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Volumn 9, Issue 3, 2015, Pages 653-657

Pancreas β cell regeneration and type 1 diabetes (Review)

Author keywords

Diabetes mellitus; Endocrine pancreas; Type 1 diabetes; cell regeneration

Indexed keywords

CARBOXYPEPTIDASE A1; CD45 ANTIGEN; CYCLIN D2; CYCLIN DEPENDENT KINASE 4; GLUCAGON; INSULIN; KI 67 ANTIGEN; MIXED LINEAGE LEUKEMIA PROTEIN; MYC PROTEIN; NEUROGENIN 3; PANCREAS TRANSCRIPTION FACTOR 1A; PEPTIDES AND PROTEINS; SURVIVIN; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

EID: 84922022071     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2014.2163     Document Type: Review
Times cited : (18)

References (61)
  • 1
    • 78650519539 scopus 로고    scopus 로고
    • β-cell regeneration: The pancreatic intrinsic faculty
    • Desgraz R, Bonal C and Herrera PL: β-cell regeneration: the pancreatic intrinsic faculty. Trends Endocrinol Metab 22: 34-43, 2011.
    • (2011) Trends Endocrinol Metab , vol.22 , pp. 34-43
    • Desgraz, R.1    Bonal, C.2    Herrera, P.L.3
  • 2
    • 84887956780 scopus 로고    scopus 로고
    • Pancreaticobiliary maljuction combining with pancreas divisum: Report of four cases
    • Zhang Y, Sun W, Zhang F, Huang J and Fan Z: Pancreaticobiliary maljuction combining with pancreas divisum: report of four cases. Exp Ther Med 7: 8-10, 2014.
    • (2014) Exp Ther Med , vol.7 , pp. 8-10
    • Zhang, Y.1    Sun, W.2    Zhang, F.3    Huang, J.4    Fan, Z.5
  • 3
    • 1542267814 scopus 로고    scopus 로고
    • Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development
    • Prado CL, Pugh-Bernard AE, Elghazi L, Sosa-Pineda B and Sussel L: Ghrelin cells replace insulin-producing beta cells in two mouse models of pancreas development. Proc Natl Acad Sci USA 101: 2924-2929, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 2924-2929
    • Prado, C.L.1    Pugh-Bernard, A.E.2    Elghazi, L.3    Sosa-Pineda, B.4    Sussel, L.5
  • 4
    • 84884731820 scopus 로고    scopus 로고
    • Insulinization: A promising strategy for the treatment of type 2 diabetes mellitus
    • Guo L, Xu Y, Zhang X, Luo Y, Liu W and Chen B: Insulinization: a promising strategy for the treatment of type 2 diabetes mellitus. Exp Ther Med 6: 1300-1306, 2013.
    • (2013) Exp Ther Med , vol.6 , pp. 1300-1306
    • Guo, L.1    Xu, Y.2    Zhang, X.3    Luo, Y.4    Liu, W.5    Chen, B.6
  • 5
    • 77957374080 scopus 로고    scopus 로고
    • Unraveling the role of the ghrelin gene peptides in the endocrine pancreas
    • Granata R, Baragli A, Settanni F, Scarlatti F and Ghigo E: Unraveling the role of the ghrelin gene peptides in the endocrine pancreas. J Mol Endocrinol 45: 107-118, 2010.
    • (2010) J Mol Endocrinol , vol.45 , pp. 107-118
    • Granata, R.1    Baragli, A.2    Settanni, F.3    Scarlatti, F.4    Ghigo, E.5
  • 7
    • 33847687194 scopus 로고    scopus 로고
    • Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion
    • Ackermann AM and Gannon M: Molecular regulation of pancreatic beta-cell mass development, maintenance, and expansion. J Mol Endocrinol 38: 193-206, 2007.
    • (2007) J Mol Endocrinol , vol.38 , pp. 193-206
    • Ackermann, A.M.1    Gannon, M.2
  • 8
    • 33847402673 scopus 로고    scopus 로고
    • Pancreas and beta-cell development: From the actual to the possible
    • Murtaugh LC: Pancreas and beta-cell development: from the actual to the possible. Development 134: 427-438, 2007.
