메뉴 건너뛰기




Volumn 58, Issue 2, 2015, Pages 374-383

Nutritional strategy to prevent fatty liver and insulin resistance independent of obesity by reducing glucose-dependent insulinotropic polypeptide responses in mice

Author keywords

Fatty liver; GIP response; Palatinose

Indexed keywords

FRUCTOSE; GASTRIC INHIBITORY POLYPEPTIDE; GLUCOSE; GLUCOSE DEPENDENT INSULINOTROPIC POLYPEPTIDE RECEPTOR; HORMONE RECEPTOR; INCRETIN; INSULIN; PALATINOSE; SUCROSE; SUPPRESSOR OF CYTOKINE SIGNALING 2; UNCLASSIFIED DRUG; GASTRIC INHIBITORY POLYPEPTIDE RECEPTOR; ISOMALTOSE;

EID: 84922087366     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-014-3423-5     Document Type: Article
Times cited : (31)

References (44)
  • 1
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study
    • PID: 20858492
    • Williams CD, Stengel J, Asike MI et al (2011) Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 140:124–131
    • (2011) Gastroenterology , vol.140 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3
  • 3
    • 0037382786 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
    • PID: 12668987
    • Marchesini G, Bugianesi E, Forlani G et al (2003) Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome. Hepatology 37:917–923
    • (2003) Hepatology , vol.37 , pp. 917-923
    • Marchesini, G.1    Bugianesi, E.2    Forlani, G.3
  • 4
    • 84884860377 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes
    • PID: 23929732
    • Birkenfeld AL, Shulman GI (2014) Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 59:713–723
    • (2014) Hepatology , vol.59 , pp. 713-723
    • Birkenfeld, A.L.1    Shulman, G.I.2
  • 5
    • 77952545900 scopus 로고    scopus 로고
    • Combination of acarbose and ezetimibe prevents non-alcoholic fatty liver disease: a break of intestinal insulin resistance?
    • PID: 20385430
    • Rudovich NN, Weickert MO, Machann J, Pfeiffer AF (2010) Combination of acarbose and ezetimibe prevents non-alcoholic fatty liver disease: a break of intestinal insulin resistance? J Hepatol 52:952–953
    • (2010) J Hepatol , vol.52 , pp. 952-953
    • Rudovich, N.N.1    Weickert, M.O.2    Machann, J.3    Pfeiffer, A.F.4
  • 6
    • 34548086478 scopus 로고    scopus 로고
    • Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats
    • COI: 1:CAS:528:DC%2BD2sXos1Cktb0%3D, PID: 17634263
    • Sato K, Arai H, Mizuno A et al (2007) Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats. J Nutr 137:1908–1915
    • (2007) J Nutr , vol.137 , pp. 1908-1915
    • Sato, K.1    Arai, H.2    Mizuno, A.3
  • 7
    • 0142024829 scopus 로고    scopus 로고
    • Sugars, insulin sensitivity, and the postprandial state
    • COI: 1:CAS:528:DC%2BD3sXnslGjtrk%3D, PID: 14522751
    • Daly M (2003) Sugars, insulin sensitivity, and the postprandial state. Am J Clin Nutr 78:865S–872S
    • (2003) Am J Clin Nutr , vol.78 , pp. 865S-872S
    • Daly, M.1
  • 8
    • 0024349280 scopus 로고
    • Usefulness of palatinose as a caloric sweetener for diabetic patients
    • COI: 1:STN:280:DyaL1MznvFSjtA%3D%3D, PID: 2673967
    • Kawai K, Yoshikawa H, Murayama Y, Okuda Y, Yamashita K (1989) Usefulness of palatinose as a caloric sweetener for diabetic patients. Horm Metab Res 21:338–340
    • (1989) Horm Metab Res , vol.21 , pp. 338-340
    • Kawai, K.1    Yoshikawa, H.2    Murayama, Y.3    Okuda, Y.4    Yamashita, K.5
  • 9
    • 74949110505 scopus 로고    scopus 로고
    • Impairment of fat oxidation under high- vs. low-glycemic index diet occurs before the development of an obese phenotype
