Systemic Inflammation with Multiorgan Dysfunction Is the Cause of Death in Murine Ligation-Induced Acute Pancreatitis

Journal of Gastrointestinal Surgery

Volumn 15, Issue 10, 2011, Pages 1670-1678

  Yuan, Zuobiao ^a   Meyerholz, David K ^a   Twait, Erik C ^a,b   Kempuraj, Duraisamy ^a   Williard, Deborah E ^a,b   Samuel, Isaac ^a,b  

^a UNIVERSITY OF IOWA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Acute pancreatitis; Extracellular signal regulated kinase; Mouse; Multiple organ dysfunction syndrome; Systemic inflammatory response syndrome

Indexed keywords

ANIMAL; ARTICLE; BILE DUCT; C57BL MOUSE; DISEASE MODEL; LIGATION; MALE; MOUSE; MULTIPLE ORGAN FAILURE; PANCREAS DUCT; PANCREATITIS; PATHOLOGY; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; BILE DUCTS; DISEASE MODELS, ANIMAL; LIGATION; MALE; MICE; MICE, INBRED C57BL; MULTIPLE ORGAN FAILURE; PANCREATIC DUCTS; PANCREATITIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 80053126578     PISSN: 1091255X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11605-011-1643-2     Document Type: Article

References (26)

1. Samuel I, Yuan Z, Meyerholz DK, Twait E, Williard DE, Kempuraj D. Rapid Communication: a novel model of severe gallstone pancreatitis-murine pancreatic duct ligation results in systemic inflammation and substantial mortality. Pancreatology. 2010; 10: 536-544.
2. Meyerholz DK, Williard DE, Grittmann AM, Samuel I. Murine pancreatic duct ligation induces stress kinase activation, acute pancreatitis, and acute lung injury. Am J Surg. 2008; 196: 675-682.
3. Boquist L, Edstrom C. Ultrastructure of pancreatic acinar and islet parenchyma in rats at various intervals after duct ligation. Virchows Arch A Pathol Pathol Anat. 1970; 349: 69-79.
4. Rakonczay Z, Jr., Hegyi P, Takacs T, McCarroll J, Saluja AK. The role of NF-kappaB activation in the pathogenesis of acute pancreatitis. Gut. 2008; 57: 259-267.
5. Samuel I, Tephly L, Williard DE, Carter AB. Enteral exclusion increases map kinase activation and cytokine production in a model of gallstone pancreatitis. Pancreatology. 2008; 8: 6-14.
6. Twait E, Williard DE, Samuel I. Dominant negative p38 MAP kinase expression inhibits NF-kappaB activation in AR42J cells. Pancreatology. 2010; 10: 119-128.
7. Isenmann R, Rau B, Beger HG. Early severe acute pancreatitis: characteristics of a new subgroup. Pancreas. 2001; 22: 274-278.
8. McKay CJ, Evans S, Sinclair M, Carter CR, Imrie CW. High early mortality rate from acute pancreatitis in Scotland, 1984-1995. Br J Surg. 1999; 86: 1302-1305.
9. de Beaux AC, Palmer KR, Carter DC. Factors influencing morbidity and mortality in acute pancreatitis; an analysis of 279 cases. Gut. 1995; 37: 121-126.
10. Tenner S, Sica G, Hughes M et al. Relationship of necrosis to organ failure in severe acute pancreatitis. Gastroenterology. 1997; 113: 899-903.
11. Karimgani I, Porter KA, Langevin RE, Banks PA. Prognostic factors in sterile pancreatic necrosis. Gastroenterology. 1992; 103: 1636-1640.
12. Johnson CD, bu-Hilal M. Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut. 2004; 53: 1340-1344.
13. Bhatia M, Moochhala S. Role of inflammatory mediators in the pathophysiology of acute respiratory distress syndrome. J Pathol. 2004; 202: 145-156.
14. Kahraman A, Barreyro FJ, Bronk SF et al. TRAIL mediates liver injury by the innate immune system in the bile duct-ligated mouse. Hepatology. 2008; 47: 1317-1330.
15. Kahraman A, Mott JL, Bronk SF et al. Overexpression of mcl-1 attenuates liver injury and fibrosis in the bile duct-ligated mouse. Dig Dis Sci. 2009; 54: 1908-1917.
16. Murr MM, Yang J, Fier A et al. Regulation of Kupffer cell TNF gene expression during experimental acute pancreatitis: The role of p38-MAPK, ERK1/2, SAPK/JNK, and NF-kappa B. Journal of Gastrointestinal Surgery. 2003; 7: 20-25.
17. Murr MM, Yang J, Fier A, Kaylor P, Mastorides S, Norman JG. Pancreatic elastase induces liver injury by activating cytokine production within Kupffer cells via nuclear factor-kappa B. Journal of Gastrointestinal Surgery. 2002; 6: 474-480.
18. Banerjee AK, Galloway SW, Kingsnorth AN. Experimental models of acute pancreatitis. British Journal of Surgery. 1994; 81: 1096-1103.
19. Churg A, Richter WR. Early changes in the exocrine pancreas of the dog and rat after ligation of the pancreatic duct. A light and electron microscopic study. Am J Pathol. 1971; 63: 521-546.
20. Schafer C, Williams JA. Stress kinases and heat shock proteins in the pancreas: possible roles in normal function and disease. J Gastroenterol. 2000; 35: 1-9.
21. Grady T, Dabrowski A, Williams JA, Logsdon CD. Stress-activated protein kinase activation is the earliest direct correlate to the induction of secretagogue-induced pancreatitis in rats. Biochem Biophys Res Commun. 1996; 227: 1-7.
22. Samuel I. Bile and pancreatic juice exclusion activates acinar stress kinases and exacerbates gallstone pancreatitis. Surgery. 2008; 143: 434-440.
23. Samuel I, Zaheer A, Fisher RA. In vitro evidence for role of ERK, p38, and JNK in exocrine pancreatic cytokine production. J Gastrointest Surg. 2006; 10: 1376-1383.
24. Samuel I, Zaheer S, Zaheer A. Bile-pancreatic juice exclusion increases p38MAPK activation and TNF-alpha production in ligation-induced acute pancreatitis in rats. Pancreatology. 2005; 5: 20-26.
25. Gukovsky I, Reyes CN, Vaquero EC, Gukovskaya AS, Pandol SJ. Curcumin ameliorates ethanol and nonethanol experimental pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2003; 284: G85-G95.
26. Chen X, Ji B, Han B, Ernst SA, Simeone D, Logsdon CD. NF-kappaB activation in pancreas induces pancreatic and systemic inflammatory response. Gastroenterology. 2002; 122: 448-457.