;146(6):904-917.
    • (2011) Cell , vol.146 , Issue.6 , pp. 904-917
    • Delmore, J.E.1    Issa, G.C.2    Lemieux, M.E.3
  • 6
    • 80055000824 scopus 로고    scopus 로고
    • RNAi screen identifies brd4 as a therapeutic target in acute myeloid leukaemia
    • Zuber J, Shi J, Wang E, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011;478(7370):524-528.
    • (2011) Nature , vol.478 , Issue.7370 , pp. 524-528
    • Zuber, J.1    Shi, J.2    Wang, E.3
  • 7
    • 84869753078 scopus 로고    scopus 로고
    • Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins
    • Lockwood WW, Zejnullahu K, Bradner JE, Varmus H. Sensitivity of human lung adenocarcinoma cell lines to targeted inhibition of BET epigenetic signaling proteins. Proc Natl Acad Sci U S A. 2012;109(47):19408-19413.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.47 , pp. 19408-19413
    • Lockwood, W.W.1    Zejnullahu, K.2    Bradner, J.E.3    Varmus, H.4
  • 8
    • 0027533679 scopus 로고
    • Oncogenic activity of the c-myc protein requires dimerization with max
    • Amati B, Brooks MW, Levy N, Littlewood TD, Evan GI, Land H. Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell. 1993;72(2):233-245.
    • (1993) Cell , vol.72 , Issue.2 , pp. 233-245
    • Amati, B.1    Brooks, M.W.2    Levy, N.3    Littlewood, T.D.4    Evan, G.I.5    Land, H.6
  • 9
    • 58849157916 scopus 로고    scopus 로고
    • Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the myc-max disruptor, 10058-F4 [Z,E]-5- [4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice
    • Guo J, Parise R, Joseph E, et al. Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc-Max disruptor, 10058-F4 [Z,E]-5- [4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice. Cancer Chemother Pharmacol. 2009;63(4):615-625.
    • (2009) Cancer Chemother Pharmacol. , vol.63 , Issue.4 , pp. 615-625
    • Guo, J.1    Parise, R.2    Joseph, E.3
  • 10
    • 84902147062 scopus 로고    scopus 로고
    • Projecting cancer incidence and deaths to 2030: The unexpected burden of thyroid, liver, and pancreas cancers in the united states
    • Rahib L, Smith BD, Aizenberg R, Rosenzweig AB, Fleshman JM, Matrisian LM. Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States. Cancer Res. 2014;74(11):2913-2921.
    • (2014) Cancer Res. , vol.74 , Issue.11 , pp. 2913-2921
    • Rahib, L.1    Smith, B.D.2    Aizenberg, R.3    Rosenzweig, A.B.4    Fleshman, J.M.5    Matrisian, L.M.6
  • 11
    • 80054866000 scopus 로고    scopus 로고
    • Targeting protein prenylation for cancer therapy
    • Berndt N, Hamilton AD, Sebti SM. Targeting protein prenylation for cancer therapy. Nat Rev Cancer. 2011;11(11):775-791.
    • (2011) Nat Rev Cancer. , vol.11 , Issue.11 , pp. 775-791
    • Berndt, N.1    Hamilton, A.D.2    Sebti, S.M.3
  • 12
    • 84859463451 scopus 로고    scopus 로고
    • Small-molecule ligands bind to a distinct pocket in ras and inhibit SOS-mediated nucleotide exchange activity
    • Maurer T, Garrenton LS, Oh A, et al. Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity. Proc Natl Acad Sci U S A. 2012;109(14):5299-5304.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.14 , pp. 5299-5304
    • Maurer, T.1    Garrenton, L.S.2    Oh, A.3
  • 13
    • 84862649997 scopus 로고    scopus 로고
    • Discovery of small molecules that bind to K-ras and inhibit sos-mediated activation
    • Sun Q, Burke JP, Phan J, et al. Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation. Angew Chem Int Ed Engl. 2012;51(25):6140-6143.
