Mannosylated poly(beta-amino esters) for targeted antigen presenting cell immune modulation

Biomaterials

Volumn 37, Issue , 2015, Pages 333-344

  Jones, Charles H ^a   Chen, Mingfu ^a   Ravikrishnan, Anitha ^a   Reddinger, Ryan ^b   Zhang, Guojian ^a   Hakansson, Anders P ^b,c   Pfeifer, Blaine A ^a  

^a State University of New York   (United States)

^b UNIVERSITY AT BUFFALO   (United States)

^c UNIVERSITY AT BUFFALO   (United States)

Author keywords

Antigen presenting cells; Cationic polymers; Gene therapy; Nonviral vector; Vaccines

Indexed keywords

ANTIGENS; CYTOLOGY; ESTERS; GENE THERAPY; GENE TRANSFER; POLYMERS; VACCINES; VECTORS;

ANTIBIOTIC RESISTANCE; ANTIGEN PRESENTING CELLS; ASSESSMENT METHODOLOGIES; CATIONIC POLYMERS; GENETIC VACCINATION; HUMORAL IMMUNE RESPONSE; NONVIRAL VECTORS; UBIQUITOUS DELIVERY;

IMMUNE SYSTEM;

MANNOSE; POLY(BETA AMINO ESTER); POLYMER; UNCLASSIFIED DRUG; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; POLY(BETA-AMINO ESTER);

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIGEN PRESENTING CELL; ARTICLE; GENE TARGETING; GENETIC IMMUNIZATION; IMMUNE RESPONSE; IMMUNOMODULATION; IN VITRO GENE TRANSFER; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; RAT; SYNTHESIS; ANIMAL; ANIMAL MODEL; BAGG ALBINO MOUSE; CHEMISTRY; FEMALE; FLUORESCENCE; GENETIC TRANSFECTION; HELA CELL LINE; HUMAN; IMMUNIZATION; IMMUNOLOGY; METABOLISM;

ANIMALS; ANTIGEN-PRESENTING CELLS; FEMALE; FLUORESCENCE; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; IMMUNIZATION; IMMUNOMODULATION; MANNOSE; MICE, INBRED BALB C; MODELS, ANIMAL; POLYMERS; TRANSFECTION;

EID: 84922227871     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.10.037     Document Type: Article

References (59)

