-
1
-
-
77953421610
-
Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death
-
Parihar, A., Eubank, T.D. & Dosef, A.I. Monocytes and macrophages regulate immunity through dynamic networks of survival and cell death. J. Innate Immun. 2, 204-215 (2010).
-
(2010)
J. Innate Immun.
, vol.2
, pp. 204-215
-
-
Parihar, A.1
Eubank, T.D.2
Dosef, A.I.3
-
2
-
-
0030666222
-
Innate immunity: The virtues of a nonclonal system of recognition
-
Medzhitov, R. & Janeway, C.A. Jr. Innate immunity: the virtues of a nonclonal system of recognition. Cell 91, 295-298 (1997).
-
(1997)
Cell
, vol.91
, pp. 295-298
-
-
Medzhitov, R.1
Janeway, C.A.2
-
3
-
-
77949940198
-
Intracellular toll-like receptors
-
Blasius, A.L. & Beutler, B. Intracellular toll-like receptors. Immunity 32, 305-315 (2010).
-
(2010)
Immunity
, vol.32
, pp. 305-315
-
-
Blasius, A.L.1
Beutler, B.2
-
4
-
-
77951877953
-
Identifcation and functions of pattern-recognition receptors
-
Kumagai, Y. & Akira, S. Identifcation and functions of pattern-recognition receptors. J. Allergy Clin. Immunol. 125, 985-992 (2010).
-
(2010)
J. Allergy Clin. Immunol.
, vol.125
, pp. 985-992
-
-
Kumagai, Y.1
Akira, S.2
-
5
-
-
77950343791
-
Pattern recognition receptors and infammation
-
Takeuchi, O. & Akira, S. Pattern recognition receptors and infammation. Cell 140, 805-820 (2010).
-
(2010)
Cell
, vol.140
, pp. 805-820
-
-
Takeuchi, O.1
Akira, S.2
-
6
-
-
77950261975
-
How are T(H)2-type immune responses initiated and amplifed?
-
Paul, W.E. & Zhu, J. How are T(H)2-type immune responses initiated and amplifed? Nat. Rev. Immunol. 10, 225-235 (2010).
-
(2010)
Nat. Rev. Immunol.
, vol.10
, pp. 225-235
-
-
Paul, W.E.1
Zhu, J.2
-
7
-
-
0025130557
-
Antagonistic and agonistic efects of transforming growth factor-beta and IL-1 in rheumatoid synovium
-
Wahl, S.M., Allen, J.B., Wong, H.L., Dougherty, S.F. & Ellingsworth, L.R. Antagonistic and agonistic efects of transforming growth factor-beta and IL-1 in rheumatoid synovium. J. Immunol. 145, 2514-2519 (1990).
-
(1990)
J. Immunol.
, vol.145
, pp. 2514-2519
-
-
Wahl, S.M.1
Allen, J.B.2
Wong, H.L.3
Dougherty, S.F.4
Ellingsworth, L.R.5
-
8
-
-
0027513170
-
Interleukin-10
-
Moore, K.W., O'Garra, A., de Waal Malefyt, R., Vieira, P. & Mosmann, T.R. Interleukin-10. Annu. Rev. Immunol. 11, 165-190 (1993).
-
(1993)
Annu. Rev. Immunol.
, vol.11
, pp. 165-190
-
-
Moore, K.W.1
O'Garra, A.2
De Waal Malefyt, R.3
Vieira, P.4
Mosmann, T.R.5
-
9
-
-
77950346282
-
Immunity infammation, and cancer
-
Grivennikov, S.I., Greten, F.R. & Karin, M. Immunity, infammation, and cancer. Cell 140, 883-899 (2010).
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
Greten, F.R.2
Karin, M.3
-
10
-
-
84894236899
-
Incidence rates of malignancies and hospitalized infectious events in patients with psoriasis with or without treatment and a general population in the U.S.A.: 2005-09
-
Kimball, A.B., Schenfeld, J., Accortt, N.A., Anthony, M.S., Rothman, K.J. & Pariser, D. Incidence rates of malignancies and hospitalized infectious events in patients with psoriasis with or without treatment and a general population in the U.S.A.: 2005-09. Br. J. Dermatol. 170, 366-373 (2014).
-
(2014)
Br. J. Dermatol.
