Pain and depression: A neurobiological perspective of their relationship

Psychiatry Investigation

Volumn 12, Issue 1, 2015, Pages 1-8

  Han, Changsu ^a   Pae, Chi Un ^b,c  

^a Korea University College of Medicine   (South Korea)

^b The Catholic University of Korea College of Medicine   (South Korea)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Aa Depression; Pain; Pathophysiology; Relationship; Symptomatology; Treatment

Indexed keywords

4 HYDROXY 3 METHOXYPHENYLETHYLENE GLYCOL; 5 HYDROXYINDOLEACETIC ACID; ANTIOXIDANT; BRAIN DERIVED NEUROTROPHIC FACTOR; C REACTIVE PROTEIN; CD40 LIGAND; CORTICOTROPIN RELEASING FACTOR; DEXAMETHASONE; DULOXETINE; ENDORPHIN; ESTROGEN; GLUCOCORTICOID; GROWTH HORMONE; HOMOVANILLIC ACID; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; LIOTHYRONINE; MELATONIN; MILNACIPRAN; NERVE GROWTH FACTOR; POLYUNSATURATED FATTY ACID; SEROTONIN 1A RECEPTOR; SEROTONIN 2A RECEPTOR; SUBSTANCE P; THYROTROPIN; TUMOR NECROSIS FACTOR ALPHA; VENLAFAXINE;

ALEXITHYMIA; ARTICLE; BEHAVIOR DISORDER; COGNITIVE DEFECT; COGNITIVE THERAPY; DEPRESSION; DISABILITY; ELECTROCORTICOGRAPHY; GENETIC SUSCEPTIBILITY; HUMAN; NEUROBIOLOGY; NEUROMODULATION; NOCICEPTION; PAIN INTENSITY; PSYCHOGENIC PAIN; REM SLEEP; SOCIAL PSYCHOLOGY;

EID: 84921964457     PISSN: 17383684     EISSN: 19763026     Source Type: Journal    
DOI: 10.4306/pi.2015.12.1.1     Document Type: Article

References (75)

1. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990;33:160-172.
2. Ratcliffe GE, Enns MW, Belik SL, Sareen J. Chronic pain conditions and suicidal ideation and suicide attempts: an epidemiologic perspective. Clin J Pain 2008;24:204-210.
3. Lepine JP, Briley M. The epidemiology of pain in depression. Hum Psychopharmacol 2004;19(Suppl 1):S3-S7.
4. Pae CU, Luyten P, Marks DM, Han C, Park SH, Patkar AA, et al. The relationship between fibromyalgia and major depressive disorder: a comprehensive review. Curr Med Res Opin 2008;24:2359-2371.
5. Pae CU, Marks DM, Patkar AA, Masand PS, Luyten P, Serretti A. Pharmacological treatment of chronic fatigue syndrome: focusing on the role of antidepressants. Expert Opin Pharmacother 2009;10:1561-1570.
6. Sansone RA, Sansone LA. Pain, pain, go away: antidepressants and pain management. Psychiatry (Edgmont) 2008;5:16-19.
7. Leone M. Deep brain stimulation in headache. Lancet Neurol 2006; 5:873-877.
8. Bai YM, Chiou WF, Su TP, Li CT, Chen MH. Pro-inflammatory cytokine associated with somatic and pain symptoms in depression. J Affect Disord 2014;155:28-34.
9. Burke NN, Geoghegan E, Kerr DM, Moriarty O, Finn DP, Roche M. Altered neuropathic pain behaviour in a rat model of depression is associated with changes in inflammatory gene expression in the amygdala. Genes Brain Behav 2013;12:705-713.
10. Blumer D, Zorick F, Heilbronn M, Roth T. Biological markers for depression in chronic pain. J Nerv Ment Dis 1982;170:425-428.
11. Magni G, Andreoli F, Arduino C, Arsie D, Ceccherelli F, Ambrosio F, et al. Modifications of [3H]imipramine binding sites in platelets of chronic pain patients treated with mianserin. Pain 1987;30:311-320.
12. Nicolson SE, Caplan JP, Williams DE, Stern TA. Comorbid pain, depression, and anxiety: multifaceted pathology allows for multifaceted treatment. Harv Rev Psychiatry 2009;17:407-420.
13. Sachs-Ericsson N, Cromer K, Hernandez A, Kendall-Tackett K. A review of childhood abuse, health, and pain-related problems: the role of psychiatric disorders and current life stress. J Trauma Dissociation 2009; 10:170-188.
14. Muhtz C, Rodriguez-Raecke R, Hinkelmann K, Moeller-Bertram T, Kiefer F, Wiedemann K, et al. Cortisol response to experimental pain in patients with chronic low back pain and patients with major depression. Pain Med 2013;14:498-503.
15. Lee EJ, Wu MY, Lee GK, Cheing G, Chan F. Catastrophizing as a cognitive vulnerability factor related to depression in workers’ compensation patients with chronic musculoskeletal pain. J Clin Psychol Med Settings 2008;15:182-192.
16. Scott KM, Von Korff M, Angermeyer MC, Benjet C, Bruffaerts R, de Girolamo G, et al. Association of childhood adversities and early-onset mental disorders with adult-onset chronic physical conditions. Arch Gen Psychiatry 2011;68:838-844.
17. Jang JM, Park JI, Oh KY, Lee KH, Kim MS, Yoon MS, et al. Predictors of suicidal ideation in a community sample: roles of anger, self-esteem, and depression. Psychiatry Res 2014;216:74-81.
18. Friborg O, Martinsen EW, Martinussen M, Kaiser S, Overgard KT, Rosenvinge JH. Comorbidity of personality disorders in mood disorders: a meta-analytic review of 122 studies from 1988 to 2010. J Affect Disord 2014;152-154:1-11.
19. Corrigan MH, Denahan AQ, Wright CE, Ragual RJ, Evans DL. Comparison of pramipexole, fluoxetine, and placebo in patients with major depression. Depress Anxiety 2000;11:58-65.
20. Max MB, Wu T, Atlas SJ, Edwards RR, Haythornthwaite JA, Bollettino AF, et al. A clinical genetic method to identify mechanisms by which pain causes depression and anxiety. Mol Pain 2006;2:14.
21. Lebe M, Hasenbring MI, Schmieder K, Jetschke K, Harders A, Epplen JT, et al. Association of serotonin-1A and-2A receptor promoter polymorphisms with depressive symptoms, functional recovery, and pain in patients 6 months after lumbar disc surgery. Pain 2013;154:377-384.
22. Dafny N. Pain Modulation and Mechanisms In Section 2: Sensory Systems. In: Byrne JH, Editor. Neuroscience Online. Houston: The University of Texas Health Science Center at Houston; 2008.
23. Marks DM, Patkar AA, Masand PS, Pae CU. Does pregabalin have neuropsychotropic effects?: a short perspective. Psychiatry Investig 2009; 6:55-58.
24. Bras M, Dordevic V, Gregurek R, Bulajic M. Neurobiological and clinical relationship between psychiatric disorders and chronic pain. Psychiatr Danub 2010;22:221-226.
25. Bendtsen L, Norregaard J, Jensen R, Olesen J. Evidence of qualitatively altered nociception in patients with fibromyalgia. Arthritis Rheum 1997;40:98-102.
