The differential clinical and neurocognitive profiles of COMT SNP rs165599 genotypes in schizophrenia

Journal of the International Neuropsychological Society

Volumn 11, Issue 2, 2005, Pages 202-204

  Chan, Raymond C K ^a,b   Chen, Ronald Y L ^b   Chen, Eric Y H ^b   Hui, Tomy C K ^b   Cheung, Eric F C ^c   Cheung, H K ^c   Sham, Pak ^b,d   Li, Tao ^d   Collier, David ^d  

^a SUN YAT SEN UNIVERSITY   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c CASTLE PEAK HOSPITAL   (Hong Kong)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; CHLORPROMAZINE; DNA FRAGMENT; GENOMIC DNA; NEUROLEPTIC AGENT; TRIHEXYPHENIDYL;

ADULT; ALLELE; ARTICLE; CHINESE; CLINICAL ARTICLE; CLINICAL STUDY; COGNITION; CONTROLLED STUDY; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; DISEASE DURATION; FEMALE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; MALE; NEUROPSYCHOLOGICAL TEST; PRIORITY JOURNAL; RATING SCALE; REACTION TIME; SCHIZOPHRENIA; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ADULT; CATECHOL O-METHYLTRANSFERASE; COGNITION; DNA; FEMALE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHIATRIC STATUS RATING SCALES; SCHIZOPHRENIA; SCHIZOPHRENIC PSYCHOLOGY;

EID: 17644372678     PISSN: 13556177     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355617705050241     Document Type: Article

References (14)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association.
2. Bray, N.J., Buckland, P.R., Williams, N.M., Williams, H.J., Norton, N., Owen, M.J., & O'Donovan, M.C. (2003). A haplotype implicated in schizophrenia susceptibility is associated with reduced COMT expression in human brain. American Journal of Human Genetics, 73, 152-161.
3. Callicott, J.H., Ramsey, N.F., Tallent, K., Bertolino, A., Knable, M.B., Coppola, R., & Weinberger, D.R. (1998). Functional magnetic resonance imaging brain mapping in psychiatry: Methodological issues illustrated in a study of working memory in schizophrenia. Neuropsychopharmacology, 18, 186-196.
4. Chan, R.C.K., Chen, E.Y.H., Cheung, E.F.C., & Cheung, H.K. (2004). Executive dysfunctions in schizophrenia: Relationships to clinical manifestations. European Archives of Psychiatry and Clinical Neuroscience, 254, 256-262
5. 108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Science, 98, 6917-6922.
6. Glatt S.J., Faraone S.V., & Tsuang M.T. (2003). Association between a functional catechol O-methyltransferase gene polymorphism and schizophrenia: Meta-analysis of case-control and family-based studies. American Journal of Psychiatry, 160, 469-476.
7. Gold, J.M., Carpenter, C., Randolph, C., Goldberg, T.E., & Weinberger, D.R. (1997). Auditory working memory and Wisconsin Card Sorting Test performance in schizophrenia. Archives of General Psychiatry, 54, 159-165.
8. Halperin, J.M., Sharma, V., Greenblatt, E., & Schwartz, S.T. (1991). Assessment of the Continuous Performance Test: Reliability and validity in a nonreferred Sample. Psychological Assessment, 3, 603-608.
9. Kay, S.R., Fiszbein, A., & Opler, L.A. (1987). The Positive and Negative Syndrome Scale (PANSS) for schizophrenia. Schizophrenia Bulletin, 13, 261-276.
10. Li, T., Sham, P.C., Vallada, H., Xie, T., Tang, X., Murray, R.M., Liu, X., & Collier, D.A. (1996). Preferential transmission of the high activity allele of COMT in schizophrenia. Psychiatry Genetics, 6 131-133.
11. National Institute of Health. (2004). SNP: Single nucleotide polymorphism. Retrieved from http://www.ncbi.nlm.nih.gov/entrez/query.fegi?db=snp
12. Shifman, S., Bronstein, M., Sternfeld, M., Pisante-Shalom, A., Lev-Lehman, E., Weizman, A., Reznik, I., Spivak, B., Grisaru, N., Karp, L., Schiffer, R., Kotler, M., Strous, R.D., Swartz-Vanetik, M., Knobler, H.Y., Shinar, E., Beckmann, J.S., Yakir, B., Risch, N., Zak, N.B., & Darvasi, A. (2002). A highly significant association between a COMT haplotype and schizophrenia. American Journal of Human Genetics, 71, 1296-1302.
13. Wechsler, D. (1997a). WAIS-III administration and scoring manual. San Antonio, TX: The Psychological Corporation.
14. Wechsler, D. (1997b). WMS-III administration and scoring manual. San Antonio, TX: The Psychological Corporation.