Anthracyclines induce double-strand DNA breaks at active gene promoters

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 773, Issue , 2015, Pages 9-15

  Yang, Fan ^a   Kemp, Christopher J ^a   Henikoff, Steven ^a,b  

^a Fred Hutchinson Cancer Research Center   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

DNA double strand breaks; Doxorubicin; Etoposide; Nucleosome turnover; Squamous cell carcinoma

Indexed keywords

ACLARUBICIN; DOUBLE STRANDED DNA; DOXORUBICIN; ETOPOSIDE; ANTHRACYCLINE; NUCLEOSOME;

ANIMAL CELL; ARTICLE; CANCER CELL; CELL METABOLISM; CONTROLLED STUDY; CPG ISLAND; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; GENE MAPPING; MOUSE; NONHUMAN; NUCLEOSOME; PROMOTER REGION; ANIMAL; DRUG EFFECTS;

ANIMALS; ANTHRACYCLINES; CPG ISLANDS; DNA BREAKS, DOUBLE-STRANDED; ETOPOSIDE; MICE; NUCLEOSOMES; PROMOTER REGIONS, GENETIC;

EID: 84922333547     PISSN: 00275107     EISSN: 09218262     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2015.01.007     Document Type: Article

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