, vol.170
, pp. 366-373
-
-
Kimball, A.B.1
Schenfeld, J.2
Accortt, N.A.3
Anthony, M.S.4
Rothman, K.J.5
Pariser, D.6
-
11
-
-
79960820132
-
The growing challenge of obesity and cancer: An infammatory issue
-
Harvey, A.E., Lashinger, L.M. & Hursting, S.D. The growing challenge of obesity and cancer: an infammatory issue. Ann. NY Acad. Sci. 1229, 45-52 (2011).
-
(2011)
Ann. NY Acad. Sci.
, vol.1229
, pp. 45-52
-
-
Harvey, A.E.1
Lashinger, L.M.2
Hursting, S.D.3
-
12
-
-
74549167737
-
Dietary and genetic obesity promote liver infammation and tumorigenesis by enhancing IL-6 and TNF expression
-
Park, E.J. et al. Dietary and genetic obesity promote liver infammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 140, 197-208 (2010).
-
(2010)
Cell
, vol.140
, pp. 197-208
-
-
Park, E.J.1
-
13
-
-
0035901090
-
Infammation and cancer: Back to Virchow?
-
Balkwill, F. & Mantovani, A. Infammation and cancer: back to Virchow? Lancet 357, 539-545 (2001).
-
(2001)
Lancet
, vol.357
, pp. 539-545
-
-
Balkwill, F.1
Mantovani, A.2
-
14
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
Galon, J. et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313, 1960-1964 (2006).
-
(2006)
Science
, vol.313
, pp. 1960-1964
-
-
Galon, J.1
-
15
-
-
34248193253
-
Immune surveillance of tumors
-
Swann, J.B. & Smyth, M.J. Immune surveillance of tumors. J. Clin. Invest. 117, 1137-1146 (2007).
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1137-1146
-
-
Swann, J.B.1
Smyth, M.J.2
-
16
-
-
2142757235
-
Analgesic therapy and the prevention of bladder cancer
-
Blumentals, W.A., Foulis, P.R., Schwartz, S.W. & Mason, T.J. Analgesic therapy and the prevention of bladder cancer. Urol. Oncol. 22, 11-15 (2004).
-
(2004)
Urol. Oncol.
, vol.22
, pp. 11-15
-
-
Blumentals, W.A.1
Foulis, P.R.2
Schwartz, S.W.3
Mason, T.J.4
-
17
-
-
35348882103
-
Analgesic and anti-infammatory drug use and risk of bladder cancer: A population based case control study
-
Fortuny, J. et al. Analgesic and anti-infammatory drug use and risk of bladder cancer: a population based case control study. BMC Urol. 7, 13 (2007).
-
(2007)
BMC Urol.
, vol.7
, pp. 13
-
-
Fortuny, J.1
-
18
-
-
21444450527
-
Low-dose aspirin in the primary prevention of cancer: The Women's Health Study: A randomized controlled trial
-
Cook, N.R. et al. Low-dose aspirin in the primary prevention of cancer: the Women's Health Study: a randomized controlled trial. JAMA 294, 47-55 (2005).
-
(2005)
JAMA
, vol.294
, pp. 47-55
-
-
Cook, N.R.1
-
19
-
-
79551696016
-
Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fber for colorectal cancer chemoprevention
-
Limburg, P.J. et al.; Cancer Prevention Network. Randomized phase II trial of sulindac, atorvastatin, and prebiotic dietary fber for colorectal cancer chemoprevention. Cancer Prev. Res. (Phila). 4, 259-269 (2011).
-
(2011)
Cancer Prev. Res. (Phila).
, vol.4
, pp. 259-269
-
-
Limburg, P.J.1
-
20
-
-
26444586236
-
Circulating levels of infammatory markers and cancer risk in the health aging and body composition cohort
-
Il'yasova, D. et al. Circulating levels of infammatory markers and cancer risk in the health aging and body composition cohort. Cancer Epidemiol. Biomarkers Prev. 14, 2413-2418 (2005).
-
(2005)
Cancer Epidemiol. Biomarkers Prev.
, vol.14
, pp. 2413-2418
-
-
Il'Yasova, D.1
-
21
-
-
62649091120
-
Impact of infectious and infammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics
-
Morgan, E.T. Impact of infectious and infammatory disease on cytochrome P450-mediated drug metabolism and pharmacokinetics. Clin. Pharmacol. Ther. 85, 434-438 (2009).
