A phase II study of medroxyprogesterone acetate in patients with hormone receptor negative metastatic breast cancer: translational breast cancer research consortium trial 007

Breast Cancer Research and Treatment

Volumn 148, Issue 1, 2014, Pages 99-106

  Miller, Kathy D ^a   Althouse, Sandra K ^a   Nabell, Lisle ^b   Rugo, Hope ^c   Carey, Lisa ^d   Kimmick, Gretchen ^e   Jones, David R ^a   Merino, Maria J ^f   Steeg, Patricia S ^f  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Angiogenesis; Glucocorticoid receptor; Metastasis suppressor gene; Nm023; Plasminogen activator inhibitor type I; Thrombospondin 1

Indexed keywords

ANTHRACYCLINE; BEVACIZUMAB; BIOLOGICAL MARKER; CAPECITABINE; CYCLOPHOSPHAMIDE; GEMCITABINE; HORMONE RECEPTOR; MEDROXYPROGESTERONE ACETATE; METHOTREXATE; NAVELBINE; PLASMINOGEN ACTIVATOR INHIBITOR 1; PLATINUM DERIVATIVE; TAXANE DERIVATIVE; THROMBOSPONDIN 1; ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR;

ADULT; AGED; ANTIANGIOGENIC ACTIVITY; ARTICLE; BREAST METASTASIS; CANCER CHEMOTHERAPY; CANCER RESEARCH; CLINICAL ARTICLE; COHORT ANALYSIS; DEHYDRATION; DISEASE COURSE; DRUG DOSE ESCALATION; DRUG ERUPTION; DRUG EXPOSURE; DRUG MEGADOSE; DRUG RESPONSE; DYSGEUSIA; DYSPHAGIA; DYSPNEA; FATIGUE; FEMALE; HORMONE RECEPTOR NEGATIVE METASTATIC BREAST CANCER; HOT FLUSH; HUMAN; HYPOKALEMIA; INSOMNIA; KIDNEY FAILURE; LOW DRUG DOSE; MALE; MENSTRUAL IRREGULARITY; METASTASIS INHIBITION; MONOTHERAPY; MUCOSA INFLAMMATION; NAUSEA; NM23 GENE; PAIN; PERIPHERAL EDEMA; PHASE 2 CLINICAL TRIAL; POSTMENOPAUSE; PRIORITY JOURNAL; SUPPRESSOR GENE; THROMBOEMBOLISM; TRANSLATIONAL RESEARCH; BIOSYNTHESIS; BLOOD; BREAST NEOPLASMS; CLINICAL TRIAL; MIDDLE AGED; PATHOLOGY; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; FEMALE; HUMANS; MEDROXYPROGESTERONE ACETATE; MIDDLE AGED; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE;

EID: 84921937598     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-014-3131-3     Document Type: Article

References (39)

1. Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57–70
2. Sledge GW Jr, Miller KD (2003) Exploiting the hallmarks of cancer: the future conquest of breast cancer. Eur J Cancer 39(12):1668–1675
3. Steeg PS, Bevilacqua G, Pozzatti R, Liotta LA, Sobel ME (1988) Altered expression of NM23, a gene associated with low tumor metastatic potential, during adenovirus 2 Ela inhibition of experimental metastasis. Cancer Res 48(22):6550–6554
4. Ouatas T, Halverson D, Steeg P (2003) Dexamethasone and medroxyprogesterone acetate elevate Nm23-H1 metastasis suppressor expression in metastatic human breast carcinoma cells: New uses for old compounds. Clin Cancer Res 9:3763–3772
5. Yoshida B, Sokoloff M, Welch D, Rinker-Schaeffer C (2000) Metastasis-suppressor genes: a review and perspective on an emerging field. J Natl Cancer Inst 92:1717–1730
6. Leone A, Flatow U, King C, Sandeen M, Margulies I, Liotta L, Steeg P (1991) Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell 65:25–35
7. Leone A, Flatow U, VanHoutte K, Steeg P (1993) Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization, and enzymatic activity. Oncogene 8:2325–2333
8. Cropp C, Lidereau R, Leone A, Liscia D, Cappa A, Campbell G, Barker E, Doussal V, Steeg P, Callahan R et al (1994) NME1 protein expression and loss of heterozygosity mutations in primary human breast tumors. J Natl Cancer Inst 86:1167–1169
9. Ouatas T, Clare S, Hartsough M, DeLaRosa A, Steeg P (2002) MMTV-associated transcription factor binding sites increase nm23-H1 metastasis suppressor gene expression in human breast carcinoma cell lines. Clin Exp Metast 19:35–42
10. Palmieri D, Halverson D, Ouatas T, Salerno M, Johnson J, Figg W, Hollingshead M, Hursting S, Berigan D, Steinberg S et al (2005) Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor—negative breast cancer. J Natl Cancer Inst 97:632–642
11. Van Veelen H, Willemse P, Tjabbes T et al (1986) Oral high-dose medroxyprogesterone acetate versus tamoxifen. Cancer 58:7–13
12. Nishimura R, Nagao K, Matsuda M, Baba K, Matsuoka Y, Yamashita H, Fukuda M, Higuchi A, Ikeda K (1997) Predictive value of serum medroxyprogesterone acetate concentration for response or recurrent breast cancer. Eur J Cancer 33(9):1407–1412
13. Tashiro H, Nomura Y (1995) Mitomycin C, methotrexate, and vincristine with medroxyprogesterone acetate or prednisolone for doxorubicin resistant advanced breast cancer–a randomized control study. Anticancer Res 15(5B):2229–2237
14. Koyama H, Tominaga T, Asaishi K, Abe R, Iino Y, Enomoto K, Miura S, Nomura Y, Nakazato H, Abe O (1999) A randomized controlled comparative study of oral medroxyprogesterone acetate 1,200 and 600 mg in patients with advanced or recurrent breast cancer. Oncology 56(4):283–290
15. Byrne MJ, Gebski V, Forbes J, Tattersall MH, Simes RJ, Coates AS, Dewar J, Lunn M, Flower C, Gill PG et al (1997) Medroxyprogesterone acetate addition or substitution for tamoxifen in advanced tamoxifen-resistant breast cancer: a phase III randomized trial. Australian-New Zealand Breast Cancer Trials Group. J Clin Oncol 15(9):3141–3148
16. Hortobagyi GN, Buzdar AU, Frye D, Yap HY, Hug V, Pinnamaneni K, Fraschini G, Halvorson HC, Blumenschein GR (1985) Oral medroxyprogesterone acetate in the treatment of metastatic breast cancer. Breast Cancer Res Treat 5(3):321–326
17. Gallagher CJ, Cairnduff F, Smith IE (1987) High dose versus low dose medroxyprogesterone acetate: a randomized trial in advanced breast cancer. Eur J Cancer Clin Oncol 23(12):1895–1900
18. Davila E, Vogel CL, East D, Cairns V, Hilsenbeck S (1988) Clinical trial of high-dose oral medroxyprogesterone acetate in the treatment of metastatic breast cancer and review of the literature. Cancer 61(11):2161–2167
19. Pannuti F, Camaggi CM, Strocchi E, Martoni A (1986) MPA at high doses in advanced breast cancer: a statistical evaluation. Chemioterapia 5(3):159–163
20. Zhou L, Isenberg J, Cao Z, Roberts D (2006) Type I collagen is a molecular target for inhibition of angiogenesis by endogenous thrombospondin-1. Oncogene 25:536–545