26. Bennett M. Emerging concepts in the neurobiology of chronic pain: evidence of abnormal sensory processing in fibromyalgia. Mayo Clin Proc 1999;74:385-398.
27. Verne GN, Price DD, Callam CS, Zhang B, Peck J, Zhou Q. Viscerosomatic facilitation in a subset of IBS patients, an effect mediated by N-methyl-D-aspartate receptors. J Pain 2012;13:901-909.
28. Doubell TP, Mannion RJ, Woolf CJ. The Dorsal Horn: State-Dependent Sensory Processing, Plasticity and the Generation of Pain. In: Wall PD, Melzack R, Editors. Textbook of pain. Edinburgh: Churchill Livingstone, 1999, p.165-181.
29. Mountz JM, Bradley LA, Modell JG, Alexander RW, Triana-Alexander M, Aaron LA, et al. Fibromyalgia in women. Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels. Arthritis Rheum 1995;38:926-938.
30. Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, et al. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis Rheum 1994;37:1593-1601.
31. Laske C, Stransky E, Eschweiler GW, Klein R, Wittorf A, Leyhe T, et al. Increased BDNF serum concentration in fibromyalgia with or without depression or antidepressants. J Psychiatr Res 2007;41:600-605.
32. Staud R, Robinson ME, Price DD. Temporal summation of second pain and its maintenance are useful for characterizing widespread central sensitization of fibromyalgia patients. J Pain 2007;8:893-901.
33. Blier P, Gobbi G, Haddjeri N, Santarelli L, Mathew G, Hen R. Impact of substance P receptor antagonism on the serotonin and norepinephrine systems: relevance to the antidepressant/anxiolytic response. J Psychiatry Neurosci 2004;29:208-218.
34. Zelman DC, Howland EW, Nichols SN, Cleeland CS. The effects of induced mood on laboratory pain. Pain 1991;46:105-111.
35. Jann MW, Slade JH. Antidepressant agents for the treatment of chronic pain and depression. Pharmacotherapy 2007;27:1571-1587.
36. Philips HC. Imagery and likelihood cognitive bias in pain. Behav Cogn Psychother 2013:1-15.
37. Goesling J, Clauw DJ, Hassett AL. Pain and depression: an integrative review of neurobiological and psychological factors. Curr Psychiatry Rep 2013;15:421.
38. Quartana PJ, Campbell CM, Edwards RR. Pain catastrophizing: a critical review. Expert Rev Neurother 2009;9:745-758.
39. Hassett AL, Cone JD, Patella SJ, Sigal LH. The role of catastrophizing in the pain and depression of women with fibromyalgia syndrome. Arthritis Rheum 2000;43:2493-2500.
40. Nicholas MK, Asghari A, Blyth FM, Wood BM, Murray R, McCabe R, et al. Self-management intervention for chronic pain in older adults: a randomised controlled trial. Pain 2013;154:824-835.
41. Burckhardt CS, O’Reilly CA, Wiens AN, Clark SR, Campbell SM, Bennett RM. Assessing depression in fibromyalgia patients. Arthritis Care Res 1994;7:35-39.
42. Saariaho AS, Saariaho TH, Mattila AK, Karukivi MR, Joukamaa MI. Alexithymia and depression in a chronic pain patient sample. Gen Hosp Psychiatry 2013;35:239-245.
43. Sayar K, Gulec H, Topbas M. Alexithymia and anger in patients with fibromyalgia. Clin Rheumatol 2004;23:441-448.
44. Moldovan I, Cooray D, Carr F, Katsaros E, Torralba K, Shinada S, et al. Pain and depression predict self-reported fatigue/energy in lupus. Lupus 2013;22:684-689.
45. Zakoscielna KM, Parmelee PA. Pain variability and its predictors in older adults: depression, cognition, functional status, health, and pain. J Aging Health 2013;25:1329-1339.
46. Martinez-Lavin M. Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia. Arthritis Res Ther 2007;9:216.
47. Toro-Velasco C, Arroyo-Morales M, Fernandez-de-Las-Penas C, Cleland JA, Barrero-Hernandez FJ. Short-term effects of manual therapy on heart rate variability, mood state, and pressure pain sensitivity in patients with chronic tension-type headache: a pilot study. J Manipulative Physiol Ther 2009;32:527-535.
48. Wilson KG, Eriksson MY, D’Eon JL, Mikail SF, Emery PC. Major depression and insomnia in chronic pain. Clin J Pain 2002;18:77-83.
49. Olie E, Guillaume S, Jaussent I, Courtet P, Jollant F. Higher psychological pain during a major depressive episode may be a factor of vulnerability to suicidal ideation and act. J Affect Disord 2010;120:226-230.
50. Jeon HJ, Lee JY, Lee YM, Hong JP, Won SH, Cho SJ, et al. Unplanned versus planned suicide attempters, precipitants, methods, and an association with mental disorders in a Korea-based community sample. J Affect Disord 2010;127:274-280.