-
(2009)
Clin. Pharmacol. Ther.
, vol.85
, pp. 434-438
-
-
Morgan, E.T.1
-
22
-
-
0035119064
-
Regulation of cytochrome p450 by infammatory mediators: Why and how? Drug Metab
-
Morgan, E.T. Regulation of cytochrome p450 by infammatory mediators: why and how? Drug Metab. Dispos. 29, 207-212 (2001).
-
(2001)
Dispos.
, vol.29
, pp. 207-212
-
-
Morgan, E.T.1
-
23
-
-
38749091688
-
Regulation of drug-metabolizing enzymes and transporters in infection, infammation, and cancer
-
Morgan, E.T. et al. Regulation of drug-metabolizing enzymes and transporters in infection, infammation, and cancer. Drug Metab. Dispos. 36, 205-216 (2008).
-
(2008)
Drug Metab. Dispos.
, vol.36
, pp. 205-216
-
-
Morgan, E.T.1
-
24
-
-
78650742546
-
Activation of the acute infammatory response alters cytochrome P450 expression and eicosanoid metabolism
-
Theken, K.N., Deng, Y., Kannon, M.A., Miller, T.M., Poloyac, S.M. & Lee, C.R. Activation of the acute infammatory response alters cytochrome P450 expression and eicosanoid metabolism. Drug Metab. Dispos. 39, 22-29 (2011).
-
(2011)
Drug Metab. Dispos.
, vol.39
, pp. 22-29
-
-
Theken, K.N.1
Deng, Y.2
Kannon, M.A.3
Miller, T.M.4
Poloyac, S.M.5
Lee, C.R.6
-
25
-
-
79952196577
-
Cytochrome P450-derived eicosanoids: The neglected pathway in cancer
-
Panigrahy, D., Kaipainen, A., Greene, E.R. & Huang, S. Cytochrome P450-derived eicosanoids: the neglected pathway in cancer. Cancer Metastasis Rev. 29, 723-735 (2010).
-
(2010)
Cancer Metastasis Rev.
, vol.29
, pp. 723-735
-
-
Panigrahy, D.1
Kaipainen, A.2
Greene, E.R.3
Huang, S.4
-
26
-
-
84882779915
-
Critical review of preclinical approaches to investigate cytochrome p450-mediated therapeutic protein drug-drug interactions and recommendations for best practices: A white paper
-
Evers, R. et al. Critical review of preclinical approaches to investigate cytochrome p450-mediated therapeutic protein drug-drug interactions and recommendations for best practices: a white paper. Drug Metab. Dispos. 41, 1598-1609 (2013).
-
(2013)
Drug Metab. Dispos.
, vol.41
, pp. 1598-1609
-
-
Evers, R.1
-
27
-
-
33144485957
-
Regulation of drug-metabolizing enzymes and transporters in infammation
-
Aitken, A.E., Richardson, T.A. & Morgan, E.T. Regulation of drug-metabolizing enzymes and transporters in infammation. Annu. Rev. Pharmacol. Toxicol. 46, 123-149 (2006).
-
(2006)
Annu. Rev. Pharmacol. Toxicol.
, vol.46
, pp. 123-149
-
-
Aitken, A.E.1
Richardson, T.A.2
Morgan, E.T.3
-
28
-
-
0027443904
-
Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture
-
Abdel-Razzak, Z. et al. Cytokines down-regulate expression of major cytochrome P-450 enzymes in adult human hepatocytes in primary culture. Mol. Pharmacol. 44, 707-715 (1993).
-
(1993)
Mol. Pharmacol.
, vol.44
, pp. 707-715
-
-
Abdel-Razzak, Z.1
-
29
-
-
0029126915
-
Diferential efects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture
-
Muntané-Relat, J., Ourlin, J.C., Domergue, J. & Maurel, P. Diferential efects of cytokines on the inducible expression of CYP1A1, CYP1A2, and CYP3A4 in human hepatocytes in primary culture. Hepatology 22, 1143-1153 (1995).
