Functional significance of single nucleotide polymorphisms in the lactase gene in diverse US patients and evidence for a novel lactase persistence allele at -13909 in those of European ancestry

Journal of Pediatric Gastroenterology and Nutrition

Volumn 60, Issue 2, 2015, Pages 182-191

  Baffour Awuah, Nana Yaa ^a   Fleet, Sarah ^a   Montgomery, Robert K ^a   Baker, Susan S ^b   Butler, Johannah L ^c   Campbell, Catarina ^c   Tischfield, Samuel ^c   Mitchell, Paul D ^c   Allende Richter, Sophie ^a   Moon, Jennifer E ^c   Fishman, Laurie ^a   Bousvaros, Athos ^a   Fox, Victor ^a   Kuokkanen, Mikko ^c   Grand, Richard J ^a   Hirschhorn, Joel N ^c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b CHILDREN S HOSPITAL OF BUFFALO   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

lactase expression; lactase mRNA; lactase SNPs; LCT genetics

Indexed keywords

DISACCHARIDASE; LACTASE; MESSENGER RNA; SUCRASE;

ADOLESCENT; ADULT; ALLELE; ALLELIC IMBALANCE; ANCESTRY GROUP; ARTICLE; CHILD; DUODENUM BIOPSY; ENZYME ACTIVITY; EUROPEAN; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HAPLOTYPE; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; UNITED STATES; CAUCASIAN; DUODENUM; ENZYMOLOGY; ETHNOLOGY; GENETICS; METABOLISM; YOUNG ADULT;

ADOLESCENT; ALLELES; CHILD; DUODENUM; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HUMANS; LACTASE; MALE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; RNA, MESSENGER; SUCRASE; UNITED STATES; YOUNG ADULT;

EID: 84922264524     PISSN: 02772116     EISSN: 15364801     Source Type: Journal    
DOI: 10.1097/MPG.0000000000000595     Document Type: Article

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