Characterization of FKGK18 as Inhibitor of Group VIA Ca2+-Independent Phospholipase A2 (iPLA2β): Candidate Drug for Preventing Beta-Cell Apoptosis and Diabetes

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Ali, Tomader ^a   Kokotos, George ^b   Magrioti, Victoria ^b   Bone, Robert N ^c   Mobley, James A ^d   Hancock, William ^a   Ramanadham, Sasanka ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ATHENS   (Greece)

^c University of Alabama at Birmingham   (United States)

^d Kentucky   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONIC ACID; BROMOENOL LACTONE; CALCIUM INDEPENDENT PHOSPHOLIPASE A2; CHYMOTRYPSIN A; ENZYME INHIBITOR; FKGK 18; GLUCOSE; PROSTAGLANDIN E2; SPHINGOMYELIN PHOSPHODIESTERASE; SPHINGOMYELINASE 2; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; ENANTIOMER; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROLYSIS; IN VIVO STUDY; INSULIN RELEASE; INSULINOMA; MEDIATOR RELEASE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CALCIUM; CELL MEMBRANE; CHYMOTRYPSIN; CYTOSOL; DIABETES MELLITUS; DINOPROSTONE; DRUG EVALUATION, PRECLINICAL; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITORS; GLUCOSE; GROUP VI PHOSPHOLIPASES A2; HUMANS; INSULIN; INSULIN-SECRETING CELLS; KETONES; MICE; MYOCARDIUM; NAPHTHALENES; PYRONES; SPHINGOMYELIN PHOSPHODIESTERASE; TIME FACTORS;

EID: 84882581578     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0071748     Document Type: Article

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