Optimization of caseinate-coated simvastatin-zein nanoparticles: Improved bioavailability and modified release characteristics

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 655-662

  Ahmed, Osama A A ^a,b   Hosny, Khaled M ^a,c   Al Sawahli, Majid M ^a,d   Fahmy, Usama A ^a  

^a KING ABDULAZIZ UNIVERSITY   (Saudi Arabia)

^b MINIA UNIVERSITY   (Egypt)

^c BENI SUEF UNIVERSITY   (Egypt)

^d Holding Company for Biological Products and Vaccines (VACSERA)   (Egypt)

Author keywords

Box Behnken design; Simvastatin; Sodium caseinate; Zein

Indexed keywords

ALCOHOL; MILK PROTEIN; NANOPARTICLE; SIMVASTATIN; SODIUM CASEINATE; STABILIZING AGENT; UNCLASSIFIED DRUG; ZEIN; CASEIN; DELAYED RELEASE FORMULATION; EXCIPIENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DIFFUSION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; ELIMINATION RATE CONSTANT; ENCAPSULATION; MALE; MAXIMUM PLASMA CONCENTRATION; MEAN RESIDENCE TIME; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; PARTICLE SIZE; PHASE SEPARATION; SLOW DRUG RELEASE; SUSPENSION; SUSTAINED DRUG RELEASE; TIME TO MAXIMUM PLASMA CONCENTRATION; ANIMAL; BIOAVAILABILITY; CHEMISTRY; DELAYED RELEASE FORMULATION; MEDICINAL CHEMISTRY; NANOTECHNOLOGY; ORAL DRUG ADMINISTRATION; PHARMACEUTICS; PROCEDURES; SOLUBILITY; WISTAR RAT;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CASEINS; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; EXCIPIENTS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; NANOPARTICLES; NANOTECHNOLOGY; PARTICLE SIZE; RATS, WISTAR; SIMVASTATIN; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; ZEIN;

EID: 84921960811     PISSN: 11778881     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S76194     Document Type: Article

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