Prevalence of adult-type hypolactasia as diagnosed with genetic and lactose hydrogen breath tests in Hungarians

European Journal of Clinical Nutrition

Volumn 63, Issue 7, 2009, Pages 909-912

  Nagy, D ^a   Bogacsi Szabo E ^a   Varkonyi A ^b   Csanyi B ^a   Czibula, A ^a   Bede, O ^b   Tari, B ^b   Rasko I ^a  

^a INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

LACTASE;

ADOLESCENT; ADULT; ARTICLE; CHILD; CONTROLLED STUDY; FEMALE; GENETIC SCREENING; GENOTYPE; HUMAN; HUNGARY; HYDROGEN BREATH TEST; LACTASE DEFICIENCY; MAJOR CLINICAL STUDY; MALE; PREVALENCE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; BIOPSY; BREATH TESTS; CELIAC DISEASE; CHILD; CHILD, PRESCHOOL; DIAGNOSIS, DIFFERENTIAL; FEMALE; GASTROINTESTINAL DISEASES; GENOTYPE; HUMANS; HUNGARY; HYDROGEN; INTESTINE, SMALL; LACTASE; LACTOSE INTOLERANCE; MALE; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS; PREVALENCE; YOUNG ADULT;

EID: 67650229878     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2008.74     Document Type: Article

References (20)

1. Arola H, Koivula T, Jokela H, Jauhiainen M, Keyrilainen O, Hola T et al. (1988). Comparison of indirect diagnostic methods for hypolactasia. Scand J Gastroenterol Suppl 23, 351-357.
2. Bernardes-Silva CF, Pereira AC, Fátima Alves da Mota G, Krieger JE, Laudanna AA (2007). Lactase persistence/non-persistence variants, C/ T_13910 and G/A_22018, as a diagnostic tool for lactose intolerance in IBS patients. Clin Chim Acta 386, 7-11.
3. Büning C, Genschel J, Jurga J, Fiedler T, Voderholzer W, Fiedler EM et al. (2005). Introducing genetic testing for adult-type hypolactasia. Digestion 71, 245-250.
4. Enattah NS, Jensen TG, Nielsen M, Lewinski R, Kuokkanen M, Rasinperä H et al. (2008). Independent introduction of two lactase-persistence alleles into human populations reflects different history of adaptation to milk culture. Am J Hum Genet 82, 57-72.
5. Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Järvelä I (2002). Identification of a variant associated with adult-type hypolactasia. Nat Genet 30, 233-237.
6. Hosking L, Lumsden S, Lewis K, Yeo A, McCarthy L, Bansal A et al. (2004). Detection of genotyping errors by Hardy-Weinberg equilibrium testing. Eur J Hum Genet 12, 395-399.
7. Högenauer C, Hammer HF, Mellitzer K, Renner W, Krejs GJ, Toplak H (2005). Evaluation of a new DNA test compared with the lactose hydrogen breath test for the diagnosis of lactase non-persistence. Eur J Gastroenterol Hepatol 17, 371-376.
8. Hüebner C, Petermann I, Browning BL, Shelling AN, Ferguson LR (2007) Triallelic single nucleotide polymorphisms and genotyping error in genetic epidemiology studies: MDR1 (ABCB1) G2677/T/A as an example. Cancer Epidemiol Biomarkers Prev 16, 1185-1192.
9. Järvelä I, Enattah NS, Kokkonen J, Varilo T, Savilahti E, Peltonen L (1998). Assignment of the locus for congenital lactase deficiency to 2q21, in the vicinity of but separate from the lactase-phlorizin hydrolase gene. Am J Genet 63, 1078-1085.
10. Krawczyk M, Wolska M, Schwartz S, Gruenhage F, Terjung B, Portincasa P et al. (2008). Concordance of genetic and breath tests for lactose intolerance in a tertiary referral centre. J Gastrointestin Liver Dis 17, 135-139.
11. -13910 DNA variant associated with lactase persistence interacts with Oct-1 and stimulates lactase promoter activity in vitro. Hum Mol Genet 14, 3945-3953.
12. Mottes M, Belpinati F, Milani M, Saccomandi D, Petrelli E, Calacoci M et al. (2008). Genetic testing for adult-type hypolactasia in Italian families. Clin Chem Lab Med 46, 980-984. (abstract).
13. Newcomer AD, McGill DB, Thomas PJ, Hofman AF (1975). Prospective comparison of indirect methods for detecting lactase deficiency. N Engl J Med 293, 1232-1236.
14. Oberhuber G (2000). Histopathology of celiac disease. Biomed Pharmacother 54, 368-372.
15. Olds LC, Sibley E (2003). Lactase persistence DNA variant enhances lactase promoter activity in vitro: Functional role as a cis regulatory element. Hum Mol Genet 12, 2333-2340.
16. Rasinperä H, Savilahti E, Enattah NS, Kuokkanen M, Totterman N, Lindahl H et al. (2004). A genetic test which can be used to diagnose adult-type hypolactasia in children. Gut 53, 1571-1576.
17. Sahi T (1994). Genetics and epidemiology of adult-type hypolactasia. Scand J Gastroenterol Suppl 202, 7-20.
18. Schirru E, Corona V, Usai-Satta P, Scarpa M, Oppia F, Lorgia F et al. (2007). Genetic testing improves the diagnosis of adult type hypolactasia in the Mediterranean population of Sardinia. Eur J Clin Nutr 61, 1220-1225.
19. Swallow DM (2003). Genetics of lactase persistence and lactose intolerance. Annu Rev Genet 37, 197-219.
20. Walsh PS, Metzger DA, Higuchi R (1991). Chelex 100 as a medium for simple extraction of DNA for PCR-based typing from forensic material. Biotechniques 10, 506-513.