메뉴 건너뛰기




Volumn 5, Issue 1, 2013, Pages 338-342

Glycolysis in panc-1 human pancreatic cancer cells is inhibited by everolimus

Author keywords

Apoptosis; Everolimus; Glycolysis; Panc 1 cells; Pancreatic cancer

Indexed keywords

EVEROLIMUS; HEXOKINASE; HEXOKINASE 2; LACTATE DEHYDROGENASE; LACTIC ACID; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA 143; S6 KINASE; UNCLASSIFIED DRUG;

EID: 84869416107     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.787     Document Type: Article
Times cited : (27)

References (37)
  • 1
    • 34648830232 scopus 로고    scopus 로고
    • Controversies in the adjuvant treatment of pancreatic adenocarcinoma
    • Saif MW: Controversies in the adjuvant treatment of pancreatic adenocarcinoma. JOP 8: 545-552, 2007.
    • (2007) JOP , vol.8 , pp. 545-552
    • Saif, M.W.1
  • 3
  • 4
    • 84860512005 scopus 로고    scopus 로고
    • Links between metabolism and cancer
    • Dang CV: Links between metabolism and cancer. Genes Dev 26: 877-890, 2012.
    • (2012) Genes Dev , vol.26 , pp. 877-890
    • Dang, C.V.1
  • 5
    • 80052041011 scopus 로고    scopus 로고
    • Warburg effect mechanism as the target for theoretical substantiation of a new potential cancer treatment
    • Ponisovskiy MR: Warburg effect mechanism as the target for theoretical substantiation of a new potential cancer treatment. Crit Rev Eukaryot Gene Expr 21: 13-28, 2011.
    • (2011) Crit Rev Eukaryot Gene Expr , vol.21 , pp. 13-28
    • Ponisovskiy, M.R.1
  • 6
    • 84857097612 scopus 로고    scopus 로고
    • Pancreatic cancer: Medical management (novel chemotherapeutics)
    • Paez D, Labonte MJ and Lenz HJ: Pancreatic cancer: medical management (novel chemotherapeutics). Gastroenterol Clin North Am 41: 189-209, 2012.
    • (2012) Gastroenterol Clin North Am , vol.41 , pp. 189-209
    • Paez, D.1    Labonte, M.J.2    Lenz, H.J.3
  • 7
    • 80155142474 scopus 로고    scopus 로고
    • Rapamycin passes the torch: A new generation of mTOR inhibitors
    • Benjamin D, Colombi M, Moroni C and Hall MN: Rapamycin passes the torch: a new generation of mTOR inhibitors. Nat Rev Drug Discov 10: 868-880, 2011.
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 868-880
    • Benjamin, D.1    Colombi, M.2    Moroni, C.3    Hall, M.N.4
  • 8
    • 84858683823 scopus 로고    scopus 로고
    • Pancreatic neuroendocr ine tumors: Enter ing a new era
    • Oberstein PE, Remotti H, Saif MW and Libutti SK: Pancreatic neuroendocr ine tumors: enter ing a new era. JOP 13: 169-173, 2012.
    • (2012) JOP , vol.13 , pp. 169-173
    • Oberstein, P.E.1    Remotti, H.2    Saif, M.W.3    Libutti, S.K.4
  • 9
    • 84865697746 scopus 로고    scopus 로고
    • The mTOR inhibitor everolimus in combination with carboplatin in metastatic breast cancer - a phase I trial
    • Schwarzlose-Schwarck S, Scholz CW, Regierer AC, et al: The mTOR inhibitor everolimus in combination with carboplatin in metastatic breast cancer - a phase I trial. Anticancer Res 32: 3435-3441, 2012.
    • (2012) Anticancer Res , vol.32 , pp. 3435-3441
    • Schwarzlose-Schwarck, S.1    Scholz, C.W.2    Regierer, A.C.3
  • 10
    • 84864055699 scopus 로고    scopus 로고
    • Everolimus enhances gemcitabine-induced cytotoxicity in bladder-cancer cell lines
