Long-term effects of an exercise and mediterranean diet intervention in the vascular function of an older, healthy population

Microvascular Research

Volumn 95, Issue 1, 2014, Pages 103-107

  Klonizakis, Markos ^a   Alkhatib, Ahmad ^a   Middleton, Geoff ^b  

^a SHEFFIELD HALLAM UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF LINCOLN   (United Kingdom)

Author keywords

Ageing; Endothelium; Fitness assessment; Mediterranean diet; Microcirculation; Nutrition

Indexed keywords

ACETYLCHOLINE; VASODILATOR AGENT;

ADULT; AGING; ARTICLE; BREATHING; CARDIORESPIRATORY FITNESS; CARDIOVASCULAR FUNCTION; EXERCISE; FEMALE; HUMAN; HUMAN EXPERIMENT; INTERVENTION STUDY; MALE; MEDITERRANEAN DIET; MICROCIRCULATION; NORMAL HUMAN; RISK REDUCTION; VASCULAR ENDOTHELIUM; AGE; ARM; BLOOD FLOW; BLOOD FLOW VELOCITY; CLINICAL TRIAL; DIAGNOSTIC USE; EXERCISE TEST; EXERCISE TOLERANCE; HEALTH STATUS; LASER DOPPLER FLOWMETRY; LEG; LUNG VENTILATION; MIDDLE AGED; SEDENTARY LIFESTYLE; SKIN; TIME; TREATMENT OUTCOME; VASCULARIZATION; VASODILATATION;

AGE FACTORS; AGING; BLOOD FLOW VELOCITY; DIET, MEDITERRANEAN; EXERCISE; EXERCISE TEST; EXERCISE TOLERANCE; FEMALE; HEALTH STATUS; HUMANS; LASER-DOPPLER FLOWMETRY; LOWER EXTREMITY; MALE; MICROCIRCULATION; MIDDLE AGED; PULMONARY VENTILATION; REGIONAL BLOOD FLOW; SEDENTARY LIFESTYLE; SKIN; TIME FACTORS; TREATMENT OUTCOME; UPPER EXTREMITY; VASODILATION; VASODILATOR AGENTS;

EID: 84922211733     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2014.07.015     Document Type: Article

References (30)

1. American College of Sports Medicine, et al. American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med. Sci. Sports Exerc. 2009, 41:1510-1530.
2. Bach-Faig A., et al. Mediterranean diet pyramid today. Science and cultural updates. Public Health Nutr. 2011, 14:2274-2284.
3. Balady G.J., et al. Clinician's Guide to cardiopulmonary exercise testing in adults: a scientific statement from the American Heart Association. Circulation 2010, 122:191-225.
4. Barton H., Grant M. A health map for the local human habitat. J. R. Soc. Promot. Health 2006, 126:252-253.
5. Dod H.S., et al. Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis. Am. J. Cardiol. 2010, 105:362-367.
6. Estruch R., et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N. Engl. J. Med. 2013, 368:1279-1290.
7. Gates P.E., et al. Human endothelial function and microvascular ageing. Exp. Physiol. 2009, 94:311-316.
8. Grosso G., et al. Mediterranean diet and cardiovascular risk factors: a systematic review. Crit. Rev. Food Sci. Nutr. 2014, 54:593-610.
9. Hamer M., Stamatakis E. Physical activity and risk of cardiovascular disease events: inflammatory and metabolic mechanisms. Med. Sci. Sports Exerc. 2009, 41:1206-1211.
10. Kahaleh B. Vascular disease in scleroderma: mechanisms of vascular injury. Rheum. Dis. Clin. North Am. 2008, 34:57-71.
11. Khan F., et al. The role of endothelial function and its assessment in rheumatoid arthritis. Nat. Rev. Rheumatol. 2010, 6:253-261.
12. Klonizakis M., et al. Effects of posture and venous insufficiency on endothelial-dependent and -independent cutaneous vasodilation in the perimalleolar area. Eur. J. Vasc. Endovasc. Surg. 2003, 26:100-104.
13. Klonizakis M., et al. Characterising the time-course of microvascular vasodilator responses in humans using laser Doppler fluximetry and Iontophoresis. J. Pharmacol. Toxicol. Methods 2011, 63:115-118.
14. Klonizakis M., et al. Mediterranean diet and exercise induce improvement in age-dependent vascular activity. Clin. Sci. 2012, 124:579-587.
15. Kumanyika S. Preventive medicine and diet-related diseases: searching for impact. Prev. Med. 2012, 55:542-543.
16. Lucas C.P., et al. Achieving therapeutic goals in insulin-using diabetic patients with non-insulin-dependent diabetes mellitus. A weight reduction-exercise-oral agent approach. Am. J. Med. 1987, 83:3-9.
17. Luengo-Fernández R., et al. Cost of cardiovascular diseases in the United Kingdom. Heart 2006, 92:1384-1389.
18. Marmot M., et al. WHO European review of social determinants of health and the health divide. Lancet 2012, 380:1011-1029.
19. Mithril C., et al. Guidelines for the new Nordic diet. Public Health Nutr. 2012, 15:1941-1947.
20. Montero D., et al. Endothelial dysfunction, inflammation, and oxidative stress in obese children and adolescents: markers and effect of lifestyle intervention. Obes. Rev. 2012, 13:441-455.
21. Office of National Statistics Population Ageing in the United Kingdom, its Constituent Countries and the European Union Available at:, (last accessed 29 July 2014). http://www.ons.gov.uk/ons/rel/mortality-ageing/focus-on-older-people/population-ageing-in-the-united-kingdom-and-europe/rpt-age-uk-eu.html.
22. Organisation for Economic Co-operation and Development Health at a Glance 2013: OECD Indicators Available at:, (last accessed 29 July 2014). http://www.oecd.org/els/health-systems/Health-at-a-Glance-2013.pdf.
23. Perona J.S., et al. The role of virgin olive oil components in the modulation of endothelial function. J. Nutr. Biochem. 2006, 17:429-445.
24. Richard C., et al. Effect of the Mediterranean diet with and without weight loss on markers of inflammation in men with metabolic syndrome. Obesity 2013, 21:51-57.
25. Sofi F., et al. Adherence to Mediterranean diet and health status: meta-analysis. Br. Med. J. 2008, 337:1344-1351.
26. Tew G.A., et al. Effects of ageing and fitness on skin-microvessel vasodilator function in humans. Eur. J. Appl. Physiol. 2010, 109:173-181.
27. Urpi-Sarda M., et al. Virgin olive oil and nuts as key foods of the Mediterranean diet effects on inflammatory biomarkers related to atherosclerosis. Pharmacol. Res. 2012, 65:577-583.
28. Versari D., et al. Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br. J. Pharmacol. 2009, 157:527-536.
29. Warburton D.E., et al. Prescribing exercise as preventive therapy. Can. Med. Assoc. J. 2006, 174:961-974.
30. Willcox B.J., Willcox D.C. Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa: controversies and clinical implications. Curr. Opin. Clin. Nutr. Metab. Care 2014, 17:51-58.