Neuroprotective effect of masitinib in rats with postischemic stroke

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 388, Issue 1, 2015, Pages 79-86

  Kocic, Ivan ^a   Kowianski, Przemyslaw ^a,b   Rusiecka, Izabela ^a   Lietzau, Grazyna ^a   Mansfield, Colin ^c   Moussy, Alain ^c   Hermine, Olivier ^c,d   Dubreuil, Patrice ^c,e  

^a MEDICAL UNIVERSITY OF GDANSK   (Poland)

^b POMERANIAN UNIVERSITY IN S UPSK   (Poland)

^c AB Science SA   (France)

^d UNIVERSITÉ PARIS DESCARTES   (France)

^e AIX MARSEILLE UNIVERSITY   (France)

Author keywords

Brain ischemia; Brain ischemic stroke; Masitinib; rt PA; Tyrosine kinase inhibitor

Indexed keywords

ALTEPLASE; MASITINIB; NEUROPROTECTIVE AGENT; TRIPHENYLTETRAZOLIUM; HYPNOTIC SEDATIVE AGENT; THIAZOLE DERIVATIVE; TISSUE PLASMINOGEN ACTIVATOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CONSCIOUSNESS; CONTROLLED STUDY; DRUG EFFECT; EXPERIMENTAL STROKE; FIBRINOLYTIC THERAPY; MALE; NEUROPROTECTION; NONHUMAN; RAT; WEIGHT REDUCTION; ANIMAL; BRAIN; DRUG COMBINATION; DRUG EFFECTS; DRUG POTENTIATION; PATHOLOGY; STROKE; WISTAR RAT;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; BRAIN ISCHEMIA; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; HYPNOTICS AND SEDATIVES; MALE; NEUROPROTECTIVE AGENTS; RATS, WISTAR; STROKE; THIAZOLES; TISSUE PLASMINOGEN ACTIVATOR;

EID: 84922072591     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-014-1061-6     Document Type: Article

References (44)

