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Volumn 136, Issue 1, 2015, Pages 162-171

An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis in lung adenocarcinoma cancer patients

Author keywords

CSF; diagnosis; leptomeningeal carcinomatosis; metabolomics; metastasis

Indexed keywords

ALANINE; CITRIC ACID; CREATINE; GLUCOSE; INOSITOL; LACTIC ACID; TUMOR MARKER;

EID: 84921692242     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28949     Document Type: Article
Times cited : (36)

References (52)
  • 1
    • 59449093825 scopus 로고    scopus 로고
    • Leptomeningeal carcinomatosis: Prognostic implications of clinical and cerebrospinal fluid features
    • Bruna J, Gonzalez L, Miro J, et al., Leptomeningeal carcinomatosis: prognostic implications of clinical and cerebrospinal fluid features. Cancer 2009; 115: 381-9.
    • (2009) Cancer , vol.115 , pp. 381-389
    • Bruna, J.1    Gonzalez, L.2    Miro, J.3
  • 2
    • 84876420549 scopus 로고    scopus 로고
    • Analysis of treatment outcomes of intraventricular chemotherapy in 105 patients for leptomeningeal carcinomatosis from non-small-cell lung cancer
    • Gwak HS, Joo J, Kim S, et al., Analysis of treatment outcomes of intraventricular chemotherapy in 105 patients for leptomeningeal carcinomatosis from non-small-cell lung cancer. J Thorac Oncol 2013; 8: 599-605.
    • (2013) J Thorac Oncol , vol.8 , pp. 599-605
    • Gwak, H.S.1    Joo, J.2    Kim, S.3
  • 3
    • 4344694453 scopus 로고    scopus 로고
    • Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System
    • Barnholtz-Sloan JS, Sloan AE, Davis FG, et al., Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System. J Clin Oncol 2004; 22: 2865-72.
    • (2004) J Clin Oncol , vol.22 , pp. 2865-2872
    • Barnholtz-Sloan, J.S.1    Sloan, A.E.2    Davis, F.G.3
  • 4
    • 84858327540 scopus 로고    scopus 로고
    • Leptomeningeal metastasis from non-small cell lung cancer: Survival and the impact of whole brain radiotherapy
    • Morris PG, Reiner AS, Szenberg OR, et al., Leptomeningeal metastasis from non-small cell lung cancer: survival and the impact of whole brain radiotherapy. J Thorac Oncol 2012; 7: 382-5.
    • (2012) J Thorac Oncol , vol.7 , pp. 382-385
    • Morris, P.G.1    Reiner, A.S.2    Szenberg, O.R.3
  • 5
    • 84860525984 scopus 로고    scopus 로고
    • Clinical outcomes of leptomeningeal metastasis in patients with non-small cell lung cancer in the modern chemotherapy era
    • Park JH, Kim YJ, Lee JO, et al., Clinical outcomes of leptomeningeal metastasis in patients with non-small cell lung cancer in the modern chemotherapy era. Lung Cancer 2012; 76: 387-92.
    • (2012) Lung Cancer , vol.76 , pp. 387-392
    • Park, J.H.1    Kim, Y.J.2    Lee, J.O.3
  • 6
    • 25644452036 scopus 로고    scopus 로고
    • Distribution of the novel antifolate pemetrexed to the brain
    • Dai H, Chen Y, Elmquist WF,. Distribution of the novel antifolate pemetrexed to the brain. J Pharmacol Exp Ther 2005; 315: 222-9.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 222-229
    • Dai, H.1    Chen, Y.2    Elmquist, W.F.3
  • 7
    • 80155136933 scopus 로고    scopus 로고
    • Pemetrexed and cisplatin as first-line chemotherapy for advanced non-small-cell lung cancer (NSCLC) with asymptomatic inoperable brain metastases: A multicenter phase II trial (GFPC 07-01)
    • Barlesi F, Gervais R, Lena H, et al., Pemetrexed and cisplatin as first-line chemotherapy for advanced non-small-cell lung cancer (NSCLC) with asymptomatic inoperable brain metastases: a multicenter phase II trial (GFPC 07-01). Ann Oncol 2011; 22: 2466-70.