    • (2012) Angew Chem Int Ed Engl. , vol.51 , Issue.25 , pp. 6140-6143
    • Sun, Q.1    Burke, J.P.2    Phan, J.3
  • 14
    • 84888639050 scopus 로고    scopus 로고
    • K-ras(G12C) inhibitors allosterically control GTP affinity and effector interactions
    • Ostrem JM, Peters U, Sos ML, Wells JA, Shokat KM. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013;503(7477):548-551.
    • (2013) Nature , vol.503 , Issue.7477 , pp. 548-551
    • Ostrem, J.M.1    Peters, U.2    Sos, M.L.3    Wells, J.A.4    Shokat, K.M.5
  • 15
    • 84878401236 scopus 로고    scopus 로고
    • Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
    • Zimmermann G, Papke B, Ismail S, et al. Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling. Nature. 2013;497(7451):638-642.
    • (2013) Nature , vol.497 , Issue.7451 , pp. 638-642
    • Zimmermann, G.1    Papke, B.2    Ismail, S.3
  • 16
    • 84885104348 scopus 로고    scopus 로고
    • Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models
    • Zhong H, Sanchez C, Spitrzer D, et al. Synergistic effects of concurrent blockade of PI3K and MEK pathways in pancreatic cancer preclinical models. PLoS ONE. 2013;8(10):e77243.
    • (2013) PLoS ONE , vol.8 , Issue.10 , pp. e77243
    • Zhong, H.1    Sanchez, C.2    Spitrzer, D.3
  • 17
    • 0034306997 scopus 로고    scopus 로고
    • Multiple ras-dependent phosphorylation pathways regulate myc protein stability
    • Sears R. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev. 2000;14(19):2501-2514.
    • (2000) Genes Dev. , vol.14 , Issue.19 , pp. 2501-2514
    • Sears, R.1
  • 18
    • 84891711129 scopus 로고    scopus 로고
    • A modular and flexible ESCbased mouse model of pancreatic cancer
    • Saborowski M, Saborowski A, Morris JP, et al. A modular and flexible ESCbased mouse model of pancreatic cancer. Genes Dev. 2014;28(1):85-97.
    • (2014) Genes Dev. , vol.28 , Issue.1 , pp. 85-97
    • Saborowski, M.1    Saborowski, A.2    Morris, J.P.3
  • 19
    • 84922394070 scopus 로고    scopus 로고
    • Therapeutic effects of anti-myc drug on mouse pancreatic cancer
    • Stellas D, Szabolcs M, Koul S, et al. Therapeutic effects of anti-Myc drug on mouse pancreatic cancer. J Natl Cancer Inst. 2014;106(12):dju320 doi:10.1093/jnci/dju320.
    • (2014) J Natl Cancer Inst. , vol.106 , Issue.12 , pp. dju320
    • Stellas, D.1    Szabolcs, M.2    Koul, S.3
  • 20
    • 19344362405 scopus 로고    scopus 로고
    • Trp53R172H and krasg12d cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
    • Hingorani SR, Wang L, Multani AS, et al. Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell. 2005;7(5):469-483.
    • (2005) Cancer Cell , vol.7 , Issue.5 , pp. 469-483
    • Hingorani, S.R.1    Wang, L.2    Multani, A.S.3
  • 21
    • 33751251034 scopus 로고    scopus 로고
    • Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
    • Bardeesy N, Cheng K-H, Berger JH, et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev. 2006;20(22):3130-3146.
    • (2006) Genes Dev. , vol.20 , Issue.22 , pp. 3130-3146
    • Bardeesy, N.1    Cheng, K.-H.2    Berger, J.H.3
  • 22
    • 84857735480 scopus 로고    scopus 로고
    • PTEN is a major tumor suppressor in pancreatic ductal adenocarcinoma and regulates an NF-κB-cytokine network
    • Ying H, Elpek KG, Vinjamoori A, et al. PTEN Is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB-Cytokine Network. Cancer Discovery. 2011;1(2):158-169.
    • (2011) Cancer Discovery , vol.1 , Issue.2 , pp. 158-169
    • Ying, H.1    Elpek, K.G.2    Vinjamoori, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.