-
(1995)
Hepatology
, vol.22
, pp. 1143-1153
-
-
Muntané-Relat, J.1
Ourlin, J.C.2
Domergue, J.3
Maurel, P.4
-
30
-
-
34548090571
-
Gene-specifc efects of infammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes
-
Aitken, A.E. & Morgan, E.T. Gene-specifc efects of infammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes. Drug Metab. Dispos. 35, 1687-1693 (2007).
-
(2007)
Drug Metab. Dispos.
, vol.35
, pp. 1687-1693
-
-
Aitken, A.E.1
Morgan, E.T.2
-
31
-
-
0034234716
-
Hepatic cytochrome P450 down-regulation during aseptic infammation in the mouse is interleukin 6 dependent
-
Siewert, E., Bort, R., Kluge, R., Heinrich, P.C., Castell, J. & Jover, R. Hepatic cytochrome P450 down-regulation during aseptic infammation in the mouse is interleukin 6 dependent. Hepatology 32, 49-55 (2000).
-
(2000)
Hepatology
, vol.32
, pp. 49-55
-
-
Siewert, E.1
Bort, R.2
Kluge, R.3
Heinrich, P.C.4
Castell, J.5
Jover, R.6
-
32
-
-
39749090014
-
Infammation and CYP3A4-mediated drug metabolism in advanced cancer: Impact and implications for chemotherapeutic drug dosing
-
Kacevska, M., Robertson, G.R., Clarke, S.J. & Liddle, C. Infammation and CYP3A4-mediated drug metabolism in advanced cancer: impact and implications for chemotherapeutic drug dosing. Expert Opin. Drug Metab. Toxicol. 4, 137-149 (2008).
-
(2008)
Expert Opin. Drug Metab. Toxicol.
, vol.4
, pp. 137-149
-
-
Kacevska, M.1
Robertson, G.R.2
Clarke, S.J.3
Liddle, C.4
-
33
-
-
84883265275
-
Extra-hepatic cancer represses hepatic drug metabolism via interleukin (IL)-6 signalling
-
Kacevska, M., Mahns, A., Sharma, R., Clarke, S.J., Robertson, G.R. & Liddle, C. Extra-hepatic cancer represses hepatic drug metabolism via interleukin (IL)-6 signalling. Pharm. Res. 30, 2270-2278 (2013).
-
(2013)
Pharm. Res.
, vol.30
, pp. 2270-2278
-
-
Kacevska, M.1
Mahns, A.2
Sharma, R.3
Clarke, S.J.4
Robertson, G.R.5
Liddle, C.6
-
34
-
-
78149251115
-
Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6-and interferon-{gamma}-null mice
-
Nyagode, B.A., Lee, C.M. & Morgan, E.T. Modulation of hepatic cytochrome P450s by Citrobacter rodentium infection in interleukin-6-and interferon-{gamma}-null mice. J. Pharmacol. Exp. Ther. 335, 480-488 (2010).
-
(2010)
J. Pharmacol. Exp. Ther.
, vol.335
, pp. 480-488
-
-
Nyagode, B.A.1
Lee, C.M.2
Morgan, E.T.3
-
35
-
-
79955465387
-
Disease-drug-drug interaction involving tocilizumab and simvastatin in patients with rheumatoid arthritis
-
Schmitt, C., Kuhn, B., Zhang, X., Kivitz, A.J. & Grange, S. Disease-drug-drug interaction involving tocilizumab and simvastatin in patients with rheumatoid arthritis. Clin. Pharmacol. Ther. 89, 735-740 (2011).
-
(2011)
Clin. Pharmacol. Ther.
, vol.89
, pp. 735-740
-
-
Schmitt, C.1
Kuhn, B.2
Zhang, X.3
Kivitz, A.J.4
Grange, S.5
-
36
-
-
0036023402
-
Diferential efect of IFNalpha-2b on the cytochrome P450 enzyme system: A potential basis of IFN toxicity and its modulation by other drugs
-
Islam, M. et al. Diferential efect of IFNalpha-2b on the cytochrome P450 enzyme system: a potential basis of IFN toxicity and its modulation by other drugs. Clin. Cancer Res. 8, 2480-2487 (2002).
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 2480-2487
-
-
Islam, M.1
-
37
-
-
79960138592
-
Interaction between adalimumab with concurrent pregabalin and duloxetine administration in a psoriasis patient with diabetic peripheral neuropathy
-
Wu, J.J. & Fleming, K.F. Interaction between adalimumab with concurrent pregabalin and duloxetine administration in a psoriasis patient with diabetic peripheral neuropathy. Cutis 87, 249-250 (2011).
