Blastocyst euploidy and implantation rates in a young (<35 years) and old (≥35 years) presumed fertile and infertile patient population

Fertility and Sterility

Volumn 102, Issue 5, 2014, Pages 1318-1323

  Taylor, Tyl H ^a,b   Patrick, Jennifer L ^a   Gitlin, Susan A ^c   Crain, Jack L ^a   Wilson, J Michael ^a   Griffin, Darren K ^b  

^a Reproductive Endocrine Associates of Charlotte   (United States)

^b UNIVERSITY OF KENT   (United Kingdom)

^c The Jones Institute for Reproductive Medicine   (United States)

Author keywords

Aneuploidy; Comprehensive chromosome screening; Embryo biopsy; IVF; Preimplantation genetic screening

Indexed keywords

ADULT; ANEUPLOIDY; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; BLASTOCYST; CHROMOSOME ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; EMBRYO TRANSFER; FEMALE; FEMALE FERTILITY; FEMALE INFERTILITY; GENETIC SCREENING; HUMAN; HUMAN TISSUE; IN VITRO STUDY; MATERNAL AGE; NIDATION; OUTCOME ASSESSMENT; PLOIDY; PREGNANCY OUTCOME; PREGNANCY RATE; PREIMPLANTATION EMBRYO; PRENATAL DIAGNOSIS; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SINGLE NUCLEOTIDE POLYMORPHISM; AGING; CHROMOSOME ABERRATION; EMBRYOLOGY; FERTILITY; FERTILIZATION IN VITRO; GENETICS; INFERTILITY, FEMALE; PREGNANCY; TREATMENT OUTCOME;

ADULT; AGING; CHROMOSOME ABERRATIONS; EMBRYO IMPLANTATION; EMBRYO TRANSFER; FEMALE; FERTILITY; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; MATERNAL AGE; PREGNANCY; PREGNANCY OUTCOME; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84922068428     PISSN: 00150282     EISSN: 15565653     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2014.07.1207     Document Type: Article

References (25)

