Mycobacterium tuberculosis EspB protein suppresses interferon-γ-induced autophagy in murine macrophages

Journal of Microbiology, Immunology and Infection

Volumn 49, Issue 6, 2016, Pages 859-865

  Huang, DanDan ^a   Bao, Lang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

ANA 1 macrophages; autophagy; EspB; interferon receptor 1; Mycobacterium tuberculosis

Indexed keywords

BACTERIAL PROTEIN; DANSYLCADAVERINE; ESPB PROTEIN; GAMMA INTERFERON; GENOMIC DNA; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; INTERFERON GAMMA R1; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 1; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 BETA I; MICROTUBULE ASSOCIATED PROTEIN 1 LIGHT CHAIN 3 BETA II; RECOMBINANT PROTEIN; STAT1 PROTEIN; UNCLASSIFIED DRUG; ESPB PROTEIN, MYCOBACTERIUM TUBERCULOSIS; GAMMA INTERFERON RECEPTOR; INTERFERON RECEPTOR; OUTER MEMBRANE PROTEIN; STAT1 PROTEIN, MOUSE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL VACUOLE; ESCHERICHIA COLI; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENE AMPLIFICATION; GENE EXPRESSION; MACROPHAGE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ANIMAL; CELL LINE; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; PHOSPHORYLATION;

ANIMALS; AUTOPHAGY; BACTERIAL OUTER MEMBRANE PROTEINS; CELL LINE; ESCHERICHIA COLI; INTERFERON-GAMMA; MACROPHAGES; MICE; MYCOBACTERIUM TUBERCULOSIS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; RECEPTORS, INTERFERON; RECOMBINANT PROTEINS; RNA, MESSENGER; STAT1 TRANSCRIPTION FACTOR;

EID: 84921978184     PISSN: 16841182     EISSN: 19959133     Source Type: Journal    
DOI: 10.1016/j.jmii.2014.11.008     Document Type: Article

References (31)

