Integrated traditional Chinese medicine improves acute pancreatitis via the downregulation of PRSS1 and SPINK1

Experimental and Therapeutic Medicine

Volumn 9, Issue 3, 2015, Pages 947-954

  Gao, Qiang ^a,b   Liang, Nusheng ^c  

^a Health Service Center   (China)

^b Traditional Chinese Medicine Hospital of Yantai   (China)

^c Tianjin the First Center Hospital   (China)

Author keywords

Acute pancreatitis; Integrated traditional Chinese medicine; Kazal type 1; Protein; Serine 1; Serine peptidase inhibitor

Indexed keywords

CHINESE DRUG; KAZAL TYPE 1; MESSENGER RNA; PLACEBO; SERINE; SERINE PROTEINASE INHIBITOR; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ACUTE PANCREATITIS; ADULT; ARTICLE; CALORIC INTAKE; CHINESE MEDICINE; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENDER; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; OBESITY; OUTCOME ASSESSMENT; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; RNA EXTRACTION; WESTERN BLOTTING;

EID: 84922032064     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2015.2191     Document Type: Article

References (64)

1. Matta A, Tandra PK, Cichowski E and Reddymasu SC: Acute necrotising pancreatitis: a late and fatal complication of pancreaticoduodenal arterial embolisation. BMJ Case Rep: bcr2014204197, 2014.
2. Rana SS, Sharma V, Sharma R and Bhasin DK: An unusual complication of acute necrotising pancreatitis detected by endoscopic ultrasound. JOP 15: 276-277, 2014.
3. Ambiru S, Furuyama N, Aono M, et al: Hyperbaric oxygen therapy for the treatment of postoperative paralytic ileus and adhesive intestinal obstruction associated with abdominal surgery: experience with 626 patients. Hepatogastroenterology 54: 1925-1929, 2007.
4. Sheikh I, Fontenot E, Waghray N, et al: The role of nonsteroidal anti-inflammatory drugs in the prevention of post endoscopic retrograde cholangiopancreatography pancreatitis. JOP 15: 219-224, 2014.
5. Sit M, Aktas G, Yilmaz EE, et al: Effects of the inflammatory response on serum omentin levels in early acute and chronic pancreatitis. Clin Ter 165: e148-e152, 2014.
6. Shalimov SA, Popov ON, Dubitskiĭ AE and Lifshits IuZ: Direct thermometry of the pancreas in the postoperative period. Vestn Khir Im I I Grek 132: 36-39, 1984 (In Russian).
7. Mascolo N, Izzo AA, Ligresti A, et al: The endocannabinoid system and the molecular basis of paralytic ileus in mice. FASEB J 16: 1973-1975, 2002.
8. Elder AS, Saccone GT, Bersten AD and Dixon DL: Evaluation of lung injury and respiratory mechanics in a rat model of acute pancreatitis complicated with endotoxin. Pancreatology 12: 240-247, 2012.
9. Fujita T: Endotoxin as a trigger of alcoholic pancreatitis. Gastroenterology 134: 640-641, 2008.
10. Verma R, Dhamija R, Ross SC, Batts DH and Loehrke ME: Symbiotic bacteria induced necrotizing pancreatitis. JOP 11: 474-476, 2010.
11. Zhang X, Tian H, Wu C, et al: Effect of baicalin on inflammatory mediator levels and microcirculation disturbance in rats with severe acute pancreatitis. Pancreas 38: 732-738, 2009.
12. Cuthbertson CM and Christophi C: Disturbances of the microcirculation in acute pancreatitis. Br J Surg 93: 518-530, 2006.
13. Yang XN, Guo J, Lin ZQ, et al: The study on causes of death in fulminant pancreatitis at early stage and late stage. Sichuan Da Xue Xue Bao Yi Xue Ban 42: 686-690, 2011 (In Chinese).