21. Isenberg J, Calzada M, Zhou L, Guo N, Lawler J, Wang XQ, Frazier W, Roberts D (2005) Endogenous thrombospondin-1 is not necessary for proliferation but is permissive for vascular smooth muscle cell responses to platelet-derived growth factor. Matrix Biol 24:110–123
22. Bocci G, Francia G, Man S, Lawler J, Kerbel RS (2003) Thrombospondin 1, a mediator of the antiangiogenic effects of low-dose metronomic chemotherapy. Proc Natl Acad Sci U S A 100(22):12917–12922
23. Therasse P, Arbuck SG, Eisenhauer EA, Wanders J, Kaplan RS, Rubinstein L, Verweij J, Van Glabbeke M, van Oosterom AT, Christian MC et al (2000) New guidelines to evaluate the response to treatment in solid tumors. European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92(3):205–216
24. Nishimura R, Nagao K, Matsuda M, Baba K, Matsuoka Y, Yamashita H, Fukuda M, Higuchi A, Ikeda K (1997) Predictive value of serum medroxyprogesterone acetate concentration for response in advanced or recurrent breast cancer. Eur J Cancer 33(9):1407–1412
25. Colleoni M, Rocca A, Sandri MT, Zorzino L, Masci G, Nole F, Peruzzotti G, Robertson C, Orlando L, Cinieri S et al (2002) Low-dose oral methotrexate and cyclophosphamide in metastatic breast cancer: antitumor activity and correlation with vascular endothelial growth factor levels. Ann Oncol 13(1):73–80
26. Adams J, Carder PJ, Downey S, Forbes MA, MacLennan K, Allgar V, Kaufman S, Hallam S, Bicknell R, Walker JJ et al (2000) Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen. Cancer Res 60(11):2898–2905
27. Verheul HM, Hoekman K, Luykx-de Bakker S, Eekman CA, Folman CC, Broxterman HJ, Pinedo HM (1997) Platelet: transporter of vascular endothelial growth factor. Clin Cancer Res 3(12 Pt 1):2187–2190
28. Wynendaele W, Derua R, Hoylaerts MF, Pawinski A, Waelkens E, de Bruijn EA, Paridaens R, Merlevede W, van Oosterom AT (1999) Vascular endothelial growth factor measured in platelet poor plasma allows optimal separation between cancer patients and volunteers: a key to study an angiogenic marker in vivo? Ann Oncol 10(8):965–971
29. Perou CM, Jeffrey SS, van de Rijn M, Rees CA, Eisen MB, Ross DT, Pergamenschikov A, Williams CF, Zhu SX, Lee JC et al (1999) Distinctive gene expression patterns in human mammary epithelial cells and breast cancers. Proc Natl Acad Sci U S A 96(16):9212–9217
30. Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y, Pietenpol JA (2011) Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 121(7):2750–2767
31. Perou C, Sorlie T, Eisen M et al (2000) Molecular portraits of human breast tumours. Nature 406:747
32. Mikosz CA, Brickley DR, Sharkey MS, Moran TW, Conzen SD (2001) Glucocorticoid receptor-mediated protection from apoptosis is associated with induction of the serine/threonine survival kinase gene, sgk-1. J Biol Chem 276(20):16649–16654
33. Pan D, Kocherginsky M, Conzen SD (2011) Activation of the glucocorticoid receptor is associated with poor prognosis in estrogen receptor-negative breast cancer. Cancer Res 71(20):6360–6370
34. Steeg PS, Zollo M, Wieland T (2011) A critical evaluation of biochemical activities reported for the nucleoside diphosphate kinase/Nm23/Awd family proteins: opportunities and missteps in understanding their biological functions. Naunyn-Schmiedeberg’s Arch Pharmacol 384(4–5):331–339
35. Chang CL, Zhu XX, Thoraval DH, Ungar D, Rawwas J, Hora N, Strahler JR, Hanash SM, Radany E (1994) Nm23-H1 mutation in neuroblastoma. Nature 370(6488):335–336
36. Leone A, Seeger RC, Hong CM, Hu YY, Arboleda MJ, Brodeur GM, Stram D, Slamon DJ, Steeg PS (1993) Evidence for nm23 RNA overexpression, DNA amplification and mutation in aggressive childhood neuroblastomas. Oncogene 8(4):855–865
37. Leone A, Flatow U, VanHoutte K, Steeg PS (1993) Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: effects on tumor metastatic potential, colonization and enzymatic activity. Oncogene 8(9):2325–2333
38. Steeg PS (2012) Perspective: the right trials. Nature 485(7400):S58–59
39. Brabletz T, Lyden D, Steeg PS, Werb Z (2013) Roadblocks to translational advances on metastasis research. Nat Med 19(9):1104–1109