Bufalin induces mitochondrial pathway-mediated apoptosis in lung adenocarcinoma cells

Asian Pacific Journal of Cancer Prevention

Volumn 15, Issue 23, 2014, Pages 10495-10500

  Ding, Da Wei ^a   Zhang, Yong Hong ^a   Huang, Xin En ^b   An, Qing ^b   Zhang, Xun ^c  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b JIANGSU CANCER HOSPITAL   (China)

^c THE FIRST AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

A549 lung cancer cells; Apoptosis; Bufalin lung cancer; Mitochondrial pathway

Indexed keywords

ANTINEOPLASTIC AGENT; BUFADIENOLIDE DERIVATIVE; BUFALIN; CASP3 PROTEIN, HUMAN; CASPASE 3; CYTOCHROME C;

ADENOCARCINOMA; APOPTOSIS; CELL PROLIFERATION; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; HUMAN; LUNG TUMOR; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; PHASE CONTRAST MICROSCOPY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; UPREGULATION; WESTERN BLOTTING;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BUFANOLIDES; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; HUMANS; LUNG NEOPLASMS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MICROSCOPY, PHASE-CONTRAST; UP-REGULATION;

EID: 84921730255     PISSN: 15137368     EISSN: None     Source Type: Journal    
DOI: 10.7314/APJCP.2014.15.23.10495     Document Type: Article

References (21)

1. Banjerdpongchai R, Kongtawelert P (2011). Ethanolic extract of fermented thunb induces human leukemic HL-60 and Molt-4 cell apoptosis via oxidative stress and a mitochondrial pathway. Asian Pac J Cancer Prev, 12, 2871-4.
2. Chen A, Yu J, Zhang L, et al (2009). Microarray and biochemical analysis of bufalin-induced apoptosis of HL-60 cells. Biotechnol Lett, 31, 487-94.
3. Fogg VC, Lanning NJ, Mackeigan JP (2011). Mitochondria in cancer: at the crossroads of life and death. Chin J Cancer, 30, 526-39.
4. Garrido C, Galluzzi L, Brunet M, et al (2006). Mechanisms of cytochrome c release from mitochondria. Cell Death Differ, 13, 1423-33.
5. Igney FH, Krammer PH (2002). Death and anti-death: tumour resistance to apoptosis. Nat Rev Cancer, 2, 277-88.
6. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90.
7. Jiang YT, Zhang Y, Luan JL, et al (2010). Effects of bufalin on the proliferation of human lung cancer cells and its molecular mechanisms of action. Cytotechnology, 62, 573-83.
8. Khan KH, Montserrat BC, Molife LR (2014). Cancer therapeutics: Targeting the apoptotic pathway. Crit Rev Oncol Hematol, 90, 200-19.
9. Kothakota S, Azuma T, Reinhard C, et al (1997). Caspase-3 generated fragment of gelsolin: effector of morphological change in apoptosis. Science, 278, 294-8.
10. Krenn L, Kopp B (1998). Bufadienolides from animal and plant sources. Phytochemistry, 48, 1-29.
11. Kulikov AV, Shilov ES, Mufazalov IA, et al (2012). Cytochrome c: the Achilles' heel in apoptosis. Cell Mol Life Sci, 69, 1787-97.
12. Li D, Qu X, Hou K, et al (2009). PI3K/Akt is involved in bufalin-induced apoptosis in gastric cancer cells. Anticancer Drugs, 20, 59-64.
13. Qi FH, Inagaki Y, Gao B, et al (2011). Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas-and mitochondria-mediated pathways. Cancer Sci, 102, 951-8.
14. Stinchcombe TE, Socinski MA (2009). Current treatments for advanced stage non-small cell lung cancer. Proc Am Thorac Soc, 6, 233-41.
15. Takai N, Kira N, Ishii T, et al (2012). Bufalin, a traditional oriental medicine, induces apoptosis in human cancer cells. Asian Pac J Cancer Prev, 13, 399-402.
16. Takai N, Ueda T, Nishida M, et al (2008). Bufalin induces growth inhibition, cell cycle arrest and apoptosis in human endometrial and ovarian cancer cells. Int J Mol Med, 21, 637-43.
17. Ulivieri C (2010). Cell death: Insights into the ultrastructure of mitochondria. Tissue Cell, 42, 339-47.
18. Xie CM, Chan WY, Yu S, et al (2011). Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation. Free Radic Biol Med, 51, 1365-75.
19. Xue X, Yu JL, Sun DQ, et al (2014). Curcumin induces apoptosis in SGC-7901 gastric adenocarcinoma cells via regulation of mitochondrial signaling pathways. Asian Pac J Cancer Prev, 15, 3987-92.
20. Yin PH, Liu X, Qiu YY, et al (2012). Anti-tumor activity and apoptosis-regulation mechanisms of bufalin in various cancers: new hope for cancer patients. Asian Pac J Cancer Prev, 13, 5339-43.
21. Zou X, Liu SL, Zhou JY, et al (2012). Beta-asarone induces LoVo colon cancer cell apoptosis by up-regulation of caspases through a mitochondrial pathway in vitro and in vivo. Asian Pac J Cancer Prev, 13, 5291-8.