Luteolin acts as a radiosensitizer in non-small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade

International Journal of Oncology

Volumn 46, Issue 3, 2015, Pages 1149-1158

  Cho, Hyun Ji ^a   Ahn, Kwang Chul ^a   Choi, Jae Yeon ^a   Hwang, Sang Gu ^a   Kim, Wun Jae ^b   Um, Hong Duck ^a   Park, Jong Kuk ^a  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b Chungbuk National University College of Medicine   (South Korea)

Author keywords

Apoptosis; Caspase; Lung cancer; Luteolin; p38 MAPK; Radiation; Radiosensitizer; ROS

Indexed keywords

CASPASE; CASPASE 3; CASPASE 8; CASPASE 9; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; RADIOSENSITIZING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; INTRACELLULAR SIGNALING; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIZATION; TUMOR XENOGRAFT; ANIMAL; BAGG ALBINO MOUSE; CELL DEATH; DRUG EFFECTS; DRUG SCREENING; LUNG TUMOR; METABOLISM; NUDE MOUSE; PATHOLOGY; RADIATION RESPONSE; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE;

ANIMALS; APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CASPASES; CELL DEATH; HUMANS; LUNG NEOPLASMS; LUTEOLIN; MICE; MICE, INBRED BALB C; MICE, NUDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84921925055     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2015.2831     Document Type: Article

References (31)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer Statistics, 2008. CA Cancer J Clin 58: 71-96, 2008.
2. Kim JS, Amorino GP, Pyo H, Cao Q, Price JO and Choy H: The novel taxane analogs, BMS-184476 and BMS-188797, potentiate the effects of radiation therapy in vitro and in vivo against human lung cancer cells. Int J Radiat Oncol Biol Phys 51: 525-534, 2001.
3. Palayoor ST, Bump EA, Calderwood SK, Bartol S and Coleman C N : Combined antitumor effect of radiation and ibuprofen in human prostate carcinoma cells. Clin Cancer Res 4: 763-771, 1998.
4. Dicker AP, Williams TL and Grant DS: Targeting angiogenic processes by combination rofecoxib and ionizing radiation. Am J Clin Oncol 24: 438-442, 2001.
5. Kim KY, Seol JY, Jeon GA and Nam MJ: The combined treatment of aspirin and radiation induces apoptosis by the regulation of bcl-2 and caspase-3 in human cervical cancer cells. Cancer Lett 189: 157-166, 2003.
6. Zhu AX and Willett CG: Chemotherapeutic and biologic agents as radiosensitizers in rectal cancer. Semin Radiat Oncol 13: 454-468, 2003.
7. Jones PD, de Lorimier LP, Kitchell BE and Losonsky JM: Gemcitabine as a radiosensitizer for nonresectable feline oral squamous cell carcinoma. J Am Anim Hosp Assoc 39: 463-467, 2003.
8. Begg AC, Stewart FA and Vens C: Strategies to improve radiotherapy with targeted drugs. Nat Rev Cancer 11: 239-253, 2011.
9. Mitsudomi T, Suda K and Yatabe Y: Surgery for NSCLC in the era of personalized medicine. Nat Rev Clin Oncol 10: 235-244, 2013.
10. Moding EJ, Kastan MB and Kirsch DG: Strategies for optimizing the response of cancer and normal tissues to radiation. Nat Rev Drug Discov 12: 526-542, 2013.
11. Travis WD, Brambilla E, Noguchi M, et al: International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society: international multidisciplinary classification of lung adenocarcinoma: executive summary. Proc Am Thorac Soc 8: 381-385, 2011.
12. Swinney DC and Anthony J: How were new medicines discovered? Nat Rev Drug Discov 10: 507-519, 2011.
13. Rask-Andersen M, Almén MS and Schiöth HB: Trends in the exploitation of novel drug targets. Nat Rev Drug Discov 10: 579-590, 2011.
14. Seelinger G, Merfort I, Wölfle U and Schempp CM: Anti-carcinogenic effects of the flavonoid luteolin. Molecules 13: 2628-2651, 2008.
15. Lin Y, Shi R, Wang X and Shen HM: Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets 8: 634-646, 2008.
16. Albert JM, Cao C, Kim KW, et al: Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin Cancer Res 13: 3033-3042, 2007.
17. Kim EM, Yang HS, Kang SW, Ho JN, Lee SB and Um HD: Amplification of the gamma-irradiation-induced cell death pathway by reactive oxygen species in human U937 cells. Cell Signal 20: 916-924, 2008.
18. Leung HW, Kuo CL, Yang WH, Lin CH and Lee HZ: Antioxidant enzymes activity involvement in luteolin-induced human lung squamous carcinoma CH27 cell apoptosis. Eur J Pharmacol 534: 12-18, 2006.
19. Rebucci M and Michiels C: Molecular aspects of cancer cell resistance to chemotherapy. Biochem. Pharmacol 85: 1219-1226, 2013.
20. Song G, Ouyang G and Bao S: The activation of Akt/PKB signaling pathway and cell survival. J Cell Mol Med 9: 59-71, 2005.
21. Park JK, Jung HY, Park SH, Kang SY, Yi MR, Um HD and Hong SH: Combination of PTEN and gamma-ionizing radiation enhances cell death and G(2)/M arrest through regulation of AKT activity and p21 induction in non-small-cell lung cancer cells. Int J Radiat Oncol Biol Phys 70: 1552-1560, 2008.
22. Prise KM, Schettino G, Folkard M and Held KD: New insights on cell death from radiation exposure. Lancet Oncol 6: 520-528, 2005.
23. Elmore S: Apoptosis: a review of programmed cell death. Toxicol Pathol 35: 495-516, 2007.
24. Katz D, Ito E and Liu FF: On the path to seeking novel radiosensitizers. Int J Radiat Oncol Biol Phys 73: 988-996, 2009.
25. Munshi A and Ramesh R: Mitogen-activated protein kinases and their role in radiation response. Genes Cancer 4: 401-408, 2013.
26. Park JK, Chung YM, Kim BG, Yoo YA, Yang BS, Kim JS and Yoo YD: N'-(phenyl-pyridin-2-yl-methylene)-hydrazine carbodithioic acid methyl ester enhances radiation-induced cell death by targeting Bcl-2 against human lung carcinoma cells. Mol Cancer Ther 3: 403-407, 2004.
27. Caputo F, Vegliante R and Ghibelli L: Redox modulation of the DNA damage response. Biochem Pharmacol 84: 1292-1306, 2012.
28. Park MT, Kim MJ, Kang YH, et al : Phytosphingosine in combination with ionizing radiation enhances apoptotic cell death in radiation-resistant cancer cells through ROS-dependent and -independent AIF release. Blood 105: 1724-1733, 2005.
29. Lee YJ, Lee DH, Cho CK, et al: HSP25 inhibits radiation-induced apoptosis through reduction of PKCdelta-mediated ROS production. Oncogene 24: 3715-3725, 2005.
30. Wagner EF and Nebreda AR: Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9: 537-549, 2009.
31. Ju W, Wang X, Shi H, Chen W, Belinsky SA and Lin Y: A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells. Mol Pharmacol 71: 1381-1388, 2007.