Andrographolide decreased VEGFD expression in hepatoma cancer cells by inducing ubiquitin/proteasome-mediated cFos protein degradation

Biochimica et Biophysica Acta - General Subjects

Volumn 1850, Issue 4, 2015, Pages 750-758

  Ji, Lili ^a   Zheng, Zhiyong ^a   Shi, Liang ^a   Huang, Yinjie ^a   Lu, Bin ^a   Wang, Zhengtao ^a  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Andrographolide; cFos; Hepatoma cancer; Protein degradation; VEGFD

Indexed keywords

ANDROGRAPHOLIDE; FLUOROURACIL; MESSENGER RNA; PROTEASOME; PROTEIN C FOS; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UBIQUITIN; VASCULOTROPIN D; DITERPENE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL NUCLEUS; CONTROLLED STUDY; GENE EXPRESSION; HEPATOCELLULAR CARCINOMA CELL LINE; IN VIVO STUDY; LIVER CELL CARCINOMA; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TRANSPORT; TUMOR XENOGRAFT; UBIQUITINATION; ANIMAL; CARCINOMA, HEPATOCELLULAR; GENETICS; HUMAN; LIVER NEOPLASMS; METABOLISM; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

ANIMALS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; DITERPENES; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER NEOPLASMS; MALE; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTO-ONCOGENE PROTEINS C-FOS; UBIQUITINS; VASCULAR ENDOTHELIAL GROWTH FACTOR D;

EID: 84921672073     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2015.01.005     Document Type: Article

References (41)

