Nanoparticle-mediated dual delivery of an antioxidant and a peptide against the L-Type Ca2+ channel enables simultaneous reduction of cardiac ischemia-reperfusion injury

ACS Nano

Volumn 9, Issue 1, 2015, Pages 279-289

  Hardy, Naviin ^a   Viola, Helena M ^a   Johnstone, Victoria P A ^a   Clemons, Tristan D ^a   Cserne Szappanos, Henrietta ^a   Singh, Ruhani ^a   Smith, Nicole M ^a   Iyer, K Swaminathan ^a   Hool, Livia C ^a,b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

Author keywords

antioxidant; curcumin; ischemia reperfusion injury; L type Ca2+ channel; nanoparticles; resveratrol

Indexed keywords

ACRYLIC MONOMERS; ANTIOXIDANTS; CALCIUM; CELL DEATH; CELL MEMBRANES; DRUG THERAPY; HEART; MITOCHONDRIA; NANOPARTICLES; OXYGEN; PEPTIDES; RESVERATROL;

ALPHA-INTERACTING DOMAINS; CURCUMIN; ISCHEMIA-REPERFUSION INJURY; L-TYPE CA2+ CHANNEL; MITOCHONDRIAL MEMBRANE POTENTIAL; POLY(GLYCIDYL METHACRYLATE); REACTIVE OXYGEN SPECIES; SIMULTANEOUS REDUCTION;

LOADING;

ANTIOXIDANT; CALCIUM CHANNEL L TYPE; CURCUMIN; DRUG CARRIER; NANOPARTICLE; PEPTIDE FRAGMENT; POLYETHYLENEIMINE; POLYGLYCIDYL METHACRYLATE; POLYMETHACRYLIC ACID DERIVATIVE; RESVERATROL; STILBENE DERIVATIVE; SUPEROXIDE;

ANIMAL; CHEMISTRY; DRUG EFFECTS; DRUG INTERACTION; HEART MUSCLE CELL; MALE; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MYOCARDIAL REPERFUSION INJURY; OXIDATIVE STRESS; PATHOLOGY; RAT;

ANIMALS; ANTIOXIDANTS; CALCIUM CHANNELS, L-TYPE; CURCUMIN; DRUG CARRIERS; DRUG INTERACTIONS; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; NANOPARTICLES; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; POLYETHYLENEIMINE; POLYMETHACRYLIC ACIDS; RATS; STILBENES; SUPEROXIDES;

EID: 84921749189     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn5061404     Document Type: Article

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