Lactose intolerance: Lactose tolerance test versus genotyping

Scandinavian Journal of Gastroenterology

Volumn 40, Issue 7, 2005, Pages 822-826

  Ridefelt, Peter ^a   Håkansson, Lena D ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Diagnostic techniques; Digestive system; Genotype; Lactose intolerance; Lactose tolerance test; Polymorphism; Single nucleotide

Indexed keywords

GLUCOSE;

ADULT; AGED; ARTICLE; CAUCASIAN; DIAGNOSTIC TEST; EUROPEAN DESCENT; FEMALE; GENE; GENOTYPE; GLUCOSE BLOOD LEVEL; HETEROZYGOSITY; HUMAN; LACTASE GENE; LACTOSE INTOLERANCE; LACTOSE INTOLERANCE TEST; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROVOCATION TEST; REAL TIME POLYMERASE CHAIN REACTION; SCREENING TEST; SINGLE NUCLEOTIDE POLYMORPHISM; SWEDEN;

ADULT; AGED; BASE SEQUENCE; CASE-CONTROL STUDIES; FEMALE; GENETIC TECHNIQUES; GENOTYPE; GLUCOSYLCERAMIDASE; HUMANS; LACTOSE INTOLERANCE; LACTOSE TOLERANCE TEST; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY; SWEDEN;

EID: 22144440502     PISSN: 00365521     EISSN: None     Source Type: Journal    
DOI: 10.1080/00365520510015764     Document Type: Article

References (15)

1. Swallow DM. Genetics of lactase persistence and lactose intolerance. Annu Rev Genet 2003;37:197-219.
2. Sahi T. Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol 1994;Suppl 202:7-20.
3. Mulcare CA, Weale ME, Jones AL, Connell B, Zeitlyn D, Tarekegn A, et al. T allele of a single-nucleotide polymorphism 13.9 kb upstream of the lactase gene (LCT) (C-13.9 kbT) does not predict or cause the lactase-persistence phenotype in Africans. Am J Hum Genet 2004;74:1102-10.
4. Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. New Engl J Med 1995;333:1-4.
5. Vesa TH, Marteau P, Korpela R. Lactose intolerance. J Am Coll Nutr 2000;19 Suppl 2:165S-75S.
6. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Jarvela I. Identification of a variant associated with adult-type hypolactasia. Nat Genet 2002;30:233-7.
7. Kuokkanen M, Enattah NS, Oksanen A, Savilahti E, Orpana A, Jarvela I. Transcriptional regulation of the lactase-phlorizin hydrolase gene by polymorphisms associated with adult-type hypolactasia. Gut 2003;52:647-52.
8. Olds LC, Sibley E. Lactase persistence DNA variant enhances lactase promoter activity in vitro: functional role as a cis regulatory element. Hum Mol Genet 2003;12: 2333-40.
9. Troelsen JT, Olsen J, Moller J, Sjostrom H. An upstream polymorphism associated with lactase persistence has increased enhancer activity. Gastroenterology 2003;125: 1686-94.
10. Bersaglieri T, Sabeti PC, Patterson N, Vanderploeg T, Schaffner SF, Drake JA, et al. Genetic signatures of strong recent positive selection at the lactase gene. Am J Hum Genet 2004;74:1111-20.
11. Poulter M, Hollox E, Harvey CB, Mulcare C, Peuhkuri K, Kajander K, et al. The causal element for the lactase persistence/non-persistence polymorphism is located in a 1 Mb region of linkage disequilibrium in Europeans. Ann Hum Genet 2003;67:298-311.
12. Risch N, Burchard E, Ziv E, Tang H. Categorization of humans in biomedical research: genes, race and disease. Genome Biol 2002;7:1-12.
13. Nilsson-Ehle P, editor. Laurells klinisk kemi. Lund: Studentlitteratur; 2003. pp 529-31.
14. Büning C, Ockenga J, Kruger S, Jurga J, Baier P, Dignass A, et al. The C/C(13910) and G/G(22018) genotypes for adult-type hypolactasia are not associated with inflammatory bowel disease. Scand J Gastroenterol 2003;38:538-42.
15. Nilsson TK, Johansson CA. A novel method for diagnosis of adult hypolactasia by genotyping of the -13910 C/T polymorphism with pyrosequencing technology. Scand J Gastroenterol 2004;39:287-90.