    • (2007) Development , vol.134 , pp. 427-438
    • Murtaugh, L.C.1
  • 9
    • 0027504105 scopus 로고
    • On the origin of pancreatic endocrine cells, proliferation and neoplastic transformation
    • Teitelman G: On the origin of pancreatic endocrine cells, proliferation and neoplastic transformation. Tumour Biol 14: 167-173, 1993.
    • (1993) Tumour Biol , vol.14 , pp. 167-173
    • Teitelman, G.1
  • 10
    • 0034121735 scopus 로고    scopus 로고
    • Adult insulin-and glucagon-producing cells differentiate from two independent cell lineages
    • Herrera PL: Adult insulin-and glucagon-producing cells differentiate from two independent cell lineages. Developmen 127: 2317-2322, 2000.
    • (2000) Developmen , vol.127 , pp. 2317-2322
    • Herrera, P.L.1
  • 11
    • 0015446766 scopus 로고
    • An ultrastructural analysis of the developing embryonic pancreas
    • Pictet RL, Clark WR, Williams RH and Rutter WJ: An ultrastructural analysis of the developing embryonic pancreas. Dev Biol 29: 436-467, 1972.
    • (1972) Dev Biol , vol.29 , pp. 436-467
    • Pictet, R.L.1    Clark, W.R.2    Williams, R.H.3    Rutter, W.J.4
  • 13
    • 33847217554 scopus 로고    scopus 로고
    • Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types
    • Johansson KA, Dursun U, Jordan N, Gu G, Beermann F, Gradwohl G and Grapin-Botton A: Temporal control of neurogenin3 activity in pancreas progenitors reveals competence windows for the generation of different endocrine cell types. Dev Cell 12: 457-465, 2007.
    • (2007) Dev Cell , vol.12 , pp. 457-465
    • Johansson, K.A.1    Dursun, U.2    Jordan, N.3    Gu, G.4    Beermann, F.5    Gradwohl, G.6    Grapin-Botton, A.7
  • 14
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G, Dierich A, LeMeur M and Guillemot F: Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 97: 1607-1611, 2000.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 15
    • 84874528910 scopus 로고    scopus 로고
    • Beta-cell regeneration in human pancreas: The lessons of pancreatic pathology
    • Maulis M and Gianani R: Beta-cell regeneration in human pancreas: the lessons of pancreatic pathology. Adv Exp Med Biol 771: 310-318, 2012.
    • (2012) Adv Exp Med Biol , vol.771 , pp. 310-318
    • Maulis, M.1    Gianani, R.2
  • 16
    • 77956213431 scopus 로고    scopus 로고
    • Expression and tissue distribution of human X-linked armadillo repeat containing-6
    • Kusama Y, Takayanagi S, Tategu M and Yoshida K: Expression and tissue distribution of human X-linked armadillo repeat containing-6. Exp Ther Med 1: 395-399, 2010.
    • (2010) Exp Ther Med , vol.1 , pp. 395-399
    • Kusama, Y.1    Takayanagi, S.2    Tategu, M.3    Yoshida, K.4
  • 17
    • 16644382591 scopus 로고    scopus 로고
    • Nesidioblastosis: An old term and a new understanding
    • Kaczirek K and Niederle B: Nesidioblastosis: an old term and a new understanding. World J Surg 28: 1227-1230, 2004.
    • (2004) World J Surg , vol.28 , pp. 1227-1230
    • Kaczirek, K.1    Niederle, B.2
  • 18
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y, Brown J, Martinez OI and Melton DA: Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429: 41-46, 2004.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 19
    • 34250858628 scopus 로고    scopus 로고
    • All beta cells contribute equally to islet growth and maintenance
    • Brennand K, Huangfu D and Melton D: All beta cells contribute equally to islet growth and maintenance. PLoS Biol 5: e163, 2007.
    • (2007) PLoS Biol , vol.5
    • Brennand, K.1    Huangfu, D.2    Melton, D.3
  • 20
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult beta cells does not involve specialized progenitors
    • Teta M, Rankin MM, Long SY, Stein GM and Kushner JA: Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev Cell 12: 817-826, 2007.