1. Anastassiadis T, Deacon SW, Devarajan K, Ma H, Peterson JR (2011) Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. Nat Biotechnol 11:1039-1045
2. Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H (1986a) Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 17:472-476
3. Bederson JB, Pitts LH, Germano SM, Nishimura MC, Davis RL, Bartkowski HM (1986b) Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats. Stroke 17:1304-1308
4. Bereczki D, Liu M, Prado GF, Fekete I (2000) Cochrane report: a systematic review of mannitol therapy for acute ischemic stroke and cerebral parenchymal hemorrhage. Stroke 31:2719-2722
5. Chu X, Qi C, Zou L, Fu X (2008) Intraluminal suture occlusion and ligation of the distal branch of internal carotid artery: an improved rat model of focal cerebral ischemia-reperfusion. J Neurosci Meth 158:1-7
6. del Zoppo GJ, Hallenbeck JM (2000) Advances in the vascular pathophysiology of ischemic stroke. Thromb Res 98:73-81
7. Diringer MN, Zazulia AR (2004) Osmotic therapy: facts and fiction. Neurocrit Care 1:219-233
8. Dubreuil P, Letard S, Ciufolini M, Gros L, Humbert M, Casteran N et al (2009) Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT. PLoS One. doi: 10.1371/journal.pone.0007258
9. Esposito P, Chandler N, Kandere K, Basu S, Jacobson S, Connolly R et al (2002) Corticotropin-releasing hormone and brain mast cells regulate blood-brain-barrier permeability induced by acute stress. J Pharmacol Exp Ther 303:1061-1066
10. Joshi CN, Jain SK, Murthy PS (2004) An optimized triphenyltetrazolium chloride method for identification of cerebral infarcts. Brain Res Protoc 13:11-17
11. Juvela S, Heiskanen O, Poranen A, Valtonen S, Kuurne T, Kaste M et al (1989) The treatment of spontaneous intracerebral hemorrhage. A prospective randomized trial of surgical and conservative treatment. J Neurosurg 70:755-758
12. Kasner SE, Wein T, Piriyawat P, Villar-Cordova CE, Chalela JA, Krieger DW et al (2002) Acetaminophen for altering body temperature in acute stroke: a randomized clinical trial. Stroke 33:130-134
13. Kinet JP (2007) The essential role of mast cells in orchestrating inflammation. Immunol Rev 217:5-7
14. Lagas SJ, van Waterschoot RAB, van Tilburg VACJ, Hillebrand MJ, Lankheet N, Rosing H et al (2009) Brain accumulation of dasatinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and cab be enhanced by elacridar treatment. Clin Cancer Res 15:2344-2351
15. Lin TN, Cheung WM, Wu JS, Chen JJ, Lin H, Chen JJ, Liou JY, Shyue SK, Wu KK (2006) 15d-prostaglandin J2 protects brain from ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol 26:481-487
16. Lin CY, Chang C, Cheung WM, Lin MH, Chen JJ, Hsu CY, Chen JH, Lin TN (2008) Dynamic changes in vascular permeability, cerebral blood volume, vascular density, and size after transient focal cerebral ischemia in rats: evaluation with contrast-enhanced magnetic resonance imaging. J Cereb Blood Flow Metab 28:1491-1501
17. Lindsberg PJ, Strbian D, Karjalainen-Lindsberg ML (2010) Mast cells as early responders in the regulation of acute blood-brain barrier changes after cerebral ischemia and hemorrhage. J Cereb Blood Flow Metab 30:689-702
18. Liu R, Liu Q, He S, Simpkins JW, Yang SH (2010) Combination therapy of 17beta-estradiol and recombinant tissue plasminogen activator for experimental ischemic stroke. J Pharmacol Exp Ther 332:1006-1012
19. Longa EZ, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91
20. Lukovits TG, Goddeau RP Jr (2011) Critical care of patients with acute ischemic and hemorrhagic stroke: update on recent evidence and international guidelines. Chest 139:694-700
21. MacDonald BK, Cockerell OC, Sander JWAS, Shorvon SD (2000) The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK. Brain 123:665-676
22. MacLellan CL, Silasi G, Auriat AM, Colbourne F (2010) Rodent models of intracerebral hemorrhage. Stroke 41:S95-S98
23. McCormick M, Hadley D, McLean JR, Macfarlane JA, Condon B, Muir KW (2010) Randomized controlled trial of insulin for acute poststroke hyperglycemia. Ann Neurol 67:570-578
24. Murray CJL, Lopez AD (1977) Mortality by cause for eight regions of the world: global burden of disease study. Lancet 349:1269-1276
25. Overgaard K, Sereghy T, Boysen G, Pedersen H, Diemer NH (1992) Reduction of infarcts volume and mortality by thrombolysis in a rat embolic stroke model. Stroke 23:1167-1173
26. Piette F, Belmin J, Vincent H, Schmidt N, Pariel S, Verny M et al (2001) Masitinib as an adjunct therapy for mild-to-moderate Alzheimer's disease: a randomized, placebo-controlled phase 2 trial. Alzheimer Res Ther 3:16
27. Rehni AK, Singh TG, Kakkar T, Arora S (2011) Involvement of src-kinase activation in ischemic preconditioning induced protection of mouse brain. Life Sci 88:825-829
28. Schaar KL, Brenneman MM, Savitz SI (2010) Functional assessments in the rodent stroke model. Exp Transl Stroke Med 2:13
29. Schallert T, Woodlee MT (2005) A handbook with tests. In: Whishaw I, Kolb B (eds) Behavior of the laboratory rat. Oxford University Press, Oxford, pp 129-140
30. Shen J, Ishii Y, Xu G, Dang TC, Hamashima T, Matsushima T et al (2012) PDGFRβ as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia. J Cereb Blood Flow Metab 32:353-367
31. Skaper SD, Giusti P, Facci L (2012) Microglia and mast cells: two tracks on the road to neuroinflammation. FASEB J 26:3103-3117
32. Skaper SD, Facci L, Guisti P (2014) Mast cells, glia and neuroinflammation: partners in crime? Immunol 141:314-327
33. Stassen M, Hültner L, Müller C, Schmitt E (2002) Mast cells and inflammation. Arch Immunol Ther Exp 50:179-185
34. Strbian D, Karjalainen-Lindsberg M-L, Tatlisumak T, Lindsberg PJ (2006) Cerebral mast cells regulate early ischemic brain swelling and neutrophil accumulation. J Cereb Blood Flow Metab 26:605-612
35. Strbian D, Karjalainen-Lindsberg ML, Kovanen PT, Tatlisumak T, Lindsberg PJ (2007) Mast cell stabilization reduces hemorrhage formation and mortality after administration of thrombolytics in experimental ischemic stroke. Circ 116:411-418
36. Strbian D, Kovanen PT, Karjalainen-Lindsberg ML, Tatlisumak T, Lindsberg PJ (2009) An emerging role of mast cells in cerebral ischemia and hemorrhage. Ann Med 41:438-450
37. Su EJ, Fredriksson MG, Folestad E, Cale J, Andrae J, Gao Y et al (2008) Activation of PDGF-CC by tissue plasminogen activator impairs blood brain barrier integrity during ischemic stroke. Nat Med 14:731-737
38. Tejima E, Zhao BQ, Tsuji K, Rosell A, van Leyen K, Gonzalez RG et al (2007) Astrocytic induction of matrix metalloproteinase-9 and edema in brain hemorrhage. J Cereb Blood Flow Metab 27:460-468
39. Vermersch P, Benrabah R, Schmidt N, Zéphir H, Clavelou P, Vongsouthi C et al (2012) Masitinib treatment in patients with progressive multiple sclerosis: a randomized pilot study. BMC Neurol 12:36. doi: 10.1186/1471-2377-12-36
40. Wang YF, Tsirka SE, Strickland S, Stieg PE, Soriano SG, Lipton SA (1998) Tissue plasminogen activator (tPA) increases neuronal damage after focal cerebral ischemia in wild-type and tPA-deficient mice. Nat Med 4:228-231
41. Wang X, Tsuji K, Lee SR, Ning M, Furie KL, Buchan AM et al (2004) Mechanisms of hemorrhagic transformation after tissue plasminogen activator reperfusion therapy for ischemic stroke. Stroke 35:2726-2730
42. Yuen CM, Sun CK, Lin YC, Chang LT, Kao YH, Yen CH et al (2011) Combination of cyclosporine and erythropoietin improves brain infarct size and neurological function in rats after ischemic stroke. J Transl Med 9:141
43. Zhang S, Boyd J, Delaney K, Murphy TH (2005) Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia. J Neurosci 25:5333-5338
44. Zhuang X, Silverman AJ, Silver R (1996) Brain mast cell degranulation regulates blood-brain barrier. J Neurobiol 31:393-403