14. Yuan Z, Meyerholz DK, Twait EC, et al: Systemic inflammation with multiorgan dysfunction is the cause of death in murine ligation-induced acute pancreatitis. J Gastrointest Surg 15: 1670-1678, 2011.
15. Tsuji Y, Takahashi N, Fletcher JG, et al: Subtraction color map of contrast-enhanced and unenhanced CT for the prediction of pancreatic necrosis in early stage of acute pancreatitis. AJR Am J Roentgenol 202: W349-W356, 2014.
16. Garip G, Sarandöl E and Kaya E: Effects of disease severity and necrosis on pancreatic dysfunction after acute pancreatitis. World J Gastroenterol 19: 8065-8070, 2013.
17. Popa D: Treatment in severe acute pancreatitis - still a reason of debate. J Med Life 6: 486-490, 2013.
18. Ge HY and Chen B: Clinical observation of acute pancreatitis treated with acupoint application combined with medicine. Zhongguo Zhen Jiu 32: 602-604, 2012 (In Chinese).
19. Bossi A, Romeo G and Pezzoli A: Side-effects, structure, and H2-receptor antagonists. Lancet 339: 1366, 1992.
20. Xia Q and Deng LH: Hot issues on the treatment of severe acute pancreatitis by integrated traditional Chinese and Western medicine. Sichuan Da Xue Xue Bao Yi Xue Ban 44: 962-965, 2013 (In Chinese).
21. Wan MH, Yao J, Li J, et al: The effectiveness of purgation and electroacupuncture in extrahepatic bile duct stone complicated with acute biliary pancreatitis: management of biliary stone pancreatitis through traditional Chinese medicine. Pancreas 40: 483-484, 2011.
22. Tang Y, Liao Y, Kawaguchi-Sakita N, et al: Sinisan, a traditional Chinese medicine, attenuates experimental chronic pancreatitis induced by trinitrobenzene sulfonic acid in rats. J Hepatobiliary Pancreat Sci 18: 551-558, 2011.
23. Solomon S, Whitcomb DC and LaRusch J: PRSS1-related hereditary pancreatitis. In: GeneReviews®. Pagon RA, Adam MP, Ardinger HH, et al (eds). University of Washington, Seattle, WA, 2012.
24. Sánchez-Ramírez CA, Flores-Martínez SE, García-Zapién AG, et al: Screening of R122H and N29I mutations in the PRSS1 gene and N34S mutation in the SPINK1 gene in Mexican pediatric patients with acute and recurrent pancreatitis. Pancreas 41: 707-711, 2012.
25. Tukiainen E, Kylänpää ML, Kemppainen E, et al: Pancreatic secretory trypsin inhibitor (SPINK1) gene mutations in patients with acute pancreatitis. Pancreas 30: 239-242, 2005.
26. Lee YJ, Kim KM, Choi JH, et al: High incidence of PRSS1 and SPINK1 mutations in Korean children with acute recurrent and chronic pancreatitis. J Pediatr Gastroenterol Nutr 52: 478-481, 2011.
27. Sobczyńska-Tomaszewska A, Bak D, Oralewska B, et al: Analysis of CFTR, SPINK1, PRSS1 and AAT mutations in children with acute or chronic pancreatitis. J Pediatr Gastroenterol Nutr 43: 299-306, 2006.
28. Kiriyama S, Gabata T, Takada T, et al: New diagnostic criteria of acute pancreatitis. J Hepatobiliary Pancreat Sci 17: 24-36, 2010.
29. Gubergrits N, Golubova O, Lukashevich G and Fomenko P: Elevated serum amylase in patients with chronic pancreatitis: acute attack or macroamylasemia? Pancreatology 14: 114-116, 2014.
30. Wojtuń S and Gil J: Utility of amylase serum and urine activity in acute biliary pancreatitis treated with biliary sphincterotomy. Pol Merkur Lekarski 22: 381-384, 2007 (In Polish).
