Downregulated TIPE2 is associated with poor prognosis and promotes cell proliferation in non-small cell lung cancer

Biochemical and Biophysical Research Communications

Volumn 457, Issue 1, 2015, Pages 43-49

  Li, Yuexia ^a   Li, Xiaohui ^b   Liu, Gang ^a   Sun, Rongqing ^a   Wang, Lirui ^a   Wang, Jing ^a   Wang, Hongmin ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b HENAN PROVINCIAL PEOPLE'S HOSPITAL   (China)

Author keywords

Invasive; Non small cell lung cancer; Proliferation; TIPE2; Tumor suppressor

Indexed keywords

NERVE CELL ADHESION MOLECULE; PROTEIN BCL XL; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 8 LIKE 2; UNCLASSIFIED DRUG; CADHERIN; PROTEIN BCL X; SIGNAL PEPTIDE; TIPE2 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER PROGNOSIS; CANCER STAGING; CELL INVASION; CELL PROLIFERATION; COLONY FORMATION; CONTROLLED STUDY; DOWN REGULATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NON SMALL CELL LUNG CANCER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; WESTERN BLOTTING; ANIMAL; BAGG ALBINO MOUSE; DISEASE COURSE; DRUG SCREENING; LUNG; LUNG TUMOR; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; PROGNOSIS; TUMOR CELL LINE; TUMOR INVASION;

ANIMALS; BCL-X PROTEIN; CADHERINS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL PROLIFERATION; DISEASE PROGRESSION; DOWN-REGULATION; FEMALE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; LUNG NEOPLASMS; MALE; MICE, INBRED BALB C; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; TUMOR STEM CELL ASSAY; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84921684086     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2014.12.080     Document Type: Article

References (19)

1. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, D. Forman, Global cancer statistics, CA Cancer J. Clin. 61 (2011) 69-90.
2. S. Peters, A.A. Adjei, C. Gridelli, M. Reck, K. Kerr, E. Felip, Metastatic non-small-cell lung cancer (NSCLC): ESMO clinical practice guidelines for diagnosis, treatment and follow-up, Ann. Oncol. 23 (Suppl. 7) (2012) vii56-vii64.
3. H. Li, Y. Zhang, X. Bai, Y. Peng, P. He, TRIM31 is downregulated in non-small cell lung cancer and serves as a potential tumor suppressor, Tumour Biol. 35 (2014) 5747-5752.
4. H. Sun, S. Gong, R.J. Carmody, A. Hilliard, L. Li, J. Sun, L. Kong, L. Xu, B. Hilliard, S. Hu, H. Shen, X. Yang, Y.H. Chen, TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis, Cell 133 (2008) 415-426.
5. G. Zhang, C. Hao, Y. Lou, W. Xi, X. Wang, Y. Wang, Z. Qu, C. Guo, Y. Chen, Y. Zhang, S. Liu, Tissue-specific expression of TIPE2 provides insights into its function, Mol. Immunol. 47 (2010) 2435-2442.
6. Y. Gus-Brautbar, D. Johnson, L. Zhang, H. Sun, P. Wang, S. Zhang, Y.H. Chen, The anti-inflammatory TIPE2 is an inhibitor of the oncogenic Ras, Mol. Cell 45 (2012) 610-618.
7. X. Cao, L. Zhang, Y. Shi, Y. Sun, S. Dai, C. Guo, F. Zhu, Q. Wang, J. Wang, X. Wang, Y.H. Chen, Human tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 suppresses hepatocellular carcinoma metastasis through inhibiting Rac1, Mol. Cancer 12 (2013) 149.
8. X.M. Li, J.R. Su, S.P. Yan, Z.L. Cheng, T.T. Yang, Q. Zhu, A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8, Cancer Biomark. 14 (2014) 233-240.
9. Y.H. Zhang, H.Q. Yan, F. Wang, Y.Y. Wang, Y.N. Jiang, Y.N. Wang, F.G. Gao, TIPE2 inhibits TNF-alpha-induced hepatocellular carcinoma cell metastasis via Erk1/2 downregulation and NF-kappaB activation, Int. J. Oncol. 46 (2015) 254-264.
10. D. Li, L. Song, Y. Fan, X. Li, Y. Li, J. Chen, F. Zhu, C. Guo, Y. Shi, L. Zhang, Downregulation of TIPE2 mRNA expression in peripheral blood mononuclear cells from patients with systemic lupus erythematosus, Clin. Immunol. 133 (2009) 422-427.
11. X. Zhang, J. Wang, C. Fan, H. Li, H. Sun, S. Gong, Y.H. Chen, Y. Shi, Crystal structure of TIPE2 provides insights into immune homeostasis, Nat. Struct. Mol. Biol. 16 (2009) 89-90.
12. Y. Lou, S. Liu, The TIPE (TNFAIP8) family in inflammation, immunity, and cancer, Mol. Immunol. 49 (2011) 4-7.
13. Z. Zhang, X. Liang, L. Gao, H. Ma, X. Liu, Y. Pan, W. Yan, H. Shan, Z. Wang, Y.H. Chen, C. Ma, TIPE1 induces apoptosis by negatively regulating Rac1 activation in hepatocellular carcinoma cells, Oncogene (2014).
14. Z. Zhang, H. Qi, S. Hou, X. Jin, TIPE2 mRNA overexpression correlates with TNM staging in renal cell carcinoma tissues, Oncol. Lett. 6 (2013) 571-575.
15. P.E. Czabotar, G. Lessene, A. Strasser, J.M. Adams, Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy, Nat. Rev. Mol. Cell Biol. 15 (2014) 49-63.
16. A. Gross, J.M. McDonnell, S.J. Korsmeyer, BCL-2 family members and the mitochondria in apoptosis, Genes Dev. 13 (1999) 1899-1911.
17. J. Yang, R.A. Weinberg, Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis, Dev. Cell 14 (2008) 818-829.
18. R. Kalluri, R.A. Weinberg, The basics of epithelial-mesenchymal transition, J. Clin. Invest. 119 (2009) 1420-1428.
19. M.A. Huber, N. Kraut, H. Beug, Molecular requirements for epithelial-mesenchymal transition during tumor progression, Curr. Opin. Cell Biol. 17 (2005) 548-558.