    • COI: 1:CAS:528:DC%2BC3cXhvVyrsr4%3D, PID: 19934403
    • Isken F, Klaus S, Petzke KJ, Loddenkemper C, Pfeiffer AF, Weickert MO (2010) Impairment of fat oxidation under high- vs. low-glycemic index diet occurs before the development of an obese phenotype. Am J Physiol Endocrinol Metab 298:E287–E295
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , pp. E287-E295
    • Isken, F.1    Klaus, S.2    Petzke, K.J.3    Loddenkemper, C.4    Pfeiffer, A.F.5    Weickert, M.O.6
  • 10
    • 0037784011 scopus 로고    scopus 로고
    • GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine
    • COI: 1:CAS:528:DC%2BD3sXkvVCltbw%3D, PID: 12832109
    • Mortensen K, Christensen LL, Holst JJ, Orskov C (2003) GLP-1 and GIP are colocalized in a subset of endocrine cells in the small intestine. Regul Pept 114:189–196
    • (2003) Regul Pept , vol.114 , pp. 189-196
    • Mortensen, K.1    Christensen, L.L.2    Holst, J.J.3    Orskov, C.4
  • 11
    • 0033520869 scopus 로고    scopus 로고
    • GIP biology and fat metabolism
    • COI: 1:CAS:528:DyaK1MXotFyis7c%3D, PID: 10666005
    • Yip RG, Wolfe MM (2000) GIP biology and fat metabolism. Life Sci 66:91–103
    • (2000) Life Sci , vol.66 , pp. 91-103
    • Yip, R.G.1    Wolfe, M.M.2
  • 12
    • 77349083897 scopus 로고    scopus 로고
    • RS4-type resistant starch prevents high-fat diet-induced obesity via increased hepatic fatty acid oxidation and decreased postprandial GIP in C57BL/6J mice
    • COI: 1:CAS:528:DC%2BC3cXjsFGgsbY%3D, PID: 20009028
    • Shimotoyodome A, Suzuki J, Fukuoka D, Tokimitsu I, Hase T (2010) RS4-type resistant starch prevents high-fat diet-induced obesity via increased hepatic fatty acid oxidation and decreased postprandial GIP in C57BL/6J mice. Am J Physiol Endocrinol Metab 298:E652–E662
    • (2010) Am J Physiol Endocrinol Metab , vol.298 , pp. E652-E662
    • Shimotoyodome, A.1    Suzuki, J.2    Fukuoka, D.3    Tokimitsu, I.4    Hase, T.5
  • 13
    • 59649114145 scopus 로고    scopus 로고
    • Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver
    • COI: 1:CAS:528:DC%2BD1MXhtVOit7w%3D, PID: 19141695
    • Musso G, Gambino R, Pacini G, De Michieli F, Cassader M (2009) Prolonged saturated fat-induced, glucose-dependent insulinotropic polypeptide elevation is associated with adipokine imbalance and liver injury in nonalcoholic steatohepatitis: dysregulated enteroadipocyte axis as a novel feature of fatty liver. Am J Clin Nutr 89:558–567
    • (2009) Am J Clin Nutr , vol.89 , pp. 558-567
    • Musso, G.1    Gambino, R.2    Pacini, G.3    De Michieli, F.4    Cassader, M.5
  • 14
    • 69949114028 scopus 로고    scopus 로고
    • Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice
    • COI: 1:CAS:528:DC%2BD1MXhtVygtLnL, PID: 19644669
    • Isken F, Weickert MO, Tschop MH et al (2009) Metabolic effects of diets differing in glycaemic index depend on age and endogenous glucose-dependent insulinotrophic polypeptide in mice. Diabetologia 52:2159–2168
    • (2009) Diabetologia , vol.52 , pp. 2159-2168
    • Isken, F.1    Weickert, M.O.2    Tschop, M.H.3
  • 15
    • 61449090547 scopus 로고    scopus 로고
    • Beneficial effects on glucose metabolism of chronic feeding of isomaltulose versus sucrose in rats
    • COI: 1:CAS:528:DC%2BD1MXltVeku78%3D, PID: 19270448
    • Haberer D, Thibault L, Langhans W, Geary N (2009) Beneficial effects on glucose metabolism of chronic feeding of isomaltulose versus sucrose in rats. Ann Nutr Metab 54:75–82
    • (2009) Ann Nutr Metab , vol.54 , pp. 75-82
    • Haberer, D.1    Thibault, L.2    Langhans, W.3    Geary, N.4