    • Pinto-Leite R, Arantes-Rodrigues R, Palmeira C, et al: Everolimus enhances gemcitabine-induced cytotoxicity in bladder-cancer cell lines. J Toxicol Environ Health A 75: 788-799, 2012.
    • (2012) J Toxicol Environ Health A , vol.75 , pp. 788-799
    • Pinto-Leite, R.1    Arantes-Rodrigues, R.2    Palmeira, C.3
  • 11
    • 84863565765 scopus 로고    scopus 로고
    • Inhibition of the mTOR/S6K signal is necessary to enhance fuorouracil-induced apoptosis in gastric cancer cells with HER2 amplifcation
    • Tomioka H, Mukohara T, Kataoka Y, et al: Inhibition of the mTOR/S6K signal is necessary to enhance fuorouracil-induced apoptosis in gastric cancer cells with HER2 amplifcation. Int J Oncol 41: 551-558, 2012.
    • (2012) Int J Oncol , vol.41 , pp. 551-558
    • Tomioka, H.1    Mukohara, T.2    Kataoka, Y.3
  • 12
    • 84862543359 scopus 로고    scopus 로고
    • Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells
    • Tai S, Sun Y, Liu N, et al: Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. Mol Cancer Ther 11: 1320-1331, 2012.
    • (2012) Mol Cancer Ther , vol.11 , pp. 1320-1331
    • Tai, S.1    Sun, Y.2    Liu, N.3
  • 14
    • 84859778293 scopus 로고    scopus 로고
    • MTOR signaling in growth control and disease
    • Laplante M and Sabatini DM: mTOR signaling in growth control and disease. Cell 149: 274-293, 2012.
    • (2012) Cell , vol.149 , pp. 274-293
    • Laplante, M.1    Sabatini, D.M.2
  • 15
    • 84055178474 scopus 로고    scopus 로고
    • Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks
    • Magnuson B, Ekim B and Fingar DC: Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J 441: 1-21, 2012.
    • (2012) Biochem J , vol.441 , pp. 1-21
    • Magnuson, B.1    Ekim, B.2    Fingar, D.C.3
  • 16
    • 84857675728 scopus 로고    scopus 로고
    • The mTOR signalling pathway in human cancer
    • Populo H, Lopes JM and Soares P: The mTOR signalling pathway in human cancer. Int J Mol Sci 13: 1886-1918, 2012.
    • (2012) Int J Mol Sci , vol.13 , pp. 1886-1918
    • Populo, H.1    Lopes, J.M.2    Soares, P.3
  • 17
    • 84861906379 scopus 로고    scopus 로고
    • Preparation and in vivo evaluation of liposomal everolimus for lung carcinoma and thyroid carcinoma
    • Iwase Y and Maitani Y: Preparation and in vivo evaluation of liposomal everolimus for lung carcinoma and thyroid carcinoma. Biol Pharm Bull 35: 975-979, 2012.
    • (2012) Biol Pharm Bull , vol.35 , pp. 975-979
    • Iwase, Y.1    Maitani, Y.2
  • 18
    • 33746924468 scopus 로고    scopus 로고
    • Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
    • Mathupala SP, Ko YH and Pedersen PL: Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25: 4777-4786, 2006.
    • (2006) Oncogene , vol.25 , pp. 4777-4786
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 19
    • 79951699777 scopus 로고    scopus 로고
    • Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme
    • Wolf A, Agnihotri S, Micallef J, et al: Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme. J Exp Med 208: 313-326, 2011.
    • (2011) J Exp Med , vol.208 , pp. 313-326
    • Wolf, A.1    Agnihotri, S.2    Micallef, J.3
  • 20
    • 84863316020 scopus 로고    scopus 로고
    • MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene
