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Volumn 35, Issue 2, 2015, Pages 441-451

Platelet-derived growth factor-b (PDGF-B) induced by hypoxia promotes the survival of pulmonary arterial endothelial cells through the PI3K/Akt/stat3 pathway

Author keywords

Apoptosis; Hypoxia; Platelet derived growth factor B; Pulmonary artery endothelial cells; Stat3

Indexed keywords

CASPASE 3; CASPASE 9; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR B; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; SMALL INTERFERING RNA; STAT3 PROTEIN; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 6,7-DIMETHOXY-3-PHENYLQUINOXALINE; BENZAMIDE DERIVATIVE; CHROMONE DERIVATIVE; IMATINIB; MORPHOLINE DERIVATIVE; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE; TYRPHOSTIN;

EID: 84921868557     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000369709     Document Type: Article
Times cited : (39)

References (39)
  • 1
    • 79958069658 scopus 로고    scopus 로고
    • The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension
    • Shao D1, Park JE, Wort SJ: The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension. Pharmacol Res 2011; 63: 504-511.
    • (2011) Pharmacol Res , vol.63 , pp. 504-511
    • Shao, D.L.1    Park, J.E.2    Wort, S.J.3
  • 3
    • 38449104742 scopus 로고    scopus 로고
    • Pulmonary endothelium in the perinatal period
    • Haworth SG: Pulmonary endothelium in the perinatal period. Pharmacol Rep 2006; 58: S153-64.
    • (2006) Pharmacol Rep , vol.58 , pp. S153-S164
    • Haworth, S.G.1
  • 4
    • 1642453778 scopus 로고    scopus 로고
    • Endothelial dysfunction in pulmonary hypertension
    • Budhiraja R, TuDer RM, Hassoun PM: Endothelial dysfunction in pulmonary hypertension. Circulation 2004; 109: 159-165.
    • (2004) Circulation , vol.109 , pp. 159-165
    • Budhiraja, R.1    Tuder, R.M.2    Hassoun, P.M.3
  • 5
    • 0027476062 scopus 로고
    • Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics
    • Celermajer DS, Cullen S, Deanfield JE: Impairment of endothelium-dependent pulmonary artery relaxation in children with congenital heart disease and abnormal pulmonary hemodynamics. Circulation 1993; 87: 440-446.
    • (1993) Circulation , vol.87 , pp. 440-446
    • Celermajer, D.S.1    Cullen, S.2    Deanfield, J.E.3
  • 8
    • 0035989383 scopus 로고    scopus 로고
    • Activation of second messenger pathways in alveolar macrophages by endotoxin
    • Monick MM, Hunninghake GW: Activation of second messenger pathways in alveolar macrophages by endotoxin. Eur Respir J 2002; 20: 210-222.
    • (2002) Eur Respir J , vol.20 , pp. 210-222
    • Monick, M.M.1    Hunninghake, G.W.2
  • 9
    • 33947504730 scopus 로고    scopus 로고
    • Sunitinib: From rational design to clinical efficacy
    • Chow LQ, Eckhardt SG: Sunitinib: from rational design to clinical efficacy. J Clin Oncol 2007; 25: 884-896.
    • (2007) J Clin Oncol , vol.25 , pp. 884-896
    • Chow, L.Q.1    Eckhardt, S.G.2
  • 10
    • 34548316976 scopus 로고    scopus 로고
    • Molecular basis for sunitinib efficacy and future clinical development
    • Faivre S, Demetri G, Sargent W, Raymond E: Molecular basis for sunitinib efficacy and future clinical development. Nat Rev Drug Discov 2007; 6: 734-745.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 734-745
    • Faivre, S.1    Demetri, G.2    Sargent, W.3    Raymond, E.4
