Resveratrol Synergistically Triggers Apoptotic Cell Death with Arsenic Trioxide via Oxidative Stress in Human Lung Adenocarcinoma A549 Cells

Biological Trace Element Research

Volumn 163, Issue 1-2, 2015, Pages 112-123

  Gu, Shiyan ^a   Chen, Chengzhi ^a   Jiang, Xuejun ^a   Zhang, Zunzhen ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Apoptosis; Arsenic trioxide; Oxidative stress; Resveratrol

Indexed keywords

ARSENIC TRIOXIDE; CYTOCHROME C; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FAS LIGAND; GLUTATHIONE; REACTIVE OXYGEN METABOLITE; RESVERATROL; ANTINEOPLASTIC AGENT; ORGANOARSENIC DERIVATIVE; OXIDE; STILBENE DERIVATIVE;

ADENOCARCINOMA CELL LINE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL SURVIVAL; CELL VIABILITY; CHROMOSOME DAMAGE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENTIATION; GENOTOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ADENOCARCINOMA; OXIDATIVE STRESS; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SURVIVAL RATE; ADENOCARCINOMA; AGONISTS; DRUG EFFECTS; LUNG NEOPLASMS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ADENOCARCINOMA; ANTICARCINOGENIC AGENTS; APOPTOSIS; ARSENICALS; CELL LINE, TUMOR; DRUG SYNERGISM; HUMANS; LUNG NEOPLASMS; OXIDATIVE STRESS; OXIDES; STILBENES;

EID: 84922106178     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-014-0186-2     Document Type: Article

References (30)

1. Zhang TD, Chen GQ, Wang ZG, Wang ZY, Chen SJ, Chen Z (2001) Arsenic trioxide, a therapeutic agent for APL. Oncogene 20(49):7146–7153
2. Emadi A, Gore SD (2010) Arsenic trioxide - an old drug rediscovered. Blood Rev 24(4–5):191–199
3. Yang C, Kuo M, Chen J, Chen Y (1999) Arsenic trioxide sensitivity is associated with low level of glutathione in cancer cells. Br J Cancer 81(5):796
4. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y (2004) Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies. Anticancer Res 24(5A):2783–2840
5. Alarcón de la Lastra C, Villegas I (2005) Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications. Mol Nutr Food Res 49(5):405–430
6. Bishayee A (2009) Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prev Res (Phila) 2(5):409–418
7. Scott E, Steward WP, Gescher AJ, Brown K (2012) Resveratrol in human cancer chemoprevention – choosing the ‘right’ dose. Mol Nutr Food Res 56(1):7–13
8. Chen C, Jiang X, Zhao W, Zhang Z (2013) Dual role of resveratrol in modulation of genotoxicity induced by sodium arsenite via oxidative stress and apoptosis. Food Chem Toxicol 59C:8–17
9. Nessa MU, Beale P, Chan C, Yu JQ, Huq F (2012) Combinations of resveratrol, cisplatin and oxaliplatin applied to human ovarian cancer cells. Anticancer Res 32(1):53–59
10. Amiri F, Zarnani AH, Zand H, Koohdani F, Jeddi-Tehrani M, Vafa M (2013) Synergistic anti-proliferative effect of resveratrol and etoposide on human hepatocellular and colon cancer cell lines. Eur J Pharmacol 718(1–3):34–40
11. Mohapatra P, Preet R, Choudhuri M, Choudhuri T, Kundu CN (2011) 5-fluorouracil increases the chemopreventive potentials of resveratrol through DNA damage and MAPK signaling pathway in human colorectal cancer cells. Oncol Res 19(7):311–321
12. Chen C, Jiang X, Hu Y, Zhang Z (2013) The protective role of resveratrol in the sodium arsenite-induced oxidative damage via modulation of intracellular GSH homeostasis. Biol Trace Elem Res 155(1):119–131
13. Beutler E, Duron O, Kelly BM (1963) Improved method for the determination of blood glutathione. J Lab Clin Med 61:882–888
14. Bainor A, Chang L, McQuade TJ, Webb B, Gestwicki JE (2011) Bicinchoninic acid (BCA) assay in low volume. Anal Biochem 410(2):310–312
15. Jiang X, Chen C, Zhao W, Zhang Z (2013) Sodium arsenite and arsenic trioxide differently affect the oxidative stress, genotoxicity and apoptosis in A549 cells: an implication for the paradoxical mechanism. Environ Toxicol Pharmacol 36(3):891–902
16. Maurya DK (2014) HaloJ: an ImageJ program for semiautomatic quantification of DNA damage at single-cell level. Int J Toxicol 33(5):362–366
17. Garcia-Rodriguez Mdel C, Carvente-Juarez MM, Altamirano-Lozano MA (2013) Antigenotoxic and apoptotic activity of green tea polyphenol extracts on hexavalent chromium-induced DNA damage in peripheral blood of CD-1 mice: analysis with differential acridine orange/ethidium bromide staining. Oxid Med Cell Longev 2013:486419
18. Jiang X, Chen C, Liu Y, Zhang P, Zhang Z (2014) Critical role of cellular glutathione homeostasis for trivalent inorganic arsenite-induced oxidative damage in human bronchial epithelial cells. Mutat Res Genet Toxicol Environ Mutagen 770:35–45
19. Miller WH, Schipper HM, Lee JS, Singer J, Waxman S (2002) Mechanisms of action of arsenic trioxide. Cancer Res 62(14):3893–3903
20. Kawanishi S, Hiraku Y (2004) Amplification of anticancer drug-induced DNA damage and apoptosis by DNA-binding compounds. Curr Med Chem Anticancer Agents 4(5):415–419
21. Kumar S, Yedjou CG, Tchounwou PB (2014) Arsenic trioxide induces oxidative stress, DNA damage, and mitochondrial pathway of apoptosis in human leukemia (HL-60) cells. J Exp Clin Cancer Res 33(1):42
22. Attia SM (2012) Influence of resveratrol on oxidative damage in genomic DNA and apoptosis induced by cisplatin. Mutat Res 741(1–2):22–31
23. Yaseen A, Chen S, Hock S, Rosato R, Dent P, Dai Y, Grant S (2012) Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway. Mol Pharmacol 82(6):1030–1041
24. Pelicano H, Carney D, Huang P (2004) ROS stress in cancer cells and therapeutic implications. Drug Resist Updat 7(2):97–110
25. Trachootham D, Alexandre J, Huang P (2009) Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8(7):579–591
26. Maiti AK (2012) Genetic determinants of oxidative stress-mediated sensitization of drug-resistant cancer cells. Int J Cancer 130(1):1–9
27. Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M (2006) Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact 160(1):1–40
28. Toyokuni S (2006) Novel aspects of oxidative stress-associated carcinogenesis. Antioxid Redox Signal 8(7–8):1373–1377
29. Gorrini C, Harris IS, Mak TW (2013) Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov 12(12):931–947
30. Lushchak VI (2012) Glutathione homeostasis and functions: potential targets for medical interventions. J Amino Acids 2012:736837