Antioxidant activity-mediated neuroprotective effects of an antagonist of at1 receptors, candesartan, against cerebral ischemia and edema in rats

Neurophysiology

Volumn 45, Issue 5-6, 2013, Pages 441-447

  Panahpour, H ^a   Bohlooli, Sh ^a   Motavallibashi, S E ^a  

^a ARDABIL UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

brain edema; candesartan; focal cerebral ischemia; glutathione; malondialdehyde

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; CANDESARTAN; GLUTATHIONE; MALONALDEHYDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN EDEMA; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; BRAIN WATER; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFECT; DRUG MECHANISM; HEMISPHERE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR DYSFUNCTION; NEUROLOGIC EXAMINATION; NEUROPROTECTION; NONHUMAN; RAT; REPERFUSION; WATER CONTENT;

EID: 84891620728     PISSN: 00902977     EISSN: 15739007     Source Type: Journal    
DOI: 10.1007/s11062-013-9391-4     Document Type: Article

References (37)

1. U. Dirnagl, C. Iadecola, and M. A. Moskowitz, "Pathobiology of ischemic stroke: an integrated view," Trends Neurosci., 22, No. 9, 391-397 (1999). (Pubitemid 29453643)
2. T. H. Jones, R. M. Crowell, F. W. Marcoux, et al., "Thresholds of focal cerebral ischemia in awake monkeys," J. Neurosurg., 54, No. 773-782 (1981).
3. F. Schuier and K. Hossmann, "Experimental brain infarcts in cats. II. Ischemic brain edema," Stroke, 11, No. 6, 593-601 (1980). (Pubitemid 11199080)
4. J. Culman, A. Blume, P. Gohlke, and T. Unger, "The renin-angiotensin system in the brain: possible therapeutic implications for AT (1)-receptor blockers," J. Hum. Hypertens., 16, Suppl. 3, S64 -S70 (2002).
5. Y Inada, M. Ojima, K. Itoh, et al., "Effects of delapril on stroke, kidney dysfunction and cardiac hypertrophy in stroke-prone spontaneously hypertensive rats," Drugs Exp. Clin. Res., 21, No. 2, 41-49 (1995).
6. Y. Inada, M. Ojima, T. Sanada, et al., "Protective effects of candesartan cilexetil (TCV-116) against stroke, kidney dysfunction and cardiac hypertrophy in strokeprone spontaneously hypertensive rats," Clin. Exp. Hypertens., 19, 1079-1099 (1997). (Pubitemid 27431498)
7. C. T. Stier, S. Levine, and P. N. Chander, "Stroke prevention by losartan in stroke-prone spontaneously hypertensive rats," J. Hypertens., Suppl., 11, No. 3, S37-S42 (1993).
8. C. Werner, W. E. Hoffman, E. Kochs, et al., "Captopril improves neurologic outcome from incomplete cerebral ischemia in rats," Stroke, 22, 910-914 (1991).
9. W. J. Dai, A. Funk, T. Herdegen, et al., "Blockade of central angiotensin AT(1) receptors improves neurological outcome and reduces expression of AP-1 transcription factors after focal brain ischemia in rats," Stroke, 30, No. 11, 2391-2399 (1999). (Pubitemid 29517740)
10. A. Boveris and B. Chance, "The mitochondria generation of hydrogen peroxide," Biochem. J., 134, 707-716 (1973).
11. G. Valen and J. Vaage, "Toxic oxygen metabolites and leukocytes in reperfusion injury. A review," Scand. J. Thor. Cardiovasc. Surg., Suppl., 41, 19-29 (1993). (Pubitemid 24074658)
12. E. Hungerhuber, S. Zausinger, T. Westermaier, et al., "Simultaneous bilateral laser Doppler fluxmetry and electrophysiological recording during middle cerebral artery occlusion in rats," J. Neurosci. Methods, 154, Nos. 1/2, 109-115 (2006). (Pubitemid 43816717)
13. E. Z. Longa, P. R. Weinstein, S. Carlson, et al., "Reversible middle cerebral artery occlusion without craniectomy in rats," Stroke, 20, No. 1, 84-91 (1989). (Pubitemid 19040218)
14. H. Panahpour and G. A. Dehghani, "Inhibition of central angiotensin-converting enzyme with enalapril protects the brain from ischemia/reperfusion injury in normotensive rat," DARU J. Pharm. Sci., 18, No. 1, 35-40 (2010).
15. A. Vakili, F. Hosseinzadeh, and T. Sadogh, "Effect of aminoguanidine on post-ischemic brain edema in transient model of focal cerebral ischemia," Brain Res., 1170, 97-102 (2007). (Pubitemid 47374656)
16. T. Gerriets, E. Stolz, M. Walberer, et al., "Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats," Brain Res. Brain Res. Protoc., 12, No. 3, 137-143 (2004). (Pubitemid 38316793)
17. S. Ashwal, B. Tone, H. R. Tian, et al., "Core and pneumbral nitric oxide synthase activity during cerebral ischemia and reperfusion," Stroke, 29, 1037-1047 (1998). (Pubitemid 28228169)
