Ischemia/reperfusion activates myocardial innate immune response: The key role of the toll-like receptor

Frontiers in Physiology

Volumn 5, Issue DEC, 2014, Pages

  Vilahur, Gemma ^a   Badimon, Lina ^a,b  

^a HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

Cytokines; Inflammation; Innate immune response; Ischemia reperfusion injury; Myocardium; Toll like receptor

Indexed keywords

BETA INTERFERON; CD11B ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; MYELOID DIFFERENTIATION FACTOR 88; PATTERN RECOGNITION RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA;

CYTOKINE RELEASE; CYTOKINE RESPONSE; HUMAN; INFLAMMATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; LEUKOCYTE ACTIVATION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPERFUSION INJURY; SHORT SURVEY; TISSUE REPAIR;

EID: 84922010075     PISSN: None     EISSN: 1664042X     Source Type: Journal    
DOI: 10.3389/fphys.2014.00496     Document Type: Short Survey

References (29)

1. Aikawa, R., Nagai, T., Tanaka, M., Zou, Y., Ishihara, T., Takano, H., et al. (2001). Reactive oxygen species in mechanical stress-induced cardiac hypertrophy. Biochem. Biophys. Res. Commun. 289, 901-907. doi: 10.1006/bbrc.2001.6068
2. Anderson, K. V., Bokla, L., and Nusslein-Volhard, C. (1985). Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell 42, 791-798. doi: 10.1016/0092-8674(85)90275-2
3. Ao, L., Zou, N., Cleveland, J. C. Jr., Fullerton, D. A., and Meng, X. (2009). Myocardial TLR4 is a determinant of neutrophil infiltration after global myocardial ischemia: mediating KC and MCP-1 expression induced by extracellular HSC70. Am. J. Physiol. Heart Circ. Physiol. 297, H21-H28. doi: 10.1152/ajpheart.00292.2009
4. Arslan, F., de Kleijn, D. P., Timmers, L., Doevendans, P. A., and Pasterkamp, G. (2008). Bridging innate immunity and myocardial ischemia/reperfusion injury: the search for therapeutic targets. Curr. Pharm. Des. 14, 1205-1216. doi: 10.2174/138161208784246090
5. Bolli, R., and Marban, E. (1999). Molecular and cellular mechanisms of myocardial stunning. Physiol. Rev. 79, 609-634.
6. Chao, W. (2009). Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart. Am. J. Physiol. Heart Circ. Physiol. 296, H1-H12. doi: 10.1152/ajpheart.00995.2008
7. Chong, A. J., Shimamoto, A., Hampton, C. R., Takayama, H., Spring, D. J., Rothnie, C. L., et al. (2004). Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J. Thorac. Cardiovasc. Surg. 128, 170-179. doi: 10.1016/j.jtcvs.2003.11.036
8. Dong, J. W., Vallejo, J. G., Tzeng, H. P., Thomas, J. A., Mann, D. L. (2010). Innate immunity mediates myocardial preconditioning through Toll-like receptor 2 and TIRAP-dependent signaling pathways. Am. J. Physiol. Heart Circ. Physiol. 298, H1079-H1087. doi: 10.1152/ajpheart.00306.2009
9. Fallach, R., Shainberg, A., Avlas, O., Fainblut, M., Chepurko, Y., Porat, E., et al. (2010). Cardiomyocyte Toll-like receptor 4 is involved in heart dysfunction following septic shock or myocardial ischemia. J. Mol. Cell. Cardiol. 48, 1236-1244. doi: 10.1016/j.yjmcc.2010.02.020
10. Flohe, L., Brigelius-Flohe, R., Saliou, C., Traber, M. G., and Packer, L. (1997). Redox regulation of NF-kappa B activation. Free Radic. Biol. Med. 22, 1115-1126. doi: 10.1016/S0891-5849(96)00501-1
11. Frantz, S., Ertl, G., and Bauersachs, J. (2007). Mechanisms of disease: toll-like receptors in cardiovascular disease. Nat. Clin. Pract. Cardiovasc. Med. 4, 444-454. doi: 10.1038/ncpcardio0938
12. Frantz, S., Kobzik, L., Kim, Y. D., Fukazawa, R., Medzhitov, R., Lee, R. T., et al. (1999). Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium. J. Clin. Invest. 104, 271-280. doi: 10.1172/JCI6709
