P53-induced microRNA-1246 inhibits the cell growth of human hepatocellular carcinoma cells by targeting NFIB

Oncology Reports

Volumn 33, Issue 3, 2015, Pages 1335-1341

  Zhang, Quan ^a,b   Cao, Li Ye ^b   Cheng, Shu Jie ^b   Zhang, Ai Min ^b   Jin, Xiao Shi ^b   Li, Yong ^a  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b HEBEI UNIVERSITY   (China)

Author keywords

Cell proliferation; HCC; MiR 1246; NFIB

Indexed keywords

MICRORNA; MICRORNA 1246; NUCLEAR FACTOR I; NUCLEAR FACTOR I BETA; PROTEIN P53; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; MIRN1246 MICRORNA, HUMAN; NFIB PROTEIN, HUMAN; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; GENE TARGETING; HEPG2 CELL LINE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; LUCIFERASE ASSAY; NUCLEAR IMPORT; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; BIOSYNTHESIS; CELL TRANSFORMATION; GENE EXPRESSION REGULATION; GENETICS; LIVER TUMOR; METABOLISM; RNA INTERFERENCE; TUMOR CELL LINE;

APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HEP G2 CELLS; HUMANS; LIVER NEOPLASMS; MICRORNAS; NFI TRANSCRIPTION FACTORS; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84921657405     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.3715     Document Type: Article

References (31)

1. Collavin L, Lunardi A and Del Sal G: p53-family proteins and their regulators: hubs and spokes in tumor suppression. Cell Death Differ 17:901-911, 2010.
2. Qian Y and Chen X: Tumor suppression by p53: making cells senescent. Histol Histopathol 25:515-526, 2010.
3. Menendez D, Inga A and Resnick MA: The expanding universe of p53 targets. Nat Rev Cancer 9:724-737, 2009.
4. Hermeking H: The miR-34 family in cancer and apoptosis. Cell Death Differ 17:193-199, 2010.
5. Hermeking H: MicroRNAs in the p53 network: micromanagement of tumour suppression. Nat Rev Cancer 12:613-626, 2012.
6. Shin S, Cha HJ, Lee EM, et al: MicroRNAs are significantly influenced by p53 and radiation in HCT116 human colon carcinoma cells. Int J Oncol 34:1645-1652, 2009.
7. He L, He X, Lowe SW and Hannon GJ: microRNAs join the p53 network - another piece in the tumour-suppression puzzle. Nat Rev Cancer 7:819-822, 2007.
8. Feng Z, Zhang C, Wu R and Hu W: Tumor suppressor p53 meets microRNAs. J Mol Cell Biol 3:44-50, 2011.
9. Zhang W and Cohen SM: The Hippo pathway acts via p53 and microRNAs to control proliferation and proapoptotic gene expression during tissue growth. Biol Open 2:822-828, 2013.
10. Liao JM, Cao B, Zhou X and Lu H: New insights into p53 functions through its target microRNAs. J Mol Cell Biol 6:206-213, 2014.
11. Tarasov V, Jung P, Verdoodt B, et al: Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 6:1586-1593, 2007.
12. Chang TC, Wentzel EA, Kent OA, et al: Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 26:745-752, 2007.
13. Raver-Shapira N, Marciano E, Meiri E, et al: Transcriptional activation of miR-34a contributes to p53-mediated apoptosis. Mol Cell 26:731-743, 2007.
14. Bommer GT, Gerin I, Feng Y, et al: p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 17:1298-1307, 2007.
15. Corney DC, Flesken-Nikitin A, Godwin AK, Wang W and Nikitin AY: MicroRNA-34b and microRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesionindependent growth. Cancer Res 67:8433-8438, 2007.
16. He L, He X, Lim LP, et al: A microRNA component of the p53 tumour suppressor network. Nature 447:1130-1134, 2007.
17. Liao JM, Zhou X, Zhang Y and Lu H: miR-1246: a new link of the p53 family with cancer and Down syndrome. Cell Cycle 11:2624-2630, 2012.
18. Zhang Y, Liao JM, Zeng SX and Lu H: p53 downregulates Down syndrome-associated DYRK1A through miR-1246. EMBO Rep 12:811-817, 2011.
19. Li W, Wu YF, Xu RH, Lu H, Hu C and Qian H: miR-1246 releases RTKN2-dependent resistance to UVB-induced apoptosis in HaCaT cells. Mol Cell Biochem 394:299-306, 2014.
20. Chen J, Yao D, Zhao S, et al: MiR-1246 promotes SiHa cervical cancer cell proliferation, invasion, and migration through suppression of its target gene thrombospondin 2. Arch Gynecol Obstet 290:725-732, 2014.
21. Xu LJ, Jiang T, Zhao W, et al: Parallel mRNA and microRNA profiling of HEV71-infected human neuroblastoma cells reveal the up-regulation of miR-1246 in association with DLG3 repression. PLoS One 9:e95272, 2014.
22. Ferlay J, Shin HR, Bray F, Forman D, Mathers C and Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 127:2893-2917, 2010.
23. Huang S and He X: The role of microRNAs in liver cancer progression. Br J Cancer 104:235-240, 2011.
24. Wu N, Liu X, Xu X, et al: MicroRNA-373, a new regulator of protein phosphatase 6, functions as an oncogene in hepatocellular carcinoma. FEBS J 278:2044-2054, 2011.
25. Zhou L, Yang ZX, Song WJ, et al: MicroRNA-21 regulates the migration and invasion of a stem-like population in hepatocellular carcinoma. Int J Oncol 43:661-669, 2013.
26. Zhou J, Lu S, Yang S, et al: MicroRNA-127 post-transcriptionally downregulates Sept7 and suppresses cell growth in hepatocellular carcinoma cells. Cell Physiol Biochem 33:1537-1546, 2 014.
27. Chen C, Ridzon DA, Broomer AJ, et al: Real-time quantification of microRNAs by stem-loop RT-PCR. Nucleic Acids Res 33:e179, 2005.
28. Ma L, Young J, Prabhala H, et al: miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 12:247-256, 2010.
29. Tang H, Yao L, Tao X, et al: miR-9 functions as a tumor suppressor in ovarian serous carcinoma by targeting TLN1. Int J Mol Med 32:381-388, 2013.
30. Dooley AL, Winslow MM, Chiang DY, et al: Nuclear factor I/B is an oncogene in small cell lung cancer. Genes Dev 25:1470-1475, 2 011.
31. Moon HG, Hwang KT, Kim JA, et al: NFIB is a potential target for estrogen receptor-negative breast cancers. Mol Oncol 5:538-544, 2011.