The coreceptor programmed death 1 inhibits T-cell adhesion by regulating Rap1

Journal of Allergy and Clinical Immunology

Volumn 135, Issue 2, 2015, Pages 564-567.e1

  Azoulay Alfaguter, Inbar ^a   Strazza, Marianne ^a   Pedoeem, Ariel ^a   Mor, Adam ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIBODY; CD3 ANTIBODY; CELL ANTIBODY; INTERCELLULAR ADHESION MOLECULE 1; PHYTOHEMAGGLUTININ; PROGRAMMED DEATH 1 RECEPTOR; RAP1 PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG; TELOMERE BINDING PROTEIN; TERF2IP PROTEIN, HUMAN;

ADHERENT CELL; ANTIGEN PRESENTING CELL; CELL ADHESION; CELL MEMBRANE; CELL STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LETTER; PRIORITY JOURNAL; STABLE EXPRESSION; T LYMPHOCYTE; IMMUNOLOGY; METABOLISM;

CELL ADHESION; HUMANS; PROGRAMMED CELL DEATH 1 RECEPTOR; T-LYMPHOCYTES; TELOMERE-BINDING PROTEINS;

EID: 84922365829     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2014.07.055     Document Type: Article

References (12)

1. L.M. Francisco, P.T. Sage, and A.H. Sharpe The PD-1 pathway in tolerance and autoimmunity Immunol Rev 236 2010 219 242
2. J. Riley PD-1 signaling in primary T-cells Immunol Rev 229 2012 114 125
3. A.K. Singh, P. Stock, and O. Akbari Role of PD-L1 and PD-L2 in allergic diseases and asthma Allergy 66 2011 155 162
4. B. Youngblood, A. Noto, F. Porichis, R.S. Akondy, Z.M. Ndhlovu, and J.W. Austin Prolonged exposure to HIV reinforces a poised epigenetic program for PD-1 expression in virus-specific CD8 T cells J Immunol 191 2013 540 544
5. Y. Kloog, and A. Mor Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1 Mol Cell Biol 34 2014 978 988
6. P.A. Saunders, V.R. Hendrycks, W.A. Lidinsky, and M.L. Woods PD-L2:PD-1 involvement in T-cell proliferation, cytokine production, and integrin-mediated adhesion Eur J Immunol 35 2005 3561 3569
7. B.T. Fife, K.E. Pauken, T.N. Eagar, T. Obu, J. Wu, and Q. Tang Interactions between PD-1 and PD-L1 promote tolerance by blocking the TCR-induced stop signal Nature 10 2009 1185 1192
8. B.H. Zinselmeyer, S. Heydari, C. Sacristan, D. Nayak, M. Cammer, and J. Herz PD-1 promotes immune exhaustion by inducing antiviral T-cell motility paralysis J Exp Med 210 2003 757 774
9. R.V. Parry, J.M. Chemnitz, K.A. Frauwirth, A.R. Lanfranco, I. Braunstein, and S.V. Kobayashi CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms Mol Cell Bio 25 2005 9543 9553
10. Y. Kloog, and A. Mor Cytotoxic-T-lymphocyte antigen 4 receptor signaling for lymphocyte adhesion is mediated by C3G and Rap1 Mol Cell Biol 34 2014 978 988
11. A. Mor, G. Campi, G. Du, Y. Zheng, D.A. Foster, and M.L. Dustin The lymphocyte function-associated antigen-1 receptor costimulates plasma membrane Ras via phospholipase D2 Nat Cell Biol 9 2007 713 719
12. M. Strazza, I. Azoulay-Alfaguter, A. Pedoeem, and A. Mor Static adhesion assay for the study of integrin activation in T lymphocytes J Vis Exp 88 2014 10.3791/51646