Involvement of β-arrestin-2 and clathrin in agonist-mediated internalization of the human cannabinoid CB2 receptor

Current Molecular Pharmacology

Volumn 7, Issue 1, 2014, Pages 67-80

  Chen, Xiaopan ^a   Zheng, Congxia ^a   Qian, Jing ^a   Sutton, Steven W ^b   Wang, Zhen ^c   Lv, Jianxin ^c   Liu, Changlu ^b   Zhou, Naiming ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c WENZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Cannabinoid; Clathrin; Internalization; Mutagenesis function approaches; Recycling; arrestin

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA ARRESTIN 2; CANNABINOID 2 RECEPTOR; CANNABINOID 2 RECEPTOR AGONIST; CLATHRIN; CLATHRIN HEAVY CHAIN; ENHANCED GREEN FLUORESCENT PROTEIN; PROTEASOME; SMALL INTERFERING RNA; SUCROSE; BENZOXAZINE DERIVATIVE; BETA ARRESTIN; DYNAMIN; MORPHOLINE DERIVATIVE; NAPHTHALENE DERIVATIVE; RETINA S ANTIGEN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL SURFACE; CONTROLLED STUDY; CYTOPLASM; DOSE TIME EFFECT RELATION; DRUG RECEPTOR BINDING; ENDOSOME; HUMAN; HUMAN CELL; INTERNALIZATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RNA INTERFERENCE; AGONISTS; ANTAGONISTS AND INHIBITORS; CONFOCAL MICROSCOPY; DRUG EFFECTS; GENETICS; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT;

ARRESTINS; BENZOXAZINES; CLATHRIN; DYNAMINS; HEK293 CELLS; HUMANS; MICROSCOPY, CONFOCAL; MORPHOLINES; NAPHTHALENES; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTOR, CANNABINOID, CB2; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84921933160     PISSN: 18744672     EISSN: 18744702     Source Type: Journal    
DOI: 10.2174/1874467207666140714115824     Document Type: Article

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