Low-frequency high-magnitude mechanical strain of articular chondrocytes activates p38 MAPK and induces phenotypic changes associated with osteoarthritis and pain

International Journal of Molecular Sciences

Volumn 15, Issue 8, 2014, Pages 14427-14441

  Rosenzweig, Derek H ^a   Quinn, Thomas M ^a   Haglun, Lisbet ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Articular cartilage; Inflammation; Mechanical stretch; Nerve growth factor; Osteoarthritis; p38 MAPK; Pain

Indexed keywords

AGGRECANASE 1; ALPHA TUBULIN; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE P38; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTHRALGIA; ARTICLE; CARTILAGE CELL; CELL VIABILITY; CONTROLLED STUDY; DENSITOMETRY; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; INNERVATION; INTERVERTEBRAL DISK; NERVE SPROUTING; NERVOUS SYSTEM DEVELOPMENT; NEURITE; NONHUMAN; OSTEOARTHRITIS; PHENOTYPIC VARIATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ARTICULAR CARTILAGE; CELL CULTURE; HUMAN; METABOLISM; PAIN; PATHOLOGY;

CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; HUMANS; NERVE GROWTH FACTOR; OSTEOARTHRITIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAIN;

EID: 84921739761     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms150814427     Document Type: Article

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