메뉴 건너뛰기




Volumn 8, Issue , 2014, Pages 71-76

Emerging trends in hepatocellular carcinoma: Focus on diagnosis and therapeutics

Author keywords

Alpha fetoprotein (AFP); Dynamic imaging; Hepatocellular carcinoma (HCC); Liver transplantation; Molecular targets; Radiofrequency ablation (RFA); Sorafenib; Trans arterial chemoembolization (TACE); Ultrasound; Yttrium 90 (Y 90) radioembolization

Indexed keywords

AXITINIB; BELINOSTAT; BEVACIZUMAB; BILIRUBIN; CABOZANTINIB; CEDIRANIB; CETUXIMAB; DOXORUBICIN; EVEROLIMUS; GADOLINIUM PENTETATE; GADOXETIC ACID; GANETESPIB; GEFITINIB; LAPATINIB; LENALIDOMIDE; LENVATINIB; LINIFANIB; PAZOPANIB; RAMUCIRUMAB; RAPAMYCIN; SORAFENIB; TEMSIROLIMUS; TIVANTINIB; YTTRIUM 90;

EID: 84901241878     PISSN: None     EISSN: 11795549     Source Type: Journal    
DOI: 10.4137/CMO.S9926     Document Type: Article
Times cited : (136)

References (57)
  • 5
    • 80053088189 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • El-Serag HB. Hepatocellular carcinoma. N Engl J Med. 2011;365:1118-27.
    • (2011) N Engl J Med. , vol.365 , pp. 1118-1127
    • El-Serag, H.B.1
  • 6
    • 0018817836 scopus 로고
    • Basic issues in population screening for cancer
    • Cole P, Morrison AS. Basic issues in population screening for cancer. J Natl Cancer Inst. 1980;64:1263-72.
    • (1980) J Natl Cancer Inst. , vol.64 , pp. 1263-1272
    • Cole, P.1    Morrison, A.S.2
  • 7
    • 0030799512 scopus 로고    scopus 로고
    • Prospective study of early detection for primary liver cancer
    • Yang B, Zhang B, Xu Y, etal. Prospective study of early detection for primary liver cancer. J Cancer Res Clin Oncol. 1997;123:357-60.
    • (1997) J Cancer Res Clin Oncol. , vol.123 , pp. 357-360
    • Yang, B.1    Zhang, B.2    Xu, Y.3
  • 8
    • 3843125293 scopus 로고    scopus 로고
    • Randomized controlled trial of screening for hepatocellular carcinoma
    • Zhang BH, Yang BH, Tang ZY. Randomized controlled trial of screening for hepatocellular carcinoma. J Cancer Res Clin Oncol. 2004;130:417-22.
    • (2004) J Cancer Res Clin Oncol. , vol.130 , pp. 417-422
    • Zhang, B.H.1    Yang, B.H.2    Tang, Z.Y.3
  • 9
    • 75449103932 scopus 로고    scopus 로고
    • Des-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma
    • Lok AS, Sterling RK, Everhart JE, etal. Des-gamma-carboxy prothrombin and alpha-fetoprotein as biomarkers for the early detection of hepatocellular carcinoma. Gastroenterology. 2010;138:493-502.
    • (2010) Gastroenterology. , vol.138 , pp. 493-502
    • Lok, A.S.1    Sterling, R.K.2    Everhart, J.E.3
  • 10
    • 67449107459 scopus 로고    scopus 로고
    • Meta-analysis: Surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis
    • Singal A, Volk ML, Waljee A, etal. Meta-analysis: surveillance with ultrasound for early-stage hepatocellular carcinoma in patients with cirrhosis. Aliment Pharmacol Ther. 2009;30:37-47.
    • (2009) Aliment Pharmacol Ther. , vol.30 , pp. 37-47
    • Singal, A.1    Volk, M.L.2    Waljee, A.3
  • 11
    • 84862895115 scopus 로고    scopus 로고
    • Effectiveness of hepatocellular carcinoma surveillance in patients with cirrhosis
    • Singal AG, Conjeevaram HS, Volk ML, etal. Effectiveness of hepatocellular carcinoma surveillance in patients with cirrhosis. Cancer Epidemiol Biomarkers Prev. 2012;21:793-9.