  • 16
    • 34250860120 scopus 로고    scopus 로고
    • The anti-obesity effect of the palatinose-based formula Inslow is likely due to an increase in the hepatic PPAR-alpha and adipocyte PPAR-gamma gene expressions
    • COI: 1:CAS:528:DC%2BD2sXovFajs7k%3D, PID: 18398502
    • Matsuo K, Arai H, Muto K et al (2007) The anti-obesity effect of the palatinose-based formula Inslow is likely due to an increase in the hepatic PPAR-alpha and adipocyte PPAR-gamma gene expressions. J Clin Biochem Nutr 40:234–241
    • (2007) J Clin Biochem Nutr , vol.40 , pp. 234-241
    • Matsuo, K.1    Arai, H.2    Muto, K.3
  • 17
    • 33751212182 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions
    • COI: 1:CAS:528:DC%2BD28Xht1eqtb7O, PID: 17070092
    • Rico-Bautista E, Flores-Morales A, Fernandez-Perez L (2006) Suppressor of cytokine signaling (SOCS) 2, a protein with multiple functions. Cytokine Growth Factor Rev 17:431–439
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 431-439
    • Rico-Bautista, E.1    Flores-Morales, A.2    Fernandez-Perez, L.3
  • 18
    • 84864665833 scopus 로고    scopus 로고
    • SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice
    • COI: 1:CAS:528:DC%2BC38Xht1Srt7bE, PID: 22562833
    • Zadjali F, Santana-Farre R, Vesterlund M et al (2012) SOCS2 deletion protects against hepatic steatosis but worsens insulin resistance in high-fat-diet-fed mice. FASEB J 26:3282–3291
    • (2012) FASEB J , vol.26 , pp. 3282-3291
    • Zadjali, F.1    Santana-Farre, R.2    Vesterlund, M.3
  • 19
    • 11144357764 scopus 로고    scopus 로고
    • Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors
    • COI: 1:CAS:528:DC%2BD2cXhsFKhtr0%3D, PID: 14966573
    • Preitner F, Ibberson M, Franklin I et al (2004) Gluco-incretins control insulin secretion at multiple levels as revealed in mice lacking GLP-1 and GIP receptors. J Clin Invest 113:635–645
    • (2004) J Clin Invest , vol.113 , pp. 635-645
    • Preitner, F.1    Ibberson, M.2    Franklin, I.3
  • 20
    • 77649272455 scopus 로고    scopus 로고
    • Effects of long-term soluble vs. insoluble dietary fiber intake on high-fat diet-induced obesity in C57BL/6J mice
    • COI: 1:CAS:528:DC%2BC3cXjt1Ght7k%3D, PID: 19369060
    • Isken F, Klaus S, Osterhoff M, Pfeiffer AF, Weickert MO (2010) Effects of long-term soluble vs. insoluble dietary fiber intake on high-fat diet-induced obesity in C57BL/6J mice. J Nutr Biochem 21:278–284
    • (2010) J Nutr Biochem , vol.21 , pp. 278-284
    • Isken, F.1    Klaus, S.2    Osterhoff, M.3    Pfeiffer, A.F.4    Weickert, M.O.5
  • 21
    • 58149472945 scopus 로고    scopus 로고
    • Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease
    • COI: 1:CAS:528:DC%2BD1MXntVyqsA%3D%3D, PID: 18849144
    • Valentini L, Wirth EK, Schweizer U et al (2009) Circulating adipokines and the protective effects of hyperinsulinemia in inflammatory bowel disease. Nutrition 25:172–181
    • (2009) Nutrition , vol.25 , pp. 172-181
    • Valentini, L.1    Wirth, E.K.2    Schweizer, U.3
  • 22
    • 33747839466 scopus 로고    scopus 로고
    • CARMAweb: comprehensive R- and bioconductor-based web service for microarray data analysis
    • COI: 1:CAS:528:DC%2BD28Xps1yisbw%3D, PID: 16845058
    • Rainer J, Sanchez-Cabo F, Stocker G, Sturn A, Trajanoski Z (2006) CARMAweb: comprehensive R- and bioconductor-based web service for microarray data analysis. Nucleic Acids Res 34:W498–W503
    • (2006) Nucleic Acids Res , vol.34 , pp. W498-W503
    • Rainer, J.1    Sanchez-Cabo, F.2    Stocker, G.3    Sturn, A.4    Trajanoski, Z.5