31. Banks PA, Bollen TL, Dervenis C, et al; Acute Pancreatitis Classification Working Group: Classification of acute pancreatitis - 2012: revision of the Atlanta classification and definitions by international consensus. Gut 62: 102-111, 2013.
32. Li YC, Dong L, Jia A, Chang XM and Xue H: Preparation of solid lipid nanoparticles loaded with traditional Chinese medicine by high-pressure homogenization. Nan Fang Yi Ke Da Xue Xue Bao 26: 541-544, 2006 (In Chinese).
33. Zhuang WJ and Qian C: Treatment of infected deciduous root canal with Samyan (traditional Chinese medicine) paste: Clinical analysis. Shanghai Kou Qiang Yi Xue 6: 185, 1997 (In Chinese).
34. Xue QM, Li N, Xue P, Wang CW and Wen Q: Therapeutic effects of electroacupuncture at ST36 acupoint on sodium-taurocholate-induced severe acute pancreatitis. Chin J Integr Med 20: 695-700, 2014.
35. Saito Y, Emura F, Matsuda T, et al: A new sinker-assisted endoscopic submucosal dissection for colorectal cancer. Gastrointest Endosc 62: 297-301, 2005.
36. Zhao J, Liao Q, Zhao Y and Hu Y: Mortality indicators and risk factors for intra-abdominal hypertension in severe acute pancreatitis. Int Surg 99: 252-257, 2014.
37. Vipperla K, Papachristou GI, Easler J, et al: Risk of and factors associated with readmission after a sentinel attack of acute pancreatitis. Clin Gastroenterol Hepatol: May 9, 2014 (Epub ahead of print).
38. Zeng YB, Zhan XB, Guo XR, et al: Risk factors for pancreatic infection in patients with severe acute pancreatitis: an analysis of 163 cases. J Dig Dis 15: 377-385, 2014.
39. Jin J, Yu YH, Zhong M and Zhang GW: Analyzing and identifying risk factors for acute pancreatitis with different etiologies in pregnancy. J Matern Fetal Neonatal Med: June 5, 1-5, 2014 (Epub ahead of print).
40. Tamasaki A, Nishimura Y, Kondo N, et al: Risk factors for acute pancreatitis in patients with severe motor and intellectual disabilities. Pediatr Int 56: 240-243, 2014.
41. Hong S, Qiwen B, Ying J, Wei A and Chaoyang T: Body mass index and the risk and prognosis of acute pancreatitis: a meta-analysis. Eur J Gastroenterol Hepatol 23: 1136-1143, 2011.
42. Shen HN, Wang WC, Lu CL and Li CY: Effects of gender on severity, management and outcome in acute biliary pancreatitis. PLoS One 8: e57504, 2013.
43. Fu P, Yuan AH, Wang CH, Li X and Wu HY: Alcohol-induced severe acute pancreatitis followed by hemolytic uremic syndrome managed with continuous renal replacement therapy. BMC Nephrol 15: 1, 2014.
44. Nikkola J, Räty S, Laukkarinen J, et al: Abstinence after first acute alcohol-associated pancreatitis protects against recurrent pancreatitis and minimizes the risk of pancreatic dysfunction. Alcohol Alcohol 48: 483-486, 2013.
45. Müller S, Kaiser H, Krüger B, et al: Age-dependent effects of UCP2 deficiency on experimental acute pancreatitis in mice. PLoS One 9: e94494, 2014.
46. Okamura D, Starr ME, Lee EY, et al: Age-dependent vulnerability to experimental acute pancreatitis is associated with increased systemic inflammation and thrombosis. Aging Cell 11: 760-769, 2012.
47. Akesson A, Andersen LF, Kristjánsdóttir AG, et al: Health effects associated with foods characteristic of the Nordic diet: a systematic literature review. Food Nutr Res: 57, 2013.
48. Overby NC, Sonestedt E, Laaksonen DE and Birgisdottir BE: Dietary fiber and the glycemic index: a background paper for the Nordic Nutrition Recommendations 2012. Food Nutr Res: 57, 2013.
