MMTV-associated transcription factor binding sites increase nm23-H1 metastasis suppressor gene expression in human breast carcinoma cell lines

Clinical and Experimental Metastasis

Volumn 19, Issue 1, 2002, Pages 35-42

  Ouatas, Taoufik ^a   Clare, Susan E ^b   Hartsough, Melanie T ^a   De La Rosa, Abel ^c   Steeg, Patricia S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c Visible Genetics   (United States)

Author keywords

Breast; Cancer; Metastasis; MMTV; Nm23

Indexed keywords

ARTICLE; BINDING SITE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE MAPPING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; METASTASIS; PROMOTER REGION; PROTEIN BINDING; REGULATORY MECHANISM;

BINDING SITES; BREAST NEOPLASMS; CARCINOMA; CCAAT-ENHANCER-BINDING PROTEINS; CONSENSUS SEQUENCE; DNA, NEOPLASM; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENHANCER ELEMENTS (GENETICS); FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, REPORTER; GENES, TUMOR SUPPRESSOR; HUMANS; MAMMARY TUMOR VIRUS, MOUSE; MONOMERIC GTP-BINDING PROTEINS; MUTAGENESIS; NEOPLASM METASTASIS; NEOPLASM PROTEINS; NFI TRANSCRIPTION FACTORS; NUCLEOSIDE-DIPHOSPHATE KINASE; ORGAN SPECIFICITY; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; TERMINAL REPEAT SEQUENCES; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0036186431     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1013897022827     Document Type: Article

References (33)

1. Metastasis-suppressor genes: A review and perspective on an emerging field
2. KAI1 protein is down-regulated during the progression of human breast cancer
3. NME1 protein expression and loss of heterozygosity mutations in primary human breast tumors
4. Nm23/Nucleoside diphosphate kinase in human cancers
5. Relationship of nm23 to proteolytic factors, proliferation and motility in breast cancer tissues and cell lines
6. Overexpression of nm23-H2/NDP Kinase B in a human oral squamous cell carcinoma cell line results in reduced metastasis, differentiated phenotype in the metastatic site, and growth factor-independent proliferative activity in culture
7. Effects of cytokine mediated modulation of Nm23 expression on the invasion and metastatic behavior of B16F10 melanoma cells
8. Two isotypes of murine nm23/Nucleoside Diphosphate Kinase, nm23-M1 and nm23-M2, are involved in metastatic suppression of a murine melanoma line
9. Metastatic potential of rat mammary adenocarcinoma cells associated with decreased expression of nucleoside diphosphate kinase/nm23: Reduction by transfection of NDP Kinase a isoform, an nm23-H2 gene homolog
10. Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: A 31P nuclear magnetic resonance study in vivo and in vitro
11. Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells
12. Transfection of human nm23-H1 into the human MDA-MB-435 breast carcinoma cell line: Effects on tumor metastatic potential, colonization, and enzymatic activity
13. Suppression of human melanoma metastasis following introduction of chromosome 6 is independent of NME1 (nm23)
14. Reduced metastatic potential and c-myc overexpression of colon adenocarcinoma cells (Colon 26 line) transfected with nm23-R2 rat nucleoside diphosphate kinase a isoform
15. Reproductive state of rat mammary gland stroma modulates human breast cancer cell migration and invasion
16. Inhibition of cell motility after nm23 transfection of human and murine tumor cells
17. Site directed mutagenesis of nm23-H1: Mutation of proline 96 or serine 120 abrogates its motility inhibitory activity upon transfection into human breast carcinoma cells
18. A novel function for Nm23: Overexpression in human breast carcinoma cells leads to the formation of basement membrane and growth arrest
19. Effects of all-trans retinoic acid and epidermal growth factor on the expression of nm23-H1 in human hepatocarcinoma cells
20. Differentiation of human breast carcinoma cells by a novel vitamin D analog: 1 alpha-hydroxyvitamin D-5
21. Elevation of breast carcinoma nm23-H1 metastasis suppressor gene expression and reduced motility by DNA methylation inhibition
22. A mammary cell-specific enhancer in mouse mammary tumor virus DNA is composed of multiple regulatory elements including binding sites for CTF/NF1 and a novel transcription factor, mammary cell-activating factor
23. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei
24. Identification and characterization of the promoter for the human metastasis suppressor gene nm23-H1
25. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines
26. Isolation and characterization of the promoter region of human nm23-H1, a metastasis suppressor gene
27. Independent and differential expression of two isotypes of human Nm23: Analysis of the promoter regions of the nm23-H1 and H2 genes
28. Involvement of Ets-regulated proteins in hormone-independent mammary cell-specific gene expression
29. Changes of tissue-specific transcription factors in the rabbit mammary gland during pregnancy and lactation
30. Embryonic expression of Nm23 during mouse organogenesis