  • 23
    • 0033304728 scopus 로고    scopus 로고
    • Growth hormone regulation of SOCS-2, SOCS-3, and CIS messenger ribonucleic acid expression in the rat
    • COI: 1:CAS:528:DyaK1MXkslKqsrc%3D, PID: 10433229
    • Tollet-Egnell P, Flores-Morales A, Stavreus-Evers A, Sahlin L, Norstedt G (1999) Growth hormone regulation of SOCS-2, SOCS-3, and CIS messenger ribonucleic acid expression in the rat. Endocrinology 140:3693–3704
    • (1999) Endocrinology , vol.140 , pp. 3693-3704
    • Tollet-Egnell, P.1    Flores-Morales, A.2    Stavreus-Evers, A.3    Sahlin, L.4    Norstedt, G.5
  • 24
    • 0036771596 scopus 로고    scopus 로고
    • Isomaltulose (Palatinose): a review of biological and toxicological studies
    • COI: 1:CAS:528:DC%2BD38Xmsl2qsbs%3D, PID: 12387299
    • Lina BA, Jonker D, Kozianowski G (2002) Isomaltulose (Palatinose): a review of biological and toxicological studies. Food Chem Toxicol 40:1375–1381
    • (2002) Food Chem Toxicol , vol.40 , pp. 1375-1381
    • Lina, B.A.1    Jonker, D.2    Kozianowski, G.3
  • 25
    • 3342974560 scopus 로고    scopus 로고
    • Effect of a novel palatinose-based liquid balanced formula (MHN-01) on glucose and lipid metabolism in male Sprague-Dawley rats after short- and long-term ingestion
    • COI: 1:CAS:528:DC%2BD2cXmt1CgsLg%3D, PID: 15281004
    • Arai H, Mizuno A, Matsuo K et al (2004) Effect of a novel palatinose-based liquid balanced formula (MHN-01) on glucose and lipid metabolism in male Sprague-Dawley rats after short- and long-term ingestion. Metabolism 53:977–983
    • (2004) Metabolism , vol.53 , pp. 977-983
    • Arai, H.1    Mizuno, A.2    Matsuo, K.3
  • 26
    • 30144436457 scopus 로고    scopus 로고
    • Control of oxidative stress and metabolic homeostasis by the suppression of postprandial hyperglycemia
    • PID: 16366512
    • Takeda E, Arai H, Yamamoto H, Okumura H, Taketani Y (2005) Control of oxidative stress and metabolic homeostasis by the suppression of postprandial hyperglycemia. J Med Invest 52(Suppl):259–265
    • (2005) J Med Invest , vol.52 , pp. 259-265
    • Takeda, E.1    Arai, H.2    Yamamoto, H.3    Okumura, H.4    Taketani, Y.5
  • 27
    • 84875379926 scopus 로고    scopus 로고
    • Fatty diets retarded the propulsive function of and attenuated motility in the gastrointestinal tract of rats
    • COI: 1:CAS:528:DC%2BC3sXhvFWltrk%3D, PID: 23507229
    • Park JH, Kwon OD, Ahn SH, Lee S, Choi BK, Jung KY (2013) Fatty diets retarded the propulsive function of and attenuated motility in the gastrointestinal tract of rats. Nutr Res 33:228–234
    • (2013) Nutr Res , vol.33 , pp. 228-234
    • Park, J.H.1    Kwon, O.D.2    Ahn, S.H.3    Lee, S.4    Choi, B.K.5    Jung, K.Y.6
  • 28
    • 84872687251 scopus 로고    scopus 로고
    • Low glycaemic index diets and blood lipids: a systematic review and meta-analysis of randomised controlled trials. Nutrition, metabolism, and cardiovascular diseases
    • COI: 1:CAS:528:DC%2BC3sXht1GnsL8%3D, PID: 22841185
    • Goff LM, Cowland DE, Hooper L, Frost GS (2013) Low glycaemic index diets and blood lipids: a systematic review and meta-analysis of randomised controlled trials. Nutrition, metabolism, and cardiovascular diseases. Nutr Metab Cardiovasc Dis 23:1–10
    • (2013) Nutr Metab Cardiovasc Dis , vol.23 , pp. 1-10
    • Goff, L.M.1    Cowland, D.E.2    Hooper, L.3    Frost, G.S.4
  • 29
    • 0041866632 scopus 로고    scopus 로고
    • The insulin resistance syndrome and coronary artery disease
    • PID: 12826934