1. Ledbetter DH. Chaos in the embryo. Nat Med 2009;15:490-1.
2. Platteau P, Staessen C, Michiels A, Van Steirteghem A, Liebaers I, Devroey P. Preimplantation genetic diagnosis for aneuploidy screening in patients with unexplained recurrent miscarriages. Fertil Steril 2005;83:393-7.
3. Wilton L, Voullaire L, Sergeant P, Williamson R, McBain J. Preimplantation aneuploidy screening using comparative genomic hybridization or fluorescence in situ hybridization of embryos from patients with recurrent implantation failure. Fertil Steril 2003;80:860-8.
4. Munne S, Sandalinas M, Magli C, Gianaroli L, Cohen J, Warburton D. Increased rate of aneuploid embryos in young women with previous aneuploid conceptions. Prenat Diagn 2004;24:638-43.
5. Silber S, Escudero T, Lenahan K, Abdelhadi I, Kilani Z, Munne S. Chromosomal abnormalities in embryos derived from testicular sperm extraction. Fertil Steril 2003;79:30-8.
6. Staessen C, Platteau P, Van Assche E, Michiels A, Tournaye H, Camus M, et al. Comparison of blastocyst transfer with or without preimplantation genetic diagnosis for aneuploidy screening in couples with advanced maternal age: a prospective randomized controlled trial. Hum Reprod 2004;19:2849-58.
7. Gianaroli L, Maglic MC, Munne S, Fiorentino A, Montanaro N, Ferraretti AP. Will preimplantation genetic diagnosis assist patients with a poor prognosis to achieve pregnancy? Hum Reprod 1997;12:1762-7.
8. Van Echten-Arends J, Mastenbroek S, Sikkema-Raddatz B, Korevaar JC, Heineman MJ, van der Veen F, et al. Chromosomal mosaicism in human preimplantation embryos: a systematic review. Hum Reprod Update 2011;17:620-7.
9. Wells D, Delhanty JD. Comprehensive chromosomal analysis of human preimplantation embryos using whole genome amplification and single cell comparative genomic hybridization. Mol Hum Reprod 2000;6:1055-62.
10. Mertzanidou A, Wilton L, Cheng J, Spits C, Vanneste E, Moreau Y, et al. Microarray analysis reveals abnormal chromosomal complements in over 70% of 14 normally developing human embryos. Hum Reprod 2013;28:256-64.
11. Vanneste E, Voet T, Caignec CL, Ampe M, Konings P, Melotte C, et al. Chromosome instability is common in human cleavage stage embryos. Nat Med 2009;15:577-83.
12. Hassold T, Hunt P. To err (meiotically) is human: the genesis of human aneuploid. Nat Rev Genet 2001;2:280-91.
13. Baart EB, Martini E, van den Berg I, Macklon NS, Galjaard RJ, Fauser BC, et al. Preimplantation genetic screening reveals high incidence of aneuploidy and mosaicism in embryos from young women undergoing IVF. Hum Reprod 2006;21:223-33.
14. Thum MY, Abdalla HI, Taylor D. Relationship between women's age and basal follicle- stimulating hormone levels with aneuploidy risk in in vitro fertilization treatment. Fertil Steril 2008;90:315-21.
15. Voullaire L, Collins V, Callaghan T, McBain J, Williamson R, Wilton L. High incidence of complex chromosome abnormality in cleavage embryos from patients with repeated implantation failure. Fertil Steril 2007;87:1053-8.
16. Nagy ZP, Liu J, Joris H, Bocken G, Desmet B, Van Ranst H, et al. The influence of the site of sperm deposition and mode of oolemma breakage at intracytoplasmic sperm injection on fertilization and embryo development rates. Hum Reprod 1995;10:3171-7.
17. Ata B, Kaplan B, Danzer H, Glassner M, Opsahl M, Lin Tan S, et al. Array CGH analysis shows that aneuploidy is not related to the number of embryos generated. Reprod Biomed Online 2012;24:614-20.
18. Fragouli E, Escalona A, Gutierrez-Mateo C, Tormasi S, Alfarawati S, Sepulveda S, et al. Comparative genomic hybridization of oocytes and first polar bodies from young donors. Reprod Biomed Online 2009;19:228-37.
19. Sher G, Keskintepe L, Keskintepe M, Ginsburg M, Maassarani G, Yakut T, et al. Oocyte karyotyping by comparative genomic hybridization provides a highly reliable method for selection "competent" embryos, markedly improving in vitro fertilization outcome: a multiphase study. Fertil Steril 2007;87:1033-40.
20. Verpoest W, Fauser BC, Papanikolaou E, Staessen C, Van Landuyt L, Donoso P, et al. Chromosomal aneuploidy in embryos conceived with unstimulated cycle IVF. Hum Reprod 2008;23:2369-71.
21. Harton GL, Munne S, Surrey M, Grifo J, Kaplan B, McCulloh DH, et al. Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization. Fertil Steril 2013;100:1695-703.
22. Grifo JA, Hodes-Wertz B, Lee HL, Amperloquio E, Clarke-Williams M, Adler A. Single thawed euploid embryo transfer improves IVF pregnancy, miscarriage, and multiple gestation outcomes and has similar implantation rates as egg donation. J Assist Reprod Genet 2013;30:259-64.
23. Hsieh RH, Au HK, Yeh TS, Chang SJ, Cheng YF, Tzeng CR. Decreased expression of mitochondrial genes in human unfertilized oocytes and arrested embryos. Fertil Steril 2004;81:912-8.
24. Wood JR, Dumesic DA, Abbott DH, Strauss JF. Molecular abnormalities in oocytes from women with polycystic ovary syndrome revealed by microarray analysis. J Clin Endocrinol Metab 2007;92:705-13.
25. Franasiak JM, Forman EJ, Kong KH, Werner MD, Upham KM, Treff NR, et al. The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. Fertil Steril 2014;101:656-63.