    • (2011) Ann Oncol , vol.22 , pp. 2466-2470
    • Barlesi, F.1    Gervais, R.2    Lena, H.3
  • 8
    • 84856297434 scopus 로고    scopus 로고
    • Role of flow cytometry immunophenotyping in the diagnosis of leptomeningeal carcinomatosis
    • Subira D, Serrano C, Castanon S, et al., Role of flow cytometry immunophenotyping in the diagnosis of leptomeningeal carcinomatosis. Neurooncology 2012; 14: 43-52.
    • (2012) Neurooncology , vol.14 , pp. 43-52
    • Subira, D.1    Serrano, C.2    Castanon, S.3
  • 9
    • 67849129119 scopus 로고    scopus 로고
    • Treatment modalities for leptomeningeal metastases
    • Shapiro WR, Johanson CE, Boogerd W,. Treatment modalities for leptomeningeal metastases. Semin Oncol 2009; 36: S46-54.
    • (2009) Semin Oncol , vol.36 , pp. S46-S54
    • Shapiro, W.R.1    Johanson, C.E.2    Boogerd, W.3
  • 10
    • 0034116976 scopus 로고    scopus 로고
    • Diagnostic evaluation of neurologic metastases
    • Jeyapalan SA, Batchelor TT,. Diagnostic evaluation of neurologic metastases. Cancer Invest 2000; 18: 381-94.
    • (2000) Cancer Invest , vol.18 , pp. 381-394
    • Jeyapalan, S.A.1    Batchelor, T.T.2
  • 11
    • 58149465354 scopus 로고    scopus 로고
    • Molecular detection of human mammaglobin in cerebrospinal fluid from breast cancer patient with leptomeningeal carcinomatosis
    • Dono M, Ferro P, Benedetti L, et al., Molecular detection of human mammaglobin in cerebrospinal fluid from breast cancer patient with leptomeningeal carcinomatosis. J Neurooncol 2009; 91: 295-8.
    • (2009) J Neurooncol , vol.91 , pp. 295-298
    • Dono, M.1    Ferro, P.2    Benedetti, L.3
  • 12
    • 0035104074 scopus 로고    scopus 로고
    • Fluoroscopy-guided lumbar puncture: Decreased frequency of traumatic tap and implications for the assessment of CT-negative acute subarachnoid hemorrhage
    • Eskey CJ, Ogilvy CS,. Fluoroscopy-guided lumbar puncture: decreased frequency of traumatic tap and implications for the assessment of CT-negative acute subarachnoid hemorrhage. AJNR Am J Neuroradiol 2001; 22: 571-6.
    • (2001) AJNR Am J Neuroradiol , vol.22 , pp. 571-576
    • Eskey, C.J.1    Ogilvy, C.S.2
  • 13
    • 84867527930 scopus 로고    scopus 로고
    • An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis
    • Cho HR, Wen H, Ryu YJ, et al., An NMR metabolomics approach for the diagnosis of leptomeningeal carcinomatosis. Cancer Res 2012; 72: 5179-87.
    • (2012) Cancer Res , vol.72 , pp. 5179-5187
    • Cho, H.R.1    Wen, H.2    Ryu, Y.J.3
  • 14
    • 84867744660 scopus 로고    scopus 로고
    • Genetic variation in metabolic phenotypes: Study designs and applications
    • Suhre K, Gieger C,. Genetic variation in metabolic phenotypes: study designs and applications. Nat Rev Genet 2012; 13: 759-69.
    • (2012) Nat Rev Genet , vol.13 , pp. 759-769
    • Suhre, K.1    Gieger, C.2
  • 15
    • 79951678399 scopus 로고    scopus 로고
    • Predicting idiopathic toxicity of cisplatin by a pharmacometabonomic approach
    • Kwon HN, Kim M, Wen H, et al., Predicting idiopathic toxicity of cisplatin by a pharmacometabonomic approach. Kidney Int 2011; 79: 529-37.