1. Chikhlikar P., Barros de Arruda L., Maciel M., Silvera P., Lewis M.G., August J.T., et al. DNA encoding an HIV-1 Gag/human lysosome-associated membrane protein-1 chimera elicits a broad cellular and humoral immune response in Rhesus macaques. Plos One 2006, 1:e135.
2. Sin J.I., Kim J., Chattergoon M., Ayyavoo V., McCallus D., Ugen K.E., et al. Engineering of DNA vaccines using molecular adjuvant plasmids. Dev Biol 2000, 104:187-198.
3. Felix N.J., Suri A., Salter-Cid L., Nadler S.G., Gujrathi S., Corbo M., et al. Targeting lymphocyte co-stimulation: from bench to bedside. Autoimmunity 2010, 43:514-525.
4. Lori F., Kelly L.M., Lisziewicz J. APC-targeted immunization for the treatment of HIV-1. Expert Rev Vaccines 2004, 3:S189-S198.
5. Ahsan M.F., Gore M.M. Comparative analysis of macrophage associated vectors for use in genetic vaccine. Genet Vaccines Ther 2011, 9:10.
6. Deliyannis G., Boyle J.S., Brady J.L., Brown L.E., Lew A.M. Afusion DNA vaccine that targets antigen-presenting cells increases protection from viral challenge. Proc Natl Acad Sci U S A 2000, 97:6676-6680.
7. Kasahara N., Dozy A.M., Kan Y.W. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science 1994, 266:1373-1376.
8. Igarashi T., Suzuki S., Takahashi M., Tamaoki T., Shimada T. Anovel strategy of cell targeting based on tissue-specific expression of the ecotropic retrovirus receptor gene. Hum Gene Ther 1998, 9:2691-2698.
9. Cieslewicz M., Tang J., Yu J.L., Cao H., Zavaljevski M., Motoyama K., et al. Targeted delivery of proapoptotic peptides to tumor-associated macrophages improves survival. Proc Natl Acad Sci U S A 2013, 110:15919-15924.
10. Ries C.H., Cannarile M.A., Hoves S., Benz J., Wartha K., Runza V., et al. Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy. Cancer Cell 2014, 25:846-859.
11. Luo Y., Zhou H., Krueger J., Kaplan C., Lee S.H., Dolman C., et al. Targeting tumor-associated macrophages as a novel strategy against breast cancer. JClin Invest 2006, 116:2132-2141.
12. Davignon J.L., Hayder M., Baron M., Boyer J.F., Constantin A., Apparailly F., et al. Targeting monocytes/macrophages in the treatment of rheumatoid arthritis. Rheumatol (Oxford) 2013, 52:590-598.
13. Onodera S., Ohshima S., Tohyama H., Yasuda K., Nishihira J., Iwakura Y., et al. Anovel DNA vaccine targeting macrophage migration inhibitory factor protects joints from inflammation and destruction in murine models of arthritis. Arthritis Rheum 2007, 56:521-530.
14. Jiang H.L., Kang M.L., Quan J.S., Kang S.G., Akaike T., Yoo H.S., et al. The potential of mannosylated chitosan microspheres to target macrophage mannose receptors in an adjuvant-delivery system for intranasal immunization. Biomaterials 2008, 29:1931-1939.
15. Pozzi L.A., Maciaszek J.W., Rock K.L. Both dendritic cells and macrophages can stimulate naive CD8 T cells invivo to proliferate, develop effector function, and differentiate into memory cells. JImmunol 2005, 175:2071-2081.
16. Kovacsovics-Bankowski M., Clark K., Benacerraf B., Rock K.L. Efficient major histocompatibility complex class I presentation of exogenous antigen upon phagocytosis by macrophages. Proc Natl Acad Sci U S A 1993, 90:4942-4946.
17. Desmedt M., Rottiers P., Dooms H., Fiers W., Grooten J. Macrophages induce cellular immunity by activating Th1 cell responses and suppressing Th2 cell responses. JImmunol 1998, 160:5300-5308.
18. Moser M. Regulation of Th1/Th2 development by antigen-presenting cells invivo. Immunobiology 2001, 204:551-557.
19. Taylor M.E. Structure and function of the macrophage mannose receptor. Results Probl Cell Differ 2001, 33:105-121.
20. Stahl P.D. The mannose receptor and other macrophage lectins. Curr Opin Immunol 1992, 4:49-52.
21. Sheikh H., Yarwood H., Ashworth A., Isacke C.M. Endo180, an endocytic recycling glycoprotein related to the macrophage mannose receptor is expressed on fibroblasts, endothelial cells and macrophages and functions as a lectin receptor. JCell Sci 2000, 113(Pt 6):1021-1032.
22. Szolnoky G., Bata-Csorgo Z., Kenderessy A.S., Kiss M., Pivarcsi A., Novak Z., et al. Amannose-binding receptor is expressed on human keratinocytes and mediates killing of Candida albicans. JInvest Dermatol 2001, 117:205-213.
23. He L.Z., Crocker A., Lee J., Mendoza-Ramirez J., Wang X.T., Vitale L.A., et al. Antigenic targeting of the human mannose receptor induces tumor immunity. JImmunol 2007, 178:6259-6267.
24. Mansour M.K., Schlesinger L.S., Levitz S.M. Optimal T cell responses to Cryptococcus neoformans mannoprotein are dependent on recognition of conjugated carbohydrates by mannose receptors. JImmunol 2002, 168:2872-2879.
25. Zhang J., Zhu J., Imrich A., Cushion M., Kinane T.B., Koziel H. Pneumocystis activates human alveolar macrophage NF-kappaB signaling through mannose receptors. Infect Immun 2004, 72:3147-3160.
26. Lin S.X., Mallet W.G., Huang A.Y., Maxfield F.R. Endocytosed cation-independent mannose 6-phosphate receptor traffics via the endocytic recycling compartment en route to the trans-Golgi network and a subpopulation of late endosomes. Mol Biol Cell 2004, 15:721-733.
27. D'Addio S.M., Baldassano S., Shi L., Cheung L., Adamson D.H., Bruzek M., et al. Optimization of cell receptor-specific targeting through multivalent surface decoration of polymeric nanocarriers. JControl Release 2013, 168:41-49.
28. Lynn D.M., Langer R. Degradable poly(β-amino esters): synthesis, characterization, and self-assembly with plasmid DNA. JAm Chem Soc 2000, 122:10761-10768.
