Processed vietnamese ginseng: Preliminary results in chemistry and biological activity

Journal of Ginseng Research

Volumn 38, Issue 2, 2014, Pages 154-159

  Le, Thi Hong Van ^a   Lee, Seo Young ^b   Kim, Tae Ryong ^b   Kim, Jae Young ^b   Kwon, Sung Won ^b   Nguyen, Ngoc Khoi ^a   Park, Jeong Hill ^b   Nguyen, Minh Duc ^a  

^a UNIVERSITY OF MEDICINE AND PHARMACY AT HO CHI MINH CITY   (Viet Nam)

^b Seoul National University   (South Korea)

Author keywords

Antiproliferation; Ginsenoside; Panax vietnamensis; Steaming; Vietnamese ginseng

Indexed keywords

GINSENG EXTRACT; GINSENOSIDE; GINSENOSIDE RB 1; GINSENOSIDE RC; GINSENOSIDE RD; GINSENOSIDE RE; GINSENOSIDE RG 1; GINSENOSIDE RG 3; GINSENOSIDE RG 5; GINSENOSIDE RH 4; GINSENOSIDE RK 1; GINSENOSIDE RK 3; SAPONIN; UNCLASSIFIED DRUG;

A549 CELL LINE; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; CELL PROLIFERATION; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; CHEMISTRY; GINSENG; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; VIET NAM;

EID: 84921928363     PISSN: 12268453     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jgr.2013.11.015     Document Type: Article

References (24)

1. Nguyen TN. StudyonPanax vietnamensisHaetGrushv.,Araliaceace.Botany, tissue culture-chemistry-biological properties. Herbal Polonica 1989;35:1-229
2. Duc NM, Kasai R, Ohtani K, Ito A, Nguyen TN, Yamasaki K, Tanaka O. Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. Collected in central Vietnam. I. Chem Pharm Bull 1993;41:2010-4
3. Duc NM, Kasai R, Ohtani K, Ito A, Nguyen TN, Yamasaki K, Tanaka O. Saponins from Vietnamese Ginseng, Panax vietnamensis Ha et Grushv. Collected in central Vietnam. II. Chem Pharm Bull 1994;42:115-22
4. Duc NM, Kasai R, Ohtani K, Ito A, Nguyen TN, Yamasaki K, Tanaka O. Saponins from Vietnamese ginseng, Panax vietnamensis Ha et Grushv. collected in central Vietnam. III. Chem Pharm Bull 1994;42:634-40
5. Tran LQ, Adnyana I, Tezuka Y, Nagaoka T, Tran Q, Kadota S. Triterpene saponins from Vietnamese ginseng (Panax vietnamensis) and their hepatocytoprotective activity. J Nat Prod 2001;64:456-61
6. Huong NT, Matsumoto K, Kasai R, Yamasaki K, Duc NM, Nguyen TN, Watanabe H. Crude saponin extracted from Vietnamese ginseng and its major constituent majonoside-R2 attenuate the psychological stress- and foot-shock stress-induced antinociception in mice. Pharmacol Biochem Behav 1995;52: 427-32
7. Huong NT, Matsumoto K, Yamasaki K, Duc NM, Nham NT, Watanabe H. Effects of majonoside-R2 on pentobarbital sleep and gastric lesion in psychologically stressed mice. Pharmacol Biochem Behav 1996;53:957-63
8. Huong NT, Matsumoto K, Yamasaki K, Duc NM, Duc NM, Watanabe H. Majonoside-R2, a major constituent of Vietnamese ginseng, attenuates opioidinduced Antinociception. Pharmacol Biochem Behav 1997;57:285-91
9. Huong NT, Matsumoto K, Yamasaki K, Watanabe H. Majonoside-R2 reverses social isolation stress-induced decrease in pentobarbital sleep in mice: possible involvement of neuroactive steroids. Life Sciences 1997;61:395-402
10. Huong NT, Matsumoto K, Watanabe H. The antistress effect of majonoside-R2, a major saponin component of Vietnamese ginseng: neuronal mechanisms of action. Methods Find Exp Clin Pharmacol 1998;20:65-76
11. Huong NT, Murakami Y, Tohda M, Watanabe H, Matsumoto K. Social isolation stress-induced oxidative damage in mouse brain and its modulation by majonoside-R2, a Vietnamese ginseng saponin. Biol Pharm Bull 2005;28: 1389-93
12. Kim WY, Kim JM, Han SB, Lee SK, Kim ND, Park MK, Kim CK, Park JH. Steaming of ginseng at high temperature enhances biological activity. J Nat Prod 2000;63:1702-4
13. Kim YJ, Kwon HC, Ko H, Park JH, Kim HY, Yoo JH, Yang HO. Anti-tumor activity of the ginsenoside Rk1 in human hepatocellular carcinoma cells through inhibition of telomerase activity and induction of apoptosis. Biol Pharm Bull 2008;31:826-30
14. Sun BS, Xu MY, Li Z, Wang YB, Sung CK. UPLC-Q-TOF-MS/MS analysis for steaming times-dependent profiling of steamed Panax quinquefolius and its ginsenosides transformations induced by repetitious steaming. J Ginseng Res 2012;36:277-90
15. Kwon SW, Han SB, Park IH, Kim JM, Park MK, Park JH. Liquid chromatographic determination of less polar ginsenosides in processed ginseng. J Chromatogr A 2001;921:335-9
16. Lee H, Kim J, Lee SY, Park JH, Hwang GS. Processed Panax ginseng, Sun Ginseng, decreases oxidative damage induced by tert-butyl hydroperoxide via regulation of antioxidant enzyme and anti-apoptotic molecules in HepG2 cells. J Ginseng Res 2012;36:248-55
17. Bae HM, Kim SS, Cho CW, Yang DC, Ko SK, Kim KT. Antioxidant activities of ginseng seeds treated by autoclaving. J Ginseng Res 2012;36:411-7
18. Wang CZ, Aung HH, Ni M, Wu JA, Tong R, Wicks S, He TC, Yuan CS. Red American ginseng: ginsenoside constituents and antiproliferative activities of heat-processed Panax quinquefolius roots. Planta Med 2007;73:669-74
19. Toh D, Patel D, Chan E, Teo A, Neo S, Koh H. Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells. Chin Med 2011;6:4
20. Wang D, Liao P, Zhu H, Chen K, Xu M, Zhang Y, Yang C. The processing of Panax notoginseng and the transformation of its saponin components. Food Chem 2012;132:1808-13
21. Sun S, Wang C, Tong R, Li X, Fishbein A, Wang Q, He T, Du W, Yuan C. Effects of steaming the root of Panax notoginseng on chemical composition and anticancer activities. Food Chem 2010;118:307-14
22. Park IH, Kwon SW, Lee YJ, Cho SY, Park MK, Park JH. Cytotoxic dammarane glycosides from processed ginseng. Chem Pharm Bull 2002;50:538-40
23. Nag SA, Qin JJ, Wang W, Wang MH, Wang H, Zhang R. Ginsenosides as anticancer agents: in vitro and in vivo activities, structureeactivity relationships, and molecular mechanisms of action. Front Pharmacol 2012;3:25
24. Yamabe N, Song KI, Lee W, Han I-H, Lee JH, Ham J, Kim S-N, Park JH, Kang KS. Chemical and free radical-scavenging activity changes of ginsenoside Re by Maillard reaction and its possible use as a renoprotective agent. J Ginseng Res 2012;36:256-62.