    • (2007) Dev Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 21
    • 0030903840 scopus 로고    scopus 로고
    • Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat
    • Scaglia L, Cahill CJ, Finegood DT and Bonner-Weir S: Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology 138: 1736-1741, 1997.
    • (1997) Endocrinology , vol.138 , pp. 1736-1741
    • Scaglia, L.1    Cahill, C.J.2    Finegood, D.T.3    Bonner-Weir, S.4
  • 23
    • 77956562845 scopus 로고    scopus 로고
    • Glucose and aging control the quiescence period that follows pancreatic beta cell replication
    • Salpeter SJ, Klein AM, Huangfu D, Grimsby J and Dor Y: Glucose and aging control the quiescence period that follows pancreatic beta cell replication. Development 137: 3205-3213, 2010.
    • (2010) Development , vol.137 , pp. 3205-3213
    • Salpeter, S.J.1    Klein, A.M.2    Huangfu, D.3    Grimsby, J.4    Dor, Y.5
  • 24
    • 0036828227 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats
    • Farilla L, Hui H, Bertolotto C, Kang E, Bulotta A, Di Mario U and Perfetti R: Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats. Endocrinology 143: 4397-4408, 2002.
    • (2002) Endocrinology , vol.143 , pp. 4397-4408
    • Farilla, L.1    Hui, H.2    Bertolotto, C.3    Kang, E.4    Bulotta, A.5    Di Mario, U.6    Perfetti, R.7
  • 26
    • 77949324263 scopus 로고    scopus 로고
    • Expansion of beta-cell mass in response to pregnancy
    • Rieck S and Kaestner KH: Expansion of beta-cell mass in response to pregnancy. Trends Endocrinol Metab 21: 151-158, 2010.
    • (2010) Trends Endocrinol Metab , vol.21 , pp. 151-158
    • Rieck, S.1    Kaestner, K.H.2
  • 27
    • 9644266753 scopus 로고    scopus 로고
    • Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass
    • Georgia S and Bhushan A: Beta cell replication is the primary mechanism for maintaining postnatal beta cell mass. J Clin Invest 114: 963-968, 2004.
    • (2004) J Clin Invest , vol.114 , pp. 963-968
    • Georgia, S.1    Bhushan, A.2
  • 29
    • 2442699174 scopus 로고    scopus 로고
    • Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes
    • Marzo N, Mora C, Fabregat ME, Martín J, Usac EF, Franco C, Barbacid M and Gomis R: Pancreatic islets from cyclin-dependent kinase 4/R24C (Cdk4) knockin mice have significantly increased beta cell mass and are physiologically functional, indicating that Cdk4 is a potential target for pancreatic beta cell mass regeneration in Type 1 diabetes. Diabetologia 47: 686-694, 2004.
    • (2004) Diabetologia , vol.47 , pp. 686-694
    • Marzo, N.1    Mora, C.2    Fabregat, M.E.3    Martín, J.4    Usac, E.F.5    Franco, C.6    Barbacid, M.7    Gomis, R.8
  • 30
    • 40449140769 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 4 hyperactivity promotes autoreactivity in the immune system but protects pancreatic cell mass from autoimmune destruction in the nonobese diabetic mouse model
    • Marzo N, Ortega S, Stratmann T, García A, Ríos M, Giménez A, Gomis R and Mora C: Cyclin-dependent kinase 4 hyperactivity promotes autoreactivity in the immune system but protects pancreatic cell mass from autoimmune destruction in the nonobese diabetic mouse model. J Immunol 180: 1189-1198, 2008.
    • (2008) J Immunol , vol.180 , pp. 1189-1198
    • Marzo, N.1    Ortega, S.2    Stratmann, T.3    García, A.4    Ríos, M.5    Giménez, A.6    Gomis, R.7    Mora, C.8
  • 34
    • 38649125276 scopus 로고    scopus 로고
    • Facultative endocrine progenitor cells in the adult pancreas
    • Dor Y and Melton DA: Facultative endocrine progenitor cells in the adult pancreas. Cell 132: 183-184, 2008.
