The utility of a new in vitro model of the stroke penumbra

Journal of Neuroscience

Volumn 28, Issue 26, 2008, Pages 6537-6538

  Dwyer, Trisha A ^a   Earl, Damien E ^a   Wang, Liping ^a  

^a MEDICAL COLLEGE OF OHIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR; CYTOKINE; NITRIC OXIDE;

BRAIN TISSUE; CELL ACTIVATION; CYTOKINE PRODUCTION; DISEASE MODEL; IMMUNE RESPONSE; IN VITRO STUDY; MICROGLIA; MONONUCLEAR PHAGOCYTE; NEUROPROTECTION; PRIORITY JOURNAL; SHORT SURVEY; STROKE; STROKE PENUMBRA; TISSUE INJURY; ANIMAL; BIOLOGICAL MODEL; BRAIN ISCHEMIA; COCULTURE; CULTURE TECHNIQUE; ENCEPHALITIS; HUMAN; IMMUNOLOGY; METABOLISM; METHODOLOGY; NOTE; PATHOPHYSIOLOGY; SECRETION; SIGNAL TRANSDUCTION;

ANIMALS; CELL CULTURE TECHNIQUES; COCULTURE TECHNIQUES; CYTOKINES; ENCEPHALITIS; HUMANS; HYPOXIA-ISCHEMIA, BRAIN; MICROGLIA; MODELS, BIOLOGICAL; NITRIC OXIDE; SIGNAL TRANSDUCTION; STROKE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 48549098024     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.1841-08.2008     Document Type: Short Survey

References (11)

1. Dirnagl U, Iadecola C, Moskowitz MA (1999) Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22:391-397.
2. Fontaine V, Mohand-Said S, Hanoteau N, Fuchs C, Pfizenmaier K, Eisel U (2002) Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2. J Neurosci 22:RC216.
3. 11C] (R)-PK11195 PET study. NeuroImage 24:591-595.
4. Graham SH, Shiraishi K, Panter SS, Simon RP, Faden AI (1990) Changes in extracellular amino acid neurotransmitters produced by focal cerebral ischemia. Neurosci Lett 110:124-130.
5. Kaushal V, Schlichter LC (2008) Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci 28:2221-2230.
6. + channel KCNN4/KCa3.1 contributes to microglia activation and nitric oxide-dependent neurodegeneration. J Neurosci 27:234-244.
7. Lai AY, Todd KG (2006) Microglia in cerebral ischemia: molecular actions and interactions. Can J Physiol Pharmacol 84:49-59.
8. Lai AY, Todd KG (2008) Differential regulation of trophic and proinflammatory microglial effectors is dependent on severity of neuronal injury. Glia 56:259-270.
9. Seki Y, Feustel PJ, Keller Jr RW, Tranmer BI, Kimelberg HK (1999) Inhibition of ischemia-induced glutamate release in rat striatum by dihydrokinate and an anion channel blocker. Stroke 30:433-440.
10. Taylor DL, Jones F, Kubota ES, Pocock JM (2005) Stimulation of microglial metabotropic glutamate receptor mGlu2 triggers tumor necrosis factor-induced neurotoxicity in concert with microglial-derived Fas ligand. J Neurosci 25:2952-2964.
11. Vannucchi MG, Bizzoco E, Corsani L, Gianfriddo M, Pedata F, Faussone-Pellegrini MS (2007) Relationships between neurons expressing neuronal nitric oxide synthase, degree of microglia activation and animal survival. A study in the rat cortex after transient ischemia. Brain Res 1132:218-227.