  • 11
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell JE, Kerr IM, Stark GR: Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994; 264: 1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 12
    • 35548944961 scopus 로고    scopus 로고
    • Snapshot: JAK-STAT signaling
    • Mertens C, Darnell JE: Snapshot: JAK-STAT signaling. Cell 2007; 131: 612.
    • (2007) Cell , vol.131 , pp. 612
    • Mertens, C.1    Darnell, J.E.2
  • 14
    • 2442459084 scopus 로고    scopus 로고
    • Plasma membrane rafts and chaperones in cytokine/STAT signaling
    • Sehgal PB: Plasma membrane rafts and chaperones in cytokine/STAT signaling. Acta Biochim Pol 2003; 50: 583-594.
    • (2003) Acta Biochim Pol , vol.50 , pp. 583-594
    • Sehgal, P.B.1
  • 15
    • 5444237088 scopus 로고    scopus 로고
    • STAT proteins as novel targets for cancer drug discovery
    • Turkson J: STAT proteins as novel targets for cancer drug discovery. Expert Opin Ther Targets 2004; 8: 409-422.
    • (2004) Expert Opin Ther Targets , vol.8 , pp. 409-422
    • Turkson, J.1
  • 16
    • 0344353645 scopus 로고    scopus 로고
    • Inhibition of platelet-Derived growth factor receptor tyrosine kinase inhibits vascular smooth muscle cell migration and proliferation
    • Myllarniemi M, CalDeron L, Lemstrom K, Buchdunger E, Hayry P: Inhibition of platelet-Derived growth factor receptor tyrosine kinase inhibits vascular smooth muscle cell migration and proliferation. FASEB J 1997; 11: 1119-1126.
    • (1997) FASEB J , vol.11 , pp. 1119-1126
    • Myllarniemi, M.1    Calderon, L.2    Lemstrom, K.3    Buchdunger, E.4    Hayry, P.5
  • 17
    • 0035912890 scopus 로고    scopus 로고
    • Functional blockade of platelet-Derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice
    • Sano H, Sudo T, Yokode M, Murayama T, Kataoka H, Takakura N, Nishikawa S, Nishikawa SI, Kita T: Functional blockade of platelet-Derived growth factor receptor-beta but not of receptor-alpha prevents vascular smooth muscle cell accumulation in fibrous cap lesions in apolipoprotein E-deficient mice. Circulation 2001; 103: 2955-2960.
    • (2001) Circulation , vol.103 , pp. 2955-2960
    • Sano, H.1    Sudo, T.2    Yokode, M.3    Murayama, T.4    Kataoka, H.5    Takakura, N.6    Nishikawa, S.7    Nishikawa, S.I.8    Kita, T.9
  • 19
    • 33846336842 scopus 로고    scopus 로고
    • Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells
    • Kawai-Kowase K, Owens GK: Multiple repressor pathways contribute to phenotypic switching of vascular smooth muscle cells. Am J Physiol Cell Physiol 2007; 292: C59-C69.
    • (2007) Am J Physiol Cell Physiol , vol.292 , pp. C59-C69
    • Kawai-Kowase, K.1    Owens, G.K.2
  • 22
    • 44249108050 scopus 로고    scopus 로고
    • 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells
    • Wang Z, Tang X, Li Y, Leu C, Guo L, Zheng X, Zhu D: 20-Hydroxyeicosatetraenoic acid inhibits the apoptotic responses in pulmonary artery smooth muscle cells. Eur J Pharmacol 2008; 588: 9-17.
    • (2008) Eur J Pharmacol , vol.588 , pp. 9-17
    • Wang, Z.1    Tang, X.2    Li, Y.3    Leu, C.4    Guo, L.5    Zheng, X.6    Zhu, D.7
  • 24
    • 48849088862 scopus 로고    scopus 로고
    • Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways
    • Mao W, Iwai C, Liu J, Sheu SS, Fu M, Liang CS: Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways. J Mol Cell Cardiol 2008; 45: 250-260.
