A novel inflammatory regulator TIPE2 inhibits TLR4-mediated development of colon cancer via caspase-8

Cancer Biomarkers

Volumn 14, Issue 4, 2014, Pages 233-240

  Li, Xue Mei ^a   Su, Jing Ran ^b   Yan, Shi Ping ^a   Cheng, Zhao Ling ^c   Yang, Ting Ting ^c   Zhu, Qiang ^a  

^a SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^b SHANDONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Department of Gastroenterology Heze Municipal Hospital ^*  (China)

Author keywords

caspase 8; colon; inflammation; TIPE2; TLR4; tumorigenesis

Indexed keywords

CASPASE 8; MESSENGER RNA; REGULATOR PROTEIN; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN 8 LIKE 2; UNCLASSIFIED DRUG; CASP8 PROTEIN, HUMAN; CASPASE INHIBITOR; LIPOPOLYSACCHARIDE; SIGNAL PEPTIDE; TIPE2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN;

ADULT; ARTICLE; CANCER STAGING; CELL DIFFERENTIATION; COLON CANCER; COLORIMETRY; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; FEMALE; FLUORESCENCE MICROSCOPY; HT 29 CELL LINE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CARCINOGENESIS; COLON TUMOR; ENZYMOLOGY; GENETIC TRANSFECTION; GENETICS; METABOLISM; MIDDLE AGED; TUMOR CELL LINE;

CARCINOGENESIS; CASPASE 8; CASPASE INHIBITORS; CELL LINE, TUMOR; COLONIC NEOPLASMS; FEMALE; HT29 CELLS; HUMANS; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOPOLYSACCHARIDES; MALE; MIDDLE AGED; RNA, SMALL INTERFERING; TOLL-LIKE RECEPTOR 4; TRANSFECTION;

EID: 84921627308     PISSN: 15740153     EISSN: 18758592     Source Type: Journal    
DOI: 10.3233/CBM-140402     Document Type: Article

References (24)