1. J.C. Lim, T.K. Chan, D.S. Ng, S.R. Sagineedu, J. Stanslas, W.S. Wong, Andrographolide and its analogues: versatile bioactive molecules for combating inflammation and cancer, Clin. Exp. Pharmacol. Physiol. 39 (2012) 300-310.
2. B. Zhou, D. Zhang, X. Wu, Biological activities and corresponding SARs of andrographolide and its derivatives, Mini. Rev. Med. Chem. 13 (2013) 298-309.
3. W. Chen, L. Feng, H. Nie, X. Zheng, Andrographolide induces autophagic cell death in human liver cancer cells through cyclophilin D-mediated mitochondrial permeability transition pore, Carcinogenesis 33 (2012) 2190-2198.
4. Y.H. Lai, S.L. Yu, H.Y. Chen, C.C. Wang, H.W. Chen, J.J. Chen, The HLJ1-targeting drug screening identified Chinese herb and rographolide that can suppress tumor growth and invasion in non-small-cell lung cancer, Carcinogenesis 34 (2013) 1069-1080.
5. C.Y. Chao, C.K. Lii, Y.T. Hsu, C.Y. Lu, K.L. Liu, C.C. Li, H.W. Chen, Induction of heme oxygenase-1 and inhibition of TPA-induced matrix metalloproteinase-9 expression by andrographolide in MCF-7 human breast cancer cells, Carcinogenesis 34 (2013) 1843-1851.
6. G.Q. Bao, B.Y. Shen, C.P. Pan, Y.J. Zhang, M.M. Shi, C.H. Peng, Andrographolide causes apoptosis via inactivation of STAT3 and Akt and potentiates antitumor activity of gemcitabine in pancreatic cancer, Toxicol. Lett. 222 (2013) 23-35.
7. S.R. Jada, C. Matthews, M.S. Saad, A.S. Hamzah, N.H. Lajis, M.F. Stevens, J. Stanslas, Benzylidene derivatives of andrographolide inhibit growth of breast and colon cancer cells in vitro by inducing G(1) arrest and apoptosis, Br. J. Pharmacol. 155 (2008) 641-654.
8. K.K. Shen, L.L. Ji, B. Lu, C. Xu, C.Y. Gong, G. Morahan, Z.T. Wang, Andrographolide inhibits tumor angiogenesis via blocking VEGFA/VEGFR2-MAPKs signaling cascade, Chem. Biol. Interact. 218C (2014) 99-106.
9. L.L. Ji, K.K. Shen, P. Jiang, G. Morahan, Z.T. Wang, Critical roles of cellular glutathione homeostasis and JNK activation in andrographolide-mediated apoptotic cell death in human hepatoma cells, Mol. Carcinog. 50 (2011) 580-591.
10. L.L. Ji, T.Y. Liu, J. Liu, Y. Chen, Z.T. Wang, Andrographolide inhibits human hepatomaderived Hep3B cell growth through the activation of c-Jun N-terminal kinase, Planta Med. 73 (2007) 1397-1401.
11. L.L. Ji, K.K. Shen, J. Liu, Y. Chen, T.Y. Liu, Z.T. Wang, Intracellular glutathione regulates Andrographolide-induced cytotoxicity on hepatoma Hep3B cells, Redox Rep. 14 (2009) 176-184.
12. J. Folkman, Y. Shing, Angiogenesis, J. Biol. Chem. 267 (1992) 10931-10934.
13. F. Bahram, L. Classon-Welsh, VEGF-mediated signal transduction in lymphatic endothelial cells, Pathophysiology 17 (2010) 253-261.
14. L. Marconcini, S. Marchio, L. Morbidelli, E. Cartocci, A. Albini, M. Ziche, F. Bussolino, S. Oliviero, c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro, Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 9671-9676.
15. M.G. Achen, M. Jeltsch, E. Kukk, T. Makinen, A. Vitali, A.F. Wilks, K. Alitalo, S.S. Stacker, Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk) and VEGF receptor 3 (Flt4), Proc. Natl. Acad. Sci. U. S. A. 95 (1998) 548-553.
16. S.A. Stacker, C. Caesar, M.E. Baldwin, G.E. Thornton, R.A. Williams, R. Prevo, D.G. Jackson, S. Nishikawa, H. Kubo, M.G. Achen, VEGF-D promotes the metastatic spread of tumor cells via the lymphatics, Nat. Med. 7 (2001) 186-191.
17. J.H. Choi, Y.H. Oh, Y.W. Park, H.K. Baik, Y.Y. Lee, I.S. Kim, Correlation of vascular endothelial growth factor-D expression and VEGFR3-positive vessel density with lymph node metastasis in gastric carcinoma, J. Korean Med. Sci. 23 (2008) 592-597.
18. G.G. Van den Eynden, I. Van der Auwera, S.J. Van Laere, X.B. Trinh, C.G. Colpaert, P. van Dam, L.Y. Dirix, P.B. Vermeulen, E.A. Van Marck, Comparison of molecular determinants of angiogenesis and lymphangiogenesis in lymph node metastases and in primary tumours of patients with breast cancer, J. Pathol. 213 (2007) 56-64.
19. J. Wang, Y. Guo, B.C. Wang, J.W. Bi, K.N. Li, X.J. Liang, H. Chu, H. Jiang, Lymphatic microvessel density and vascular endothelial growth factor-C and -D as prognostic factors in breast cancer: a systematic review and meta-analysis of the literature, Mol. Biol. Rep. 39 (2012) 11153-111565.