    • (2011) Kidney Int , vol.79 , pp. 529-537
    • Kwon, H.N.1    Kim, M.2    Wen, H.3
  • 16
    • 63049134550 scopus 로고    scopus 로고
    • Urine metabolomic analysis for kidney cancer detection and biomarker discovery
    • Kim K, Aronov P, Zakharkin SO, et al., Urine metabolomic analysis for kidney cancer detection and biomarker discovery. Mol Cell Proteomics 2009; 8: 558-70.
    • (2009) Mol Cell Proteomics , vol.8 , pp. 558-570
    • Kim, K.1    Aronov, P.2    Zakharkin, S.O.3
  • 17
    • 0036913503 scopus 로고    scopus 로고
    • Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics
    • Brindle JT, Antti H, Holmes E, et al., Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med 2002; 8: 1439-44.
    • (2002) Nat Med , vol.8 , pp. 1439-1444
    • Brindle, J.T.1    Antti, H.2    Holmes, E.3
  • 18
    • 46749146517 scopus 로고    scopus 로고
    • Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques
    • Wikoff WR, Pendyala G, Siuzdak G, et al., Metabolomic analysis of the cerebrospinal fluid reveals changes in phospholipase expression in the CNS of SIV-infected macaques. J Clin Invest 2008; 118: 2661-9.
    • (2008) J Clin Invest , vol.118 , pp. 2661-2669
    • Wikoff, W.R.1    Pendyala, G.2    Siuzdak, G.3
  • 19
    • 84884414039 scopus 로고    scopus 로고
    • The metabolomic window into hepatobiliary disease
    • Beyoglu D, Idle JR,. The metabolomic window into hepatobiliary disease. J Hepatol 2013; 59: 842-58.
    • (2013) J Hepatol , vol.59 , pp. 842-858
    • Beyoglu, D.1    Idle, J.R.2
  • 20
    • 75549086735 scopus 로고    scopus 로고
    • A new NMR-based metabolomics approach for the diagnosis of biliary tract cancer
    • Wen H, Yoo SS, Kang J, et al., A new NMR-based metabolomics approach for the diagnosis of biliary tract cancer. J Hepatol 2010; 52: 228-33.
    • (2010) J Hepatol , vol.52 , pp. 228-233
    • Wen, H.1    Yoo, S.S.2    Kang, J.3
  • 21
    • 84883328075 scopus 로고    scopus 로고
    • Metabolite profiles during oral glucose challenge
    • Ho JE, Larson MG, Vasan RS, et al., Metabolite profiles during oral glucose challenge. Diabetes 2013; 62: 2689-98.
    • (2013) Diabetes , vol.62 , pp. 2689-2698
    • Ho, J.E.1    Larson, M.G.2    Vasan, R.S.3
  • 22
    • 43749087841 scopus 로고    scopus 로고
    • Human metabolic phenotype diversity and its association with diet and blood pressure
    • Holmes E, Loo RL, Stamler J, et al., Human metabolic phenotype diversity and its association with diet and blood pressure. Nature 2008; 453: 396-400.
    • (2008) Nature , vol.453 , pp. 396-400
    • Holmes, E.1    Loo, R.L.2    Stamler, J.3
  • 23
    • 84255199617 scopus 로고    scopus 로고
    • Metabolomic profiling reveals potential markers and bioprocesses altered in bladder cancer progression
    • Putluri N, Shojaie A, Vasu VT, et al., Metabolomic profiling reveals potential markers and bioprocesses altered in bladder cancer progression. Cancer Res 2011; 71: 7376-86.
    • (2011) Cancer Res , vol.71 , pp. 7376-7386
    • Putluri, N.1    Shojaie, A.2    Vasu, V.T.3
  • 24
    • 73649147390 scopus 로고    scopus 로고
    • Metabolic profiling of human lung cancer tissue by 1H high resolution magic angle spinning (HRMAS) NMR spectroscopy
    • Rocha CM, Barros AS, Gil AM, et al., Metabolic profiling of human lung cancer tissue by 1H high resolution magic angle spinning (HRMAS) NMR spectroscopy. J Proteome Res 2010; 9: 319-32.