29. Sunshine J.C., Sunshine S.B., Bhutto I., Handa J.T., Green J.J. Poly(beta-amino ester)-nanoparticle mediated transfection of retinal pigment epithelial cells invitro and invivo. Plos One 2012, 7:e37543.
30. Sunshine J.C., Peng D.Y., Green J.J. Uptake and transfection with polymeric nanoparticles are dependent on polymer end-group structure, but largely independent of nanoparticle physical and chemical properties. Mol Pharmacol 2012, 9:3375-3383.
31. Jones C.H., Chen C.K., Jiang M., Fang L., Cheng C., Pfeifer B.A. Synthesis of cationic polylactides with tunable charge densities as nanocarriers for effective gene delivery. Mol Pharmacol 2013, 10:1138-1145.
32. Jones C.H., Chen C.K., Ravikrishnan A., Rane S., Pfeifer B.A. Overcoming nonviral gene delivery barriers: perspective and future. Mol Pharmacol 2013, 9:3375-3383.
33. Chen C.K., Jones C.H., Mistriotis P., Yu Y., Ma X., Ravikrishnan A., et al. Poly(ethylene glycol)-block-cationic polylactide nanocomplexes of differing charge density for gene delivery. Biomaterials 2013, 34:9688-9699.
34. Matsuda T., Cepko C.L. Electroporation and RNA interference in the rodent retina invivo and invitro. Proc Natl Acad Sci U S A 2004, 101:16-22.
35. Yang J., Sanderson N.S., Wawrowsky K., Puntel M., Castro M.G., Lowenstein P.R. Kupfer-type immunological synapse characteristics do not predict anti-brain tumor cytolytic T-cell function invivo. Proc Natl Acad Sci U S A 2010, 107:4716-4721.
36. Zugates G.T., Tedford N.C., Zumbuehl A., Jhunjhunwala S., Kang C.S., Griffith L.G., et al. Gene delivery properties of end-modified poly(beta-amino ester)s. Bioconjug Chem 2007, 18:1887-1896.
37. Sovadinova I., Palermo E.F., Huang R., Thoma L.M., Kuroda K. Mechanism of polymer-induced hemolysis: nanosized pore formation and osmotic lysis. Biomacromolecules 2011, 12:260-268.
38. Fischer D., Li Y., Ahlemeyer B., Krieglstein J., Kissel T. Invitro cytotoxicity testing of polycations: influence of polymer structure on cell viability and hemolysis. Biomaterials 2003, 24:1121-1131.
39. Zhang X., Edwards J.P., Mosser D.M. The expression of exogenous genes in macrophages: obstacles and opportunities. Methods Mol Biol 2009, 531:123-143.
40. Fernandez N., Alonso S., Valera I., Vigo A.G., Renedo M., Barbolla L., et al. Mannose-containing molecular patterns are strong inducers of cyclooxygenase-2 expression and prostaglandin E2 production in human macrophages. JImmunol 2005, 174:8154-8162.
41. Ransom J., Wu R., Fischer M., Zlotnik A. Antigen presenting ability of thymic macrophages and epithelial cells: evidence for defects in the antigen processing function of thymic epithelial cells. Cell Immunol 1991, 134:180-190.
42. Stahl P., Schlesinger P.H., Sigardson E., Rodman J.S., Lee Y.C. Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: characterization and evidence for receptor recycling. Cell 1980, 19:207-215.
43. Simmons B.M., Stahl P.D., Russell J.H. Mannose receptor-mediated uptake of ricin toxin and ricin A chain by macrophages. Multiple intracellular pathways for a chain translocation. JBiol Chem 1986, 261:7912-7920.
44. Gage E., Hernandez M.O., O'Hara J.M., McCarthy E.A., Mantis N.J. Role of the mannose receptor (CD206) in innate immunity to ricin toxin. Toxins 2011, 3:1131-1145.
45. Shin J.S., Abraham S.N. Cell biology. Caveolae-not just craters in the cellular landscape. Science 2001, 293:1447-1448.
46. Pelkmans L., Helenius A. Endocytosis via caveolae. Traffic 2002, 3:311-320.
47. Parton R.G., Simons K. The multiple faces of caveolae. Nat Rev Mol Cell Biol 2007, 8:185-194.
48. Rehman Z., Zuhorn I.S., Hoekstra D. How cationic lipids transfer nucleic acids into cells and across cellular membranes: recent advances. JControl Release 2013, 166:46-56.
49. Sahay G., Querbes W., Alabi C., Eltoukhy A., Sarkar S., Zurenko C., et al. Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling. Nat Biotechnol 2013, 31:653-658.
50. Rehman Z.U., Hoekstra D., Zuhorn I.S. Mechanism of polyplex- and lipoplex-mediated delivery of nucleic acids: real-time visualization of transient membrane destabilization without endosomal lysis. Acs Nano 2013, 7:3767-3777.
51. Sun X., Chen S., Han J., Zhang Z. Mannosylated biodegradable polyethyleneimine for targeted DNA delivery to dendritic cells. Int J Nanomed 2012, 7:2929-2942.
52. Pack D.W., Hoffman A.S., Pun S., Stayton P.S. Design and development of polymers for gene delivery. Nat Rev Drug Discov 2005, 4:581-593.
53. Boyle J.S., Silva A., Brady J.L., Lew A.M. DNA immunization: induction of higher avidity antibody and effect of route on T cell cytotoxicity. Proc Natl Acad Sci U S A 1997, 94:14626-14631.
54. Jones C.H., Ravikrishnan A., Chen M., Reddinger R., Kamal Ahmadi M., Rane S., et al. Hybrid biosynthetic gene therapy vector development and dual engineering capacity. Proc Natl Acad Sci U S A 2014, 111:12360-12365.
55. Xu W., Banchereau J. The antigen presenting cells instruct plasma cell differentiation. Front Immunol 2014, 4:504.
56. Xu W., Joo H., Clayton S., Dullaers M., Herve M.C., Blankenship D., et al. Macrophages induce differentiation of plasma cells through CXCL10/IP-10. JExp Med 2012, 209:1813-1823. S1-2.
57. Unanue E.R., Cerottini J.C., Bedford M. Persistence of antigen on the surface of macrophages. Nature 1969, 222:1193-1195.
58. Junt T., Moseman E.A., Iannacone M., Massberg S., Lang P.A., Boes M., et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 2007, 450:110-114.
59. Phan T.G., Grigorova I., Okada T., Cyster J.G. Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat Immunol 2007, 8:992-1000.