Interaction between passive smoking and two HLA genes with regard to multiple sclerosis risk

International Journal of Epidemiology

Volumn 43, Issue 6, 2014, Pages 1791-1798

  Hedström, Anna Karin ^a   Bomfim, Izaura Lima ^a   Barcellos, Lisa F ^b   Briggs, Farren ^b   Schaefer, Catherine ^c   Kockum, Ingrid ^d   Olsson, Tomas ^d   Alfredsson, Lars ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c DIVISION OF RESEARCH   (United States)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Case control study; Gene environment interaction; HLA genotype; Immunology; Multiple sclerosis; Passive smoking; Smoking

Indexed keywords

HLA A2 ANTIGEN; HLA DRB1 ANTIGEN; HLA-A*02 ANTIGEN; HLA-DRB1*15 ANTIGEN; PASSIVE SMOKING;

DISEASE INCIDENCE; DISEASE PREVALENCE; DISEASE SEVERITY; GENE EXPRESSION; GENETIC ANALYSIS; GENOTYPE; PUBLIC HEALTH; SMOKING;

ADOLESCENT; ADULT; AGED; ALLELE; AMERICAN; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; MULTIPLE SCLEROSIS; PASSIVE SMOKING; PRIORITY JOURNAL; SWEDISH CITIZEN; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; PROTECTION; RISK FACTOR; SMOKING; STATISTICS AND NUMERICAL DATA; SWEDEN; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; FEMALE; GENE-ENVIRONMENT INTERACTION; GENETIC PREDISPOSITION TO DISEASE; HLA-A2 ANTIGEN; HLA-DRB1 CHAINS; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; PROTECTIVE FACTORS; RISK FACTORS; SMOKING; SWEDEN; TOBACCO SMOKE POLLUTION; YOUNG ADULT;

EID: 84922379740     PISSN: 03005771     EISSN: 14643685     Source Type: Journal    
DOI: 10.1093/ije/dyu195     Document Type: Article

References (21)

1. Lincoln MR, Montpetit A, Cader MZ et al. A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis. Nat Genet 2005;37:1108-12.
2. Brynedal B, Duvefelt K, Jonasdottir G et al. HLA-A confers an HLA-DRB1 independent influence on the risk of multiple sclerosis. PLoS One 2007;2:e664.
3. International Multiple Sclerosis Genetics Consortium (IMSGC). Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis. Nature 2011;476:214-219.
4. Hedström AK, Hillert J, Olsson T, Alfredsson L. Smoking and multiple sclerosis susceptibility. Eur J Epidemiol 2013;28: 867-74.
5. Hedström AK, Sundqvist E, Bäärnhielm M et al. Smoking and two human leukocyte antigen genes interact to increase the risk for multiple sclerosis. Brain 2011;134:653-64.
6. Dilthey A, Leslie S, Moutsianas L et al. Multi-population classical HLA type imputation. PLoS Comput Biol 2013;9: e1002877.
7. Cortes A, Brown MA. Promise and pitfalls of the Immunochip. Arthritis Res Ther 2011;13:101.
8. Barcellos LF, Sawcer S, Ramsay PP et al. Heterogeneity at the HLA-DRB1 locus and risk for multiple sclerosis. Hum Mol Genet 2006;15:2813-24.
9. Rothman KJ, Greenland S, Lash TL, eds. Modern Epidemiology. 3rd edn. Philadelphia, PA: Lippincott Williams & Wilkins, 2008.
10. VanderWeele TJ. Sufficient cause interactions and statistical interactions. Epidemiology 2009;20:6-13.
11. Rothman KJ, Greenland S, Walker AM. Concepts of interaction. Am J Epidemiol 1980;112:467-70.
12. VanderWeele TJ. Reconsidering the denominator of the attributable proportion for interaction. Eur J Epidemiol 2013;28: 779-84.
13. Statistics Sweden. Socioeconomic Classification SEI. Stockholm: Statistics Sweden, 1982.
14. Internet based information. http://www.scb.se. Statistics Sweden. Alkohol och tobaksbruk. (15 November 2012, date last accessed).
15. Hedström AK, Bäärnhielm M, Olsson T, Alfredsson L. Tobacco smoking, but not Swedish snuff use, increases the risk of multiple sclerosis. Neurology 2009;73:696-701.
16. Makrygiannakis D, Hermansson M, Ulfgren AK et al. Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells. Ann Rheum Dis 2008;67:1488-92.
17. Doyle HA, Mamula MJ. Posttranslational protein modifications: new flavors in the menu of autoantigens. Curr Opin Rheumatol 2002;14:244-49. Review.
18. Cloos PA, Christgau S. Post-translational modifications of proteins: implications for aging, antigen recognition, and autoimmunity. Biogerontology 2004;5:139-58. Review.
19. Odoardi F, Sie C, Streyl K et al. T cells become licensed in the lung to enter the central nervous system. Nature 2012;488: 675-79.
20. Olsson T, Hillert J. The genetics of multiple sclerosis and its experimental models. Curr Opin Neurol 2008;21:255-60. Review.
21. Klareskog L, Stolt P, Lundberg K et al. A new model for an etiology of RA; Smoking may trigger HLA-DR (SE)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006;54:38-46.