51. Holman AJ, Myers RR. A randomized, double-blind, placebo-controlled trial of pramipexole, a dopamine agonist, in patients with fibromyalgia receiving concomitant medications. Arthritis Rheum 2005;52: 2495-2505.
52. Leitl MD, Onvani S, Bowers MS, Cheng K, Rice KC, Carlezon WA Jr, et al. Pain-related depression of the mesolimbic dopamine system in rats: expression, blockade by analgesics, and role of endogenous k-opioids. Neuropsychopharmacology 2014;39:614-624.
53. Matthey A, Cedraschi C, Piguet V, Besson M, Chabert J, Daali Y, et al. Dual reuptake inhibitor milnacipran and spinal pain pathways in fibromyalgia patients: a randomized, double-blind, placebo-controlled trial. Pain Physician 2013;16:E553-E562.
54. Semenchuk MR, Sherman S, Davis B. Double-blind, randomized trial of bupropion SR for the treatment of neuropathic pain. Neurology 2001; 57:1583-1588.
55. Marks DM, Pae CU, Patkar AA. Triple reuptake inhibitors: a premise and promise. Psychiatry Investig 2008;5:142-147.
56. Eccleston C, Morley SJ, Williams AC. Psychological approaches to chronic pain management: evidence and challenges. Br J Anaesth 2013; 111:59-63.
57. Williams AC, Eccleston C, Morley S. Psychological therapies for the management of chronic pain (excluding headache) in adults. Cochrane Database Syst Rev 2012;11:CD007407.
58. Eccleston C, Palermo TM, Fisher E, Law E. Psychological interventions for parents of children and adolescents with chronic illness. Cochrane Database Syst Rev 2012;8:CD009660.
59. Turk DC, Swanson KS, Tunks ER. Psychological approaches in the treatment of chronic pain patients--when pills, scalpels, and needles are not enough. Can J Psychiatry 2008;53:213-223.
60. Mutschler I, Ball T, Wankerl J, Strigo IA. Pain and emotion in the insular cortex: evidence for functional reorganization in major depression. Neurosci Lett 2012;520:204-209.
61. Rodriguez-Raecke R, Ihle K, Ritter C, Muhtz C, Otte C, May A. Neuronal differences between chronic low back pain and depression regarding long-term habituation to pain. Eur J Pain 2014;18:701-711.
62. Sotres-Bayon F, Torres-Lopez E, Lopez-Avila A, del Angel R, Pellicer F. Lesion and electrical stimulation of the ventral tegmental area modify persistent nociceptive behavior in the rat. Brain Res 2001;898:342-349.
63. Finan PH, Smith MT. The comorbidity of insomnia, chronic pain, and depression: dopamine as a putative mechanism. Sleep Med Rev 2013;17: 173-183.
64. Raphael KG, Janal MN, Nayak S, Schwartz JE, Gallagher RM. Familial aggregation of depression in fibromyalgia: a community-based test of alternate hypotheses. Pain 2004;110:449-460.
65. Blumer D, Heilbronn M. Chronic pain as a variant of depressive disease: the pain-prone disorder. J Nerv Ment Dis 1982;170:381-406.
66. Beghi M, Rosenbaum JF, Cerri C, Cornaggia CM. Risk factors for fatal and nonfatal repetition of suicide attempts: a literature review. Neuropsychiatr Dis Treat 2013;9:1725-1736.
67. Robinson D, Renshaw C, Okello C, Moller H, Davies EA. Suicide in cancer patients in South East England from 1996 to 2005: a population-based study. Br J Cancer 2009;101:198-201.
68. Fall K, Fang F, Mucci LA, Ye W, Andren O, Johansson JE, et al. Immediate risk for cardiovascular events and suicide following a prostate cancer diagnosis: prospective cohort study. PLoS Med 2009;6:e1000197.
69. Ilgen MA, Kleinberg F, Ignacio RV, Bohnert AS, Valenstein M, McCarthy JF, et al. Noncancer pain conditions and risk of suicide. JAMA Psychiatry 2013;70:692-697.
70. Pompili M, Di Cosimo D, Innamorati M, Lester D, Tatarelli R, Martelletti P. Psychiatric comorbidity in patients with chronic daily headache and migraine: a selective overview including personality traits and suicide risk. J Headache Pain 2009;10:283-290.
71. Grichnik KP, Ferrante FM. The difference between acute and chronic pain. Mt Sinai J Med 1991;58:217-220.
72. Koh JS, Ko HJ, Wang SM, Cho KJ, Kim JC, Lee SJ, et al. Depression and somatic symptoms may influence on chronic prostatitis/chronic pelvic pain syndrome: a preliminary study. Psychiatry Investig 2014;11:495-499.
73. Bonezzi C, Demartini L, Buonocore M. Chronic pain: not only a matter of time. Minerva Anestesiol 2012;78:704-711.
74. Devon HA, Piano MR, Rosenfeld AG, Hoppensteadt DA. The association of pain with protein inflammatory biomarkers: a review of the literature. Nurs Res 2014;63:51-62.
75. Miller AH, Maletic V, Raison CL. Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression. Biol Psychiatry 2009;65:732-741.