    • Fang R, Xiao T, Fang Z, et al: MicroRNA-143 (miR-143) regulates cancer glycolysis via targeting hexokinase 2 gene. J Biol Chem 287: 23227-23235, 2012.
    • (2012) J Biol Chem , vol.287 , pp. 23227-23235
    • Fang, R.1    Xiao, T.2    Fang, Z.3
  • 21
    • 33846887975 scopus 로고    scopus 로고
    • MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers
    • Akao Y, Nakagawa Y and Naoe T: MicroRNAs 143 and 145 are possible common onco-microRNAs in human cancers. Oncol Rep 16: 845-850, 2006.
    • (2006) Oncol Rep , vol.16 , pp. 845-850
    • Akao, Y.1    Nakagawa, Y.2    Naoe, T.3
  • 22
    • 84861544698 scopus 로고    scopus 로고
    • Identifcation of aberrantly expressed miRNAs in rectal cancer
    • Li X, Zhang G, Luo F, et al: Identifcation of aberrantly expressed miRNAs in rectal cancer. Oncol Rep 28: 77-84, 2012.
    • (2012) Oncol Rep , vol.28 , pp. 77-84
    • Li, X.1    Zhang, G.2    Luo, F.3
  • 23
    • 84859880428 scopus 로고    scopus 로고
    • The miRNA-kallikrein axis of interaction: A new dimension in the pathogenesis of prostate cancer
    • White NM, Youssef YM, Fendler A, Stephan C, Jung K and Yousef GM: The miRNA-kallikrein axis of interaction: a new dimension in the pathogenesis of prostate cancer. Biol Chem 393: 379-389, 2012.
    • (2012) Biol Chem , vol.393 , pp. 379-389
    • White, N.M.1    Youssef, Y.M.2    Fendler, A.3    Stephan, C.4    Jung, K.5    Yousef, G.M.6
  • 24
    • 35548995316 scopus 로고    scopus 로고
    • Downregulation of microRNAs-143 and -145 in B-cell malignancies
    • Akao Y, Nakagawa Y, Kitade Y, Kinoshita T and Naoe T: Downregulation of microRNAs-143 and -145 in B-cell malignancies. Cancer Sci 98: 1914-1920, 2007.
    • (2007) Cancer Sci , vol.98 , pp. 1914-1920
    • Akao, Y.1    Nakagawa, Y.2    Kitade, Y.3    Kinoshita, T.4    Naoe, T.5
  • 25
    • 62549160416 scopus 로고    scopus 로고
    • MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma
    • Chen HC, Chen GH, Chen YH, et al: MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma. Br J Cancer 100: 1002-1011, 2009.
    • (2009) Br J Cancer , vol.100 , pp. 1002-1011
    • Chen, H.C.1    Chen, G.H.2    Chen, Y.H.3
  • 26
    • 49749107841 scopus 로고    scopus 로고
    • Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth
    • e2557
    • Wang X, Tang S, Le SY, et al: Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth. PLoS One 3: e2557, 2008.
    • (2008) PLoS One , vol.3
    • Wang, X.1    Tang, S.2    Le, S.Y.3
  • 27
    • 58149381996 scopus 로고    scopus 로고
    • MicroRNAs differentially expressed in ACTH-secreting pituitary tumors
    • Amaral FC, Torres N, Saggioro F, et al: MicroRNAs differentially expressed in ACTH-secreting pituitary tumors. J Clin Endocrinol Metab 94: 320-323, 2009.
    • (2009) J Clin Endocrinol Metab , vol.94 , pp. 320-323
    • Amaral, F.C.1    Torres, N.2    Saggioro, F.3
  • 28
    • 66649131351 scopus 로고    scopus 로고
    • The expression profile of microRNAs in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in Syrian hamster
    • Yu T, Wang XY, Gong RG, et al: The expression profile of microRNAs in a model of 7,12-dimethyl-benz[a]anthrance-induced oral carcinogenesis in Syrian hamster. J Exp Clin Cancer Res 28: 64, 2009.