13. Ha, T., Liu, L., Kelley, J., Kao, R., Williams, D., and Li, C. (2011). Toll-like receptors: new players in myocardial ischemia/reperfusion injury. Antioxid. Redox Signal. 15, 1875-1893. doi: 10.1089/ars.2010.3723
14. Kiechl, S., Lorenz, E., Reindl, M., Wiedermann, C. J., Oberhollenzer, F., Bonora, E., et al. (2002). Toll-like receptor 4 polymorphisms and atherogenesis. N. Engl. J. Med. 347, 185-192. doi: 10.1056/NEJMoa012673
15. Kim, H. M., Park, B. S., Kim, J. I., Kim, S. E., Lee, J., Oh, S. C., et al. (2007a). Crystal structure of the TLR4-MD-2 complex with bound endotoxin antagonist Eritoran. Cell 130, 906-917. doi: 10.1016/j.cell.2007.08.002
16. Kim, S. C., Ghanem, A., Stapel, H., Tiemann, K., Knuefermann, P., Hoeft, A., et al. (2007b). Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function. BMC Physiol. 7:5. doi: 10.1186/1472-6793-7-5
17. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M., and Hoffmann, J. A. (1996). The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983. doi: 10.1016/S0092-8674(00)80172-5
18. Lin, E., Freedman, J. E., and Beaulieu, L. M. (2009). Innate immunity and toll-like receptor antagonists: a potential role in the treatment of cardiovascular diseases. Cardiovasc. Ther. 27, 117-123. doi: 10.1111/j.1755-5922.2009.00077.x
19. Lin, L., and Knowlton, A. A. (2014). Innate immunity and cardiomyocytes in ischemic heart disease. Life Sci. 100, 1-8. doi: 10.1016/j.lfs.2014.01.062
20. Mann, D. L. (2011). The emerging role of innate immunity in the heart and vascular system: for whom the cell tolls. Circ. Res. 108, 1133-1145. doi: 10.1161/CIRCRESAHA.110.226936
21. Mersmann, J., Berkels, R., Zacharowski, P., Tran, N., Koch, A., Iekushi, K., et al. (2010). Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury. Crit. Care Med. 38, 903-909. doi: 10.1097/CCM.0b013e3181ce50e6
22. Murry, C. E., Jennings, R. B., and Reimer, K. A. (1986). Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74, 1124-1136. doi: 10.1161/01.CIR.74.5.1124
23. Oyama, J., Blais, C. Jr., Liu, X., Pu, M., Kobzik, L., Kelly, R. A., et al. (2004). Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 109, 784-789. doi: 10.1161/01.CIR.0000112575.66565.84
24. Scaffidi, P., Misteli, T., and Bianchi, M. E. (2002). Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418, 191-195. doi: 10.1038/nature00858
25. Scheibner, K. A., Lutz, M. A., Boodoo, S., Fenton, M. J., Powell, J. D., and Horton, M. R. (2006). Hyaluronan fragments act as an endogenous danger signal by engaging TLR2. J. Immunol. 177, 1272-1281. doi: 10.4049/jimmunol.177.2.1272
26. Shishido, T., Nozaki, N., Yamaguchi, S., Shibata, Y., Nitobe, J., Miyamoto, T., et al. (2003). Toll-like receptor-2 modulates ventricular remodeling after myocardial infarction. Circulation 108, 2905-2910. doi: 10.1161/01.CIR.0000101921.93016.1C
27. Vilahur, G., Hernandez-Vera, R., Molins, B., Casani, L., Duran, X., Padro, T., et al. (2009). Short-term myocardial ischemia induces cardiac modified C-reactive protein expression and proinflammatory gene (cyclo-oxygenase-2, monocyte chemoattractant protein-1, and tissue factor) upregulation in peripheral blood mononuclear cells. J. Thromb. Haemost. 7, 485-493. doi: 10.1111/j.1538-7836.2008.03244.x
28. Vilahur, G., Juan-Babot, O., Pena, E., Onate, B., Casani, L., and Badimon, L. (2011). Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. J. Mol. Cell. Cardiol. 50, 522-533. doi: 10.1016/j.yjmcc.2010.12.021
29. Wang, Y., Abarbanell, A. M., Herrmann, J. L., Weil, B. R., Poynter, J., Manukyan, M. C., et al. (2010). Toll-like receptor signaling pathways and the evidence linking toll-like receptor signaling to cardiac ischemia/reperfusion injury. Shock 34, 548-557. doi: 10.1097/SHK.0b013e3181e686f5