1. 1 Swanson, M.S., Autophagy: eating for good health. J Immunol 177 (2006), 4945–4951.
2. 2 Levine, B., Deretic, V., Unveiling the roles of autophagy in innate and adaptive immunity. Nat Rev Immunol 7 (2007), 767–777.
3. 3 Eskelinen, E.L., Saftig, P., Autophagy: a lysosomal degradation pathway with a central role in health and disease. Biochim Biophys Acta 1793 (2009), 664–673.
4. 4 Rich, K.A., Burkett, C., Webster, P., Cytoplasmic bacteria can be targets for autophagy. Cell Microbiol 5 (2003), 455–468.
5. 5 Zumla, A., Raviglione, M., Hafner, R., von Reyn, C.F., Tuberculosis. New Engl J Med 368 (2013), 745–755.
6. 6 Deretic, V., Singh, S., Master, S., Harris, J., Roberts, E., Kyei, G., et al. Mycobacterium tuberculosis inhibition of phagolysosome biogenesis and autophagy as a host defence mechanism. Cell Microbiol 8 (2006), 719–727.
7. 7 Gutierrez, M.G., Master, S.S., Singh, S.B., Taylor, G.A., Colombo, M.I., Deretic, V., Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell 119 (2004), 753–766.
8. 8 Petruccioli, E., Romagnoli, A., Butera, O., Palucci, I., Delogu, G., Fimia, G.M., et al. Autophagy modulation by Mycobacterium tuberculosis after in vitro infection of human primary macrophages. Simit, 9, 2011, 349.
9. 9 Abdallah, A.M., Gey van Pittius, N.C., Champion, P.A., Cox, J., Luirink, J., Vandenbroucke-Grauls, C.M., et al. Type VII secretion – mycobacteria show the way. Nat Rev Microbiol 5 (2007), 883–891.
10. 10 McLaughlin, B., Chon, J.S., MacGurn, J.A., Carlsson, F., Cheng, T.L., Cox, J.S., et al. A mycobacterium ESX-1-secreted virulence factor with unique requirements for export. PLoS Pathogens, 3, 2007, e105.
11. 11 Gao, L.Y., Guo, S., McLaughlin, B., Morisaki, H., Engel, J.N., Brown, E.J., A mycobacterial virulence gene cluster extending RD1 is required for cytolysis, bacterial spreading and ESAT-6 secretion. Mol Microbiol 53 (2004), 1677–1693.
12. 12 Ohol, Y.M., Goetz, D.H., Chan, K., Shiloh, M.U., Craik, C.S., Cox, J.S., Mycobacterium tuberculosis MycP1 protease plays a dual role in regulation of ESX-1 secretion and virulence. Cell Host Microbe 7 (2010), 210–220.
13. 13 Xu, J., Laine, O., Masciocchi, M., Manoranjan, J., Smith, J., Du, S.J., et al. A unique Mycobacterium ESX-1 protein co-secretes with CFP-10/ESAT-6 and is necessary for inhibiting phagosome maturation. Mol Microbiol 66 (2007), 787–800.
14. 14 Biederbick, A., Kern, H.F., Elsasser, H.P., Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles. Eur J Cell Biol 66 (1995), 3–14.
15. 15 Deretic, V., Levine, B., Autophagy, immunity, and microbial adaptations. Cell Host Microbe 5 (2009), 527–549.
16. 16 Marino, G., Lopez-Otin, C., Autophagy: molecular mechanisms, physiological functions and relevance in human pathology. Cell Mol Life Sci 61 (2004), 1439–1454.
17. 17 Shin, D.M., Yuk, J.M., Lee, H.M., Lee, S.H., Son, J.W., Harding, C.V., et al. Mycobacterial lipoprotein activates autophagy via TLR2/1/CD14 and a functional vitamin D receptor signalling. Cell Microbiol 12 (2010), 1648–1665.
18. 18 Shin, D.M., Jeon, B.Y., Lee, H.M., Jin, H.S., Yuk, J.M., Song, C.H., et al. Mycobacterium tuberculosis eis regulates autophagy, inflammation, and cell death through redox-dependent signaling. PLoS Pathogens, 6, 2010, e1001230.
19. 19 Ting, L.M., Kim, A.C., Cattamanchi, A., Ernst, J.D., Mycobacterium tuberculosis inhibits IFN-gamma transcriptional responses without inhibiting activation of STAT1. J Immunol 163 (1999), 3898–3906.
20. 20 Flynn, J.L., Why is IFN-gamma insufficient to control tuberculosis?. Trends Microbiol 7 (1999), 477–479.
21. 21 Kumar, D., Nath, L., Kamal, M.A., Varshney, A., Jain, A., Singh, S., et al. Genome-wide analysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell 140 (2010), 731–743.
22. 22 MacMicking, J.D., Taylor, G.A., McKinney, J.D., Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 302 (2003), 654–659.
23. 23 Singh, S.B., Davis, A.S., Taylor, G.A., Deretic, V., Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313 (2006), 1438–1441.
24. 24 Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., et al. LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J 19 (2000), 5720–5728.
25. 25 Yoshimori, T., Autophagy: a regulated bulk degradation process inside cells. Biochem Biophys Res Comms 313 (2004), 453–458.
26. 26 Darnell, J.E. Jr., Kerr, I.M., Stark, G.R., Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264 (1994), 1415–1421.
27. 27 Ihle, J.N., Cytokine receptor signalling. Nature 377 (1995), 591–594.
28. 28 Ihle, J.N., STATs: signal transducers and activators of transcription. Cell 84 (1996), 331–334.
29. 29 Sekimoto, T., Nakajima, K., Tachibana, T., Hirano, T., Yoneda, Y., Interferon-gamma-dependent nuclear import of Stat1 is mediated by the GTPase activity of Ran/TC4. J Biol Chem 271 (1996), 31017–31020.
30. 30 Li, J.C., Au, K.Y., Fang, J.W., Yim, H.C., Chow, K.H., Ho, P.L., et al. HIV-1 trans-activator protein dysregulates IFN-gamma signaling and contributes to the suppression of autophagy induction. AIDS 25 (2011), 15–25.
31. 31 Flynn, J.L., Chan, J., Immune evasion by Mycobacterium tuberculosis: living with the enemy. Curr Opin Immunol 15 (2003), 450–455.