    • (2009) J Exp Clin Cancer Res , vol.28 , pp. 64
    • Yu, T.1    Wang, X.Y.2    Gong, R.G.3
  • 29
    • 67649425233 scopus 로고    scopus 로고
    • Over- and under-expressed microRNAs in human colorectal cancer
    • Motoyama K, Inoue H, Takatsuno Y, et al: Over- and under-expressed microRNAs in human colorectal cancer. Int J Oncol 34: 1069-1075, 2009.
    • (2009) Int J Oncol , vol.34 , pp. 1069-1075
    • Motoyama, K.1    Inoue, H.2    Takatsuno, Y.3
  • 30
    • 62249137047 scopus 로고    scopus 로고
    • Role of miR-143 targeting KRAS in colorectal tumorigenesis
    • Chen X, Guo X, Zhang H, et al: Role of miR-143 targeting KRAS in colorectal tumorigenesis. Oncogene 28: 1385-1392, 2009.
    • (2009) Oncogene , vol.28 , pp. 1385-1392
    • Chen, X.1    Guo, X.2    Zhang, H.3
  • 31
    • 68749097208 scopus 로고    scopus 로고
    • MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer
    • Ng EK, Tsang WP, Ng SS, et al: MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer. Br J Cancer 101: 699 -706, 2009.
    • (2009) Br J Cancer , vol.101 , pp. 699-706
    • Ng, E.K.1    Tsang, W.P.2    Ng, S.S.3
  • 32
    • 70350433121 scopus 로고    scopus 로고
    • MicroRNA-143 reduces viability and increases sensitivity to 5-fuorouracil in HCT116 human colorectal cancer cells
    • Borralho PM, Kren BT, Castro RE, da Silva IB, Steer CJ and Rodrigues CM: MicroRNA-143 reduces viability and increases sensitivity to 5-fuorouracil in HCT116 human colorectal cancer cells. FEBS J 276: 6689-6700, 2009.
    • (2009) FEBS J , vol.276 , pp. 6689-6700
    • Borralho, P.M.1    Kren, B.T.2    Castro, R.E.3    da Silva, I.B.4    Steer, C.J.5    Rodrigues, C.M.6
  • 34
    • 84860169530 scopus 로고    scopus 로고
    • MicroRNA-143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer
    • Zhang Y, Wang Z, Chen M, et al: MicroRNA-143 targets MACC1 to inhibit cell invasion and migration in colorectal cancer. Mol Cancer 11: 23, 2012.
    • (2012) Mol Cancer , vol.11 , pp. 23
    • Zhang, Y.1    Wang, Z.2    Chen, M.3
  • 35
    • 84863011861 scopus 로고    scopus 로고
    • MiR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2
    • Liu L, Yu X, Guo X, et al: miR-143 is downregulated in cervical cancer and promotes apoptosis and inhibits tumor formation by targeting Bcl-2. Mol Med Report 5: 753-760, 2012.
    • (2012) Mol Med Report , vol.5 , pp. 753-760
    • Liu, L.1    Yu, X.2    Guo, X.3
  • 36
    • 84862812020 scopus 로고    scopus 로고
    • A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells
    • Jiang S, Zhang LF, Zhang HW, et al: A novel miR-155/miR-143 cascade controls glycolysis by regulating hexokinase 2 in breast cancer cells. EMBO J 31: 1985-1998, 2012.
    • (2012) EMBO J , vol.31 , pp. 1985-1998
    • Jiang, S.1    Zhang, L.F.2    Zhang, H.W.3
  • 37
    • 84871122805 scopus 로고    scopus 로고
    • Krogh A and Lund AH: MicroRNA-143 down-regulates Hexokinase 2 in colon cancer cells
    • Gregersen LH, Jacobsen A, Frankel LB, Wen J, Krogh A and Lund AH: microRNA-143 down-regulates Hexokinase 2 in colon cancer cells. BMC Cancer 12: 232, 2012.
    • (2012) BMC Cancer , vol.12 , pp. 232
    • Gregersen, L.H.1    Jacobsen, A.2    Frankel, L.B.3    Wen, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.