    • (2008) Cell , vol.132 , pp. 183-184
    • Dor, Y.1    Melton, D.A.2
  • 35
    • 84887978467 scopus 로고    scopus 로고
    • Evaluation of the revised versus the simplified scoring system in patients with autoimmune hepatitis
    • Li Y, Peng M and Gong G: Evaluation of the revised versus the simplified scoring system in patients with autoimmune hepatitis. Exp Ther Med 7: 131-136, 2014.
    • (2014) Exp Ther Med , vol.7 , pp. 131-136
    • Li, Y.1    Peng, M.2    Gong, G.3
  • 40
    • 74949085342 scopus 로고    scopus 로고
    • Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury
    • Liu H, Guz Y, Kedees MH, Winkler J and Teitelman G: Precursor cells in mouse islets generate new beta-cells in vivo during aging and after islet injury. Endocrinology 151: 520-528, 2010.
    • (2010) Endocrinology , vol.151 , pp. 520-528
    • Liu, H.1    Guz, Y.2    Kedees, M.H.3    Winkler, J.4    Teitelman, G.5
  • 42
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • Thorel F, Népote V, Avril I, Kohno K, Desgraz R, Chera S and Herrera PL: Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464: 1149-1154, 2010.
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1    Népote, V.2    Avril, I.3    Kohno, K.4    Desgraz, R.5    Chera, S.6    Herrera, P.L.7
  • 43
    • 77958099053 scopus 로고    scopus 로고
    • Pancreatic β-cell neogenesis by direct conversion from mature α-cells
    • Chung CH, Hao E, Piran R, Keinan E and Levine F: Pancreatic β-cell neogenesis by direct conversion from mature α-cells. Stem Cells 28: 1630-1638, 2010.
    • (2010) Stem Cells , vol.28 , pp. 1630-1638
    • Chung, C.H.1    Hao, E.2    Piran, R.3    Keinan, E.4    Levine, F.5
  • 44
    • 84861467247 scopus 로고    scopus 로고
    • Inflammation and type one diabetes
    • Bending D, Zaccone P and Cooke A: Inflammation and type one diabetes. Int Immunol 24: 339-346, 2012.
    • (2012) Int Immunol , vol.24 , pp. 339-346
    • Bending, D.1    Zaccone, P.2    Cooke, A.3
  • 45
    • 68149162957 scopus 로고    scopus 로고
    • The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells
    • Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen OD, et al: The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells. Cell 138: 449-462, 2009.
    • (2009) Cell , vol.138 , pp. 449-462
    • Collombat, P.1    Xu, X.2    Ravassard, P.3    Sosa-Pineda, B.4    Dussaud, S.5    Billestrup, N.6    Madsen, O.D.7
  • 48
    • 77952472242 scopus 로고    scopus 로고
    • Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass
    • Lee JH, Jo J, Hardikar AA, Periwal V and Rane SG: Cdk4 regulates recruitment of quiescent beta-cells and ductal epithelial progenitors to reconstitute beta-cell mass. PLoS One 5: e8653, 2010.
    • (2010) PLoS One , vol.5
    • Lee, J.H.1    Jo, J.2    Hardikar, A.A.3    Periwal, V.4    Rane, S.G.5
  • 50
    • 80755146047 scopus 로고    scopus 로고
    • Potential pathways to restore β-cell mass: Pluripotent stem cells, reprogramming, and endogenous regeneration
    • Baiu D, Merriam F and Odorico J: Potential pathways to restore β-cell mass: pluripotent stem cells, reprogramming, and endogenous regeneration. Curr Diab Rep 11: 392-401, 2011.
    • (2011) Curr Diab Rep , vol.11 , pp. 392-401
    • Baiu, D.1    Merriam, F.2    Odorico, J.3
  • 52
    • 27744603796 scopus 로고    scopus 로고
    • Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: Indirect evidence for islet regeneration?
    • Meier JJ, Bhushan A, Butler AE, Rizza RA and Butler PC: Sustained beta cell apoptosis in patients with long-standing type 1 diabetes: indirect evidence for islet regeneration? Diabetologia 48: 2221-2228, 2005.