    • Kendall DM, Sobel BE, Coulston AM et al (2003) The insulin resistance syndrome and coronary artery disease. Coron Artery Dis 14:335–348
    • (2003) Coron Artery Dis , vol.14 , pp. 335-348
    • Kendall, D.M.1    Sobel, B.E.2    Coulston, A.M.3
  • 30
    • 0028930814 scopus 로고
    • Gastrointestinal effects of food carbohydrate
    • COI: 1:CAS:528:DyaK2MXls1Git7g%3D, PID: 7900692
    • Cummings JH, Englyst HN (1995) Gastrointestinal effects of food carbohydrate. Am J Clin Nutr 61:938S–945S
    • (1995) Am J Clin Nutr , vol.61 , pp. 938S-945S
    • Cummings, J.H.1    Englyst, H.N.2
  • 31
    • 3543147777 scopus 로고    scopus 로고
    • The fermentation of different dietary fibers is associated with fecal clostridia levels in men
    • COI: 1:CAS:528:DC%2BD2cXmsFChsLY%3D, PID: 15284370
    • Chinda D, Nakaji S, Fukuda S et al (2004) The fermentation of different dietary fibers is associated with fecal clostridia levels in men. J Nutr 134:1881–1886
    • (2004) J Nutr , vol.134 , pp. 1881-1886
    • Chinda, D.1    Nakaji, S.2    Fukuda, S.3
  • 32
    • 79951676066 scopus 로고    scopus 로고
    • Studies on absorption and metabolism of palatinose (isomaltulose) in rats
    • COI: 1:CAS:528:DC%2BC3MXht1Sntg%3D%3D, PID: 20807468
    • Tonouchi H, Yamaji T, Uchida M et al (2011) Studies on absorption and metabolism of palatinose (isomaltulose) in rats. Br J Nutr 105:10–14
    • (2011) Br J Nutr , vol.105 , pp. 10-14
    • Tonouchi, H.1    Yamaji, T.2    Uchida, M.3
  • 33
    • 52049090801 scopus 로고    scopus 로고
    • Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice
    • COI: 1:CAS:528:DC%2BD1cXhtFyqt7bE, PID: 18723001
    • Naitoh R, Miyawaki K, Harada N et al (2008) Inhibition of GIP signaling modulates adiponectin levels under high-fat diet in mice. Biochem Biophys Res Commun 376:21–25
    • (2008) Biochem Biophys Res Commun , vol.376 , pp. 21-25
    • Naitoh, R.1    Miyawaki, K.2    Harada, N.3
  • 34
    • 37149047560 scopus 로고    scopus 로고
    • GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet
    • COI: 1:CAS:528:DC%2BD2sXhsVGls7jK, PID: 17848629
    • McClean PL, Irwin N, Cassidy RS, Holst JJ, Gault VA, Flatt PR (2007) GIP receptor antagonism reverses obesity, insulin resistance, and associated metabolic disturbances induced in mice by prolonged consumption of high-fat diet. Am J Physiol Endocrinol Metab 293:E1746–E1755
    • (2007) Am J Physiol Endocrinol Metab , vol.293 , pp. E1746-E1755
    • McClean, P.L.1    Irwin, N.2    Cassidy, R.S.3    Holst, J.J.4    Gault, V.A.5    Flatt, P.R.6
  • 35
    • 77955326815 scopus 로고    scopus 로고
    • Hyperleptinemia is required for the development of leptin resistance
    • PID: 20613882
    • Knight ZA, Hannan KS, Greenberg ML, Friedman JM (2010) Hyperleptinemia is required for the development of leptin resistance. PLoS One 5:e11376
    • (2010) PLoS One , vol.5 , pp. e11376
    • Knight, Z.A.1    Hannan, K.S.2    Greenberg, M.L.3    Friedman, J.M.4
  • 36
    • 0028793697 scopus 로고
    • Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action
    • COI: 1:CAS:528:DyaK2MXpslGhur8%3D, PID: 7489415
    • Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS (1995) Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1:1311–1314
    • (1995) Nat Med , vol.1 , pp. 1311-1314
    • Frederich, R.C.1    Hamann, A.2    Anderson, S.3    Lollmann, B.4    Lowell, B.B.5    Flier, J.S.6
  • 37
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • COI: 1:CAS:528:DC%2BD2MXltVWru7c%3D, PID: 15897298