-
(2011)
Cutis
, vol.87
, pp. 249-250
-
-
Wu, J.J.1
Fleming, K.F.2
-
38
-
-
67651205738
-
The efect of infiximab on hepatic cytochrome P450 and pharmacokinetics of verapamil in rats with pre-adjuvant arthritis: A drug-disease and drug-drug interaction
-
Ling, S. & Jamali, F. The efect of infiximab on hepatic cytochrome P450 and pharmacokinetics of verapamil in rats with pre-adjuvant arthritis: a drug-disease and drug-drug interaction. Basic Clin. Pharmacol. Toxicol. 105, 24-29 (2009).
-
(2009)
Basic Clin. Pharmacol. Toxicol.
, vol.105
, pp. 24-29
-
-
Ling, S.1
Jamali, F.2
-
39
-
-
84890483496
-
An update on drug-drug interactions with biologics for the treatment of moderate-to-severe psoriasis
-
Gupta, R., Levin, E., Wu, J.J., Koo, J. & Liao, W. An update on drug-drug interactions with biologics for the treatment of moderate-to-severe psoriasis. J. Dermatolog. Treat. 25, 87-89 (2014).
-
(2014)
J. Dermatolog. Treat.
, vol.25
, pp. 87-89
-
-
Gupta, R.1
Levin, E.2
Wu, J.J.3
Koo, J.4
Liao, W.5
-
40
-
-
84875870177
-
Interleukins-12 and-23 do not alter expression or activity of multiple cytochrome P450 enzymes in cryopreserved human hepatocytes
-
Dallas, S., Chattopadhyay, S., Sensenhauser, C., Batheja, A., Singer, M. & Silva, J. Interleukins-12 and-23 do not alter expression or activity of multiple cytochrome P450 enzymes in cryopreserved human hepatocytes. Drug Metab. Dispos. 41, 689-693 (2013).
-
(2013)
Drug Metab. Dispos.
, vol.41
, pp. 689-693
-
-
Dallas, S.1
Chattopadhyay, S.2
Sensenhauser, C.3
Batheja, A.4
Singer, M.5
Silva, J.6
-
41
-
-
0026730325
-
Spontaneous regression of histologically proved pulmonary metastases from renal cell carcinoma: A case with 5-year followup
-
Vogelzang, N.J., Priest, E.R. & Borden, L. Spontaneous regression of histologically proved pulmonary metastases from renal cell carcinoma: a case with 5-year followup. J. Urol. 148, 1247-1248 (1992).
-
(1992)
J. Urol.
, vol.148
, pp. 1247-1248
-
-
Vogelzang, N.J.1
Priest, E.R.2
Borden, L.3
-
42
-
-
0035908490
-
Spontaneous regression of melanoma may ofer insight into cancer immunology
-
Printz, C. Spontaneous regression of melanoma may ofer insight into cancer immunology. J. Natl. Cancer Inst. 93, 1047-1048 (2001).
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 1047-1048
-
-
Printz, C.1
-
43
-
-
47549105549
-
Cytochrome P450 2C9 mediated metabolism in people with and without cancer
-
Shord, S.S. et al. Cytochrome P450 2C9 mediated metabolism in people with and without cancer. Int. J. Clin. Pharmacol. Ther. 46, 365-374 (2008).
-
(2008)
Int. J. Clin. Pharmacol. Ther.
, vol.46
, pp. 365-374
-
-
Shord, S.S.1
-
44
-
-
33846193632
-
Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer
-
Charles, K.A., Rivory, L.P., Brown, S.L., Liddle, C., Clarke, S.J. & Robertson, G.R. Transcriptional repression of hepatic cytochrome P450 3A4 gene in the presence of cancer. Clin. Cancer Res. 12, 7492-7497 (2006).
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 7492-7497
-
-
Charles, K.A.1
Rivory, L.P.2
Brown, S.L.3
Liddle, C.4
Clarke, S.J.5
Robertson, G.R.6
-
45
-
-
19944427867
-
Factors afecting cytochrome P-450 3A activity in cancer patients
-
Baker, S.D. et al. Factors afecting cytochrome P-450 3A activity in cancer patients. Clin. Cancer Res. 10, 8341-8350 (2004).
