Systems analysis of transcriptional data provides insights into muscle's biological response to botulinum toxin

Muscle and Nerve

Volumn 50, Issue 5, 2014, Pages 744-758

  Mukund, Kavitha ^a   Mathewson, Margie ^b   Minamoto, Viviane ^a   Ward, Samuel R ^a,d   Subramaniam, Shankar ^a,b,c   Lieber, Richard L ^a,b,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

Botulinum toxin A; Cross sectional study; Microarray gene expression; Neurotoxin; Skeletal muscle; Time course

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACYL COENZYME A DESATURASE; ADENOSINE MONOPHOSPHATE DEAMINASE; ATROGIN 1; BOTULINUM TOXIN; CALPAIN 2; CALPAIN 3; CALVASCULIN; CASPASE 3; FATTY ACID; GLUCOSE TRANSPORTER 4; GLUTATHIONE TRANSFERASE; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE T2; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MYC PROTEIN; MYOD1 PROTEIN; MYOGENIC FACTOR; NUCLEAR FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN P53; SMAD7 PROTEIN; SOMATOMEDIN BINDING PROTEIN 5; SOMATOMEDIN RECEPTOR; TRANSFERASE; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; ACETYLCHOLINE RELEASE INHIBITOR; BOTULINUM TOXIN A;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATROPHY; BASEMENT MEMBRANE; BIOGENESIS; CELL CYCLE REGULATION; COLLAGEN FIBRIL; CONTROLLED STUDY; DNA DENATURATION; ENERGY METABOLISM; EXCITATION CONTRACTION COUPLING; EXTRACELLULAR MATRIX; GENE ACTIVATION; GENE EXPRESSION; GLYCOLYSIS; MALE; MICROARRAY ANALYSIS; MITOCHONDRION; MUSCLE ATROPHY; MUSCLE CONTRACTION; MUSCLE DENERVATION; MUSCLE FUNCTION; MUSCLE ISOMETRIC CONTRACTION; NEUROMUSCULAR SYNAPSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; SYSTEM ANALYSIS; TIBIALIS ANTERIOR MUSCLE; UPREGULATION; ANIMAL; CHEMICALLY INDUCED; DNA MICROARRAY; DRUG EFFECTS; GENE EXPRESSION PROFILING; METABOLISM; MITOCHONDRIAL DYNAMICS; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT; STATISTICS; TIME; TRANSCRIPTION INITIATION;

ACETYLCHOLINE RELEASE INHIBITORS; ADAPTATION, PHYSIOLOGICAL; ANIMALS; BOTULINUM TOXINS, TYPE A; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; MALE; MITOCHONDRIAL TURNOVER; MUSCLE CONTRACTION; MUSCLE, SKELETAL; MUSCULAR ATROPHY; NEUROMUSCULAR JUNCTION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; STATISTICS AS TOPIC; TIME FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84921960183     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.24211     Document Type: Article

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