    • (2012) Cancer Epidemiol Biomarkers Prev. , vol.21 , pp. 793-799
    • Singal, A.G.1    Conjeevaram, H.S.2    Volk, M.L.3
  • 12
    • 80051758429 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma in Japan: Consensus-Based Clinical Practice Guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version
    • Kudo M, Izumi N, Kokudo N, etal. Management of hepatocellular carcinoma in Japan: Consensus-Based Clinical Practice Guidelines proposed by the Japan Society of Hepatology (JSH) 2010 updated version. Dig Dis. 2011;29:339-64.
    • (2011) Dig Dis. , vol.29 , pp. 339-364
    • Kudo, M.1    Izumi, N.2    Kokudo, N.3
  • 13
    • 34848886470 scopus 로고    scopus 로고
    • Clinical utility of AFP-L3% measurement in North American patients with HCV-related cirrhosis
    • Sterling RK, Jeffers L, Gordon F, etal. Clinical utility of AFP-L3% measurement in North American patients with HCV-related cirrhosis. Am J Gastroenterol. 2007;102:2196-205.
    • (2007) Am J Gastroenterol. , vol.102 , pp. 2196-2205
    • Sterling, R.K.1    Jeffers, L.2    Gordon, F.3
  • 14
    • 0037698789 scopus 로고    scopus 로고
    • Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients
    • Marrero JA, Su GL, Wei W, etal. Des-gamma carboxyprothrombin can differentiate hepatocellular carcinoma from nonmalignant chronic liver disease in american patients. Hepatology. 2003;37:1114-21.
    • (2003) Hepatology. , vol.37 , pp. 1114-1121
    • Marrero, J.A.1    Su, G.L.2    Wei, W.3
  • 15
    • 16244388266 scopus 로고    scopus 로고
    • Improving the prediction of hepatocellular carcinoma in cirrhotic patients with an arterially-enhancing liver mass
    • Marrero JA, Hussain HK, Nghiem HV, Umar R, Fontana RJ, Lok AS. Improving the prediction of hepatocellular carcinoma in cirrhotic patients with an arterially-enhancing liver mass. Liver Transpl. 2005;11:281-9.
    • (2005) Liver Transpl. , vol.11 , pp. 281-289
    • Marrero, J.A.1    Hussain, H.K.2    Nghiem, H.V.3    Umar, R.4    Fontana, R.J.5    Lok, A.S.6
  • 16
    • 79952231921 scopus 로고    scopus 로고
    • Management of hepatocellular carcinoma: An update
    • Bruix J, Sherman M. Management of hepatocellular carcinoma: an update. Hepatology. 2011;53:1020-2.
    • (2011) Hepatology. , vol.53 , pp. 1020-1022
    • Bruix, J.1    Sherman, M.2
  • 17
    • 77349103260 scopus 로고    scopus 로고
    • Pathology of early hepatocellular carcinoma: Conventional and molecular diagnosis
    • Roskams T, Kojiro M. Pathology of early hepatocellular carcinoma: conventional and molecular diagnosis. Semin Liver Dis. 2010;30:17-25.
    • (2010) Semin Liver Dis. , vol.30 , pp. 17-25
    • Roskams, T.1    Kojiro, M.2
  • 18
    • 38649114052 scopus 로고    scopus 로고
    • Diagnosis of hepatic nodules 20mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma
    • Forner A, Vilana R, Ayuso C, etal. Diagnosis of hepatic nodules 20mm or smaller in cirrhosis: Prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma. Hepatology. 2008;47:97-104.
    • (2008) Hepatology. , vol.47 , pp. 97-104
    • Forner, A.1    Vilana, R.2    Ayuso, C.3
  • 19
    • 84858658381 scopus 로고    scopus 로고
    • EASL-EORTC clinical practice guidelines: Management of hepatocellular carcinoma
    • European Association for the Study of the Liver; European Organisation for Research and Treatment of Cancer
    • European Association for the Study of the Liver; European Organisation for Research and Treatment of Cancer. EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol. 2012;56:908-43.
    • (2012) J Hepatol. , vol.56 , pp. 908-943
  • 20
    • 33745285710 scopus 로고    scopus 로고
    • Liver tumor characterization: Comparison between liver-specific gadoxetic acid disodium-enhanced MRI and biphasic CT-a multicenter trial
    • Halavaara J, Breuer J, Ayuso C, etal. Liver tumor characterization: comparison between liver-specific gadoxetic acid disodium-enhanced MRI and biphasic CT-a multicenter trial. J Comput Assist Tomogr. 2006;30:345-54.