1. Gus-Brautbar Y, Johnson D, Zhang L, Sun H, Wang P, Zhang S, Zhang L, Chen YH. The Anti-inflammatory TIPE2 Is an Inhibitor of the Oncogenic Ras. Molecular Cell. 2012; 45(5):610-618. [PubMed: 22326055]
2. Lou YW, Liu SX. The TIPE (TNFAIP8) family in inflammation, immunity, and cancer. Molecular Immunology. 2011; 49(1-2):4-7. [PubMed: 21924498]
3. Sun H, Gong S, Carmody RJ, Hilliard A, Li L, Sun J, Kong L, Xu L, Hilliard B, Hu S, Shen H, Yang X, et al. TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis. Cell. 2008;133(3):415-426. [PubMed: 18455983]
4. Freundt EC, Bidere N, Lenardo MJ. A different TIPE of immune homeostasis. Cell. 2008;133(3):401-402. [PubMed: 18455981]
5. Greten FR, Eckmann L, Greten TF, Park JM, Li ZW, Egan LJ, Kagnoff MF, Karin M. IKKβ Links Inflammation and Tumorigenesis in a Mouse Model of Colitis-Associated Cancer. Cell. 2004;118(3):285-296. [PubMed: 15294155]
6. Swann JB, Vesely MD, Silva A, Sharkey J, Akira S, Schreiber RD, Smyth MJ. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. PNAS. 2008;105(2):652-656. [PubMed: 18178624]
7. Asquith M, Powrie F. An innately dangerous balancing act: Intestinal homeostasis, inflammation, and colitis-associated cancer. J. Exp. Med. 2010;207(8):1573-1577. [PubMed: 20679404]
8. Janoš Terzić, Sergei Grivennikov, Eliad Karin, Michael Karin. Inflammation and Colon Cancer. Gastroenterology. 2010; 138(6):2101-2114. [PubMed: 20420949]
9. Apetoh L, Ghiringhelli F, Tesniere A, Obeid M, Ortiz C, Criollo A, Mignot G, Maiuri MC, Ullrich E, Saulnier P, Yang H, Amigorena S, et al. Toll-like receptor 4-dependent contribution of the immune system to anticancer chemotherapy and radiotherapy. Nature Medicine. 2007;13:1050-1059. [PubMed: 17704786]
10. Maelfait J, Vercammen E, Janssens S, Schotte P, Haegman M, Magez S, Beyaert R. Stimulation of Toll-like receptor 3 and 4 induces interleukin-1β maturation by caspase-8. J. Exp. Med. 2008;205(9):1967-1973. [PubMed: 18725521]
11. Macarthur M, Hold GL, El-Omar EM. Inflammation and Cancer II. Role of chronic inflammation and cytokine gene polymorphisms in the pathogenesis of gastrointestinal malignancy. Am J Physiol Gastrointest Liver Physiol. 2004; 286:G515-G520. [PubMed: 15010360]
12. Tsan MF. Toll-like receptors, inflammation and cancer. Seminars in Cancer Biology. 2006;16(1):32-37. [PubMed: 16153858]
13. Kumar D, Gokhale P, Broustas C, Chakravarty D, Ahmad I, Kasid U. Expression of SCC-S2, an antiapoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB 435 cells. Oncogene. 2004;23:612-616. [PubMed: 14724590]
14. Yoshinaga-Hirabayashi T, Yoneda Y. Expression of SCC in ovarian granulosa cells and cultured cells, induced rapid structural changes in mitochondria. Ital. J. Anat. Embryol. 2001; 106 (2):51-57. [PubMed: 11729997]
15. Zhang C, Chakravarty D, Sakabe I, Mewani RR, Boudreau HE, Kumar D, Ahmad I, Kasid UN. Role of SCC-S2 in experimental metastasis and modulation of VEGFR-2, MMP- 1, and MMP-9 expression. Moleluar Therapy. 2006;13:947-955. [PubMed: 16455304]
16. Laliberté B, Wilson AM, Nafisi H, Mao H, Zhou YY, Daigle M, Albert PR. TNFAIP8: a new effector for Galpha(i) coupling to reduce cell death and induce cell transforma tion. Journal of Cellular Physiology. 2010;225(3):865-874. [PubMed: 18455983]
17. Huang B, Zhao J, Li H, He KL, Chen Y, Chen SH, Mayer L, Unkeless JC, Xiong H. Toll-like receptors on tumor cells facilitate evasion of immune surveillance. Cancer Res. 2005;65(12):5009-5014. [PubMed: 15958541]
18. Fukata M, Chen A, Vamadevan AS, Cohen J, Breglio K, Krishnareddy S, Hsu D, Xu R, Harpaz N, Dannenberg AJ, Subbaramaiah K, Cooper HS, et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology. 2007;133(6):1869-1881. [PubMed: 18054559]
19. kata M, Chen A, Klepper A, Krishnareddy S, Vamadevan AS, Thomas LS, Xu R, Inoue H, Arditi M, Dannenberg AJ, Abreu MT. Cox-2 is regulated by Toll-like receptor-4 (TLR4) signaling: role in proliferation and apoptosis in the intestine. Gastroenterology. 2006;131(3):862-877. [PubMed: 16952555]
20. Su H, Bidère N, Zheng L, Cubre A, Sakai K, Dale J, Salmena L, Hakem R, Straus S, Lenardo M. Requirement for caspase- 8 in NF-kappaB activation by antigen receptor. Science. 2005;307(5714):1465-1468. [PubMed: 15746428]
21. Bidère N, Snow AL, Sakai K, Zheng L, Lenardo MJ. Caspase-8 regulation by direct interaction with TRAF6 in T cell receptor-induced NF-kappaB activation. Current Biology. 2006;16 (16): 1666-1671. [PubMed: 16920630]
22. Lemmers B, Salmena L, Bidère N, Su H, Matysiak-Zablocki E,Murakami K, Ohashi PS, Jurisicova A, Lenardo M, Hakem R, Hakem A. Essential role for caspase-8 in Toll-like receptors and NfkappaB signaling. J. Biol. Chem. 2007; 282:7416-7423. [PubMed: 17213198]
23. Chun HJ, Zheng L, Ahmad M,Wang J, Speirs CK, Siegel RM, Dale JK, Puck J, Davis J, Hall CG, Skoda-Smith S, Atkinson TP, et al. Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency. Nature. 2002;419:395-399. [PubMed: 12353035]
24. Karin M, Greten FR. NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol. 2005;5:749-759. [PubMed: 16175180]