    • Kadowaki T, Yamauchi T (2005) Adiponectin and adiponectin receptors. Endocr Rev 26:439–451
    • (2005) Endocr Rev , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 38
    • 0030898516 scopus 로고    scopus 로고
    • Direct antidiabetic effect of leptin through triglyceride depletion of tissues
    • COI: 1:CAS:528:DyaK2sXjtVylsbc%3D, PID: 9114043
    • Shimabukuro M, Koyama K, Chen G et al (1997) Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci U S A 94:4637–4641
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 4637-4641
    • Shimabukuro, M.1    Koyama, K.2    Chen, G.3
  • 39
    • 67749130653 scopus 로고    scopus 로고
    • Hepatic gene expression in morbidly obese women: implications for disease susceptibility
    • COI: 1:CAS:528:DC%2BD1MXptlKnurY%3D
    • Elam MB, Cowan GS Jr, Rooney RJ et al (2009) Hepatic gene expression in morbidly obese women: implications for disease susceptibility. Obesity (Silver Spring) 17:1563–1573
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1563-1573
    • Elam, M.B.1    Cowan, G.S.2    Rooney, R.J.3
  • 40
    • 79953174921 scopus 로고    scopus 로고
    • Growth hormone-dependent pathogenesis of human hepatic steatosis in a novel mouse model bearing a human hepatocyte-repopulated liver
    • COI: 1:CAS:528:DC%2BC3MXkvVOkt74%3D, PID: 21303949
    • Tateno C, Kataoka M, Utoh R et al (2011) Growth hormone-dependent pathogenesis of human hepatic steatosis in a novel mouse model bearing a human hepatocyte-repopulated liver. Endocrinology 152:1479–1491
    • (2011) Endocrinology , vol.152 , pp. 1479-1491
    • Tateno, C.1    Kataoka, M.2    Utoh, R.3
  • 41
    • 67749111843 scopus 로고    scopus 로고
    • Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism
    • COI: 1:CAS:528:DC%2BD1MXos1egu7o%3D, PID: 19460757
    • Fan Y, Menon RK, Cohen P et al (2009) Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem 284:19937–19944
    • (2009) J Biol Chem , vol.284 , pp. 19937-19944
    • Fan, Y.1    Menon, R.K.2    Cohen, P.3
  • 42
    • 0344010159 scopus 로고    scopus 로고
    • Glucose-dependent insulinotropic polypeptide induced growth hormone secretion in acromegaly
    • COI: 1:CAS:528:DC%2BD2cXmt1Gqtw%3D%3D, PID: 14614222
    • Umahara M, Okada S, Ohshima K, Mori M (2003) Glucose-dependent insulinotropic polypeptide induced growth hormone secretion in acromegaly. Endocr J 50:643–650
    • (2003) Endocr J , vol.50 , pp. 643-650
    • Umahara, M.1    Okada, S.2    Ohshima, K.3    Mori, M.4
  • 43
    • 80455135090 scopus 로고    scopus 로고
    • The glucose-dependent insulinotropic polypeptide receptor is overexpressed amongst GNAS1 mutation-negative somatotropinomas and drives growth hormone (GH)-promoter activity in GH3 cells
    • COI: 1:CAS:528:DC%2BC3MXosFeqsrs%3D, PID: 21554434
    • Occhi G, Losa M, Albiger N et al (2011) The glucose-dependent insulinotropic polypeptide receptor is overexpressed amongst GNAS1 mutation-negative somatotropinomas and drives growth hormone (GH)-promoter activity in GH3 cells. J Neuroendocrinol 23:641–649
    • (2011) J Neuroendocrinol , vol.23 , pp. 641-649
    • Occhi, G.1    Losa, M.2    Albiger, N.3
  • 44
    • 84900410413 scopus 로고    scopus 로고
    • Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity
    • COI: 1:CAS:528:DC%2BC2cXmtlWhsL8%3D, PID: 24717514
    • Kraus D, Yang Q, Kong D et al (2014) Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity. Nature 508:258–262
    • (2014) Nature , vol.508 , pp. 258-262
    • Kraus, D.1    Yang, Q.2    Kong, D.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.