    • (2010) J Proteome Res , vol.9 , pp. 319-332
    • Rocha, C.M.1    Barros, A.S.2    Gil, A.M.3
  • 25
    • 77951874479 scopus 로고    scopus 로고
    • Leptomeningeal metastases in the MRI era
    • Clarke JL, Perez HR, Jacks LM, et al., Leptomeningeal metastases in the MRI era. Neurology 2010; 74: 1449-54.
    • (2010) Neurology , vol.74 , pp. 1449-1454
    • Clarke, J.L.1    Perez, H.R.2    Jacks, L.M.3
  • 26
    • 27644528997 scopus 로고    scopus 로고
    • Leptomeningeal metastases from solid malignancy: A review
    • Taillibert S, Laigle-Donadey F, Chodkiewicz C, et al., Leptomeningeal metastases from solid malignancy: a review. J Neurooncol 2005; 75: 85-99.
    • (2005) J Neurooncol , vol.75 , pp. 85-99
    • Taillibert, S.1    Laigle-Donadey, F.2    Chodkiewicz, C.3
  • 27
    • 4444351752 scopus 로고    scopus 로고
    • Correlation optimized warping and dynamic time warping as preprocessing methods for chromatographic data
    • Tomasi G, van den Berg F, Andersson C,. Correlation optimized warping and dynamic time warping as preprocessing methods for chromatographic data. J Chemometr 2004; 18: 231-41.
    • (2004) J Chemometr , vol.18 , pp. 231-241
    • Tomasi, G.1    Van Den Berg, F.2    Andersson, C.3
  • 28
    • 84875552323 scopus 로고    scopus 로고
    • Translational biomarker discovery in clinical metabolomics: An introductory tutorial
    • Xia J, Broadhurst DI, Wilson M, et al., Translational biomarker discovery in clinical metabolomics: an introductory tutorial. Metabolomics 2013; 9: 280-99.
    • (2013) Metabolomics , vol.9 , pp. 280-299
    • Xia, J.1    Broadhurst, D.I.2    Wilson, M.3
  • 29
    • 77958456122 scopus 로고    scopus 로고
    • Leptomeningeal metastasis
    • Chamberlain MC,. Leptomeningeal metastasis. Curr Opin Oncol 2010; 22: 627-35.
    • (2010) Curr Opin Oncol , vol.22 , pp. 627-635
    • Chamberlain, M.C.1
  • 30
    • 0029038868 scopus 로고
    • Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis
    • Freilich RJ, Krol G, DeAngelis LM,. Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis. Ann Neurol 1995; 38: 51-7.
    • (1995) Ann Neurol , vol.38 , pp. 51-57
    • Freilich, R.J.1    Krol, G.2    DeAngelis, L.M.3
  • 31
    • 0032871973 scopus 로고    scopus 로고
    • The diagnostic accuracy of magnetic resonance imaging and cerebrospinal fluid cytology in leptomeningeal metastasis
    • Straathof CS, de Bruin HG, Dippel DW, et al., The diagnostic accuracy of magnetic resonance imaging and cerebrospinal fluid cytology in leptomeningeal metastasis. J Neurol 1999; 246: 810-4.
    • (1999) J Neurol , vol.246 , pp. 810-814
    • Straathof, C.S.1    De Bruin, H.G.2    Dippel, D.W.3
  • 32
    • 0025240870 scopus 로고
    • Leptomeningeal metastasis: A comparison of gadolinium-enhanced MR and contrast-enhanced CT of the brain
    • Chamberlain MC, Sandy AD, Press GA,. Leptomeningeal metastasis: a comparison of gadolinium-enhanced MR and contrast-enhanced CT of the brain. Neurology 1990; 40: 435-8.
    • (1990) Neurology , vol.40 , pp. 435-438
    • Chamberlain, M.C.1    Sandy, A.D.2    Press, G.A.3
  • 34
    • 68949092126 scopus 로고    scopus 로고
    • Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2
    • Baumann F, Leukel P, Doerfelt A, et al., Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neurooncology 2009; 11: 368-80.