    • (2006) J Comput Assist Tomogr. , vol.30 , pp. 345-354
    • Halavaara, J.1    Breuer, J.2    Ayuso, C.3
  • 21
    • 80054953740 scopus 로고    scopus 로고
    • Gadoxetic acid-enhanced hepatobiliary phase MRI and high-b-value diffusion-weighted imaging to distinguish well-differentiated hepatocellular carcinomas from benign nodules in patients with chronic liver disease
    • Lee MH, Kim SH, Park MJ, Park CK, Rhim H. Gadoxetic acid-enhanced hepatobiliary phase MRI and high-b-value diffusion-weighted imaging to distinguish well-differentiated hepatocellular carcinomas from benign nodules in patients with chronic liver disease. AJR Am J Roentgenol. 2011;197:W868-75.
    • (2011) AJR Am J Roentgenol. , vol.197
    • Lee, M.H.1    Kim, S.H.2    Park, M.J.3    Park, C.K.4    Rhim, H.5
  • 22
    • 84865423409 scopus 로고    scopus 로고
    • Small hepatocellular carcinomas: Improved sensitivity by combining gadoxetic acid-enhanced and diffusion-weighted MR imaging patterns
    • Park MJ, Kim YK, Lee MW, etal. Small hepatocellular carcinomas: improved sensitivity by combining gadoxetic acid-enhanced and diffusion-weighted MR imaging patterns. Radiology. 2012;264:761-70.
    • (2012) Radiology. , vol.264 , pp. 761-770
    • Park, M.J.1    Kim, Y.K.2    Lee, M.W.3
  • 23
    • 84867573623 scopus 로고    scopus 로고
    • Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT
    • Inoue T, Kudo M, Komuta M, etal. Assessment of Gd-EOB-DTPA-enhanced MRI for HCC and dysplastic nodules and comparison of detection sensitivity versus MDCT. J Gastroenterol. 2012;47:1036-47.
    • (2012) J Gastroenterol. , vol.47 , pp. 1036-1047
    • Inoue, T.1    Kudo, M.2    Komuta, M.3
  • 24
    • 16244369103 scopus 로고    scopus 로고
    • Prognosis of hepatocellular carcinoma: Comparison of 7staging systems in an American cohort
    • Marrero JA, Fontana RJ, Barrat A, etal. Prognosis of hepatocellular carcinoma: comparison of 7staging systems in an American cohort. Hepatology. 2005;41:707-16.
    • (2005) Hepatology. , vol.41 , pp. 707-716
    • Marrero, J.A.1    Fontana, R.J.2    Barrat, A.3
  • 25
    • 20344367769 scopus 로고    scopus 로고
    • Resection and liver transplantation for hepatocellular carcinoma
    • Llovet JM, Schwartz M, Mazzaferro V. Resection and liver transplantation for hepatocellular carcinoma. Semin Liver Dis. 2005;25:181-200.
    • (2005) Semin Liver Dis. , vol.25 , pp. 181-200
    • Llovet, J.M.1    Schwartz, M.2    Mazzaferro, V.3
  • 26
    • 0032742183 scopus 로고    scopus 로고
    • Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: Resection versus transplantation
    • Llovet JM, Fuster J, Bruix J. Intention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation. Hepatology. 1999;30:1434-40.
    • (1999) Hepatology. , vol.30 , pp. 1434-1440
    • Llovet, J.M.1    Fuster, J.2    Bruix, J.3
  • 27
    • 84868659263 scopus 로고    scopus 로고
    • Systematic review of outcomes of liver resection for early hepatocellular carcinoma within the Milan criteria
    • Lim KC, Chow PK, Allen JC, Siddiqui FJ, Chan ES, Tan SB. Systematic review of outcomes of liver resection for early hepatocellular carcinoma within the Milan criteria. Br J Surg. 2012;99:1622-9.
    • (2012) Br J Surg. , vol.99 , pp. 1622-1629
    • Lim, K.C.1    Chow, P.K.2    Allen, J.C.3    Siddiqui, F.J.4    Chan, E.S.5    Tan, S.B.6
  • 28
    • 0642310849 scopus 로고    scopus 로고
    • Predictors and patterns of recurrence after resection of hepatocellular carcinoma
    • Cha C, Fong Y, Jarnagin WR, Blumgart LH, DeMatteo RP. Predictors and patterns of recurrence after resection of hepatocellular carcinoma. J Am Coll Surg. 2003;197:753-8.