20. T. Karpanen, K. Alitalo, Lymphatic vessels as targets of tumor therapy, J. Exp. Med. 194 (2001) F37-F42.
21. J. Ferlay, H.R. Shin, F. Bray, D. Forman, C. Mathers, D.M. Parkin, Estimates of worldwide burden of cancer in 2008: globocan 2008, Int. J. Cancer 127 (2010) 2893-2917.
22. A. Jemal, F. Bray, M.M. Center, J. Ferlay, E. Ward, D. Forman, Global cancer statistics, CA Cancer J. Clin. 61 (2011) 69-90.
23. A. Flores, J.A. Marrero, Emerging trends in hepatocellular carcinoma: focus on diagnosis and therapeutics, Clin. Med. Insights Oncol. 8 (2014) 71-76.
24. C. Cha, Y. Fong, W.R. Jarnagin, L.H. Blumgart, R.P. DeMatteo, Predictors and patterns of recurrence after resection of hepatocellular carcinoma, J. Am. Coll. Surg. 197 (2003) 753-758.
25. M. Peck-Radosavljevic, Drug therapy for advanced-stage liver cancer, Liver Cancer 3 (2014) 125-131.
26. L. Yang, D. Wu, K. Luo, S. Wu, P. Wu, Andrographolide enhances 5-fluorouracil-induced apoptosis via caspase-8-dependent mitochondrial pathway involving p53 participation in hepatocellular carcinoma (SMMC-7721) cells, Cancer Lett. 276 (2009) 180-188.
27. M. Orlandini, L. Marconcini, R. Ferruzzi, S. Oliviero, Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family, Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 11675-11680.
28. Y. Yamada, J. Nezu, M. Shimane, Y. Hirata, Molecular cloning of a novel vascular endothelial growth factor, VEGF-D, Genomics 42 (1997) 483-488.
29. T. Yu, Z. Wang, K. Liu, Y. Wu, J. Fan, J. Chen, C. Li, G. Zhu, L. Li, High interstitial fluid pressure promotes tumor progression through inducing lymphatic metastasis-related protein expressions in oral squamous cell carcinoma, Clin. Transl. Oncol. 16 (2014) 539-547.
30. Y.C. Zhao, X.J. Ni, Y. Li, M. Dai, Z.X. Yuan, Y.Y. Zhu, C.Y. Luo, Peritumoral lymphangiogenesis induced by vascular endothelial growth factor C and D promotes lymph node metastasis in breast cancer patients, World J. Surg. Oncol. 10 (2012) 165.
31. F. Bolat, D. Gumurdulu, S. Erkanli, F. Kayaselcuk, H. Zeren, M. Ali Vardar, E. Kuscu, Maspin overexpression correlates with increased expression of vascular endothelial growth factors A, C, and D in human ovarian carcinoma, Pathol. Res. Pract. 204 (2008) 379-387.
32. J. Deng, H. Liang, D. Sun, Y. Pan, B. Wang, Y. Guo, Vascular endothelial growth factor - D is correlated with hepatic metastasis from gastri cancer after radical gastrectomy, Surgey 146 (2009) 896-905.
33. A. Thelen, A. Scholz, C. Benckert, Z. von Marschall, M. Schroder, B. Wiedenmann, P. Neuhaus, S. Rosewicz, S. Jonas, VEGF-D promotes tumor growth and lymphatic spread in a mouse model of hepatocellular carcinoma, Int. J. Cancer 122 (2008) 2471-2481.
34. J. Hess, P. Angel, M. Schorpp-Kistner, AP-1 subunits: quarrel and harmony among siblings, J. Cell Sci. 117 (2004) 5965-5973.
35. J. Basbous, I. Jariel-Encontre, T. Gomard, G. Bossis, M. Piechaczyk, Ubiquitin-independent- versus ubiquitin-dependent proteasomal degradation of the c-Fos and Fra-1 transcription factors: is there a unique answer? Biochimie 90 (2008) 296-305.
36. T. Gomard, I. Jariel-Encontre, J. Basbous, G. Bossis, G. Mocquet-Torcy, Fos family protein degradation by the proteasome, Biochem. Soc. Trans. 36 (2008) 858-863.
37. I. Stancovski, H. Gonen, A. Orian, A.L. Schwartz, A. Ciechanover, Degradation of the Proto-Oncogene product c-Fos by the Ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes, Mol. Cell. Biol. 15 (1995) 7106-7116.
38. T. Sasaki, H. Kojima, R. Kishimoto, A. Ikeda, H. Kunimoto, K. Nakajima, Spatiotemporal regulation of c-Fos by ERK5 and the E3 ubiquitin ligase UBR1, and its biological role, Mol. Cell 24 (2006) 63-75.
39. K. Terasawa, K. Okazaki, E. Nishida, Regulation of c-Fos and Fra-1 by the MEK5-ERK5 pathway, Genes Cells 8 (2003) 263-273.
40. R.H. Chen, P.C. Juo, T. Curran, J. Blenis, Phosphorylation of c-Fos at the C-terminus enhances its transforming activity, Oncogene 12 (1996) 1493e1502.
41. P. Monje, M.J. Marinissen, J.S. Gutkind, Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor, Mol. Cell. Biol. 23 (2003) 7030e7043.