    • (2005) Diabetologia , vol.48 , pp. 2221-2228
    • Meier, J.J.1    Bhushan, A.2    Butler, A.E.3    Rizza, R.A.4    Butler, P.C.5
  • 53
    • 84869416107 scopus 로고    scopus 로고
    • Glycolysis in Panc-1 human pancreatic cancer cells is inhibited by everolimus
    • Liu L, Gong L, Zhang Y and Li N: Glycolysis in Panc-1 human pancreatic cancer cells is inhibited by everolimus. Exp Ther Med 5: 338-342, 2013.
    • (2013) Exp Ther Med , vol.5 , pp. 338-342
    • Liu, L.1    Gong, L.2    Zhang, Y.3    Li, N.4
  • 54
    • 84860342715 scopus 로고    scopus 로고
    • Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness
    • Lonardo E, Frias-Aldeguer J, Hermann PC and Heeschen C: Pancreatic stellate cells form a niche for cancer stem cells and promote their self-renewal and invasiveness. Cell Cycle 11: 1282-1290, 2012.
    • (2012) Cell Cycle , vol.11 , pp. 1282-1290
    • Lonardo, E.1    Frias-Aldeguer, J.2    Hermann, P.C.3    Heeschen, C.4
  • 55
    • 84879369217 scopus 로고    scopus 로고
    • Bone marrow stem cell as a potential treatment for diabetes
    • Li M and Ikehara S: Bone marrow stem cell as a potential treatment for diabetes. J Diabetes Res 2013: 329596, 2013.
    • (2013) J Diabetes Res , vol.2013
    • Li, M.1    Ikehara, S.2
  • 57
    • 0024374618 scopus 로고
    • Changes in microvascular structure of the fibrotic pancreas and their influence on pancreatic endocrine function
    • Yatagai T, Suzuki T and Tobe T: Changes in microvascular structure of the fibrotic pancreas and their influence on pancreatic endocrine function. Int J Pancreatol 4: 291-301, 1989.
    • (1989) Int J Pancreatol , vol.4 , pp. 291-301
    • Yatagai, T.1    Suzuki, T.2    Tobe, T.3
  • 58
    • 0033496629 scopus 로고    scopus 로고
    • Focal and Diffuse Beta Cell Changes in Persistent Hyperinsulinemic Hypoglycemia of Infancy
    • Klöppel G, Reinecke-Lüthge A and Koschoreck F: Focal and Diffuse Beta Cell Changes in Persistent Hyperinsulinemic Hypoglycemia of Infancy. Endocr Pathol 10: 299-304, 1999.
    • (1999) Endocr Pathol , vol.10 , pp. 299-304
    • Klöppel, G.1    Reinecke-Lüthge, A.2    Koschoreck, F.3
  • 59
    • 0034119682 scopus 로고    scopus 로고
    • Persistent hyperinsulinaemic hypoglycaemia of infancy: A heterogeneous syndrome unrelated to nesidioblastosis
    • Rahier J, Guiot Y and Sempoux C: Persistent hyperinsulinaemic hypoglycaemia of infancy: a heterogeneous syndrome unrelated to nesidioblastosis. Arch Dis Child Fetal Neonatal Ed 82: F108-F112, 2000.
    • (2000) Arch Dis Child Fetal Neonatal Ed , vol.82 , pp. F108-F112
    • Rahier, J.1    Guiot, Y.2    Sempoux, C.3
  • 60
    • 65549125523 scopus 로고    scopus 로고
    • Hyperinsulinism in developmental syndromes
    • Kapoor RR, James C and Hussain K: Hyperinsulinism in developmental syndromes. Endocr Dev 14: 95-113, 2009.
    • (2009) Endocr Dev , vol.14 , pp. 95-113
    • Kapoor, R.R.1    James, C.2    Hussain, K.3
  • 61
    • 84863895776 scopus 로고    scopus 로고
    • Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases
    • Bae GS, Park KC, Koo BS, Jo IJ, Choi SB, Song HJ and Park SJ: Nardostachys jatamansi inhibits severe acute pancreatitis via mitogen-activated protein kinases. Exp Ther Med 4: 533-537, 2012.
    • (2012) Exp Ther Med , vol.4 , pp. 533-537
    • Bae, G.S.1    Park, K.C.2    Koo, B.S.3    Jo, I.J.4    Choi, S.B.5    Song, H.J.6    Park, S.J.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.