    • (2009) Neurooncology , vol.11 , pp. 368-380
    • Baumann, F.1    Leukel, P.2    Doerfelt, A.3
  • 35
    • 33745519159 scopus 로고    scopus 로고
    • Lactate stimulates endothelial cell migration
    • Beckert S, Farrahi F, Aslam RS, et al., Lactate stimulates endothelial cell migration. Wound Repair Regen 2006; 14: 321-4.
    • (2006) Wound Repair Regen , vol.14 , pp. 321-324
    • Beckert, S.1    Farrahi, F.2    Aslam, R.S.3
  • 36
    • 0036347515 scopus 로고    scopus 로고
    • Lactate stimulates fibroblast expression of hyaluronan and CD44: The Warburg effect revisited
    • Stern R, Shuster S, Neudecker BA, et al., Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited. Exp Cell Res 2002; 276: 24-31.
    • (2002) Exp Cell Res , vol.276 , pp. 24-31
    • Stern, R.1    Shuster, S.2    Neudecker, B.A.3
  • 37
    • 0037731447 scopus 로고    scopus 로고
    • Lactate-sensitive response elements in genes involved in hyaluronan catabolism
    • Formby B, Stern R,. Lactate-sensitive response elements in genes involved in hyaluronan catabolism. Biochem Biophys Res Commun 2003; 305: 203-8.
    • (2003) Biochem Biophys Res Commun , vol.305 , pp. 203-208
    • Formby, B.1    Stern, R.2
  • 38
    • 0027314603 scopus 로고
    • Glycerol 3-phosphate and lactate as indicators of the cerebral cytoplasmic redox state in severe and mild hypoxia, respectively: A 13C- and 31P-n.m.r
    • Ben-Yoseph O, Badar-Goffer RS, Morris PG, et al., Glycerol 3-phosphate and lactate as indicators of the cerebral cytoplasmic redox state in severe and mild hypoxia, respectively: a 13C- and 31P-n.m.r. study. Biochem J 1993; 291: 915-9.
    • (1993) Study. Biochem J , vol.291 , pp. 915-919
    • Ben-Yoseph, O.1    Badar-Goffer, R.S.2    Morris, P.G.3
  • 39
    • 12244252777 scopus 로고    scopus 로고
    • Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy
    • Howe FA, Barton SJ, Cudlip SA, et al., Metabolic profiles of human brain tumors using quantitative in vivo 1H magnetic resonance spectroscopy. Magn Reson Med 2003; 49: 223-32.
    • (2003) Magn Reson Med , vol.49 , pp. 223-232
    • Howe, F.A.1    Barton, S.J.2    Cudlip, S.A.3
  • 40
    • 79957941802 scopus 로고    scopus 로고
    • The metabolic advantage of tumor cells
    • Israel M, Schwartz L,. The metabolic advantage of tumor cells. Mol Cancer 2011; 10: 70.
    • (2011) Mol Cancer , vol.10 , pp. 70
    • Israel, M.1    Schwartz, L.2
  • 42
    • 68549085318 scopus 로고    scopus 로고
    • Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM)
    • Fan TW, Lane AN, Higashi RM, et al., Altered regulation of metabolic pathways in human lung cancer discerned by (13)C stable isotope-resolved metabolomics (SIRM). Mol Cancer 2009; 8: 41.
    • (2009) Mol Cancer , vol.8 , pp. 41
    • Fan, T.W.1    Lane, A.N.2    Higashi, R.M.3
  • 43
    • 84876926672 scopus 로고    scopus 로고
    • GC/MS-based metabolomic analysis of cerebrospinal fluid (CSF) from glioma patients
    • Nakamizo S, Sasayama T, Shinohara M, et al., GC/MS-based metabolomic analysis of cerebrospinal fluid (CSF) from glioma patients. J Neurooncol 2013; 113: 65-74.