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 8341-8350
-
-
Baker, S.D.1
-
46
-
-
0037194409
-
Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase response
-
Rivory, L.P., Slaviero, K.A. & Clarke, S.J. Hepatic cytochrome P450 3A drug metabolism is reduced in cancer patients who have an acute-phase response. Br. J. Cancer 87, 277-280 (2002).
-
(2002)
Br. J. Cancer
, vol.87
, pp. 277-280
-
-
Rivory, L.P.1
Slaviero, K.A.2
Clarke, S.J.3
-
47
-
-
84886722102
-
Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profling and midazolam clearance
-
Shin, K.H., Choi, M.H., Lim, K.S., Yu, K.S., Jang, I.J. & Cho, J.Y. Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profling and midazolam clearance. Clin. Pharmacol. Ther. 94, 601-609 (2013).
-
(2013)
Clin. Pharmacol. Ther.
, vol.94
, pp. 601-609
-
-
Shin, K.H.1
Choi, M.H.2
Lim, K.S.3
Yu, K.S.4
Jang, I.J.5
Cho, J.Y.6
-
48
-
-
61449182121
-
Principles of cancer therapy: Oncogene and non-oncogene addiction
-
Luo, J., Solimini, N.L. & Elledge, S.J. Principles of cancer therapy: oncogene and non-oncogene addiction. Cell 136, 823-837 (2009).
-
(2009)
Cell
, vol.136
, pp. 823-837
-
-
Luo, J.1
Solimini, N.L.2
Elledge, S.J.3
-
49
-
-
84908691666
-
Agonistic anti-CD137 antibody treatment leads to antitumor response in mice with liver cancer
-
e-pub ahead of print 2 May 2014
-
Gauttier, V., Judor, J.P., Le Guen, V., Cany, J., Ferry, N. & Conchon, S. Agonistic anti-CD137 antibody treatment leads to antitumor response in mice with liver cancer. Int. J. Cancer (2014); e-pub ahead of print 2 May 2014.
-
(2014)
Int. J. Cancer
-
-
Gauttier, V.1
Judor, J.P.2
Le Guen, V.3
Cany, J.4
Ferry, N.5
Conchon, S.6
-
50
-
-
84880651129
-
Cutting edge: IL-12 and type i IFN diferentially program CD8 T cells for programmed death 1 re-expression levels and tumor control
-
Gerner, M.Y., Heltemes-Harris, L.M., Fife, B.T. & Mescher, M.F. Cutting edge: IL-12 and type I IFN diferentially program CD8 T cells for programmed death 1 re-expression levels and tumor control. J. Immunol. 191, 1011-1015 (2013).
-
(2013)
J. Immunol.
, vol.191
, pp. 1011-1015
-
-
Gerner, M.Y.1
Heltemes-Harris, L.M.2
Fife, B.T.3
Mescher, M.F.4
-
51
-
-
43049147611
-
Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice
-
Hamzah, J., Nelson, D., Moldenhauer, G., Arnold, B., Hämmerling, G.J. & Ganss, R. Vascular targeting of anti-CD40 antibodies and IL-2 into autochthonous tumors enhances immunotherapy in mice. J. Clin. Invest. 118, 1691-1699 (2008).
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 1691-1699
-
-
Hamzah, J.1
Nelson, D.2
Moldenhauer, G.3
Arnold, B.4
Hämmerling, G.J.5
Ganss, R.6
-
52
-
-
78449237498
-
Signaling through OX40 enhances antitumor immunity
-
Jensen, S.M. et al. Signaling through OX40 enhances antitumor immunity. Semin. Oncol. 37, 524-532 (2010).
-
(2010)
Semin. Oncol.
, vol.37
, pp. 524-532
-
-
Jensen, S.M.1
-
53
-
-
1342344700
-
Kupfer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes
-
Sunman, J.A., Hawke, R.L., LeCluyse, E.L. & Kashuba, A.D. Kupfer cell-mediated IL-2 suppression of CYP3A activity in human hepatocytes. Drug Metab. Dispos. 32, 359-363 (2004).
-
(2004)
Drug Metab. Dispos.