    • (2003) J Am Coll Surg. , vol.197 , pp. 753-758
    • Cha, C.1    Fong, Y.2    Jarnagin, W.R.3    Blumgart, L.H.4    DeMatteo, R.P.5
  • 29
    • 0345299824 scopus 로고    scopus 로고
    • Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis
    • Mazzaferro V, Regalia E, Doci R, etal. Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med. 1996;334:693-9.
    • (1996) N Engl J Med. , vol.334 , pp. 693-699
    • Mazzaferro, V.1    Regalia, E.2    Doci, R.3
  • 30
    • 9644265250 scopus 로고    scopus 로고
    • Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma, or = 4 cm
    • Lin SM, Lin CJ, Lin CC, Hsu CW, Chen YC. Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma, or = 4 cm. Gastroenterology. 2004;127:1714-23.
    • (2004) Gastroenterology. , vol.127 , pp. 1714-1723
    • Lin, S.M.1    Lin, C.J.2    Lin, C.C.3    Hsu, C.W.4    Chen, Y.C.5
  • 31
    • 22344454922 scopus 로고    scopus 로고
    • A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma
    • Shiina S, Teratani T, Obi S, etal. A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma. Gastroenterology. 2005;129:122-30.
    • (2005) Gastroenterology. , vol.129 , pp. 122-130
    • Shiina, S.1    Teratani, T.2    Obi, S.3
  • 32
    • 38649141497 scopus 로고    scopus 로고
    • Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: Is resection still the treatment of choice?
    • Livraghi T, Meloni F, Di Stasi M, etal. Sustained complete response and complications rates after radiofrequency ablation of very early hepatocellular carcinoma in cirrhosis: Is resection still the treatment of choice? Hepatology. 2008;47:82-9.
    • (2008) Hepatology. , vol.47 , pp. 82-89
    • Livraghi, T.1    Meloni, F.2    Di Stasi, M.3
  • 33
    • 0036237822 scopus 로고    scopus 로고
    • Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma
    • Lo CM, Ngan H, Tso WK, etal. Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology. 2002;35:1164-71.
    • (2002) Hepatology. , vol.35 , pp. 1164-1171
    • Lo, C.M.1    Ngan, H.2    Tso, W.K.3
  • 34
    • 0037308133 scopus 로고    scopus 로고
    • Systematic review of randomized trials for unresectable hepatocellular carcinoma: Chemoembolization improves survival
    • Llovet JM, Bruix J. Systematic review of randomized trials for unresectable hepatocellular carcinoma: chemoembolization improves survival. Hepatology. 2003;37:429-42.
    • (2003) Hepatology. , vol.37 , pp. 429-442
    • Llovet, J.M.1    Bruix, J.2
  • 35
    • 51349117878 scopus 로고    scopus 로고
    • Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: An intention-to-treat analysis
    • Yao FY, Kerlan RK Jr, Hirose R, etal. Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis. Hepatology. 2008;48:819-27.
    • (2008) Hepatology. , vol.48 , pp. 819-827
    • Yao, F.Y.1    Kerlan Jr., R.K.2    Hirose, R.3
  • 36
    • 33846847728 scopus 로고    scopus 로고
    • Chemoembolization of hepatocellular carcinoma with drug eluting beads: Efficacy and doxorubicin pharmacokinetics
    • Varela M, Real MI, Burrel M, etal. Chemoembolization of hepatocellular carcinoma with drug eluting beads: efficacy and doxorubicin pharmacokinetics. J Hepatol. 2007;46:474-81.
    • (2007) J Hepatol. , vol.46 , pp. 474-481
    • Varela, M.1    Real, M.I.2    Burrel, M.3
  • 37
    • 77949264899 scopus 로고    scopus 로고
    • Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: Results of the PRECISION V study
    • Lammer J, Malagari K, Vogl T, etal. Prospective randomized study of doxorubicin-eluting-bead embolization in the treatment of hepatocellular carcinoma: results of the PRECISION V study. Cardiovasc Intervent Radiol. 2010;33:41-52.
    • (2010) Cardiovasc Intervent Radiol. , vol.33 , pp. 41-52
    • Lammer, J.1    Malagari, K.2    Vogl, T.3
  • 38
    • 77953138048 scopus 로고    scopus 로고
    • Prospective randomized comparison of chemoembolization with doxorubicin-eluting beads and bland embolization with BeadBlock for hepatocellular carcinoma
    • Malagari K, Pomoni M, Kelekis A, etal. Prospective randomized comparison of chemoembolization with doxorubicin-eluting beads and bland embolization with BeadBlock for hepatocellular carcinoma. Cardiovasc Intervent Radiol. 2010;33:541-51.