    • (2013) J Neurooncol , vol.113 , pp. 65-74
    • Nakamizo, S.1    Sasayama, T.2    Shinohara, M.3
  • 44
    • 33746835711 scopus 로고    scopus 로고
    • Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: Status of endogenous citrate and dependence on aconitase and fatty acid synthase
    • Mycielska ME, Broke-Smith TP, Palmer CP, et al., Citrate enhances in vitro metastatic behaviours of PC-3M human prostate cancer cells: status of endogenous citrate and dependence on aconitase and fatty acid synthase. Int J Biochem Cell Biol 2006; 38: 1766-77.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 1766-1777
    • Mycielska, M.E.1    Broke-Smith, T.P.2    Palmer, C.P.3
  • 45
    • 0037292138 scopus 로고    scopus 로고
    • Visualizing metabolic changes in breast-cancer tissue using 1H-NMR spectroscopy and self-organizing maps
    • Beckonert O, Monnerjahn J, Bonk U, et al., Visualizing metabolic changes in breast-cancer tissue using 1H-NMR spectroscopy and self-organizing maps. NMR Biomed 2003; 16: 1-11.
    • (2003) NMR Biomed , vol.16 , pp. 1-11
    • Beckonert, O.1    Monnerjahn, J.2    Bonk, U.3
  • 46
    • 60149091657 scopus 로고    scopus 로고
    • Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
    • Sreekumar A, Poisson LM, Rajendiran TM, et al., Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature 2009; 457: 910-4.
    • (2009) Nature , vol.457 , pp. 910-914
    • Sreekumar, A.1    Poisson, L.M.2    Rajendiran, T.M.3
  • 47
    • 0027008438 scopus 로고
    • An investigation of tumor 1H nuclear magnetic resonance spectra by the application of chemometric techniques
    • Howells SL, Maxwell RJ, Peet AC, et al., An investigation of tumor 1H nuclear magnetic resonance spectra by the application of chemometric techniques. Magn Reson Med 1992; 28: 214-36.
    • (1992) Magn Reson Med , vol.28 , pp. 214-236
    • Howells, S.L.1    Maxwell, R.J.2    Peet, A.C.3
  • 48
    • 0031772702 scopus 로고    scopus 로고
    • Mechanisms of action of antiestrogens: Relevance to clinical benefits and risks
    • Carmichael PL,. Mechanisms of action of antiestrogens: relevance to clinical benefits and risks. Cancer Invest 1998; 16: 604-11.
    • (1998) Cancer Invest , vol.16 , pp. 604-611
    • Carmichael, P.L.1
  • 49
    • 2642686624 scopus 로고    scopus 로고
    • Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens
    • Cheng LL, Chang IW, Louis DN, et al., Correlation of high-resolution magic angle spinning proton magnetic resonance spectroscopy with histopathology of intact human brain tumor specimens. Cancer Res 1998; 58: 1825-32.
    • (1998) Cancer Res , vol.58 , pp. 1825-1832
    • Cheng, L.L.1    Chang, I.W.2    Louis, D.N.3
  • 50
    • 51449084616 scopus 로고    scopus 로고
    • Prognostic value of choline and creatine in WHO grade II gliomas
    • Hattingen E, Raab P, Franz K, et al., Prognostic value of choline and creatine in WHO grade II gliomas. Neuroradiology 2008; 50: 759-67.
    • (2008) Neuroradiology , vol.50 , pp. 759-767
    • Hattingen, E.1    Raab, P.2    Franz, K.3
  • 51
    • 1542311356 scopus 로고    scopus 로고
    • 1H magnetic resonance spectroscopy of invasive cervical cancer: An in vivo study with ex vivo corroboration
    • Mahon MM, Williams AD, Soutter WP, et al., 1H magnetic resonance spectroscopy of invasive cervical cancer: an in vivo study with ex vivo corroboration. NMR Biomed 2004; 17: 1-9.
    • (2004) NMR Biomed , vol.17 , pp. 1-9
    • Mahon, M.M.1    Williams, A.D.2    Soutter, W.P.3
  • 52
    • 0030741163 scopus 로고    scopus 로고
    • Absolute concentrations of metabolites in human brain tumors using in vitro proton magnetic resonance spectroscopy
    • Kinoshita Y, Yokota A,. Absolute concentrations of metabolites in human brain tumors using in vitro proton magnetic resonance spectroscopy. NMR Biomed 1997; 10: 2-12.
    • (1997) NMR Biomed , vol.10 , pp. 2-12
    • Kinoshita, Y.1    Yokota, A.2


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