, vol.32
, pp. 359-363
-
-
Sunman, J.A.1
Hawke, R.L.2
Lecluyse, E.L.3
Kashuba, A.D.4
-
54
-
-
0033561594
-
Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy
-
Elkahwaji, J. et al. Decrease in hepatic cytochrome P450 after interleukin-2 immunotherapy. Biochem. Pharmacol. 57, 951-954 (1999).
-
(1999)
Biochem. Pharmacol.
, vol.57
, pp. 951-954
-
-
Elkahwaji, J.1
-
55
-
-
84874889330
-
Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination
-
Melero, I., Grimaldi, A.M., Perez-Gracia, J.L. & Ascierto, P.A. Clinical development of immunostimulatory monoclonal antibodies and opportunities for combination. Clin. Cancer Res. 19, 997-1008 (2013).
-
(2013)
Clin. Cancer Res.
, vol.19
, pp. 997-1008
-
-
Melero, I.1
Grimaldi, A.M.2
Perez-Gracia, J.L.3
Ascierto, P.A.4
-
56
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
Hodi, F.S. et al. Improved survival with ipilimumab in patients with metastatic melanoma. N. Engl. J. Med. 363, 711-723 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 711-723
-
-
Hodi, F.S.1
-
57
-
-
84859393995
-
CTLA-4 blockade with ipilimumab: Long-term follow-up of 177 patients with metastatic melanoma
-
Prieto, P.A. et al. CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma. Clin. Cancer Res. 18, 2039-2047 (2012).
-
(2012)
Clin. Cancer Res.
, vol.18
, pp. 2039-2047
-
-
Prieto, P.A.1
-
58
-
-
77955256254
-
Efcacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: A multicenter single-arm phase II study
-
O'Day, S.J. et al. Efcacy and safety of ipilimumab monotherapy in patients with pretreated advanced melanoma: a multicenter single-arm phase II study. Ann. Oncol. 21, 1712-1717 (2010).
-
(2010)
Ann. Oncol.
, vol.21
, pp. 1712-1717
-
-
O'Day, S.J.1
-
59
-
-
75249100054
-
Ipilimumab monotherapy in patients with pretreated advanced melanoma: A randomised, double-blind, multicentre, phase 2, dose-ranging study
-
Wolchok, J.D. et al. Ipilimumab monotherapy in patients with pretreated advanced melanoma: a randomised, double-blind, multicentre, phase 2, dose-ranging study. Lancet Oncol. 11, 155-164 (2010).
-
(2010)
Lancet Oncol.
, vol.11
, pp. 155-164
-
-
Wolchok, J.D.1
-
60
-
-
84874605864
-
Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
-
Ribas, A. et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J. Clin. Oncol. 31, 616-622 (2013).
-
(2013)
J. Clin. Oncol.
, vol.31
, pp. 616-622
-
-
Ribas, A.1
-
61
-
-
36748999428
-
Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
-
Downey, S.G. et al. Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin. Cancer Res. 13, 6681-6688 (2007).
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 6681-6688
-
-
Downey, S.G.1
-
62
-
-
84904855312
-
Immunologic and clinical efects of targeting PD-1 in lung cancer
-
Harvey, R.D. Immunologic and clinical efects of targeting PD-1 in lung cancer. Clin. Pharmacol. Ther. 96, 214-223 (2014).
-
(2014)
Clin. Pharmacol. Ther.
, vol.96
, pp. 214-223
-
-
Harvey, R.D.1
-
63
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian, S.L. et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 366, 2443-2454 (2012).
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
-
64
-
-
58149483422
-
CTLA-4 blockade enhances polyfunctional NY-ESO-1 specifc T cell responses in metastatic melanoma patients with clinical beneft
-
Yuan, J. et al. CTLA-4 blockade enhances polyfunctional NY-ESO-1 specifc T cell responses in metastatic melanoma patients with clinical beneft. Proc. Natl. Acad. Sci. USA 105, 20410-20415 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 20410-20415
-
-
Yuan, J.1
-
65
-
-
84856862354
-
PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer
-
Dulos, J. et al. PD-1 blockade augments Th1 and Th17 and suppresses Th2 responses in peripheral blood from patients with prostate and advanced melanoma cancer. J. Immunother. 35, 169-178 (2012).
