Ketogenic diet provides neuroprotective effects against ischemic stroke neuronal damages

Advanced Pharmaceutical Bulletin

Volumn 4, Issue , 2014, Pages 479-481

  Shaafi, Sheyda ^a   Mahmoudi, Javad ^a   Pashapour, Ali ^a   Farhoudi, Mehdi ^a   Sadigh Eteghad, Saeed ^a   Akbari, Hossein ^a  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Apoptosis; Excitotoxicity; Ketogenic diet; Oxidative stress; Stroke

Indexed keywords

CALCIUM ION; CASPASE; GLUTAMIC ACID;

APOPTOSIS; BRAIN ISCHEMIA; CLINICAL EFFECTIVENESS; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EDITORIAL; ENERGY METABOLISM; EXCITOTOXICITY; HUMAN; KETOGENIC DIET; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; REPERFUSION INJURY;

EID: 84921960557     PISSN: 22285881     EISSN: 22517308     Source Type: Journal    
DOI: 10.5681/apb.2014.071     Document Type: Editorial

References (23)

1. Panahpour H, Nouri M. Post-Ischemic Treatment with candesartan protect from cerebral ischemic/reperfusioninjury in normotensive rats. Int J Pharm Pharm Sci 2012;4(4):286-9.
2. Woodruff TM, Thundyil J, Tang SC, Sobey CG, Taylor SM, Arumugam TV. Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Mol Neurodegener 2011;6(1):11.
3. De Jesus Llibre J, Valhuerdi A, Fernandez O, Llibre JC, Porto R, Lopez AM, et al. Prevalence of stroke and associated risk factors in older adults in Havana City and Matanzas Provinces, Cuba (10/66 population-based study). MEDICC Rev 2010;12(3):20-6.
4. Dwyer TA, Earl DE, Wang L. The utility of a new in vitro model of the stroke penumbra. J Neurosci 2008;28(26):6537-8.
5. Bradley WG. Neurology in clinical practice: principles of diagnosis and management. New York: Taylor & Francis; 2004.
6. Kavey RE, Daniels SR, Lauer RM, Atkins DL, Hayman LL, Taubert K. American Heart Association guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood. Circulation 2003;107(11):1562-6.
7. Haas S, Weidner N, Winkler J. Adult stem cell therapy in stroke. Curr Opin Neurol 2005;18(1):59-64.
8. Liu YMC. Medium-chain triglyceride (MCT) ketogenic therapy. Epilepsia 2008;49(s8):33-6.
9. Gasior M, Rogawski MA, Hartman AL. Neuroprotective and disease-modifying effects of the ketogenic diet. Behav Pharmacol 2006;17(5-6):431-9.
10. Hartman AL, Gasior M, Vining EP, Rogawski MA. The neuropharmacology of the ketogenic diet. Pediatr Neurol 2007;36(5):281-92.
11. Prins ML. Cerebral metabolic adaptation and ketone metabolism after brain injury. J Cereb Blood Flow Metab 2008;28(1):1-16.
12. Pan JW, Rothman DL, Behar KL, Stein DT, Hetherington HP. Human Brain β-Hydroxybutyrate and Lactate Increase in Fasting-Induced Ketosis. J Cereb Blood Flow Metab 2000;20(10):1502-7.
13. Van Der Auwera I, Wera S, Van Leuven F, Henderson ST. A ketogenic diet reduces amyloid beta 40 and 42 in a mouse model of Alzheimer's disease. Nutr Metab (Lond) 2005;2:28.
14. Cheng B, Yang X, An L, Gao B, Liu X, Liu S. Ketogenic diet protects dopaminergic neurons against 6-OHDA neurotoxicity via up-regulating glutathione in a rat model of Parkinson's disease. Brain Res 2009;1286:25-31.
15. Ruskin DN, Ross JL, Kawamura M Jr, Ruiz TL, Geiger JD, Masino SA. A ketogenic diet delays weight loss and does not impair working memory or motor function in the R6/2 1J mouse model of Huntington's disease. Physiol Behav 2011;103(5):501-7.
16. Streijger F, Plunet WT, Lee JH, Liu J, Lam CK, Park S, et al. Ketogenic diet improves forelimb motor function after spinal cord injury in rodents. PLoS One 2013;8(11):e78765.
17. Rang HP, Dale MM, Ritter JM, Flower R. Rang and Dale's pharmacology. 6th ed. Philadelphia: Churchill Livingstone Elsevier; 2007.
18. Maalouf M, Sullivan PG, Davis L, Kim DY, Rho JM. Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation. Neuroscience 2007;145(1):256-64.
19. Ray SK, Fidan M, Nowak MW, Wilford GG, Hogan EL, Banik NL. Oxidative stress and Ca2+ influx upregulate calpain and induce apoptosis in PC12 cells. Brain Res 2000;852(2):326-34.
20. Panahpour H, Bohlooli S, Motavallibashi SE. Antioxidant Activity-Mediated Neuroprotective Effects of an Antagonist of AT1 Receptors, Candesartan, against Cerebral Ischemia and Edema in Rats. Neurophysiology 2013;45(5-6):441-7.
21. Broughton BR, Reutens DC, Sobey CG. Apoptotic mechanisms after cerebral ischemia. Stroke 2009;40(5):e331-9.
22. Maalouf M, Rho JM, Mattson MP. The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev 2009;59(2):293-315.
23. Noh HS, Kim YS, Lee HP, Chung KM, Kim DW, Kang SS, et al. The protective effect of a ketogenic diet on kainic acid-induced hippocampal cell death in the male ICR mice. Epilepsy Res 2003;53(1-2):119-28.