49. Knaan T, Endevelt R and Singer P: Evaluating the validity of the 'categories method': A new method for self-report assessment of daily calorie intake: A pilot study. Can J Diabetes 37 (Suppl 2): S283, 2013.
50. Pelaez-Luna M, Robles-Diaz G, Canizales-Quinteros S and Tusie-Luna MT: PRSS1 and SPINK1 mutations in idiopathic chronic and recurrent acute pancreatitis. World J Gastroenterol 20: 11788-11792, 2014.
51. Roncati L, Gualandri G, Fortuni G and Barbolini G: Sudden death and lipomatous infiltration of the heart involved by fat necrosis resulting from acute pancreatitis. Forensic Sci Int 217: e19-e22, 2012.
52. Chen H, Li F, Jia JG, et al: Effects of traditional Chinese medicine on intestinal mucosal permeability in early phase of severe acute pancreatitis. Chin Med J (Engl) 123: 1537-1542, 2010.
53. Zhang MJ, Zhang GL, Yuan WB, Ni J and Huang LF: Treatment of abdominal compartment syndrome in severe acute pancreatitis patients with traditional Chinese medicine. World J Gastroenterol 14: 3574-3578, 2008.
54. Athwal T, Huang W, Mukherjee R, et al: Expression of human cationic trypsinogen (PRSS1) in murine acinar cells promotes pancreatitis and apoptotic cell death. Cell Death Dis 5: e1165, 2014.
55. Wang J, Ohmuraya M, Suyama K, et al: Relationship of strain-dependent susceptibility to experimentally induced acute pancreatitis with regulation of Prss1 and Spink3 expression. Lab Invest 90: 654-664, 2010.
56. Corleto VD, Gambardella S, Gullotta F, et al: New PRSS1 and common CFTR mutations in a child with acute recurrent pancreatitis, could be considered an 'Hereditary' form of pancreatitis? BMC Gastroenterol 10: 119, 2010.
57. Ohmuraya M and Yamamura K: Roles of serine protease inhibitor Kazal type 1 (SPINK1) in pancreatic diseases. Exp Anim 60: 433-444, 2011.
58. Rai P, Sharma A, Gupta A and Aggarwal R: Frequency of SPINK1 N34S mutation in acute and recurrent acute pancreatitis. J Hepatobiliary Pancreat Sci 21: 663-668, 2014.
59. Tremblay K, Dubois-Bouchard C, Brisson D and Gaudet D: Association of CTRC and SPINK1 gene variants with recurrent hospitalizations for pancreatitis or acute abdominal pain in lipoprotein lipase deficiency. Front Genet 5: 90, 2014.
60. Terlizzi V, De Gregorio F, Sepe A, et al: Brand new SPINK1 and CFTR mutations in a child with acute recurrent pancreatitis: a case report. Minerva Pediatr 65: 669-672, 2013.
61. Jøergensen MT, Brusgaard K, Novovic S, et al: Is the SPINK1 variant p.N34S overrepresented in patients with acute pancreatitis? Eur J Gastroenterol Hepatol 24: 309-315, 2012.
62. Baudry C, Rebours V, Houillier P, et al: Recurrent acute pancreatitis caused by association of a novel mutation of the calcium-sensing receptor gene and a heterozygous mutation of the SPINK1 gene. Pancreas 39: 420-421, 2010.
63. Aoun E, Muddana V, Papachristou GI and Whitcomb DC: SPINK1 N34S is strongly associated with recurrent acute pancreatitis but is not a risk factor for the first or sentinel acute pancreatitis event. Am J Gastroenterol 105: 446-451, 2010.
64. Liu XB, Jiang JM, Huang ZW, et al: Clinical study on the treatment of severe acute pancreatitis by integrated traditional Chinese medicine and Western medicine. J Sichuan University (medical science edition) 35: 204-208, 2004 (In Chinese).