-
(2012)
J. Immunother.
, vol.35
, pp. 169-178
-
-
Dulos, J.1
-
66
-
-
79955581263
-
A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naïve patients with advanced melanoma
-
Hersh, E.M. et al. A phase II multicenter study of ipilimumab with or without dacarbazine in chemotherapy-naïve patients with advanced melanoma. Invest. New Drugs 29, 489-498 (2011).
-
(2011)
Invest. New Drugs
, vol.29
, pp. 489-498
-
-
Hersh, E.M.1
-
67
-
-
84863911486
-
Ipilimumab in combination with paclitaxel and carboplatin as frst-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
-
Lynch, T.J. et al. Ipilimumab in combination with paclitaxel and carboplatin as frst-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J. Clin. Oncol. 30, 2046-2054 (2012).
-
(2012)
J. Clin. Oncol.
, vol.30
, pp. 2046-2054
-
-
Lynch, T.J.1
-
68
-
-
84871532643
-
Ipilimumab in combination with paclitaxel and carboplatin as frst-line therapy in extensive-disease-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial
-
Reck, M. et al. Ipilimumab in combination with paclitaxel and carboplatin as frst-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann. Oncol. 24, 75-83 (2013).
-
(2013)
Ann. Oncol.
, vol.24
, pp. 75-83
-
-
Reck, M.1
-
69
-
-
79959772576
-
Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
-
Robert, C. et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N. Engl. J. Med. 364, 2517-2526 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, pp. 2517-2526
-
-
Robert, C.1
-
70
-
-
84879045360
-
Randomized phase i pharmacokinetic study of ipilimumab with or without one of two diferent chemotherapy regimens in patients with untreated advanced melanoma
-
Weber, J. et al. Randomized phase I pharmacokinetic study of ipilimumab with or without one of two diferent chemotherapy regimens in patients with untreated advanced melanoma. Cancer Immun. 13, 7 (2013).
-
(2013)
Cancer Immun.
, vol.13
, pp. 7
-
-
Weber, J.1
-
71
-
-
84865567547
-
Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): An open-label, single-arm phase 2 trial
-
Di Giacomo, A.M. et al. Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): an open-label, single-arm phase 2 trial. Lancet Oncol. 13, 879-886 (2012).
-
(2012)
Lancet Oncol.
, vol.13
, pp. 879-886
-
-
Di Giacomo, A.M.1
-
72
-
-
84874721742
-
Phase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferon-α in advanced malignant melanoma
-
Daponte, A. et al.; Southern Italy Cooperative Oncology Group (SICOG). Phase III randomized study of fotemustine and dacarbazine versus dacarbazine with or without interferon-α in advanced malignant melanoma. J. Transl. Med. 11, 38 (2013).
-
(2013)
J. Transl. Med.
, vol.11
, pp. 38
-
-
Daponte, A.1
-
73
-
-
84875785905
-
Hepatotoxicity with combination of vemurafenib and ipilimumab
-
Ribas, A., Hodi, F.S., Callahan, M., Konto, C. & Wolchok, J. Hepatotoxicity with combination of vemurafenib and ipilimumab. N. Engl. J. Med. 368, 1365-1366 (2013).
-
(2013)
N. Engl. J. Med.
, vol.368
, pp. 1365-1366
-
-
Ribas, A.1
Hodi, F.S.2
Callahan, M.3
Konto, C.4
Wolchok, J.5
-
74
-
-
84879777241
-
Nivolumab plus ipilimumab in advanced melanoma
-
Wolchok, J.D. et al. Nivolumab plus ipilimumab in advanced melanoma. N. Engl. J. Med. 369, 122-133 (2013).
-
(2013)
N. Engl. J. Med.
, vol.369
, pp. 122-133
-
-
Wolchok, J.D.1
-
75
-
-
71149090173
-
Quantifcation of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specifc evaluation of the metabolic ratio as biomarker of CYP3A activity
-
Lutz, U., Bittner, N., Ufer, M. & Lutz, W.K. Quantifcation of cortisol and 6 beta-hydroxycortisol in human urine by LC-MS/MS, and gender-specifc evaluation of the metabolic ratio as biomarker of CYP3A activity. J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878, 97-101 (2010).
-
(2010)
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci.
, vol.878
, pp. 97-101
-
-
Lutz, U.1
Bittner, N.2
Ufer, M.3
Lutz, W.K.4
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