Regulation of AMPK activation by CD36 links fatty acid uptake to β-oxidation

Diabetes

Volumn 64, Issue 2, 2015, Pages 353-359

  Samovski, Dmitri ^a,b   Sun, Jingyu ^b   Pietka, Terri ^a   Gross, Richard W ^a,b   Eckel, Robert H ^c   Su, Xiong ^d   Stahl, Philip D ^b   Abumrad, Nada A ^a,b  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d SOOCHOW UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE FYN; PROTEIN KINASE LKB1; FYN PROTEIN, HUMAN; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; PROTEIN SERINE THREONINE KINASE; STK11 PROTEIN, MOUSE; TRIACYLGLYCEROL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; LIPID HOMEOSTASIS; MALE; MOUSE; MUSCLE CELL; MYOBLAST; MYOTUBE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LIPID INTERACTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; GENE EXPRESSION REGULATION; GENETICS; KNOCKOUT MOUSE; METABOLISM; OXIDATION REDUCTION REACTION; PROTEIN TRANSPORT; SKELETAL MUSCLE CELL;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTIGENS, CD36; CELL LINE; ENZYME ACTIVATION; FATTY ACIDS; GENE EXPRESSION REGULATION; LIPOPROTEINS, LDL; MALE; MICE; MICE, KNOCKOUT; MUSCLE FIBERS, SKELETAL; MYOBLASTS; OXIDATION-REDUCTION; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-FYN; TRIGLYCERIDES;

EID: 84921899983     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db14-0582     Document Type: Article

References (23)

1. Hardie DG. AMPK: a target for drugs and natural products with effects on both diabetes and cancer. Diabetes 2013;62:2164-2172
2. Shirwany NA, Zou MH. AMPK: a cellular metabolic and redox sensor. A minireview. Front Biosci (Landmark Ed) 2014;19:447-474
3. Glatz JF, Luiken JJ, Bonen A. Membrane fatty acid transporters as regulators of lipid metabolism: implications for metabolic disease. Physiol Rev 2010;90:367-417
4. Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest 2013;123:2764-2772
5. Pepino MY, Kuda O, Samovski D, Abumrad NA. Structure-function of CD36 and importance of fatty acid signal transduction in fat metabolism. Annu Rev Nutr 2014;34:281-303
6. Ibrahimi A, Bonen A, Blinn WD, et al. Muscle-specific overexpression of FAT/CD36 enhances fatty acid oxidation by contracting muscle, reduces plasma triglycerides and fatty acids, and increases plasma glucose and insulin. J Biol Chem 1999;274:26761-26766
7. Dramane G, Abdoul-Azize S, Hichami A, et al. STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice. J Clin Invest 2012;122:2267-2282
8. Sundaresan S, Shahid R, Riehl TE, Chandra R, Nassir F, Stenson WF, Liddle RA, Abumrad NA. CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. FASEB J 2013;27:1191-1202
9. Febbraio M, Abumrad NA, Hajjar DP, et al. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 1999;274:19055-19062
10. Hajri T, Hall AM, Jensen DR, et al. CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue. Diabetes 2007;56:1872-1880
11. Han X, Yang J, Cheng H, Ye H, Gross RW. Toward fingerprinting cellular lipidomes directly from biological samples by two-dimensional electrospray ionization mass spectrometry. Anal Biochem 2004;330:317-331
12. Kuda O, Pietka TA, Demianova Z, et al. Sulfo-N-succinimidyl oleate (SSO) inhibits fatty acid uptake and signaling for intracellular calcium via binding CD36 lysine 164: SSO also inhibits oxidized low density lipoprotein uptake by macrophages. J Biol Chem 2013;288:15547-15555
13. Smith BK, Jain SS, Rimbaud S, et al. FAT/CD36 is located on the outer mitochondrial membrane, upstream of long-chain acyl-CoA synthetase, and regulates palmitate oxidation. Biochem J 2011;437:125-134
14. Watt MJ, Steinberg GR, Chen ZP, Kemp BE, Febbraio MA. Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. J Physiol 2006;574:139-147
15. Han X, Cheng H, Mancuso DJ, Gross RW. Caloric restriction results in phospholipid depletion, membrane remodeling, and triacylglycerol accumulation in murine myocardium. Biochemistry 2004;43:15584-15594
16. Yamada E, Pessin JE, Kurland IJ, Schwartz GJ, Bastie CC. Fyn-dependent regulation of energy expenditure and body weight is mediated by tyrosine phosphorylation of LKB1. Cell Metab 2010;11:113-124
17. Mariotti A, Kedeshian PA, Dans M, Curatola AM, Gagnoux-Palacios L, Giancotti FG. EGF-R signaling through Fyn kinase disrupts the function of integrin alpha6beta4 at hemidesmosomes: role in epithelial cell migration and carcinoma invasion. J Cell Biol 2001;155:447-458
18. Miao WM, Vasile E, Lane WS, Lawler J. CD36 associates with CD9 and integrins on human blood platelets. Blood 2001;97:1689-1696
19. Garner AE, Smith DA, Hooper NM. Visualization of detergent solubilization of membranes: implications for the isolation of rafts. Biophys J 2008;94:1326-1340
20. Chen K, Febbraio M, Li W, Silverstein RL. A specific CD36-dependent signaling pathway is required for platelet activation by oxidized low-density lipoprotein. Circ Res 2008;102:1512-1519
21. Bastie CC, Hajri T, Drover VA, Grimaldi PA, Abumrad NA. CD36 in myocytes channels fatty acids to a lipase-accessible triglyceride pool that is related to cell lipid and insulin responsiveness. Diabetes 2004;53:2209-2216
22. Coort SL, Hasselbaink DM, Koonen DP, et al. Enhanced sarcolemmal FAT/CD36 content and triacylglycerol storage in cardiac myocytes from obese zucker rats. Diabetes 2004;53:1655-1663
23. Love-Gregory L, Abumrad NA. CD36 genetics and the metabolic complications of obesity. Curr Opin Clin Nutr Metab Care 2011;14:527-534