    • (2010) Cardiovasc Intervent Radiol. , vol.33 , pp. 541-551
    • Malagari, K.1    Pomoni, M.2    Kelekis, A.3
  • 39
    • 0036279057 scopus 로고    scopus 로고
    • Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: Clinical manifestation and dosimetric description
    • Cheng JC, Wu JK, Huang CM, etal. Radiation-induced liver disease after radiotherapy for hepatocellular carcinoma: clinical manifestation and dosimetric description. Radiother Oncol. 2002;63:41-5.
    • (2002) Radiother Oncol. , vol.63 , pp. 41-45
    • Cheng, J.C.1    Wu, J.K.2    Huang, C.M.3
  • 40
    • 72249087123 scopus 로고    scopus 로고
    • Radioembolization for hepatocellular carcinoma using Yttrium-90microspheres: A comprehensive report of long-term outcomes
    • Salem R, Lewandowski RJ, Mulcahy MF, etal. Radioembolization for hepatocellular carcinoma using Yttrium-90microspheres: a comprehensive report of long-term outcomes. Gastroenterology. 2010;138:52-64.
    • (2010) Gastroenterology. , vol.138 , pp. 52-64
    • Salem, R.1    Lewandowski, R.J.2    Mulcahy, M.F.3
  • 41
    • 55749088393 scopus 로고    scopus 로고
    • Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling
    • Wilhelm SM, Adnane L, Newell P, Villanueva A, Llovet JM, Lynch M. Preclinical overview of sorafenib, a multikinase inhibitor that targets both Raf and VEGF and PDGF receptor tyrosine kinase signaling. Mol Cancer Ther. 2008;7:3129-40.
    • (2008) Mol Cancer Ther. , vol.7 , pp. 3129-3140
    • Wilhelm, S.M.1    Adnane, L.2    Newell, P.3    Villanueva, A.4    Llovet, J.M.5    Lynch, M.6
  • 42
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V, etal. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359:378-90.
    • (2008) N Engl J Med. , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 43
    • 57749189578 scopus 로고    scopus 로고
    • Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomised, double-blind, placebo-controlled trial
    • Cheng AL, Kang YK, Chen Z, etal. Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10:25-34.
    • (2009) Lancet Oncol. , vol.10 , pp. 25-34
    • Cheng, A.L.1    Kang, Y.K.2    Chen, Z.3
  • 44
    • 77953820596 scopus 로고    scopus 로고
    • Design and rationale for the non-interventional Global Investigation of Therapeutic DEcisions in Hepatocellular Carcinoma and Of its Treatment with Sorafenib (GIDEON) study
    • Lencioni R, Marrero J, Venook A, Ye SL, Kudo M. Design and rationale for the non-interventional Global Investigation of Therapeutic DEcisions in Hepatocellular Carcinoma and Of its Treatment with Sorafenib (GIDEON) study. Int J Clin Pract. 2010;64:1034-41.
    • (2010) Int J Clin Pract. , vol.64 , pp. 1034-1041
    • Lencioni, R.1    Marrero, J.2    Venook, A.3    Ye, S.L.4    Kudo, M.5
  • 45
    • 84860261590 scopus 로고    scopus 로고
    • Sorafenib or placebo in combination with transarterial chemoembolization (TACE) with doxorubicin-eluting beads (DEBDOX) for intermediate-stage hepatocellular carcinoma (HCC): Phase II, randomized, double-blind SAPCE trial
    • Lencioni R, Llovet JM, Han G, etal. Sorafenib or placebo in combination with transarterial chemoembolization (TACE) with doxorubicin-eluting beads (DEBDOX) for intermediate-stage hepatocellular carcinoma (HCC): phase II, randomized, double-blind SAPCE trial. J Clin Oncol. 2012;30.
    • (2012) J Clin Oncol. , pp. 30
    • Lencioni, R.1    Llovet, J.M.2    Han, G.3
  • 46
    • 79960805810 scopus 로고    scopus 로고
    • Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma
    • Kudo M, Imanaka K, Chida N, etal. Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma. Eur J Cancer. 2011;47:2117-27.
    • (2011) Eur J Cancer. , vol.47 , pp. 2117-2127
    • Kudo, M.1    Imanaka, K.2    Chida, N.3
  • 47
    • 84855323080 scopus 로고    scopus 로고
    • Adjuvant therapy after curative treatment for hepatocellular carcinoma
    • Kudo M. Adjuvant therapy after curative treatment for hepatocellular carcinoma. Oncology. 2011;81(Suppl 1):50-5.