    • (2008) J Mol Cell Cardiol , vol.45 , pp. 250-260
    • Mao, W.1    Iwai, C.2    Liu, J.3    Sheu, S.S.4    Fu, M.5    Liang, C.S.6
  • 25
    • 15744378615 scopus 로고    scopus 로고
    • Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a PI3K/Akt and p38 kinase dependent STAT3 pathway during anoxiareoxygenation injury
    • Zhang X, Shan P, Alam J, Fu XY, Lee PJ: Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a PI3K/Akt and p38 kinase dependent STAT3 pathway during anoxiareoxygenation injury. J Biol Chem 2005; 280: 8714-8721.
    • (2005) J Biol Chem , vol.280 , pp. 8714-8721
    • Zhang, X.1    Shan, P.2    Alam, J.3    Fu, X.Y.4    Lee, P.J.5
  • 26
    • 70350721791 scopus 로고    scopus 로고
    • Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways
    • 13
    • Ponnusamy M, Pang M, Annamaraju PK, Zhang Z, Gong R, Chin YE, Zhuang S: Transglutaminase-1 protects renal epithelial cells from hydrogen peroxide-induced apoptosis through activation of STAT3 and AKT signaling pathways. Am J Physiol Renal Physiol 2009; 297: F1361-70. 13
    • (2009) Am J Physiol Renal Physiol , vol.297 , pp. F1361-F1370
    • Ponnusamy, M.1    Pang, M.2    Annamaraju, P.K.3    Zhang, Z.4    Gong, R.5    Chin, Y.E.6    Zhuang, S.7
  • 27
    • 80051557093 scopus 로고    scopus 로고
    • Pulmonary hypertension and idiopathic pulmonary fibrosis: A tale of angiogenesis, apoptosis, and growth factors
    • Farkas L, Gauldie J, Voelkel NF, Kolb M: Pulmonary hypertension and idiopathic pulmonary fibrosis: a tale of angiogenesis, apoptosis, and growth factors. Am J Respir Cell Mol Biol 2011; 45: 1-15.
    • (2011) Am J Respir Cell Mol Biol , vol.45 , pp. 1-15
    • Farkas, L.1    Gauldie, J.2    Voelkel, N.F.3    Kolb, M.4
  • 28
    • 0035130107 scopus 로고    scopus 로고
    • Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension
    • Taraseviciene-Stewart L, Kasahara Y, Alger L, Hirth P, Mc Mahon G, Waltenberger J, Voelkel NF, TuDer RM: Inhibition of the VEGF receptor 2 combined with chronic hypoxia causes cell death-dependent pulmonary endothelial cell proliferation and severe pulmonary hypertension. FASEB J 2001; 15: 427-438.
    • (2001) FASEB J , vol.15 , pp. 427-438
    • Taraseviciene-Stewart, L.1    Kasahara, Y.2    Alger, L.3    Hirth, P.4    Mc Mahon, G.5    Waltenberger, J.6    Voelkel, N.F.7    Tuder, R.M.8
  • 29
    • 79959934494 scopus 로고    scopus 로고
    • The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases
    • Xu X, Zhang XA, Wang DW: The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases. Adv Drug Deliv Rev 2011; 63: 597-609.
    • (2011) Adv Drug Deliv Rev , vol.63 , pp. 597-609
    • Xu, X.1    Zhang, X.A.2    Wang, D.W.3
  • 30
    • 0035720168 scopus 로고    scopus 로고
    • Phenotypic heterogeneity influences apoptotic susceptibility to retinoic acid and cis-platinum of rat arterial smooth muscle cells in vitro: Implications for the evolution of experimental intimal thickening
    • Orlandi A, Francesconi A, Cocchia D, Corsini A, Spagnoli LG: Phenotypic heterogeneity influences apoptotic susceptibility to retinoic acid and cis-platinum of rat arterial smooth muscle cells in vitro: Implications for the evolution of experimental intimal thickening. Arterioscler Thromb Vasc Biol 2001; 21: 1118-1123.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1118-1123