18. B. Lie, S. Popp, J. E. Cottrell, and I. S. Kass, "Lidocaine attenuates apoptosis in the ischemic penumbra and reduces infarct size after transient focal cerebral ischemia in rats," Neuroscience, 125, 691-701 (2004). (Pubitemid 38510179)
19. M. Raquel, E. Lecumberri, S. Ramos, et al., "Determination of malondialdehyde by highperformance liquid chromatography in serum and liver as a biomarker for oxidative stress application to a rat model for hypercholesterolemia and evaluation of the effect of diets rich in phenolic antioxidant from fruits," J. Chromatogr. B, 827, 76-82 (2005). (Pubitemid 41551599)
20. D. Giustarini, I. Dalle-Donne, R. Colombo, et al., "An improved HPLC measurement for GSH and GSSG in human blood," Free Radic. Biol. Med., 35, No. 11, 1365-1372 (2003). (Pubitemid 37452462)
21. R. Ferrari, A. Cargnoni, S. Curello, et al., "Protection of the ischemic myocardium by the converting-enzyme inhibitor zofenopril: insight into its mechanism of action," J. Cardiovasc. Pharmacol., 20, 694-704 (1992).
22. K. Kohara, H. Mikami, N. Okuda, et al., "Angiotensin blockade and the progression of renal damage in the spontaneously hypertensive rat," Hypertension, 21, 975-979 (1993). (Pubitemid 23166951)
23. C. Thone-Reineke, M. Zimmermann, C. Neumann, et al., "Are angiotensin receptor blockers neuroprotective?" Curr. Hypertens. Rep., 6, 257-266 (2004). (Pubitemid 39144650)
24. H. Panahpour, A. A. Nekoueian, and G. A. Dehghani, "Inhibition of angiotensin-converting enzyme reduces cerebral infarction size in experimental-induced focal cerebral ischemia in the rat," Iran. J. Med. Sci., IJMS, 32, No. 1, 12-17 (2007). (Pubitemid 47451120)
25. A. Ravati, V. Junker, M. Kouklei, et al., "Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats," Eur. J. Pharmacol., 373, 21-33 (1999). (Pubitemid 29306707)
26. W. Groth, A. Blume, P. Gohlke, et al., "Chronic pretreatment with candesartan improves recovery from focal cerebral ischaemia in rats," J. Hypertens., 21, 2175-2182 (2003). (Pubitemid 38296880)
27. W. Kozak, A. Kozak, M. H. Johnson, et al., "Vascular protection with candesartan after experimental acute stroke in hypertensive rats: a dose-response study," J. Pharmacol. Exp. Ther., 326, No. 3, 773-782 (2008).
28. E. Omura-Matsuoka, Y. Yagita, T. Sasaki, et al., "Postischemic administration of angiotensin II type 1 receptor blocker reduces cerebral infarction size in hypertensive rats," Hypertens. Res., 7, 548-553 (2009).
29. T. Vraamark, G. Waldemar, S. Strandgaard, and O.B. Paulson, "Angiotensin receptor antagonist CV-11974 and cerebral blood flow autoregulation," J. Hypertens., Suppl, 13, 755-761 (1995).
30. Y. Nishimura, T. Xu, O. Johren, et al., "The angiotensin AT1 receptor antagonist candesartan regulates cerebral blood flow and brain angiotensin AT1 receptor expression," Basic Res. Cardiol., 93, 63-68 (1998). (Pubitemid 28498134)
31. Y. Nishimura, T. Ito, and J. M. Saavedra, "Angiotensin II AT1 blockade normalizes cerebrovascular autoregulation and reduces cerebral ischemia in spontaneously hypertensive rats," Stroke, 31, 2478-2486 (2000).
32. A. Blume, T. Herdegen, and T. Unger, "Angiotensin peptides and inducible transcription factors," J. Mol. Med., 77, 339-357 (1999). (Pubitemid 29144070)
33. T. Sugawara, H. Kinouchi, M. Oda, et al., "Candesartan reduces superoxide production after global cerebral ischemia," Neuroreport, 16, 325-328 (2005). (Pubitemid 40434559)
34. P. H. Chan, J. W. Schmidley, R. A. Fishman, and S. M. Longar, "Brain injury, edema, and vascular permeability changes induced by oxygen-derived free radicals," Neurology, 34, No. 3, 315-320 (1984). (Pubitemid 14173207)
35. H. Kinouchi, C. J. Epstein, T. Mizui, et al., "Attenuation of focal cerebral ischemic injury in transgenic mice overexpressing CuZn superoxide dismutase," Proc. Natl. Acad. Sci. USA, 88, No. 24, 11158-11162 (1991). (Pubitemid 21915999)
36. M. E. Pueyo, J. F. Arnal, J. Rami, and J. B. Michel, "Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells," Am. J. Physiol., 274, Part 1, No. 1, C214-C220 (1998).
37. 2 radicals in arachidonate-induced increased blood-brain barrier permeability to proteins," Am. J. Physiol., 251, Part 2, No. 4, H693-H699 (1986).