    • (2011) Oncology. , vol.81 , Issue.SUPPL. 1 , pp. 50-55
    • Kudo, M.1
  • 48
    • 12244301581 scopus 로고    scopus 로고
    • In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: Determination of a pharmacokinetic/pharmacodynamic relationship
    • Mendel DB, Laird AD, Xin X, etal. In vivo antitumor activity of SU11248, a novel tyrosine kinase inhibitor targeting vascular endothelial growth factor and platelet-derived growth factor receptors: determination of a pharmacokinetic/pharmacodynamic relationship. Clinical Cancer Res. 2003;9:327-37.
    • (2003) Clinical Cancer Res. , vol.9 , pp. 327-337
    • Mendel, D.B.1    Laird, A.D.2    Xin, X.3
  • 49
    • 80054730200 scopus 로고    scopus 로고
    • Phase III trial of sunitinib (Su) versus sorafenib (So) in advanced hepatocellular carcinoma (HCC)
    • Cheng AL, Kang YK, Lin D, etal. Phase III trial of sunitinib (Su) versus sorafenib (So) in advanced hepatocellular carcinoma (HCC). J Clin Oncol 2011;29.
    • (2011) J Clin Oncol , pp. 29
    • Cheng, A.L.1    Kang, Y.K.2    Lin, D.3
  • 51
    • 78349298645 scopus 로고    scopus 로고
    • Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: A randomized trial
    • Abou-Alfa GK, Johnson P, Knox JJ, etal. Doxorubicin plus sorafenib vs doxorubicin alone in patients with advanced hepatocellular carcinoma: a randomized trial. JAMA. 2010;304:2154-60.
    • (2010) JAMA. , vol.304 , pp. 2154-2160
    • Abou-Alfa, G.K.1    Johnson, P.2    Knox, J.J.3
  • 52
    • 27644488740 scopus 로고    scopus 로고
    • Knockdown of c-MET by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo
    • Zhang SZ, Pan FY, Xu JF, etal. Knockdown of c-MET by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo. Mol Cancer Ther. 2005;4:1577-84.
    • (2005) Mol Cancer Ther. , vol.4 , pp. 1577-1584
    • Zhang, S.Z.1    Pan, F.Y.2    Xu, J.F.3
  • 53
    • 84871721240 scopus 로고    scopus 로고
    • Tivantinib for second-line treatment of advanced hepatocellular carcinoma: A randomised, placebo-controlled phase 2 study
    • Santoro A, Rimassa L, Borbath I, etal. Tivantinib for second-line treatment of advanced hepatocellular carcinoma: a randomised, placebo-controlled phase 2 study. Lancet Oncol. 2013;14:55-63.
    • (2013) Lancet Oncol. , vol.14 , pp. 55-63
    • Santoro, A.1    Rimassa, L.2    Borbath, I.3
  • 54
    • 84872549428 scopus 로고    scopus 로고
    • Activity of cabozantinib (XL184) in hepatocellular carcinoma patients: Results from a phase II randomized discontinuation trial (RDT)
    • Cohn A, Kelley, RK, Yang TS, etal. Activity of cabozantinib (XL184) in hepatocellular carcinoma patients: results from a phase II randomized discontinuation trial (RDT). J Clin Oncol. 2012;30(suppl 4).
    • (2012) J Clin Oncol. , vol.30 , Issue.SUPPL. 4
    • Cohn, A.1    Kelley, R.K.2    Yang, T.S.3
  • 55
    • 84860254547 scopus 로고    scopus 로고
    • A phase II study of ramucirumab as first-line monotherapy in patients (pts) with advanced hepatocellular carcinoma (HCC)
    • Zhu AX, Finn RS, Mulcahy, MF etal. A phase II study of ramucirumab as first-line monotherapy in patients (pts) with advanced hepatocellular carcinoma (HCC). J Clin Oncol. 2010;28.
    • (2010) J Clin Oncol. , pp. 28
    • Zhu, A.X.1    Finn, R.S.2    Mulcahy, M.F.3
  • 56
    • 57349087153 scopus 로고    scopus 로고
    • Pivotal role of mTOR signaling in hepatocellular carcinoma
    • Villanueva A, Chiang DY, Newell P, etal. Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology. 2008;135:1972-83.
    • (2008) Gastroenterology. , vol.135 , pp. 1972-1983
    • Villanueva, A.1    Chiang, D.Y.2    Newell, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.