    • Orlandi, A.1    Francesconi, A.2    Cocchia, D.3    Corsini, A.4    Spagnoli, L.G.5
  • 31
    • 68049137909 scopus 로고    scopus 로고
    • Targeting the PI3K/AKT pathway for the treatment of prostate cancer
    • Sarker D, Reid AH, Yap TA, de Bono JS: Targeting the PI3K/AKT pathway for the treatment of prostate cancer. Clin Cancer Res 2009; 15: 4799-805.
    • (2009) Clin Cancer Res , vol.15 , pp. 4799-4805
    • Sarker, D.1    Reid, A.H.2    Yap, T.A.3    De Bono, J.S.4
  • 32
    • 33947417336 scopus 로고    scopus 로고
    • Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: Clinical implications
    • Huang S: Regulation of metastases by signal transducer and activator of transcription 3 signaling pathway: clinical implications. Clin Cancer Res 2007; 13: 1362-1366.
    • (2007) Clin Cancer Res , vol.13 , pp. 1362-1366
    • Huang, S.1
  • 33
    • 33645524134 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase/Akt1/Par-4 axis: A cancer-selective therapeutic target
    • Goswami A, Ranganathan P, Rangnekar VM: The phosphoinositide 3-kinase/Akt1/Par-4 axis: a cancer-selective therapeutic target. Cancer Res 2006; 66: 2889-2892.
    • (2006) Cancer Res , vol.66 , pp. 2889-2892
    • Goswami, A.1    Ranganathan, P.2    Rangnekar, V.M.3
  • 34
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME: Cellular survival: a play in three Akts. Genes 1999; 13: 2905-2927.
    • (1999) Genes , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 35
    • 0035190026 scopus 로고    scopus 로고
    • Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
    • Katso R, Okkenhaug K, Ahmadi K, White S, Timms J, Waterfield MD: Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Annu Rev Cell Dev Biol 2001; 17: 615-675.
    • (2001) Annu Rev Cell Dev Biol , vol.17 , pp. 615-675
    • Katso, R.1    Okkenhaug, K.2    Ahmadi, K.3    White, S.4    Timms, J.5    Waterfield, M.D.6
  • 36
    • 0142227019 scopus 로고    scopus 로고
    • Targeting the PI3K-Akt pathway in human cancer: Rationale and promise
    • Luo J, Manning BD, Cantley LC: Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell 2003; 4: 257-262.
    • (2003) Cancer Cell , vol.4 , pp. 257-262
    • Luo, J.1    Manning, B.D.2    Cantley, L.C.3
  • 38
    • 77956523665 scopus 로고    scopus 로고
    • Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif
    • Ding J, Zhang Z, Roberts GJ, Falcone M, Miao Y, Shao Y, Zhang XC, Andrews DW, Lin J: Bcl-2 and Bax interact via the BH1-3 groove-BH3 motif interface and a novel interface involving the BH4 motif. J Biol Chem 2010; 285: 28749-2863.
    • (2010) J Biol Chem , vol.285 , pp. 28749-32863
    • Ding, J.1    Zhang, Z.2    Roberts, G.J.3    Falcone, M.4    Miao, Y.5    Shao, Y.6    Zhang, X.C.7    Andrews, D.W.8    Lin, J.9
  • 39
    • 0037102148 scopus 로고    scopus 로고
    • Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2: Bax ratio
    • Childs AC, Phaneuf SL, Dirks AJ, Phillips T, Leeuwenburgh C: Doxorubicin treatment in vivo causes cytochrome C release and cardiomyocyte apoptosis, as well as increased mitochondrial efficiency, superoxide dismutase activity, and Bcl-2: Bax ratio. Cancer Res 2002; 62: 4592-4598.
    • (2002) Cancer Res , vol.62 , pp. 4592-4598
    • Childs, A.C.1    Phaneuf, S.L.2    Dirks, A.J.3    Phillips, T.4    Leeuwenburgh, C.5


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