Hsp27 (HSPB1) differential expression in normal salivary glands and pleomorphic adenomas and association with an increased Bcl2/Bax ratio

Tumor Biology

Volumn 36, Issue 1, 2015, Pages 213-217

  de Siqueira, Elisa C ^a   Souza, Fabrício T A ^a   Diniz, Marina G ^a   Gomez, Ricardo S ^a   Gomes, Carolina C ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

Apoptosis; Heat shock protein; hsp; p53; Pleomorphic adenoma; Salivary gland tumours

Indexed keywords

HEAT SHOCK PROTEIN 27; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; BAX PROTEIN, HUMAN; HSPB1 PROTEIN, HUMAN;

ARTICLE; BAX GENE; BCL2 GENE; CASPASE 3 GENE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; MALE; PLEOMORPHIC ADENOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GENE; TUMOR VOLUME; ADULT; APOPTOSIS; CASE CONTROL STUDY; GENE EXPRESSION; GENETICS; METABOLISM; PATHOLOGY; SALIVARY GLAND; SALIVARY GLAND TUMOR;

ADENOMA, PLEOMORPHIC; ADULT; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASE-CONTROL STUDIES; FEMALE; GENE EXPRESSION; HSP27 HEAT-SHOCK PROTEINS; HUMANS; MALE; PROTO-ONCOGENE PROTEINS C-BCL-2; SALIVARY GLAND NEOPLASMS; SALIVARY GLANDS;

EID: 84922259281     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-014-2634-1     Document Type: Article

References (24)

1. Haslbeck M, Franzmann T, Weinfurtner D, Buchner J. Some like it hot: the structure and function of small heat-shock proteins. Nat Struct Mol Biol. 2005;12(10):842–6.
2. Landry J, Chrétien P, Lambert H, Hickey E, Weber LA. Heat shock resistance conferred by expression of the human HSP27 gene in rodent cells. J Cell Biol. 1989;109(1):7–15.
3. Huot J, Houle F, Spitz DR, Landry J. HSP27 phosphorylation-mediated resistance against actin fragmentation and cell death induced by oxidative stress. Cancer Res. 1996;56(2):273–9.
4. Mymrikov EV, Seit-Nebi AS, Gusev NB. Large potentials of small heat shock proteins. Physiol Rev. 2011;91(4):1123–59.
5. Ciocca RD, Adams DJ, Edwards DP, Bjercke RJ, McGuire WL. Distribution of an estrogen-induced protein with a molecular weight of 24,000 in normal and malignant human tissues and cells. Cancer Res. 1983;43(3):1204–10.
6. Dunn DK, Whelan RDH, Hill B, King RJB. Relationship of HSP27 andoestrogen receptor in hormone sensitive and insensitive cell lines. J Steroid Biochem Mol Biol. 1993;46(4):469–79.
7. Soldes OS, Kuick RD, Thompson IA, Hughes SJ, Orringer MB, Iannettoni MD, et al. Differential expression of Hsp27 in normal oesophagus, Barrett’s metaplasia and oesophageal adenocarcinomas. Br J Cancer. 1999;79(3–4):595–603.
8. Lo Muzio L, Leonardi R, Mariggiò MA, Mignogna MD, Rubini C, Vinella A, et al. HSP 27 as possible prognostic factor in patients with oral squamous cell carcinoma. Histol Histopathol. 2004;19(1):119–28.
9. Acunzo J, Katsogiannou M, Rocchi P. Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death. Int J Biochem Cell Biol. 2012;44(10):1622–31.
10. O’Callaghan-Sunol C, Gabai VL, Sherman MY. Hsp27 modulates p53 signaling and suppresses cellular senescence. Cancer Res. 2007;67(24):11779–88.
11. Xu Y, Diao Y, Qi S, Pan X, Wang Q, Xin Y, et al. Phosphorylated Hsp27 activates ATM-dependent p53 signaling and mediates the resistance of MCF-7 cells todoxorubicin-induced apoptosis. Cell Signal. 2013;25(5):1176–85.
12. Murray-Zmijewski F, Slee EA, Lu X. A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol. 2008;9(9):702–12.
13. Cheng Q, Cao X, Yuan F, Li G, Tong T. Knockdown of WWP1 inhibits growth and induces apoptosis in hepatoma carcinoma cells through the activation of caspase3 and p53. Biochem Biophys Res Commun. 2014;448(3):248–54.
14. Chandrika BB, Maney SK, Lekshmi SU, Retnabhai ST. Endoplasmic reticulum targeted Bcl2 confers long term cell survival through phosphorylation of heat shockprotein 27. Int J Biochem Cell Biol. 2010;42(12):1984–92.
15. Havasi A, Li Z, Wang Z, Martin JL, Botla V, Ruchalski K, et al. Hsp27 inhibits Bax activation and apoptosis via a phosphatidylinositol 3-kinase-dependent mechanism. J Biol Chem. 2008;283(18):12305–13.
16. Rosa DV, Souza RP, Souza BR, Motta BS, Caetano F, Jornada LK, et al. NCS-1 expression in rat brain after electroconvulsive stimulation. Neurochem Res. 2007;32(1):81–5.
17. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 1976;72:248–54.
18. Gomes CC, Bernardes VF, Diniz MG, De Marco L, Gomez RS. Anti-apoptotic gene transcription signature of salivary gland neoplasms. BMC Cancer. 2012;12:61.
19. Gomes CC, Diniz MG, Oliveira CS, Tavassoli M, Odell EW, Gomez RS, et al. Impact of WWOX alterations on p73, ΔNp73, p53, cell proliferation and DNA ploidy in salivary gland neoplasms. Oral Dis. 2011;17(6):564–71.
20. Vanmuylder N, Evrard L, Daelemans P, Dourov N. Chaperones in the parotid gland: localization of heat shock proteins in human adult salivary glands. Cells Tissues Organs. 2000;167(2–3):199–205.
21. Amano O, Kudo Y, Shimada M, Wakayama T, Yamamoto M, Iseki S. Transient occurrence of 27 kDa heat-shock protein in the terminal tubule cells during postnatal development of the rat submandibular gland. Anat Rec. 2001;264(4):358–66.
22. Takahashi-Horiuchi Y, Sugiyama K, Sakashita H, Amano O. Expression of heat shock protein 27 with the transition from proliferation to differentiation of acinar precursor cell in regenerating submandibular gland of rats. Tohoku J Exp Med. 2008;214(3):221–30.
23. Vanmuylder N, Evrard L, Daelemans P, Van Reck J, Dourov N. Expression of heat shock proteins in salivary gland tumors. Immunohistochemical study of HSP27, HSP70, HSP90, and HSP110: apropos of 50 cases. Ann Pathol. 2000;20(3):190–5.
24. Fan GC, Ren X, Qian J, Yuan Q, Nicolaou P, Wang Y, et al. Novel cardioprotective role of a small heat-shock protein, Hsp20, against ischemia/reperfusion injury. Circulation. 2005;111(14):1792–9.